The Regenerative Potential of Facial Nerve Motoneurons following Chronic Axotomy in Rats by Yusu Ni, Diyan Chen, Yi Jiang, Danhong Qiu, Wen Li, Huawei Li

“…The rats were housed in the animal facility of the Eye and ENT Hospital of Shanghai Medical School, Fudan University (Shanghai, China). Expression of Shh (sonic hedgehog) and growth-associated protein 43 (GAP43, a neuronal marker) was detected in bilateral facial nuclei using reverse transcriptase PCR, western blotting analysis, and immunohistochemistry. …”
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Human Neonatal Thymus Mesenchymal Stem Cells Promote Neovascularization and Cardiac Regeneration by Shuyun Wang, Shan Huang, Lianghui Gong, Zhize Yuan, Joshua Wong, Jeffrey Lee, Ming-Sing Si

“…We found that ntMSCs expressed and secreted the proangiogenic and cardiac regenerative morphogen sonic hedgehog (Shh) in vitro more than patient-matched bone-derived MSCs. …”
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Enhancer-driven Shh signaling promotes glia-to-mesenchyme transition during bone repair by Xin Shen, Hang Zhang, Zesheng Song, Yangjiele Dong, Xiao Ge, Shenghao Jin, Songsong Guo, Ping Zhang, Yu Fu, Yuchi Zhu, Na Xiao, Dongmiao Wang, Jie Cheng, Rongyao Xu, Hongbing Jiang

“…Importantly, our data demonstrated that the Sonic hedgehog (Shh) signaling was responsible for the transition process initiation, which was strongly activated by c-Jun/SIRT6/BAF170 complex-driven Shh enhancers. …”
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Shh Signaling from the Injured Lung Microenvironment Drives BMSCs Differentiation into Alveolar Type II Cells for Acute Lung Injury Treatment in Mice by Mengyu Wu, Jing Liu, Shu Zhang, Yi Jian, Ling Guo, Huacai Zhang, Junwei Mi, Guoxin Qu, Yaojun Liu, Chu Gao, Qingli Cai, Dalin Wen, Di Liu, Jianhui Sun, Jianxin Jiang, Hong Huang

“…The mechanisms of BMSC differentiation into AT2 cells have not been determined. The Sonic Hedgehog (Shh) pathway is involved in regulating multiple differentiation of MSCs. …”
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Differentiation of Rat Adipose-Derived Stem Cells into Parathyroid-Like Cells by Ping Zhang, Hao Zhang, Wenwu Dong, Zhihong Wang, Yuan Qin, Changhao Wu, Qi Dong

“…The adipose-derived stem cells were stimulated by sonic hedgehog (SHH) and activin A. The differentiation of the adipose-derived stem cells to parathyroid-like cells was confirmed by the detection of parathyroid hormone and the related parathyroid markers. …”
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