Long-Term Real-World Outcomes of Tenofovir Alafenamide in Chronic Hepatitis B: Detailed Analysis of Treatment-Naive and Experienced Patients by Yu-Xuan Song, Guang-Jun Song, Hui Ma, Bo Feng, Yan-Di Xie

“…Methods: Patients who were candidates for TAF treatment and were followed up at 12-week intervals over 192 weeks were enrolled in this study. Results: One hundred and forty-four patients (50 treatment-naive and 94 treatment-experienced) were included in this study. …”
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Characterization and Detection Strategy Exploration in Cryptogenic Hepatocellular Carcinoma: Insights From a Super‐Aged Region in Japan by Takaaki Sugihara, Takakazu Nagahara, Takuya Kihara, Suguru Ikeda, Yoshiki Hoshino, Yukako Matsuki, Takuki Sakaguchi, Hiroki Kurumi, Takumi Onoyama, Tomoaki Takata, Tomomitsu Matono, Hajime Isomoto

“…Methods A retrospective study was conducted from April 2012 to March 2022, enrolling 372 newly diagnosed hepatocellular carcinoma (HCC) patients. …”
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Patient satisfaction with radio-frequency identification (RFID) tag localization compared with wire localization for nonpalpable breast lesions: the RFID trial by Raphaël Pete, Céleste Pinard, Fanny Sirodot, Ioana Molnar, Margot Dressaire, Angeline Ginzac, Catherine Abrial, Xavier Durando, Marielle Tekath

“…Results Eighty patients were sequentially enrolled in two groups: the wire group (n = 40) and the RFID group (n = 40). …”
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Efficacy of Early Endoscopic Ultrasound-Guided Transluminal Drainage for Postoperative Pancreatic Fistula by Nao Fujimori, Takashi Osoegawa, Akira Aso, Soichi Itaba, Yosuke Minoda, Masatoshi Murakami, Kazuhide Matsumoto, Katsuhito Teramatsu, Yu Takamatsu, Takehiro Takaoka, Takamasa Oono, Eikichi Ihara, Tomoharu Yoshizumi, Takao Ohtsuka, Masafumi Nakamura, Yoshihiro Ogawa

“…Thirty patients (median age, 64.5 years) were enrolled. The most common initial operation was distal pancreatectomy with splenectomy (60.0%). …”
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sST2 as a New Biomarker of Chronic Kidney Disease-Induced Cardiac Remodeling: Impact on Risk Prediction by Maëlle Plawecki, Marion Morena, Nils Kuster, Leila Chenine, Hélène Leray-Moragues, Bernard Jover, Pierre Fesler, Manuela Lotierzo, Anne-Marie Dupuy, Kada Klouche, Jean-Paul Cristol

“…A retrospective study was carried out on 218 CKD patients enrolled from 2004 to 2015 at Montpellier University Hospital. sST2 was measured by ELISA (Presage ST2® kit). …”
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Comparative Study on the Efficacy and Safety of Tumor Resection in Vitrectomy for Retinal Vasoproliferative Tumors by Bin Zheng, Yan Chen, Lifeng Chen, Huan Chen, Jingwei Zheng, Feng Chen, Zongming Song, Lin Fu, Xuting Hu, Jiandong Pan, Hengli Lian, Lijun Shen, Qiuming Li

“…Altogether, 16 patients with 17 eyes were enrolled with follow-up of no less than 6 months. Eight eyes were in the resection treatment group (Group R) and 9 eyes were in the conservative treatment group (Group C). …”
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Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design. by Rachel S Gross, Tanayott Thaweethai, Erika B Rosenzweig, James Chan, Lori B Chibnik, Mine S Cicek, Amy J Elliott, Valerie J Flaherman, Andrea S Foulkes, Margot Gage Witvliet, Richard Gallagher, Maria Laura Gennaro, Terry L Jernigan, Elizabeth W Karlson, Stuart D Katz, Patricia A Kinser, Lawrence C Kleinman, Michelle F Lamendola-Essel, Joshua D Milner, Sindhu Mohandas, Praveen C Mudumbi, Jane W Newburger, Kyung E Rhee, Amy L Salisbury, Jessica N Snowden, Cheryl R Stein, Melissa S Stockwell, Kelan G Tantisira, Moriah E Thomason, Dongngan T Truong, David Warburton, John C Wood, Shifa Ahmed, Almary Akerlundh, Akram N Alshawabkeh, Brett R Anderson, Judy L Aschner, Andrew M Atz, Robin L Aupperle, Fiona C Baker, Venkataraman Balaraman, Dithi Banerjee, Deanna M Barch, Arielle Baskin-Sommers, Sultana Bhuiyan, Marie-Abele C Bind, Amanda L Bogie, Tamara Bradford, Natalie C Buchbinder, Elliott Bueler, Hülya Bükülmez, B J Casey, Linda Chang, Maryanne Chrisant, Duncan B Clark, Rebecca G Clifton, Katharine N Clouser, Lesley Cottrell, Kelly Cowan, Viren D'Sa, Mirella Dapretto, Soham Dasgupta, Walter Dehority, Audrey Dionne, Kirsten B Dummer, Matthew D Elias, Shari Esquenazi-Karonika, Danielle N Evans, E Vincent S Faustino, Alexander G Fiks, Daniel Forsha, John J Foxe, Naomi P Friedman, Greta Fry, Sunanda Gaur, Dylan G Gee, Kevin M Gray, Stephanie Handler, Ashraf S Harahsheh, Keren Hasbani, Andrew C Heath, Camden Hebson, Mary M Heitzeg, Christina M Hester, Sophia Hill, Laura Hobart-Porter, Travis K F Hong, Carol R Horowitz, Daniel S Hsia, Matthew Huentelman, Kathy D Hummel, Katherine Irby, Joanna Jacobus, Vanessa L Jacoby, Pei-Ni Jone, David C Kaelber, Tyler J Kasmarcak, Matthew J Kluko, Jessica S Kosut, Angela R Laird, Jeremy Landeo-Gutierrez, Sean M Lang, Christine L Larson, Peter Paul C Lim, Krista M Lisdahl, Brian W McCrindle, Russell J McCulloh, Kimberly McHugh, Alan L Mendelsohn, Torri D Metz, Julie Miller, Elizabeth C Mitchell, Lerraughn M Morgan, Eva M Müller-Oehring, Erica R Nahin, Michael C Neale, Manette Ness-Cochinwala, Sheila M Nolan, Carlos R Oliveira, Onyekachukwu Osakwe, Matthew E Oster, R Mark Payne, Michael A Portman, Hengameh Raissy, Isabelle G Randall, Suchitra Rao, Harrison T Reeder, Johana M Rosas, Mark W Russell, Arash A Sabati, Yamuna Sanil, Alice I Sato, Michael S Schechter, Rangaraj Selvarangan, S Kristen Sexson Tejtel, Divya Shakti, Kavita Sharma, Lindsay M Squeglia, Shubika Srivastava, Michelle D Stevenson, Jacqueline Szmuszkovicz, Maria M Talavera-Barber, Ronald J Teufel, Deepika Thacker, Felicia Trachtenberg, Mmekom M Udosen, Megan R Warner, Sara E Watson, Alan Werzberger, Jordan C Weyer, Marion J Wood, H Shonna Yin, William T Zempsky, Emily Zimmerman, Benard P Dreyer, RECOVER-Pediatric Consortium

“…The de novo cohort incorporates three tiers of data collection: 1) remote baseline assessments (Tier 1, n = 6000); 2) longitudinal follow-up for up to 4 years (Tier 2, n = 6000); and 3) a subset of participants, primarily the most severely affected by PASC, who will undergo deep phenotyping to explore PASC pathophysiology (Tier 3, n = 600). Youth enrolled in the ABCD study participate in Tier 1. The pediatric protocol was developed as a collaborative partnership of investigators, patients, researchers, clinicians, community partners, and federal partners, intentionally promoting inclusivity and diversity. …”
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Prognostic utility of neutrophil gelatinase-associated lipocalin (NGAL) levels for cardiovascular events in patients with stable coronary artery disease treated with percutaneous c... by Ting-Yu Lin, Hsin-Bang Leu, Yen-Wen Wu, Wei-Kung Tseng, Tsung-Hsien Lin, Hung-I Yeh, Kuan-Cheng Chang, Ji-Hung Wang, Wei-Hsian Yin, Chau-Chung Wu, Chun-Yao Huang, Shing-Jong Lin, Chien-Yi Hsu, Jaw-Wen Chen

“…Methods A total of 2,238 stable patients with CAD and a previous PCI were enrolled in a multicenter prospective observational study (The National Taiwan Biosignature Research, NTBR) in Taiwan. …”
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Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus by Haoyi Yang, Yuwen Zhang, Yuxin Hong, Yuan Wei, Yuning Zhu, Lei Huang, Yuanxun Yang, Runbin Sun, Runbin Sun, Runbin Sun, Juan Li, Juan Li, Juan Li

“…However, the effects of SY-009 on human plasma metabolomics are still unknown.ObjectiveThis study aimed to explore the effects of SY-009 on plasma metabolomics in patients with T2DM and the potential metabolic regulatory mechanism involved.Study designIn the phase Ib study, a total of 50 participants with T2DM were enrolled and randomly assigned to the 0.5 mg BID, 1 mg BID, 2 mg BID, 1 mg QD, and 2 mg QD dose groups, with a 4:1 random allocation within each group to receive either the SY-009 capsule or placebo. …”
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The effects of growth hormone on the outcomes of in vitro fertilization and embryo transfer in age-grouped patients with decreased ovarian reserve: a prospective cohort study by Jiexiu Chen, Xumei Kong, Zonghui Luan, Yu Qiu, Yu Qiu, Shiqi Chen, Jesse Li−Ling, Yan Gong

“…This study aims to explore the outcome of IVF-ET among differently aged patients with DOR treated with GH.MethodsA total of 846 patients with DOR undergoing IVF-ET from May 2018 to June 2023 at the Reproductive Medicine Center of Sichuan Provincial Women’s and Children’s Hospital were prospectively enrolled. The patients were divided into group A (< 35 year old, n = 399), group B (35 ~ 40 year old, n = 286), and group C (> 40 year old, n = 161). …”
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Estimating the need for diabetic retinopathy services in north India: evidence from a population-based survey in the catchment population of an eye care provider in central Uttar P... by Andrew Bastawrous, Vaibhav Jain, Ian McCormick, Shalinder Sabherwal, Ishaana Sood, Atanu Majumdar, Shamanna B R, Mohd Javed, Sandeep Buttan, Simrat Chandi, Basitali Lakhani, Shreya Tyagi, Utsav Deep

“…Objective The aim of this study was to assess the prevalence of diabetic retinopathy (DR) and retina screening coverage among people with diabetes in the catchment area of a high-volume eye care organisation in north India.Design A population-based cross-sectional study using Rapid Assessment of Avoidable Blindness survey, including the DR module.Setting A customised rural district in the catchment of Dr Shroff’s Charity Eye Hospital in Uttar Pradesh in north India.Participants 4095 people of age 50 years and above were enrolled using a two-staged cluster sampling, 3867 (94.4%) participated; 2167 (52.9%) were women. 3803 of 4095 (92.9%) participants were assessed for diabetes. …”
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Neural structural alterations correlates of quadriceps muscle strength deficits in patients after anterior cruciate ligament reconstruction by Le Yu, Shanshan Zheng, Yushi Chen, Xiao'ao Xue, Zikun Wang, JiaYan Cheng, Yang Sun, He Wang, Yinghui Hua

“…Methods: Twenty-nine participants who had undergone unilateral ACLR (29 males; age = 32.61 ± 6.72 years) were enrolled in a cross-sectional investigation. We chose CST as a region of interest and performed diffusion tensor imaging (DTI) that measured the microstructure of white matter tracts. …”
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Physical and Sensory Long-Term Disabilities from <i>Bothrops</i> Snakebite Envenomings in Manaus, Western Brazilian Amazon by Eduardo M. G. Fernández, Débora N. Oliveira, Alexandre V. Silva-Neto, Rafaela N. Dávila, Ligia Lengler, Marco A. Sartim, Altair S. Farias, Luiz C. L. Ferreira, Érica da Silva Carvalho, Fan H. Wen, Felipe Murta, Fernando Almeida-Val, Manuela B. Pucca, Jacqueline A. G. Sachett, Wuelton M. Monteiro

“…Fifty participants were enrolled. A frequency of 20% of the participants reported difficulty in moving the affected limb (20%), and 23.7% reported difficulty in walking. …”
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Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma by Li Zhang, Matthew Crocker, Lawrence Fong, Lisa M Coussens, Charles D Lopez, Shamilene Sivagnanam, Meenal Sinha, Brandon Chen, Jaqueline Marquez, Alexander Cheung, Whitney Tamaki, Jacob Stultz, Kendra Todd, Courtney Betts, Madeline J Griffith, Isabelle Solman, Eric Liu, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Margaret Tempero

“…This led to a phase 1b clinical trial to determine the safety, tolerability, and immunologic effects of ibrutinib treatment in patients with advanced PDAC.Methods Previously untreated patients with PDAC were enrolled in a phase 1b clinical trial (ClinicalTrials.gov) to determine the safety, toxicity, and maximal tolerated dose of ibrutinib when administered with the standard regimen of gemcitabine and nab-paclitaxel. …”
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Elevated blood glucose and unfavourable tuberculosis treatment outcomes in a low-income setting: findings from a prospective cohort study in Eswatini by Diederick E Grobbee, Kerstin Klipstein-Grobusch, Kennedy Otwombe, Victor Williams, Alinda G Vos-Seda, Marianne Calnan, Colani S Ngwenya, Samson Haumba, Lindiwe Mdluli-Dlamini

“…We computed the prevalence of elevated blood glucose and used logistic regression to determine the predictors of elevated baseline blood glucose and unfavourable treatment outcomes.Results Of 369 consecutively enrolled patients, the mean age was 38.4 (SD 12.9) years, and 202 (54.7%) were males. …”
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Does high body mass index increase the risk of shoulder instability surgery? The LUXE prospective cohort study on 227 recurrent anterior shoulder instability by Vincent Roy, MD, MSc, Claire Bastard, MD, MSc, Emilie Sandman, MD, MSc, FRCSC, Alexis Rousseau-Saine, MD, FRCSC, Marie-Lyne Nault, MD, PhD, FRCSC, Dominique M. Rouleau, MD, MSc, FRCSC

“…Patient data (demographic, strength, laxity and functional outcomes (Disability of the Arm, Shoulder, and Hand [QuickDASH]; Western Ontario Shoulder Instability Index; and QuickDASH Pain subscore) were compared at enrollment and last postoperative follow-up. Functional outcomes, complications, and postoperative outcomes were compared between the different groups and then subdivided by BMI. …”
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Heatwave warnings mitigate long-term cardiovascular diseases risk from heat-related illness: a real-world prospective cohort studyResearch in context by Qi Huang, Limei Ke, Linfeng Liu, Yuyang Liu, Yanjun Li, Guoqing Feng, Bo Yin, Wenxin Xiang, Jiarun Li, Keyi Lyu, Miao Wang, Qiannan Tian, Liqun Wu, Xiaofeng He, Wannian Liang, Huatang Zeng, Jiming Zhu, Kuiying Gu, Qian Di

“…Methods: Our cohort study enrolled 9,658,745 participants free of cardiovascular disease (CVD) at baseline from 1332 hospitals and 922 primary care centres in Shenzhen, China. …”
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[Translated article] Preoperative instillation of epinephrine and lidocaine can reduce surgical time in the endoscopic treatment of GTPS by R. Seijas Vazquez, F. Montaña I Pararols, A. Ferré-Aniorte, P. Laiz Boada, M. Vázquez Gómez, R. Cugat

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La instilación preoperatoria de epinefrina y lidocaína puede reducir el tiempo quirúrgico del tratamiento endoscópico del SDTM by R. Seijas Vazquez, F. Montaña I Pararols, A. Ferré-Aniorte, P. Laiz Boada, M. Vázquez Gómez, R. Cugat

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Hypothermia during Surgical Treatment of Type A Aortic Dissection: A 16 Years’ Experience by Francesco Macrina, Maria Cristina Acconcia, Luigi Tritapepe, Mizar D’abramo, Wael Saade, Alessandra Capelli, Fabio Miraldi

“…Data from 241 patients enrolled between August 2002 and March 2018 were analyzed. …”
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