Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy by Coraline Radermecker, Pascale Hubert, Patrick Roncarati, Stephanie Demoulin, Charlotte Pilard, Marie Ancion, Celia Reynders, Thomas Lerho, Diane Bruyere, Alizee Lebeau, Margot Meunier, Marie-Julie Nokin, Elodie Hendrick, Olivier Peulen, Philippe Delvenne, Michael Herfs

“…Background High-mobility group box 1 (HMGB1) is a multifunctional redox-sensitive protein involved in various intracellular (eg, chromatin remodeling, transcription, autophagy) and extracellular (inflammation, autoimmunity) processes. …”
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Clinical and ultrasound characteristics in patients with sars-cov-2 pneumonia, associated with hospitalization prognosis. e-covid project by Noemí Fàbrega Ramon, Marta Ortega Bravo, Gerard Torres Cortada, Joaquim Sol Culleré, Mònica Solanes Cabús, Jose María Palacín Peruga

“…Several scientific articles that demonstrated the sensitivity of lung ultrasound, being superior to chest x-ray [Cleverley J et al., BMJ 370, 202013] and comparable to CT scan [Tung-Chen Y et al., Ultrasound Med Biol 46:2918-2926, 2020], promoted the incorporation of this technique in the assessment of COVID-19 patients in PC. …”
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Challenges and opportunities for assessing trends of amphibians with heterogeneous data – a call for better metadata reporting by Klaus Henle, Reinhard A. Klenke, M. Benjamin Barth, Annegret Grimm-Seyfarth, Diana E. Bowler

“…For most other species, some inconsistencies appeared amongst models or approaches, indicating that trend assessments are sensitive to analytical choices. While heterogeneous data have proved useful for other taxa, our results highlight the complexity of using them for amphibians. …”
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Foliar application of 24-epibrassinolide enhances leaf nicotine content under low temperature conditions during the mature stage of flue-cured tobacco by regulating cold stress tol... by Haiyang Chen, Shuaitao Zhang, Jianbo Chang, Hongru Wei, Hongchen Li, Chaoyang Li, Junjie Yang, Zhengxiong Song, Zhaojun Wang, Jin Lun, Xuelin Zhang, Lihua Li, Xiaoquan Zhang

“…Furthermore, these findings may be applicable to other cold-sensitive crops, offering broader benefits for improving resilience and productivity under low temperatures. …”
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Detection of Vibrio harveyi using hemolysin primer in tiger shrimp Penaeus monodon by Irma Suriyani, Ince Ayu Khairana Kadriah, ilmiah Kuruseng

“…ABSTRACT   This study was aimed to analyze the sensitivity and ability of primer hemolysin in detecting pathogenetic Vibrio on tiger shrimp post-larvae (PL) exposed under different exposure times in media inoculated with Vibrio harveyi. …”
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The role of L.M. Karakhan in the Chinese policy of the Soviet Union (1923–1926) by I. N. Sotnikova

“…Karakhan, who was sent as a Soviet emissary to the Republic of China to address these sensitive issues, are of particular interest. The figure of L.M. …”
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Antiplasmodial and Cytotoxic Activities of Extracts of Selected Medicinal Plants Used to Treat Malaria in Embu County, Kenya by Bibianne Waiganjo, Gervason Moriasi, Jared Onyancha, Nelson Elias, Francis Muregi

“…In vitro antiplasmodial activity studies of organic and water extracts were carried out against chloroquine-sensitive (D6) and chloroquine-resistance (W2) strains of Plasmodium falciparum. …”
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Performance evaluation of the high-throughput quantitative Alinity m Epstein-Barr virus assay by D. Yitzchak Goldstein, Mark M. Sasaki, Momka Narlieva, Nhi Nhan, Tianxi Liu, April Kegl, Tanjina Akter, Tanisha Dickerson, Eriel Thornton, Patricia Jim, Stephen Young, Danijela Lucic, Julie W. Hirschhorn

“…Nucleic acid amplification tests (NAATs) with high sensitivity and specificity are available on fully automated high-throughput instruments to provide accurate quantitation and improve test result turn-around time. …”
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Optimization of in vitro propagation and virus eradication using meristem culture and thermotherapy in two geranium species Pelargonium X hortorum (‘Zonal’) and Pelargonium × domes... by Maryam Karimi Alavijeh, Hossein Bayat, Dorsa Kianpour, Siamak Kalantari, Abolkarim zarei

“…The results of this investigation revealed that RT-PCR using universal and specific primers is a reliable sensitive virus detection procedure that coupled with culturing the heat-treated meristem can result in successful viral eradication in Pelargonium species.…”
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Soil carbon-food synergy: sizable contributions of small-scale farmers by Toshichika Iizumi, Nanae Hosokawa, Rota Wagai

“…The estimated SOC increase was converted into global decadal mean temperature change using the temperature sensitivity to cumulative total anthropogenic CO2 emissions from preindustrial levels. …”
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Association between the composite dietary antioxidant index and non-alcoholic fatty liver disease: evidence from National Health and Nutrition Examination Survey 2005–2016 by Yidian Fu, Yidian Fu, Chao Jiang, Zonglin Li, Xiangyun Shi, Peiyuan Lv, Peiyuan Lv, Jingbo Zhang

“…The interaction tests revealed significant differences in these subgroups (P for interaction = 0.04 for BMI and 0.003 for metabolic syndrome). Sensitivity analyses confirmed this association using the hepatic steatosis index (HSI) to define NAFLD, applying unweighted logistic regression, adjusting for physical activity or after excluding non-Hispanic Black participants, and after excluding medications known for their potential hepatotoxic effects.Conclusions and relevanceIn this cross-sectional study based on six cycles (2005–2016) of the NHANES, CDAI was negatively associated with NAFLD in US adult population. …”
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Development of SacB-based counterselection for efficient allelic exchange in Fusobacterium nucleatum by Peng Zhou, Bibek G C, Bo Hu, Chenggang Wu

“…We demonstrated that F. nucleatum cells expressing sacB in either a shuttle or suicide plasmid exhibit a lethal sensitivity to supplemental sucrose. Utilizing sucrose counterselection, we created an in-frame deletion of the F. nucleatum tonB gene, a critical gene for energy-dependent transport processes in Gram-negative bacteria, and a precise knock-in of the luciferase gene immediately following the stop codon of the hslO gene, the last gene of a five-gene operon possibly related to the natural competence of F. nucleatum. …”
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Community-based HPV self-collection versus visual inspection with acetic acid in Uganda: a cost-effectiveness analysis of the ASPIRE trial by Joel Singer, Angeli Rawat, Heather Armstrong, Josaphat Byamugisha, Gina S Ogilvie, Alex K Mezei, Heather N Pedersen, Stephen Sy, Catherine Regan, Sheona M Mitchell-Foster, Musa Sekikubo, Jane J Kim, Nicole G Campos

“…Findings were robust across sensitivity analyses, unless HPV costs were more than quadrupled.Conclusions Community-based self-collected HPV testing followed by treatment for HPV-positive women has the potential to be an effective and cost-effective screening strategy.…”
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Corneal protective effects of a new ophthalmic formulation based on vitamin B12 and sodium hyaluronate by Francesca Lazzara, Federica Conti, Grazia Maugeri, Velia D’Agata, Velia D’Agata, Ludovica Sotera, Claudio Bucolo, Claudio Bucolo

“…For instance, the corneal epithelium is sensitive to oxidative stress caused by reactive oxygen species (ROS) or by ultraviolet B (UVB) radiation. …”
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Nursing professionalism and associated factors in Ethiopia: a systematic review and meta-analysis by Moges Tadesse Abebe, Agerie Mengistie Zeleke, Yeshiwas Ayale Ferede, Yosef Aragaw Gonete, Worku Chekol Tassew

“…We also computed a sensitivity analysis and subgroup analysis by sample size and study period. …”
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Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary by Madhu Singh, Linda Mileshkin, Penelope Schofield, Bo Gao, Gary Richardson, Andrew Pattison, Rodney J Hicks, Niko Thio, Mark Warren, Colin Wood, Stephen B Fox, Anna DeFazio, Andrew Fellowes, Christopher Steer, David Bowtell, Nicholas Wilcken, Tharani Sivakumaran, Atara Posner, Dariush Etemadmoghadam, Krista Fisher, Samantha Webb, Christos S Karapetis, Ian M Collins, Narayan Karanth, Owen W J Prall, Richard William Tothill

“…High IR score was the most sensitive predictive feature of ICI response, warranting evaluation in a larger patient series.…”
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Protocol for a systematic review and meta-analysis of the combination of ezetimibe and statins for hyperlipidemia. by Tianfu Yang, Weijuan Li, Weiwei Chen, Donghong Zhu, Yuxi Ren, Xiongfeng Huang

“…Subgroup analysis, sensitivity analysis, and publication bias analysis will be performed to assess consistency and reliability. …”
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Carbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging by Zhang Y, Liu F, Shao C, Huang J, Yan G

“…However, conventional methods are often incompetent to provide intraoperative guidance due to lack specificity and sensitivity. Recently fluorescence-guided surgery for tumors to delineate between cancerous and healthy tissues has attracted widespread attention. …”
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Qualitative application of the diffusion of innovation theory to maternity waiting homes in rural Zambia by Jeanette L. Kaiser, Rachel M. Fiorillo, Taryn Vian, Thandiwe Ngoma, Kayla J. Kuhfeldt, Michelle L. Munro-Kramer, Davidson H. Hamer, Misheck Bwalya, Viviane R. Sakanga, Jody R. Lori, Eden Ahmed Mdluli, Peter C. Rockers, Godfrey Biemba, Nancy A. Scott

“…Women at intervention sites received sensitization about MWHs from a wider range of sources, including traditional leaders. …”
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Analyzing Land Use/Land Cover Changes Using Google Earth Engine and Random Forest Algorithm and Their Implications to the Management of Land Degradation in the Upper Tekeze Basin,... by Alemu Eshetu Fentaw, Assefa Abegaz

“…Landsat surface reflectance images from Landsat Thematic Mapper (TM) (1990, 2000, and 2010) and Landsat 8 Operational land imager (OLI) sensors (2021) were used. Besides, auxiliary data were utilized to improve the classification of LULC classes. …”
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