Association between estimated glucose disposal rate and cardiovascular diseases in patients with diabetes or prediabetes: a cross-sectional study by Jinhao Liao, Linjie Wang, Lian Duan, Fengying Gong, Huijuan Zhu, Hui Pan, Hongbo Yang

“…Methods 10,690 respondents with diabetes and prediabetes from the NHANES 1999–2016 were enrolled in the study. Three machine learning methods (SVM-RFE, XGBoost, and Boruta algorithms) were employed to select the most critical variables. …”
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Seasonal fluctuation of total water intake and hydration status among young men and women: a prospective cohort study by Jianfen Zhang, Jianfen Zhang, Na Zhang, Na Zhang, Junbo Lu, Junbo Lu, Shufang Liu, Yongwei Lin, Guansheng Ma, Guansheng Ma

“…This study investigated seasonal fluctuations of total water intake and hydration status among young adults in Baoding, China.MethodsThis prospective cohort study enrolled 82 young adults aged 18–23 years in Baoding, China. …”
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Echo- and B-Type Natriuretic Peptide-Guided Follow-Up versus Symptom-Guided Follow-Up: Comparison of the Outcome in Ambulatory Heart Failure Patients by Gani Bajraktari, Nicola Riccardo Pugliese, Andreina D’Agostino, Gian Marco Rosa, Pranvera Ibrahimi, Luan Perçuku, Mario Miccoli, Gian Giacomo Galeotti, Iacopo Fabiani, Roberto Pedrinelli, Michael Henein, Frank L. Dini

“…Consecutive outpatients with LV ejection fraction (EF) ≤ 50% have been prospectively enrolled. In Group I (n=224), follow-up was guided by echo and BNP with the goal of achieving E-wave deceleration time (EDT) ≥ 150 ms, tissue Doppler index E/e′ < 13, B-line numbers < 15, and BNP ≤ 125 pg/ml or decrease >30%; in Group II (n=293), follow-up was clinically guided, while the remaining 277 patients (Group III) did not receive any dedicated follow-up. …”
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Presence of liver metastasis correlated with high tumor abundance and indicated adverse prognostic feature in EGFR mutation non-small-cell lung cancer patients by Piyada Sitthideatphaiboon, Pronwasun Simseekeaw, Chinachote Teerapakpinyo, Nicha Zungsontiporn, Wariya Chintanapakdee, Itthi Itthisawatpan, Shanop Shuangshoti, Virote Sriuranpong, Thanisa Tongbai, Chanida Vinayanuwattikun

“…A prospective cohort of 130 patients with advanced EGFR mutation NSCLC were enrolled. Pre-and post-treatment plasma from subjects treated with EGFR-TKIs were obtained. …”
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Evaluation of the feasibility, acceptability, and impact of Group Antenatal Care at the health post level on continuation in antenatal care and facility based delivery in Ethiopia... by Reena Sethi, Rediet Fasil, Walelegn W. Yallew, Della Berhanu, Yenealem Woldemariam, Gayane Yenokyan, Alemayehu Worku, Dedefo Teshite, Konjit Wolde, Anne Hyre, Stephanie Suhowatsky, Lisa Noguchi

“…Qualitative research will be conducted using in-depth interviews with pregnant women, health workers, facility managers, and regional health managers. The study will enroll 770 women across all phases. Conclusions The study will inform decision-makers locally and globally on whether G-ANC is a feasible service delivery model at the health-post level. …”
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Improper lung volume-dose parameters are risk factors for acute fatal radiation pneumonitis among esophageal cancer patients receiving chemoradiotherapy: a case-control study by Ruinuo Jia, Liuyan Li, Xiaoyi Liu, Junqian Zhang, Shuoguo Li, Ziqi Wang, Jingxia Li, Bingyi Xu, Manxi Sheng, Lei Ni, Danni Yang, Shegan Gao, Shegan Gao, Shegan Gao

“…However, acute fatal radiation pneumonitis (AFRP) is one of the most harmful complications and it is still controversial which factors pose a greater risk.AimThis case-control study aims to investigate the relationship between AFRP and lung volume-dose parameters in patients with esophageal cancer undergoing DCRT.MethodsCases are patients who died of AFRP after DCRT, whereas controls are patients who did not develop RP. Participants were enrolled using the International Classification of Diseases Codes Searching and then verified by medical record review. …”
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Prospective analysis of the effects of RAS mutation on local tumor progression and overall survival after radiofrequency ablation for colorectal liver metastases by Ji-Chen Wang, Yu-Hui Liu, Bin-Bin Jiang, Li-Jin Shao, Song Wang, Wei Yang, Wei Wu, Kun Yan, Zhong-Yi Zhang

“…Objectives To investigate the effects of RAS mutation on local tumor progression (LTP) and overall survival (OS) after radiofrequency ablation (RFA) for colorectal liver metastases (CRLMs).Methods This prospective study consecutively enrolled patients with CRLM who underwent ultrasound-guided RFA between June 2020 and July 2022. …”
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Early risk assessment in paediatric and adult household contacts of confirmed tuberculosis cases by novel diagnostic tests (ERASE-TB): protocol for a prospective, non-interventiona... by Ursula Panzner, Katharina Kranzer, Tsitsi Bandason, Kuda Mutasa, Sandra Rukobo, Charles Sandy, Bariki Mtafya, Andrea Rachow, Norbert Heinrich, Michael Hoelscher, Judith Bruchfeld, Olena Ivanova, Nyanda Elias Ntinginya, Doreen Pamba, Laura Olbrich, Issa Sabi, Simeon Mwanyonga, Elmar Saathoff, Willyhelmina Olomi, Junior Mutsvangwa, Hazel M Dockrell, Edson Tawanda Marambire, Denise Banze, Alfred Mfinanga, Theodora D Mbunda, Khosa Celso, Gunilla Kallenius, Claire J Calderwood, Christof Geldmacher, Kathrin Held, Tejaswi Appalarowthu, Friedrich Rieß, Anna Shepherd, Christopher Sundling, Mishelle Mugava, Martha Chipinduro, Lwitiho Sudi, Antelmo Haule, Emmanuel Sichone, Paschal Qwaray, Harrieth Mwambola, Lilian Minja, Peter Edwin, Dogo Ngalison, Stella Luswema, Celina Nhamuave, António Machiana, Carla Madeira, Emelva Manhiça, Nádia Sitoe, Jorge Ribeiro

“…Study outcomes will be coprevalent TB (diagnosed at enrolment), incident TB (diagnosed during follow-up) or no TB at completion of follow-up. …”
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Young, Empowered & strong (YES): a study protocol paper for a randomized controlled trial of an mHealth symptom monitoring and self-management intervention for adolescent and young... by Kate E Dibble, Shoshana M Rosenberg, Craig Snow, Gregory J Kirkner, Nabihah Tayob, Magnolia Contreras, Noel D Roma, Cecilia R DeGraffinreid, Timiya S Nolan, Dawn L Hershman, Michelle Naughton, Ann H Partridge

“…All participants complete REDCap surveys at baseline, and at 3, 6, and 9 months post-enrollment. The primary outcome is quality of life as measured by the Quality of Life in Adult Cancer Survivors Scale (QLACS), with changes from baseline to 6-months in QLACS scores, compared by arm. …”
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Correlation between immune signature and high‐density lipoprotein cholesterol level in stage II/III colorectal cancer by Yun Wang, Xiao‐qiang Sun, Hao‐cheng Lin, De‐shen Wang, Zhi‐qiang Wang, Qiong Shao, Feng‐hua Wang, Shu‐mei Yan, Jie‐ying Liang, Zhao‐lei Zeng, Huai‐qiang Ju, Rui‐hua Xu, Yu‐hong Li

“…A total of 667 CRC patients were enrolled and divided into two groups based on the lower limit of normal HDL‐C values (0.78 mmol/L). …”
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Hearing Phenotypes of Patients with Hearing Loss Homozygous for the GJB2 c.235delc Mutation by Chang Guo, Sha-Sha Huang, Yong-Yi Yuan, Ying Zhou, Ning Wang, Dong-Yang Kang, Su-Yan Yang, Xin Zhang, Xue Gao, Pu Dai

“…A total of 244 patients with the GJB2 c.235delC homozygous mutation encountered from 2007 to 2015 were enrolled. The severity of hearing loss was scaled with the American Speech-Language-Hearing Association (ASHA). …”
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Glucagon: a potential protective factor against peripheral nerve compromise in patients with type 2 diabetes and obesity by Hao Hua, Rui Wang, Yu-xian Xu, Feng Xu, Chun-hua Wang, Li-hua Zhao, Li-hua Wang, Cheng-wei Duan, Jian-bin Su

“…Methods We consecutively enrolled 174 individuals with T2D and obesity (T2D/OB, BMI ≥ 28 kg/m2), and 480 individuals with T2D and nonobesity (T2D/non-OB, BMI < 28 kg/m2), all of whom underwent oral glucose tolerance tests to determine the area under the curve for glucagon (AUCgla). …”
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A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model by Mitsuru Sugimoto, Tadayuki Takagi, Tomohiro Suzuki, Hiroshi Shimizu, Goro Shibukawa, Yuki Nakajima, Yutaro Takeda, Yuki Noguchi, Reiko Kobayashi, Hidemichi Imamura, Hiroyuki Asama, Naoki Konno, Yuichi Waragai, Hidenobu Akatsuka, Rei Suzuki, Takuto Hikichi, Hiromasa Ohira

“…Methods: This multicenter study enrolled 2074 patients who underwent ERCP. Among them, 1037 patients each were randomly assigned to the development and validation cohorts. …”
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Insights from serial cardiovascular magnetic resonance imaging show early progress in diastolic dysfunction relates to impaired right ventricular deformation by Sören J. Backhaus, Alexander Schulz, Torben Lange, Simon F. Rösel, Lennart S. Schmidt-Schweda, Shelby Kutty, Johannes T. Kowallick, Julia Treiber, Andreas Rolf, Samuel Sossalla, Gerd Hasenuß, Andreas Schuster

“…Patients presenting with exertional dyspnoea and signs of diastolic dysfunction (E/e’>8, left ventricular (LV) ejection fraction > 50%) were prospectively enrolled in the HFpEF Stress Trial (NCT03260621). Rest and exercise-stress echocardiography, CMR and right heart catheterisation were performed at baseline. …”
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Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography by Zhubin Lun, Jin Liu, Liwei Liu, Jingjing Liang, Guanzhong Chen, Shiqun Chen, Bo Wang, Qiang Li, Haozhang Huang, Zhidong Huang, Danyuan Xu, Yunzhao Hu, Ning Tan, Jiyan Chen, Yong Liu, Jianfeng Ye

“…Methods. We retrospectively enrolled 3206 patients with preoperative serum creatinine (Scr) and at least twice SCr measurement after CAG. …”
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Concomitant exposure to benzodiazepines during pembrolizumab-based therapy for advanced non-small-cell lung cancer: a propensity-score matched analysis of monitoring agency data by Fabrizio Nelli, Enzo Maria Ruggeri, Antonella Virtuoso, Diana Giannarelli, Armando Raso, Federica Natoni, Gloria Pessina, Daniele Remotti, Mario Giovanni Chilelli, Carlo Signorelli, Agnese Fabbri

“…Results: During the time frame from April 2018 to May 2023, we enrolled 258 patients, 156 (60.5%) and 102 (39.5%) of whom received pembrolizumab alone or the combination regimen, respectively. …”
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Association between sleep duration and hypertension in southwest China: a population-based cross-sectional study by Yu Guo, Liming Li, Zhengming Chen, Qiang Sun, Pei Pei, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Guojin Luo, John S Ji, Xiaoyu Chang, Xiaofang Chen*

“…We examined the association between sleep duration and hypertension in southwest China.Design Population-based cross-sectional study.Setting This study was part of the baseline survey of a large ongoing prospective cohort study, the China Kadoorie Biobank. Participants were enrolled in 15 townships of Pengzhou city in Sichuan province during 2004–2008.Participants 55 687 participants aged 30–79 years were included. …”
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Intramedullary Fixation for Metacarpal Fractures: A Multi-Institutional Prospective Outcomes Study by Michael B. Gehring, MD, Brandon Wolfe, BA, Riley Kahan, BS, Stephanie D. Malliaris, MD, Kia M. Washington, MD, Matthew D. Folchert, MD, Kyros Ipaktchi, MD, Mark A. Greyson, MD, Alexander Lauder, MD, Matthew L. Iorio, MD

“…Methods: A prospective multicenter trial enrolled consecutive patients with closed, extra-articular metacarpal fractures treated with IMF. …”
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Durvalumab and tremelimumab in combination with metronomic oral vinorelbine for recurrent advanced cervical cancer: an open-label phase I/II study by Pernelle Lavaud, Esma Saada-Bouzid, Renaud Sabatier, Olivia Le Saux, Thibault de la Motte Rouge, Anthony Gonçalves, Elodie Coquan, Jean-Sébastien Frenel, Marta Jiménez, Alice Hervieu, Laurent Mathiot, François Legrand, Claire Cropet, Edith Borcoman, Emmanuelle Charafe

“…The primary efficacy endpoint was the clinical benefit rate (CBR) based on the Response Evaluation Criteria in Solid Tumors V.1.1, which was analyzed using a Bayesian approachResults A total of 31 patients were enrolled and treated in the cervical cancer cohort. …”
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Durvalumab, Tremelimumab, and Platinum Chemotherapy in EGFR Mutation–Positive NSCLC: An Open-Label Phase 2 Trial (ILLUMINATE) by Chee Khoon Lee, PhD, Bin-Chi Liao, MD, Shalini Subramaniam, MMed (Clin Epi), Chao-Hua Chiu, MD, Antony J. Mersiades, MMed (Clin Epi), Chao-Chi Ho, MD, PhD, Chris Brown, MBiostats, Chun-Liang Lai, MD, PhD, Brett G.M. Hughes, M.B.B.S. (Hons), Tsung-Ying Yang, MD, PhD, Ken O’Byrne, MD, Yung-Hung Luo, MD, PhD, Sonia Yip, PhD, Ching-Liang Ho, MD, Victoria Bray, PhD, Wu-Chou Su, MD, PhD, Melissa Moore, PhD, Wei-Lien Feng, MS, Ya-Ying Bai, MS, Kate Ford, MHSc, Michelle M. Cummins, PhD, Martin R. Stockler, MSc (Clin Epi), Benjamin J. Solomon, PhD, Thomas John, PhD, James Chih-Hsin Yang, MD, PhD

“…Results: One hundred participants from Australia and Taiwan were enrolled. Median follow-up was 26 months with 88% and 96% experiencing progression events for T790M− and T790M+, respectively. …”
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