Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure by Yan Chen, Xiao-fang Tang, Run-lin Gao, Yue-jin Yang, Bo Xu, Jin-qing Yuan

“…A total of 10,724 consecutive patients who underwent PCI throughout 2013 were prospectively enrolled in the study. Among these, we analyzed 5,631 ACS patients who were discharged with LVEF≥40%. …”
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The mC2HEST Score for Incident Atrial Fibrillation by Yanguang Li, MD, Qiaoyuan Li, MD, Lili Wang, MD, Tao Zhang, MD, Hai Gao, MD, Daniele Pastori, MD, PhD, Zhuo Liang, MD, Gregory Y.H. Lip, MD, Yunlong Wang, MD

“…Methods: Participants from the MESA (Multi-Ethnic Study of Atherosclerosis were enrolled in the present study, which involved population of different ethnicities (Caucasian, African-American, Chinese-American, and Hispanic) aged between 45 and 84 from 6 communities in the United States. …”
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Risk Factors for Incident Myopia among Teenaged Students of the Experimental Class of the Air Force in China by Lin-song Qi, Lu Yao, Xue-feng Wang, Jiu-mei Shi, Yong Liu, Teng-yun Wu, Zhi-kang Zou

“…In May 2015, this 3-year prospective cohort study enrolled 522 boys (age, 14–16 years) attending grade 10 in 16 high schools in 15 cities in China. …”
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Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes by Yu-Yen Chen, Ying-Cheng Shen, Yun-Ju Lai, Chun-Yuan Wang, Keng-Hung Lin, Shih-Chao Feng, Chiao-Ying Liang, Li-Chen Wei, Pesus Chou

“…Using the Taiwan National Health Insurance Research Database from 2001 to 2013, 68205 subjects with type 2 diabetes were enrolled in the study cohort. Among them, 45524 were metformin users and 22681 were nonusers. …”
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Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT) by Ashley E. Mason, Anoushka Chowdhary, Wendy Hartogensis, Chelsea J. Siwik, Osnat Lupesko-Persky, Leena S. Pandya, Stefanie Roberts, Claudine Anglo, Patricia J. Moran, J. Craig Nelson, Christopher A. Lowry, Rhonda P. Patrick, Charles L. Raison, Frederick M. Hecht

“…The n = 12 participants who attended the final assessment visit completed 100% of administered self-report depression assessments; all enrolled participants (n = 16) completed 89% of these assessments. …”
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The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): study protocol for a randomised placebo-controlled mult... by Toby M Maher, A John Simpson, Anthony Cahn, David Thickett, Luke Vale, Allan B Clark, Nazia Chaudhuri, Ian Forrest, Lisa G Spencer, Christopher Ward, Stephen Jones, Ganesh Raghu, Andrew M Wilson, Helen Parfrey, Megan Jones, Matthew Hammond, Jaclyn Ann Smith, Shajahan Wahed

“…We aim to undertake an adequately powered double-blind placebo-controlled randomised multicentre clinical trial to assess the change in forced vital capacity (FVC), cough and other important patient-reported outcomes, following 12-month therapy with PPIs in people with IPF.Methods and analysis A total of 298 patients with IPF diagnosed by a multidisciplinary team according to international guidelines who are not receiving PPIs will be enrolled. Patients are randomised equally to receive two capsules of lansoprazole or two placebo capsules, two times per day for 12 months. …”
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High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study by Liang Zhang, Min Zhang, Ying Cui, Lixin Zhang, Guanrong Zhang, Qingyang Liu, Haike Guo, Qianli Meng, Siwen Zang, Chun-Han Lo, Yanlei Chen, Jin Zeng

“…Objectives To investigate the relationship between serum lipids and pterygium in a large-scale rural population aged 40 years or older from Southern China.Study design The Dongguan Eye Study was a cross-sectional population-based study from September 2011 to February 2012.Setting The area was set in the rural area of Dongguan, Southern China.Participants Adult rural population aged 40 or older.Methods Participants underwent physical, haematological and ophthalmic examinations.Primary and secondary outcome measures The frequency and risk factors of pterygium.Results A total of 11 357 participants were eligible for inclusion and 8952 (78.8%) participants were enrolled for the systemic and ophthalmic examinations. …”
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Identifying strokes in Nigerian children with sickle cell disease as part of clinical trials: training curriculum for healthcare professionals in low-income settings by Djamila L. Ghafuri, Halima Bello-Manga, Fenella J. Kirkham, Mariana Ciobanu, Edwin Trevathan, Edwin Trevathan, Mark Rodeghier, Michael R. DeBaun, Michael R. DeBaun, Lori C. Jordan

“…We describe our health professional stroke training curriculum and specific application to detect strokes in clinical trials in low-resource settings.MethodsChildren aged 5–12 and 2–16 years with SCA in northern Nigeria were enrolled in the SPRING and SPRINT primary and secondary stroke prevention trials, respectively. …”
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Time in Range, as a Novel Metric of Glycemic Control, Is Reversely Associated with Presence of Diabetic Cardiovascular Autonomic Neuropathy Independent of HbA1c in Chinese Type 2 D... by Qingyu Guo, Pu Zang, Shaoying Xu, Wenjing Song, Zhen Zhang, Chunyan Liu, Zhanhong Guo, Jing Chen, Bin Lu, Ping Gu, Jiaqing Shao

“…A total of 349 individuals with T2DM were enrolled in this study. Evaluating by the standard cardiac autonomic reflex tests (CARTs), there were 228 diabetic individuals without cardiovascular autonomic neuropathy (without confirmed CAN) including absent CAN (n=83 cases) and early CAN (n=145 cases) and 121 diabetic individuals complicated with cardiovascular autonomic neuropathy (CAN) including definite CAN (n=109 cases) and severe CAN (n=12 cases). …”
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Pediatric bacterial meningitis in southern China: analysis of 838 cases by Lianfeng Chen, Wen-Lin Wu, Yuanyuan Gao, Xiaojing Li, Sida Yang, Huici Liang, Kelu Zheng, Yani Zhang, Haixia Zhu, Yang Tian, Bingwei Peng, Haisheng Lin, Xiuying Wang, Shuyao Ning, Yinyan Gan, Chi Hou, Yinting Liao, Huiling Sheng, Wen-Xiong Chen, Wen-Xiong Chen

“…ObjectiveThis work aims to study the clinical features and risk factors of children with bacterial meningitis (BM) in southern China.MethodsClinical data of children with BM between 2012 and 2018 from one national center were analyzed retrospectively.ResultsA total of 838 patients (male/female = 1.8:1) were enrolled, with 90.6% under 1 year old. Common symptoms included fever, seizure, lethargy, vomiting, anorexia, poor feeding, and irritability. …”
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Endoscopic retrograde cholangiopancreatography combined with extracorporeal shock wave lithotripsy for the removal of large gallbladder stones: a pilot study by Liang Zhu, Jinli He, Zhenzhen Yang, Xi Huang, Junbo Hong, Xiaojiang Zhou, Youxiang Chen, Guohua Li

“…Methods In total, six patients (aged 23–72 years, 3 males and 3 females, Han ethnicity) who had large gallbladder stones (diameter ≥ 1 cm) complicated with common bile duct (CBD) stones and who underwent ERCP combined with ESWL at the First Affiliated Hospital of Nanchang University from July 2022 to December 2022 were enrolled. The patients’ clinical characteristics, endoscopic treatment and follow-up data were analyzed. …”
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Clinical Findings in Diabetes Mellitus Patients with COVID-19 by Ting Guo, Qinxue Shen, Xiaoli Ouyang, Wei Guo, Jinhua Li, Wenlong He, Bo Yu, Chenfang Wu, Zhiguo Zhou, Hong Luo, Hong Peng

“…A total of 241 patients confirmed with COVID-19 were enrolled, including 19 DM patients. There were more patients in DM group admitted to the ICU than non-DM group (36.8% vs. 15.8%, P=0.045). …”
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Cross-sectional design and protocol for Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI) by Gerald McGwin, Linda M Zangwill, Nicholas Evans, Shannon McWeeney, Cecilia S Lee, Bhavesh Patel, Jeffrey C Edberg, Cynthia Owsley, Aaron Lee, Cecilia Lee, Sally L Baxter, Michael Snyder, Samantha Hurst, Nicole Ehrhardt, Christopher Chute, Dawn S Matthies, Julia P Owen, Amir Bahmani, Sally Baxter, Edward Boyko, Aaron Cohen, Jorge Contreras, Garrison Cottrell, Virginia de Sa, Jeffrey Edberg, Irl Hirsch, Michelle Hribar, T.Y. Alvin Liu, Bonnie Maldenado, Sara Singer, Bradley Voytek, Joseph Yracheta, Linda Zangwill

“…The fundamental rationale for promoting health resilience in T2DM stems from its high prevalence of 10.5% of the world’s adult population and its contribution to many adverse health events.Methods AI-READI is a cross-sectional study whose target enrollment is 4000 people aged 40 and older, triple-balanced by self-reported race/ethnicity (Asian, black, Hispanic, white), T2DM (no diabetes, pre-diabetes and lifestyle-controlled diabetes, diabetes treated with oral medications or non-insulin injections and insulin-controlled diabetes) and biological sex (male, female) (Clinicaltrials.org approval number STUDY00016228). …”
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Effects of Switching to Netarsudil/Latanoprost Fixed Dose Combination from Various Latanoprost Regimens: The Phase 4 MORE Study by Bacharach J, Sadri E, Sawhney G, Kopczynski C, Merchea MM

“…Jason Bacharach,1 Ehsan Sadri,2 Gagan Sawhney,3 Casey Kopczynski,4 Mohinder M Merchea4 1North Bay Eye Associates, Inc, Petaluma, CA, USA; 2Visionary Eye Institute, Newport Beach, CA, USA; 3Georgia Eye Partners, Atlanta, GA, USA; 4Alcon, Inc, Fort Worth, TX, USACorrespondence: Jason Bacharach, North Bay Eye Associates, Inc, 104 Lynch Creek Way, Suite 15, Petaluma, CA, USA, Tel +1(707) 762-3573, Fax +1 (707) 762-6873, Email jbacharach@northbayeye.comPurpose: To determine the effect on intraocular pressure (IOP) of switching to a once-daily netarsudil/latanoprost fixed dose combination (FDC) from various topical treatment regimens including latanoprost monotherapy or latanoprost combined with other IOP-lowering agents for the treatment of open-angle glaucoma or ocular hypertension.Methods: A total of 136 participants enrolled. Eligible participants were aged ≥ 18 years and had a current diagnosis of open-angle glaucoma or ocular hypertension. …”
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Clinical Characteristics of 31 Patients with Chest Pain Variant Asthma by Mao W, Gao Y, Sun W, Li J, Wang J, Wang Z, Zhang L, Huang K

“…Here, we aim to introduce the characteristics of their symptoms, lung function and chest imaging features to arouse the attention of physicians to know better of the disease.Patients and Methods: We retrospectively analyzed thirty-one patients who had been diagnosed with CPVA based on clinical data and positive bronchial provocation tests (BPTs).Results: The mean age of all enrolled patients was forty-seven years, and females accounted for 64.5%. …”
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Prevalence of Self-Medication Practice and Associated Factors among Pregnant Women Who Attended Antenatal Care at Public Hospitals of North Shewa Zone, Amhara Region, Ethiopia by Abrham Demis, Birhanetensay Masresha Altaye, Mulugeta Emiru, Mitiku Tefera

“…Therefore, preventive measures such as proper counseling during dispensing, awareness creation programs on preconception care, and enrolling in health insurance programs to minimize the practice of self-medication are necessary.…”
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Risk Prediction of Liver Injury in Pediatric Tuberculosis Treatment: Development of an Automated Machine Learning Model by Zeng Y, Lu H, Li S, Shi QZ, Liu L, Gong YQ, Yan P

“…The area under the receiver operating characteristic curve (AUC) was used to evaluate model’s performance, and then the TreeShap algorithm was employed to interpret the variable contributions.Results: A total of 184 children were enrolled in this study, of whom 19 (10.33%) developed ATB-DILI. …”
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Opioid agonist therapy discontinuation in British Columbia: a cross-sectional study of people who access harm reduction services by Michael Otterstatter, Jane A Buxton, Kristi Papamihali, Brittany Graham, Lisa Liu, Kimia Ziafat, Bradley Kievit

“…Continued access to harm reduction services can allow for safer consumption of substances for individuals enrolled in OAT programs.…”
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Impact of Hypoglycemia on Health-Related Quality of Life among Type 2 Diabetes: A Cross-Sectional Study in Thailand by Thongchai Pratipanawatr, Bancha Satirapoj, Boonsong Ongphiphadhanakul, Sompongse Suwanwalaikorn, Wannee Nitiyanant

“…Prespecified medical factors were extracted from medical records 12 months prior to patients’ enrolment. The experience of hypoglycemia questionnaire was used to collect and measure severity of hypoglycemia experienced during the previous 6 months. …”
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Development and approval of a Lasso score based on nutritional and inflammatory parameters to predict prognosis in patients with glioma by Huixian Li, Hui Hong, Jinling Zhang

“…Model performance was evaluated utilizing Harrell’s c-index, calibration curves, DCA, and clinical utility (stratification into low-risk and high-risk groups), and verified utilizing the independent validation cohort.ResultsA total of 380 glioma patients were enrolled and separated into training (n = 266) and validation (n = 114) cohorts. …”
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