Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics by Angelica Frusteri Chiacchiera, Michela Casanova, Massimo Bellato, Aurora Piazza, Roberta Migliavacca, Gregory Batt, Paolo Magni, Lorenzo Pasotti

“…However, the emergence of target sequence mutations triggered by Cas-cleavage was identified as an escape strategy, posing the risk of generating new antibiotic-resistance gene (ARG) variants. Here, we evaluated an antibiotic re-sensitization strategy based on CRISPR interference (CRISPRi), which inhibits gene expression without damaging target DNA. …”
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TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma by Sheng Cheng, Jutang Li, Ming Xu, Qun Bao, Jiaoxiang Wu, Peng Sun, Bo Han

“…The functions of the TMEM147-related differentially expressed genes (DEGs) were identified by Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses and gene set enrichment analysis (GSEA). …”
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Promising genetic sources for the creation of varieties of durum spring wheat in Western Siberia by M. G. Evdokimov, V. S. Yusov, M. N. Kiryakova, L. V. Meshkova, I. V. Pakhotina, D. A. Glushakov

“…The study, expansion and preservation of the genetic diversity of the source material, and its purposeful use in hybridization is the basis for the creation of adaptive varieties of durum spring wheat that are resistant to biotic and abiotic factors of the environment of Western Siberia. …”
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CRISPR/Cas9-Mediated Editing of a <i>NODULATION SIGNALING PATHWAY 1</i> Homolog Alters the Production of Strigolactones in Sunflower Roots by Maria A. Lebedeva, Maria S. Gancheva, Maksim R. Losev, Sofia V. Sokornova, Oleg S. Yuzikhin, Anna A. Krutikova, Kirill V. Plemyashov, Lyudmila A. Lutova

“…However, the selection of new resistant sunflower varieties was accompanied by the emergence of new virulent races of broomrape, which overcame the effect of resistance genes. …”
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Modern trends in breeding and genetic improvement of sunflower varieties and hybrids at VNIIMK by V. M. Lukomets, M. V. Trunovа, Ya. N. Demurin

“…The breeding use of germplasm with genes for herbicide resistance wasaccompanied by their extensive genetic study. …”
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Whole genome studies of origin, selection and adaptation of the Russian cattle breeds by N. S. Yudin, D. M. Larkin

“…Our review presents several recent studies on the genetic history and signatures of selection in genomes of the native Russian cattle breeds. …”
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Runaway Train: A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas by Børre Fevang, Unn Merete Fagerli, Hanne Sorte, Harald Aarset, Håkon Hov, Marit Langmyr, Thomas Morten Keil, Ellen Bjørge, Pål Aukrust, Asbjørg Stray-Pedersen, Tobias Gedde-Dahl

“…Here, we present the case of a young man who had increasingly aggressive lymphoproliferative skin lesions from 2 years of age which developed into multiple EBV+ B-cell lymphomas, where a hypomorphic mutation in the Artemis gene was found in a diagnostic race against time using whole exome sequencing. …”
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Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients by C Wheeler, C Masimirembwa, B Mthembu, J Botha, J Scholefield, J Fabian

“…Pharmacogenetic research, although not representative of SA population groups, suggests that single-nucleotide polymorphisms within the cytochrome P450 3A5 (CYP3A5) gene contribute to the variability in tacrolimus dosing requirements. …”
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The Genetic Structure of Wild Orobanche cumana Wallr. (Orobanchaceae) Populations in Eastern Bulgaria Reflects Introgressions from Weedy Populations by Rocío Pineda-Martos, Antonio J. Pujadas-Salvà, José M. Fernández-Martínez, Kiril Stoyanov, Leonardo Velasco, Begoña Pérez-Vich

“…The occurrence of bidirectional gene flow may have an impact on wild populations, as new physiological races continuously emerge in weedy populations. …”
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Seedling and adult plant resistance to leaf rust in some Bulgarian common wheat lines by V. Ivanova

“…Their response partially coincided with the reaction of 5 isogenic lines, and the presence of some of these genes in the above lines is quite possible. Lines carrying this type of resistance are to be subjected to further genetic and breeding investigations to prove the presence of a race-specific gene. …”
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Complex System Analysis of Blumeria graminis f.sp. tritici Isolates Collected in Central Hebei Province, China by Qingping Zhou, Lingli Li, Long Wang

“…Race 077 is the second dominant race. (2) The frequency of virulence genes VEra, V8, V1, V3c, and V3f in population toxicity frequency analysis was more than 70%, while the frequency of virulence genes V2, MID, V20, V21, V4b, and V4 was less than 16.7%, and 46% of virulence genes of powdery mildew were higher than 40%. …”
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The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review by Xue Zhao, Qing Han, Yujia Liu, Chenglin Sun, Xiaokun Gang, Guixia Wang

“…Factors influencing BCAA level can be divided into four parts: race, gender, dietary patterns, and gene variants. …”
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Field apple scab susceptibility of a diverse Malus germplasm collection identifies potential sources of resistance for apple breeding by David Papp, Liqiang Gao, Ranjita Thapa, Dan Olmstead, Awais Khan

“…We also screened a differential host set for 2 years to monitor for changes in the effectiveness of ten known scab resistance genes, which allowed us to confirm the presence of virulent pathogen races in the orchard. …”
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The role of epigenetics in plant pathogens interactions under the changing environments: A systematic review by Wenhao Wu, Guoqiang Fan

“…DNA methylation influences plant immunity by modulating gene expression and chromatin accessibility, while histone modifications, such as acetylation and methylation, enable plants to establish robust defenses by fine-tuning stress-responsive genes. …”
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Адам и Ева как прообраз Нового Адама и Новой Евы (по учению святителя Иринея Лионского, Тертуллиана и святителя Викторина Петавийского). К вопросу о теории рекапитуляции в раннехри... by Nikolay A. Khandoga

“…The saint of Poetovio taught, first, that on that day (that is on friday), on which Adam was born, the incarnate Son of God was born; secondly, on that day (that is on saturday), on which Adam and Eve violated the only commandment of God (see: Gen. 2, 16-17), the Annunciation of the Blessed Virgin Mary took place and the Lord Jesus Christ suffered; and, thirdly, on that day (that is on the resurrection), on which God the Father and the Son of God created light, the conception of the Blessed Virgin Mary took place, the incarnate Son of God rose from the dead and the second time He will come to earth to judge all human genus. …”
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Epigenome-wide association study of perceived discrimination in the Multi-Ethnic Study of Atherosclerosis (MESA) by Wei Zhao, Lisha Lin, Kristen M. Kelly, Lauren A. Opsasnick, Belinda L. Needham, Yongmei Liu, Srijan Sen, Jennifer A. Smith

“…DNA methylation (DNAm) may be a potential mechanism by which stressors get embedded into the human body at the molecular level and subsequently affect health outcomes. …”
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Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies by Gerald Mboowa, Ivan Sserwadda, Marion Amujal, Norah Namatovu

“…Human populations are constantly locked in evolutionary arms races with pathogens; therefore, identification of common infectious disease-associated genomic variants/markers is important in therapeutic, vaccine development, and screening susceptible individuals in a population. …”
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Chromosomes and speciation in tuco-tuco (Ctenomys, Hystricognathi, Rodentia) by A. A. Torgasheva, E. A. Basheva, M. J. Gomez Fernandez, P. Mirol, P. M. Borodin

“…These changes can modulate the flow of genes between chromosomal races and amplify the divergence which has arisen due to spatial isolation. …”
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Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results Database by Hai Yu, Shuping Xie, Xinkai Zheng, Qiqi Zhao, Xichun Xia, Wai-Kit Ming, Leong Nga Cheng, Xi Duan, WenHsien Ethan Huang, Fang Huang, Jun Lyu, Liehua Deng

“…This study identified 3874 patients with KTSCC from the Surveillance, Epidemiology, and End Results (SEER) database, and these patients were randomly divided into the training (70%, (n = 2711) and validation (30%, n = 1163) cohorts. …”
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Physical behaviours during pregnancy may alter the association of maternal insulin sensitivity with neonatal adiposity: a prospective pre-birth cohort of mother-child pairs by Piraveena Satkunanathan, Catherine Allard, Myriam Doyon, Patrice Perron, Luigi Bouchard, Marie-France Hivert, Tricia M. Peters

“…Methods Pregnant women (n = 812) from the Gen3G cohort were recruited during the first trimester of pregnancy and followed until delivery. …”
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