Targeting Trichloroethylene-Induced Renal Endothelial Cell Injuries: A Role of Poly I:C in Amplification of HMGB1 Acetylation by Feng Wang, Yiting Hong, Jihong Gao, Ruixuan Cheng, Muyue Chen, Dandan Zang, Jiaxiang Zhang, Qixing Zhu

“…Although our previous research has demonstrated that poly I:C exacerbates TCE-caused hepatitis in mice, the crucial role of poly I:C in THS renal injury remains largely unknown. …”
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Integrated bioinformatics and experimental analysis of mitochondrial-associated membrane function and mechanism in acute respiratory distress syndrome​​ by Yanqiong Zhou, Qiuying Chen, Xiaoxia Wang, Kaimin Lv, Hui Huang, Jifeng Feng, Bijun Luo

“…Experimental validation confirmed that Poly I: C-induced ARDS mice exhibited severe lung injury and increased inflammatory reaction, while Poly I: C-treated MLE-12 cells showed increased cytotoxicity and LDH release. …”
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Molecular characterization and expression analysis of hypoxia inducible factor-1α during hypoxic stress in speckled blue grouper (Epinephelus cyanopodus) by Along Gao, Qiaoyi Chen, Yukun Huang, Zhiya Yu, Wenjie He, Jinhui Wu, Jinxiong Huang, Tiangaung Cai, Hu Shu

“…Meanwhile, EcHIF-1α was significantly induced by Vibrio harveyi, LPS and Poly (I:C) in the head kidney and liver, indicating that EcHIF-1α was involved in the immune response. …”
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Identification and characterization of GLDC as host susceptibility gene to severe influenza by Jie Zhou, Dong Wang, Bosco Ho‐Yin Wong, Cun Li, Vincent Kwok‐Man Poon, Lei Wen, Xiaoyu Zhao, Man Chun Chiu, Xiaojuan Liu, Ziwei Ye, Shuofeng Yuan, Kong‐Hung Sze, Jasper Fuk‐Woo Chan, Hin Chu, Kelvin Kai‐Wang To, Kwok Yung Yuen

“…We demonstrated that GLDC inhibitor AOAA and siRNA depletion boosted IFNβ‐ and IFN‐stimulated genes (ISGs) in combination with PolyI:C stimulation. GLDC inhibition and depletion significantly amplified antiviral response of type I IFNs and ISGs upon viral infection and suppressed the replication of H1N1 and H7N9 viruses. …”
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A versatile silica nanoparticle platform for induction of T cell responses – applied for therapeutic vaccination against HPV16 E6/E7-positive tumors in MHC-humanized mice by Sebastian Kruse, Lia T. Fricke, Samantha Zottnick, Ann-Katrin Schlosser, Agnieszka K. Grabowska, Eva Feidt, Philipp Uhl, Ellen Junglas, Jonas D. Förster, Josephine Blersch, Philip Denner, Manina Günter, Stella E. Autenrieth, Eugenio Fava, Walter Mier, Armin Kübelbeck, Angelika B. Riemer

“…Furthermore, treatment with SiNPs, especially when combined with the adjuvant poly(I:C), resulted in activation of dendritic cells capable of priming CD8+ T cells. …”
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