Clinical Utility of the Trajectory of Serum Bilirubin and International Normalized Ratio Values in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure by Song YQ, Fu XY, Yan SY, Qi RB, Zhou YJ, Liang JW, Zhang JQ, Ye LP, Mao XL, Li SW

“…Ya-qi Song,1,2,* Xin-yu Fu,1,3,* Si-yan Yan,4 Rong-bin Qi,5 Yi-jing Zhou,1 Jia-wei Liang,6 Jin-qiu Zhang,1 Li-ping Ye,1 Xin-li Mao,1 Shao-wei Li1 1Department of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, People’s Republic of China; 2Department of Gastroenterology, Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang, People’s Republic of China; 3Dalian Medical University, Dalian, People’s Republic of China; 4Department of Gastroenterology, Taizhou Hospital of Zhejiang Province, Zhejiang University, Linhai, Zhejiang, People’s Republic of China; 5Department of Respiratory Medicine, TaiZhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, People’s Republic of China; 6Department of Thoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin-li Mao; Shao-wei Li, Department of Gastroenterology, Taizhou Hospital of Zhejiang Province affiliated With Wenzhou Medical University, Linhai, Zhejiang Province, People’s Republic of China, Email maoxl@enzemed.com; li_shaowei81@hotmail.comBackground and Aim: Acute-on-chronic liver failure (ACLF) is a rapidly progressive and highly fatal condition. …”
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Integrating Bulk and Single-Cell Transcriptomic Data to Identify Ferroptosis-Associated Inflammatory Gene in Alzheimer’s Disease by Zhou H, Peng Y, Huo X, Li B, Liu H, Wang J, Zhang G

“…FuRong Laboratory, Changsha, Hunan, 410078, People’s Republic of China, Email ghzhang@hunnu.edu.cn Jian Wang, The Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, 410006, People’s Republic of China, Email 205106@csu.edu.cnBackground: Ferroptosis is a form of programmed cell death triggered by iron-dependent lipid peroxidation, characterized by iron accumulation and elevated reactive oxygen species (ROS), leading to cell membrane damage. …”
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Systematic Risk Analysis and Mitigation Strategies for Near-Miss Events in Interventional Operating Room Nursing by Ma LY, Shan RF, Lu Y, Cong LY, Gu HY

“…Ling-Yu Ma,1 Rong-Fang Shan,1 Yong Lu,1 Lu-Yi Cong,1 Hai-Yan Gu2 1Department of Operating Room, Affiliated Hospital 2 of Nantong University, Nantong, 226001, People’s Republic of China; 2Department of Nursing, Affiliated Hospital 2 of Nantong University, Nantong, 226001, People’s Republic of ChinaCorrespondence: Hai-Yan Gu, Department of Nursing, Affiliated Hospital 2 of Nantong University, No. 666 Shengli Road, Chongchuan District, Nantong, 226001, People’s Republic of China, Tel +86 13862938568, Email guhaiyan_ghy01@126.comPurpose: The aim of this study is to examine the characteristics of intraoperative nursing near-miss events in interventional operating rooms, systematically identify and analyze associated risks, and propose effective mitigation strategies.Patients and Methods: A retrospective study was conducted using a specially designed survey focused on nursing near-miss events in Interventional operating rooms. …”
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Predictive Value of Urinary KIM-1, TIMP-2 and sTREM-1 for Contrast-Induced Acute Kidney Injury in Elderly Patients After Percutaneous Coronary Intervention by Huang W, Wang R, Zhang P

“…Wu Huang, Rong Wang, Ping Zhang Department of Geriatric Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People’s Republic of ChinaCorrespondence: Rong Wang, Department of Geriatric Medicine, The Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, Hunan, 410011, People’s Republic of China, Tel +86-0731-85295173, Email Wangrong5913@163.comObjective: We aimed to address the predictive value of urinary kidney injury molecule-1 (KIM-1), tissue inhibitor of metalloproteinases-2 (TIMP-2) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for contrast-induced acute kidney injury (CI-AKI) in elderly patients after percutaneous coronary intervention (PCI).Methods: One hundred thirty-six patients who underwent PCI were separated into the CI-AKI group (n = 36) and the non-CI-AKI group (n = 100) based on CI-AKI occurrence after operation, and their general data were collected. …”
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The Joint Association of Sleep Quality and Outdoor Activity with Asthma and Allergic Rhinitis in Children: A Cross-Sectional Study in Shanghai by Lu R, Zhang Y, Chen Y, Lyu J, Li R, Kang W, Zhao A, Ning Z, Hu Y, Lin X, Tong S, Lu Z, Li S

“…Ruoyu Lu,1,* Ye Zhang,1,* Yiting Chen,1 Jiajun Lyu,1 Rong Li,1 Wenhui Kang,1 Anda Zhao,1,2 Zidi Ning,1 Yabin Hu,3 Xiaya Lin,4 Shilu Tong,3 Zhaohui Lu,3 Shenghui Li1,5 1School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Huadong Hospital, Fudan University, Shanghai, People’s Republic of China; 3National Children’s Medical Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 4Hainan Branch, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, Hainan Province, People’s Republic of China; 5MOE-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhaohui Lu, National Children’s Medical Center; Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Road, Pudong District, Shanghai, 200127, People’s Republic of China, Tel +86-18930830796, Email luzhaohui@sjtu.edu.cn Shenghui Li, School of Public Health, Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Huangpu District, Shanghai, 200025, People’s Republic of China, Tel +86-21-63846590, Email lsh9907@163.com; submission9907@163.comPurpose: Aiming to investigate the combined association of sleep quality and outdoor activity with the risk of asthma and allergic rhinitis in children.Patients and Methods: 16,936 children from kindergartens and primary schools in 13 administrative districts of Shanghai, China were involved in the analyses. …”
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Epidemiology, Controversies, and Dilemmas of Perioperative Nutritional Risk/Malnutrition: A Narrative Literature Review by He M, Long Y, Peng R, He P, Luo Y, Zhang Y, Wang W, Yu X, Deng L, Zhu Z

“…Miao He,1– 3 Yuanzhu Long,2 Rong Peng,4 Pinglin He,5 Yue Luo,6 Yan Zhang,6 Weiwei Wang,7 Xiaoqian Yu,8 Lei Deng,1,9 Zhaoqiong Zhu2,3 1Department of Anesthesiology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, People’s Republic of China; 2Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China; 3Suzhou Medical College of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 4Department of Clinical Nutrition, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, People’s Republic of China; 5Department of Urological Surgery, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, People’s Republic of China; 6Nursing School of Zunyi Medical University, Zunyi, Guizhou, People’s Republic of China; 7Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium; 8Department of Painology, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China; 9School of Public Administration, Southwest Minzu University, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Lei Deng, Department of Anesthesiology, Affiliated Hospital of Chengdu University, No. 82, North Second Section 2nd Ring Road, Jinniu District, Chengdu, Sichuan, 610081, People’s Republic of China, Tel +86-13666278563, Email denglei@cdu.edu.cn Zhaoqiong Zhu, Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, 149, Da Lian Road, Zunyi, Hui Chuan District, 563003, People’s Republic of China, Tel +86-13035529980, Email zhuzhaoqiong@zmu.edu.cnAbstract: Current perioperative nutrition management is discouraging due to the under-recognition of clinical nutrition and the lagging development of clinical nutriology. …”
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Small Extracellular Vesicles from Young Healthy Human Plasma Inhibit Cardiac Fibrosis After Myocardial Infarction via miR-664a-3p Targeting SMAD4 by Wang W, Li Y, Zhang C, Zhou H, Li C, Cheng R, Chen X, Pu Y, Chen Y

“…Weiwei Wang,1,* Ying Li,1,* Cheng Zhang,2,* Haoyang Zhou,1 Chunyu Li,3 Rong Cheng,1 Xufeng Chen,1 Yanan Pu,4 Yan Chen1,5,6 1Department of Emergency and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 2Long Jiang Central Laboratory, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of China; 3Long Jiang Intensive Care Unit, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 4Department of Clinical Laboratory, Nanjing Chest Hospital, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, 210029, People’s Republic of China; 5Department of Emergency and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215000, People’s Republic of China; 6Department of Emergency Management, School of Health Policy & Management, Nanjing Medical University, Nanjing, 211166, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Chen; Yanan Pu, Email chenyandoc@njmu.edu.cn; pyn342626@njmu.edu.cnPurpose: Cardiac fibrosis, a key contributor to ventricular pathologic remodeling and heart failure, currently lacks effective therapeutic approaches.Patients and Methods: Small extracellular vesicles from young healthy human plasma (Young-sEVs) were characterized via protein marker, transmission electron microscopy, and nanoparticle tracking analysis, then applied in cellular models and mouse models of cardiac fibrosis. …”
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Molecular Epidemiological Characteristics of blaIMP-4-Carrying Klebsiella pneumoniae ST-11 in Hospitalized Patients by Xue YE, Zhang D, Du S, Chen D, Liu S, Peng T, Li C, Zhang J, Wang X

“…Yu e Xue,1,* Dongmei Zhang,1,* Shuaixian Du,2,* Du Chen,3,* Shihan Liu,2 Tianfeng Peng,4 Chong Li,5 Jianchu Zhang,1 Xiaorong Wang1 1Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 3Department of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China; 4Emergency Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 5Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaorong Wang; Jianchu Zhang, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Number 1277, Jie Fang Rode, Wuhan, Hubei, 430022, People’s Republic of China, Tel + 86-27-85726707, Email rong-100@163.com; zsn0928@163.comPurpose: To investigate the molecular epidemiology and risk factors of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection.Patients and Methods: Patient’s clinical data and CRKP strains were collected from November 2017 to December 2018 at a tertiary hospital in Wuhan, China. …”
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Case report: Novel multi-exon homozygous deletion of ZBTB24 causes immunodeficiency, centromeric instability, and facial anomalies syndrome 2 by Yan Long, Chenghan Wang, Jie Xiao, Yunhua Huang, Xiaoting Ling, Chaoyu Huang, Ying Chen, Jiaqi Luo, Rongheng Tang, Faquan Lin, Yifang Huang

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Whole-Genome Methylation Sequencing Analysis and Functional Verification of LIM-Homeobox Family Genes in Cervical Cancer by Yu R, Yu Q, Shi J, Meng X, Deng Z, Suo J, Yang H

“…Rong Yu,1,* Qin Yu,1,* Jie Shi,2,* Xue Meng,3 Zhiyuan Deng,3 Jing Suo,4 Hao Yang1 1Department of Radiation Oncology, Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia Autonomous Region, 010020, People’s Republic of China; 2Department of Gynecology and Oncology, Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia Autonomous Region, 010020, People’s Republic of China; 3Department of Graduate School, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, 010059, People’s Republic of China; 4Department of Gynecology and Obstetrics, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, 010050, China*These authors contributed equally to this workCorrespondence: Hao Yang, Department of Radiation Oncology, Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, No. 42, Zhao Wu Da Road, Huhhot, Inner Mongolia Autonomous Region, 010020, People’s Republic of China, Tel +86 471-3280801, Email hdgeu98@163.com Jing Suo, Department of Gynecology and Oncology, Affiliated People’s Hospital of Inner Mongolia Medical University, 1 Tongdao North Street, Hohhot, Inner Mongolia Autonomous Region, 010050, People’s Republic of China, Tel +86 471-3451350, Email suojing49@sina.comBackground: Gene methylation in cells is an important factor in tumorigenesis, and radiotherapy can change DNA methylation in cells. …”
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ATF3 Knockdown Exacerbates Astrocyte Activation by Inhibiting Phosphorylation of Drp1 in Ischemic Stroke by Huang R, Huang X, Yang H, Wu H, Liu F, Saw PE, Cao M

“…Rong Huang,1 Xiaoyan Huang,1 Hongmei Yang,1 Haixuan Wu,1 Fan Liu,1 Phei Er Saw,2,3 Minghui Cao1,4 1Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 4Department of Anesthesiology, Shenshan Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Shanwei, 516600, People’s Republic of ChinaCorrespondence: Phei Er Saw; Minghui Cao, Email caipeie@mail.sysu.edu.cn; caomh@mail.sysu.edu.cnIntroduction: ATF3, a stress-induced transcription factor, has been implicated in the injury processes of various cell types, including neurons. …”
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Empathy and Mental Health of Preschool Teachers: A Latent Profile Analysis by Jin R, Li X, Huang H

“…Rong Jin, Xiangyu Li, Heqing Huang Faculty of Preschool Education, Capital Normal University, Beijing, People’s Republic of ChinaCorrespondence: : Heqing Huang, Faculty of Preschool Education, Capital Normal University, No. 5, North Third Street, Fucheng Road, Haidian District, Beijing, People’s Republic of China, Tel +86 13520262816, Email aivita@126.comPurpose: This research, grounded in the self-other oriented empathy theoretical framework, aimed to explore the classification of empathy and its relationship with mental health among preschool teachers.Methods: A total of 4345 preschool teachers participated in the study. …”
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