Investigation and analysis of clinical medical undergraduate learning behaviors under different teaching models by Yang-Zheng Lan, Yang-Zheng Lan, Wen-Ting Lin, Zheng Wu, Zheng Wu, Wen-Jia Chen, Wen-Jia Chen, Dan Guo, Shu-Hui Liu, Shu-Hui Liu, Jing Liu, Jing Liu

“…Within the set-up of different teaching models, involving active-learning classes, English-medium instruction classes, and conventional clinical classes, we employed a comprehensive survey targeting undergraduates enrolled in three distinct teaching models. The survey explored multiple dimensions of learning behaviors, including classroom engagement, study time, and overall motivation. …”
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Longer disease progression milestone-free time in people with amyotrophic lateral sclerosis treated versus not treated with intravenous edaravone: results from an administrative cl... by James D Berry, Melissa Hagan, Jeffrey Zhang, Ying Liu, Malgorzata Ciepielewska

“…Patients & methods: This retrospective observational analysis included PALS continuously enrolled in Optum’s Clinformatics Data Mart between 8 August 2017 and 31 December 2021. …”

Neoadjuvant everolimus in renal angiomyolipoma with or without tuberous sclerosis complex: Results from a multicenter, retrospective study by Ruopeng Su, Tingxuan Huang, Liangyou Gu, Yige Bao, Zhihong Liu, Pinghong Dao, Lin Yao, Xiaoyi Hu, Guanghou Fu, Jitao Wu, Thibault Tricard, Guangyu Wu, Minfeng Chen, Chancan Li, Zhiyang Huang, Bing Zheng, Yonghui Chen, Wei Xue, Gang Guo, Pei Dong, Jiwei Huang, Jin Zhang

“…Materials and Methods This multi‐institutional retrospective study enrolled renal AML patients who underwent partial nephrectomy (PN) or total nephrectomy after receiving at least 1 month of pre‐operative everolimus. …”
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Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults by Yasunobu Amari, Masahiro Hosonuma, Takuya Mizukami, Junya Isobe, Yuki Azetsu, Eiji Funayama, Yuki Maruyama, Toshiaki Tsurui, Kohei Tajima, Aya Sasaki, Yoshitaka Yamazaki, Ryota Nakano, Yutaka Sano, Atsushi Ishida, Tatsuya Nakanishi, Seiji Mochizuki, Yuri Yoshizawa, Sumito Kumagai, Sakiko Yasuhara, Kakei Ryu, Tatsunori Oguchi, Atsuo Kuramasu, Kiyoshi Yoshimura, Takehiko Sambe, Sei Kobayashi, Naoki Uchida

“…In otolaryngology, the resident bacterial microbiota is reportedly altered in non-infectious ear diseases, such as otitis media pearls and exudative otitis media. We hypothesized that a single-nucleotide polymorphism in the ATP-binding cassette sub-family C member 11 (ABCC11) gene, which determines earwax properties, regulates the ear canal microbiota. …”
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Long-term Prospective Comparative Analysis of Ototoxic and Survival Outcomes of Sequential Boost and Simultaneous Integrated Boost of Volumetric Modulated Arc Therapy for Head-Neck... by Nidhin Das, Sri Harsha Kombathula, Vidhu Sharma, Puneet Pareek, Kapil Soni, Amit Goyal

“…Methods: This long-term prospective study enrolled patients with histologically confirmed head and neck carcinoma, all receiving VMAT treatment. …”
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Impact of a Novel Oblique-Tip Papillotome for Biliary Cannulation during ERCP: A Nonrandomized Coarsened Exact Matching Study by Hiroo Imazu, Shiaw-Hooi Ho, Shoryoku Hino, Khean-Lee Goh, Mitsuhiko Moriyama, Kazuki Sumiyama, Hisao Tajiri

“…Eighty patients were enrolled in each of the OT-CGC, OT-WGC, and ST-WGC groups. …”
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Enterotype Bacteroides Is Associated with a High Risk in Patients with Diabetes: A Pilot Study by Jiajia Wang, Wenjuan Li, Chuan Wang, Lingshu Wang, Tianyi He, Huiqing Hu, Jia Song, Chen Cui, Jingting Qiao, Li Qing, Lili Li, Nan Zang, Kewei Wang, Chuanlong Wu, Lin Qi, Aixia Ma, Huizhen Zheng, Xinguo Hou, Fuqiang Liu, Li Chen

“…Materials and Methods. We enrolled 134 patients with type 2 diabetes and 37 nondiabetic controls. …”
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Screening for schistosomiasis in a non-endemic setting: Accuracy of a rapid antibody test using finger prick blood by Margherita Ortalli, Bianca Granozzi, Michele Bacchiega, Concettina Di Lillo, Greta Roncarati, Silvia Stefania Longoni, Cristina Mazzi, Elisa Vanino, Zeno Bisoffi, Stefania Varani

“…Statistical analysis was performed using a Bayesian latent class model.We enrolled 198 subjects in the study. Black-ICT had a sensitivity of 86.6 % (95 % credible interval 76.9–94.7) and a specificity of 88.4 % (82.0–94.3). …”
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The Influence of Near Vision Tasks on Intraocular Pressure in Normal Subjects and Glaucoma Patients by Mohammad Pakravan, Azadeh Samaeili, Hamed Esfandiari, Kiana Hassanpour, Sadid Hooshmandi, Shahin Yazdani, Farideh Sharifipour, Azadeh Doozandeh, Bahram Einollahi, Parastou Pakravan, Mohammad Hasan Shahriari, Bahareh Kheiri

“…Methods: Four groups of subjects categorized as primary open-angle glaucoma (POAG), primary angle-closure suspects (PACS), normal age-matched controls, and normal young adults (NYA; age < 40 years) were enrolled. The baseline IOPs were measured after the subjects were looking at a distant target for 15 min. …”
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Clinical effect analysis of posterior longitudinal ligament resection during anterior cervical discectomy and fusion in the treatment of cervical spondylotic myelopathy by NIU Hai‐ying, MENG Xiang‐yu, ZUO Shan‐shan, SUN Xiao‐li, LI Yan, LIU Hong‐lei

“…Methods A total of 38 patients with CSM completed resection of posterior longitudinal ligament during ACDF under microscopy were enrolled in The First Hospital of Hebei Medical University from August 2023 to August 2024. …”
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Percutaneous microwave ablation, perfusion, and reconstruction combined with a synthetic bone substitute in symptomatic bone cysts: a minimum of 26 months follow-up by Wenhan Huang, Yuan Yan, Chongquan Huang, Hongyi Liao, Jinpeng Lin, Yu Zhang

“…Purpose The objective was to describe the technique and clinical outcome of microwave thermal ablation (MWA) and perfusion combined with synthetic bone substitutes in treating unicameral bone cysts (UBCs) in adolescents.Materials and Methods A total of 14 consecutive patients were enrolled by percutaneous MWA and saline irrigation combined with synthetic bone substitutes. …”
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Clinical and biochemical characteristics for patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome: a pilot observational study by Pei Li, Ye Zhang, Li-Min Luo, Wen-Qing Wang, Jing Li, Yan Cheng, Xiao Dang, Yang Chen, Wei Jiang

“…BackgroundPolyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is rare life-threatening condition associated with a clonal plasma cell neoplasm.ObjectiveThe aim of this study is to investigate the clinical and biochemical features in patients with POEMS syndrome before and post-therapy.MethodsCharacteristics of demographic information, underlying diseases, clinical manifestations, laboratory indicators, and imaging examination were retrospectively collected when diagnosed and post-therapy in the patients POEMS syndrome between 2018 and 2024.ResultsNineteen newly-diagnosed, treatment-naïve patients with POEMS syndrome were enrolled. The diagnosis of POEMS syndrome was re-analyzed and matched the diagnostic criteria updated in 2023. …”
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Effectiveness of a personal health coaching intervention (diabetescoach) in patients with type 2 diabetes: protocol for an open-label, pragmatic randomised controlled trial by Oliver Faude, Fiona Streckmann, Lukas Zahner, Markus Gerber, Vivien Hohberg, Jan-Niklas Kreppke, Jan Kohl, Eleonora Seelig, Daniel König

“…This superiority study will be conducted in Switzerland. All enrolled patients (n=90) will receive the standard medical treatment for T2D. …”
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Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer by Mitchell S. von Itzstein, MD, Jialiang Liu, PhD, Hong Mu-Mosley, PhD, Farjana Fattah, PhD, Jason Y. Park, MD, PhD, Jeffrey A. SoRelle, MD, J. David Farrar, PhD, Mary E. Gwin, MD, David Hsiehchen, MD, Yvonne Gloria-McCutchen, Edward K. Wakeland, PhD, Suzanne Cole, MD, Sheena Bhalla, MD, Radhika Kainthla, MD, Igor Puzanov, MD, MSCI, Benjamin Switzer, DO, MHSA, MS, Gregory A. Daniels, MD, PhD, Yousef Zakharia, MD, Montaser Shaheen, MD, Jianjun Zhang, MD, PhD, Yang Xie, PhD, David E. Gerber, MD

“…Methods: Patients scheduled to receive cancer immunotherapy were enrolled in a multi-institutional prospective biospecimen collection registry. …”
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Multilayer network analysis in patients with end-stage kidney disease by Jiyae Yi, Chang Min Heo, Bong Soo Park, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Dong Ah Lee, Kang Min Park, Jinseung Kim, Junghae Ko

“…In all, 38 ESKD patients and 43 healthy participants were prospectively enrolled. They exhibited normal brain magnetic resonance imaging (MRI) without any structural lesions. …”
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Early effects of LT3 + LT4 combination therapy on quality of life in hypothyroid patients: a randomized, double-blind, parallel-group comparison trial by Fatemeh Hajtalebi, Fariba Alaei-Shahmiri, Fatemeh Golgiri, Najmeh Shahini, Hamideh Akbari, Kasra Assadian, Seyedarad Mosalamiaghili

“…Methods In a randomized, double-blind, parallel-group trial, 151 Iranian patients diagnosed with primary hypothyroidism between 2020 and 2021 were enrolled. One group received LT4 alone (n = 80), while the other received LT4 and LT3 (n = 71) for a minimum of six months. …”
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Comparative Evaluation of Consumer Wearable Devices for Atrial Fibrillation Detection: Validation Study by Femke Wouters, Henri Gruwez, Christophe Smeets, Anessa Pijalovic, Wouter Wilms, Julie Vranken, Zoë Pieters, Hugo Van Herendael, Dieter Nuyens, Maximo Rivero-Ayerza, Pieter Vandervoort, Peter Haemers, Laurent Pison

“…MethodsPatients exhibiting sinus rhythm or AF were enrolled through a cardiology outpatient clinic. The participants were instructed to perform heart rhythm measurements using a handheld 6-lead electrocardiogram (ECG) device (KardiaMobile 6L), a smartwatch-derived single-lead ECG (Apple Watch), and two PPG-based smartphone apps (FibriCheck and Preventicus) in a random sequence, with simultaneous 12-lead reference ECG as the gold standard. …”
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Conventional endotracheal tubes versus polymer-coated tubes in ventilator-associated pneumonia development: A systematic review and meta-analysis by Oscar Inácio de Mendonça Bisneto, Luanna Paula Garcez de Carvalho Feitoza, Larissa Calixto Hespanhol, Sávio Benvindo Ferreira, Caroline Serafim Dagostin, Roberto Augusto Mazetto Silva Vieira, Lucas Alencar Queiroz, Lucas Chen, Taniela Marli Bes, Ho Yeh Li

“…Results: Our search identified 6 RCTs eligible in our inclusion criteria, enrolling 2680 patients, with 1361 (50,78 %) undergoing intubation using a polymer-coated tube. …”
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Efficacy and Safety of HAPC in Barrett's Esophagus – A Multicenter Italian Prospective Study by Davide Massimi, Roberta Maselli, Silvia Pecere, Cristiano Spada, Gianluca Andrisani, Francesco Maria Di Matteo, Antonella La Terra, Franco Coppola, Antonio Capogreco, Roberto De Sire, Ludovico Alfarone, Maddalena Menini, Marco Spadaccini, Cesare Hassan, Alessandro Repici

“…(NCT05645679) Results. Among the 51 enrolled patients (mean C 0.43 cm (SD 0.72), mean M 2.20 cm (SD 1.09)) who completed the treatment (80 H-APC sessions), 45.1% (23/51) had prior ER of visible lesions . …”
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Multiple use of preservative-free single dose unit dexamethasone 0.1% eye drops is safe within 24 hours by Marco Rossi, Michael A Thiel, Frank Bochmann, Philipp B Baenninger, Claude Kaufmann, Fabienne C Fierz, Silvan Locher, Lucas Bachmann, Irena Mitrovic, Jeremy P Howell

“…We investigated whether repeated use of dexamethasone 0.1% SDUs in the same patient increases the bacterial contamination rate.Methods We prospectively enrolled patients scheduled for inpatient corneal and glaucoma surgery receiving dexamethasone 0.1% SDU four times per day from the same vial. …”
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