How to Reliably Measure Stroke Volume Index in Pulmonary Arterial Hypertension: A Comparison of Thermodilution, Direct and Indirect Fick, and Cardiac MRI by Andrea Baccelli, Deepa Gopalan, Rachel J. Davies, Gulammehdi Haji, Wendy Gin-Sing, Luke S. Howard, Francesco Lo Giudice

“…We aimed to compare these different invasive methods, and in a subgroup of patients, to a non-invasive method using MRI. Methods. We enrolled 103 PAH patients undergoing a diagnostic or follow-up right heart catheterization at our centre (mean age 56 years, 56% female). …”
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A Clinical Prediction Model for Pathologic Upgrade to Invasive Carcinoma Following Conization of Cervical High‐Grade Squamous Intraepithelial Lesions by Qiao Liu, Jing Yang, Hui Cheng, Chuqiang Shu, Yi Tang, Jing Zhao

“…A total of 277 patients were enrolled from April 2022 to October 2022 for external validation. …”
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Association between Interferon-Inducible Protein 6 () Polymorphisms and Hepatitis B Virus Clearance by Geun-Hee Park, Kyoung-Yeon Kim, Sung Won Cho, Jae Youn Cheong, Gyeong Im Yu, Dong Hoon Shin, Kyu Bum Kwack

“…We were unable to replicate the association shown by secondary enrolled samples. A large-scale validation study should be performed to confirm the association between IFI6 and HBV clearance.…”
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Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial by Guoshuang Shen, Zhilin Liu, Miaozhou Wang, Yi Zhao, Xinlan Liu, Yujin Hou, Wenbiao Ma, Jingqi Han, Xiaofeng Zhou, Dengfeng Ren, Fuxing Zhao, Zitao Li, Shifen Huang, Yongzhi Chen, Yingjian He, Yan Liu, Zijun Zhu, Yongxin Li, Jinming Li, Mengting Da, Hongnan Mo, Feng Du, Liang Cui, Jing Bai, Zhen Liu, Fei Ma, Jiuda Zhao

“…Specimens collected pre-neoadjuvant therapy and post-surgery were retained for comprehensive analysis of predictive biomarkers and the impact on the tumor microenvironment. Among 34 enrolled patients, 24 achieved pCR (70.6%; 95% confidence interval (CI), 53.0-85.3), and 79.4% (95% CI, 65.1-93.7) had residual cancer burden 0-I. …”
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Analysis of factors affecting pregnancy outcomes in patients with adenomyosis after high intensity focused ultrasound ablation: a retrospective study by Rong Ma, Diego Armando Burgos Briones, Min Zou, Yu Xiong, Jin Bai, Lian Zhang

“…Objectives To investigate all pregnancies and analyze the factors influencing pregnancy outcomes in patients with adenomyosis after high intensity focused ultrasound (HIFU).Materials and methods A total of 231 patients with adenomyosis who completed HIFU and wished to conceive were enrolled. The symptom improvement and information of pregnancy were recorded during the follow-up period. …”
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Continuous Glucose Monitoring Among Patients With Type 1 Diabetes in Rwanda (CAPT1D) Phase I: Prospective Observational Feasibility Study by Jason Baker, Giacomo Cappon, Jean Claude Habineza, Corey H Basch, Steven Mey, Diana L Malkin-Washeim, Christian Schuetz, Niyonsenga Simon Pierre, Etienne Uwingabire, Alvera Mukamazimpaka, Paul Mbonyi, Sandhya Narayanan

“…A cohort of 50 participants diagnosed with T1D were enrolled. Participants were at least 21 years old, undergoing multiple daily insulin therapy, and not currently pregnant. …”
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Validation of a delirium predictive model in patients admitted to surgical intensive care units: a multicentre prospective observational cohort study by Kaweesak Chittawatanarat, Onuma Chaiwat, Sirirat Mueankwan, Sunthiti Morakul, Pitchaya Dilokpattanamongkol, Chayanan Thanakiattiwibun, Arunotai Siriussawakul

“…Objective To internally and externally validate a delirium predictive model for adult patients admitted to intensive care units (ICUs) following surgery.Design A prospective, observational, multicentre study.Setting Three university-affiliated teaching hospitals in Thailand.Participants Adults aged over 18 years were enrolled if they were admitted to a surgical ICU (SICU) and had the surgery within 7 days before SICU admission.Main outcome measures Postoperative delirium was assessed using the Thai version of the Confusion Assessment Method for the ICU. …”
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The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney dise... by Dan Liu, Xiaoyang Guan, Ruoxin Chen, Ci Song, Shanhu Qiu, Shengchun Xu, Jingyuan Cao, Hong Liu

“…Logistic regression analysis was used to determine the related factors of CAD and severe CAS.Results A total of 943 patients were enrolled in this cross-sectional study and 720 (76.4%) of these patients were diagnosed with CAD. …”
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Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery by Jeng-Fu You, Cheng-Chi Lee, Yun-Shien Lee, Yih-Jong Chern, Chun-Kai Liao, Hung-Chih Hsu

“…Methods: We prospectively enrolled 45 patients with CRC. Venous blood samples were collected preoperatively and on postoperative day 3 (POD3) and 30 (POD30). …”
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Prevalence of piriformis syndrome and its associated risk factors among university students in Pakistan: a cross-sectional study by Hassan N Moafa, Nusrat Batool, Naila Azam, Azka Hafeez, Humaira Mehmood, Nimbal Imtiaz, Waqas A Shehzad, Asaad Saleem Malik, Ajiad Alhazmi, Manal Almalki, Almutasim B Moafa, Jobran M Moshi

“…Objective To determine the prevalence of piriformis syndrome (PS) among undergraduate university health sciences students aged 18 to 25 and assess the significant predictors of PS regardless of its type and severe PS in particular.Design A cross-sectional study.Setting The study was conducted at a tertiary care hospital of a public university in Pakistan from December 2023 to May 2024.Participants A total of 190 subjects enrolled in the study who met the eligibility criteria, which included being an undergraduate health sciences student (medical and allied health specialities), aged 18 up to 25 years, and willing to participate in the study. …”
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Association between body size and atrial myopathy: Investigation using the prevalence of left atrial low-voltage areas by Yasuhiro Matsuda, Masaharu Masuda, Hiroyuki Uematsu, Ayako Sugino, Hirotaka Ooka, Satoshi Kudo, Subaru Fujii, Mitsutoshi Asai, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takuya Tsujimura, Yosuke Hata, Naoko Higashino, Sho Nakao, Masaya Kusuda, Toshiaki Mano

“…Methods: In total, 1,479 (age, 68 ± 10 years; female, 500 [34 %]) consecutive patients who underwent initial AF ablation were enrolled. Body mass index (BMI), height and body weight were used as indicators of body size. …”
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Prognostic impact of tumor size on cancer-specific survival for postoperative WHO grade II oligodendroglioma: a SEER-based study by Qin Lu, Yongyan Wu, Yonglin Xie, Shuxu Yang, Hongchuan Jin

“…Subsequently, Subgroup analyses were performed based on tumor size.Result676 OG/II patients were enrolled in our study. Multivariate Cox analyses revealed that age > 60 (HR 3.52), male (HR 1.48), total resection (HR 0.38), and tumor size (HR 2.04) were independent factors in predicting cancer-specific survival (CCS). …”
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Association of Intensive Endoscopic Burden with Esophageal Cancer Detection: A Nationwide Cohort Study by Yeunji Lee, Eunyoung Lee, Bumhee Park, Gil Ho Lee, Sun Gyo Lim, Sung Jae Shin, Choong-Kyun Noh, Kee Myung Lee

“…Results: This study enrolled 28,032,590 participants who underwent upper endoscopy. …”
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Changes in PD-1 expression on T lymphocyte subsets and related immune indicators before and after definitive chemoradiotherapy for esophageal squamous cell carcinoma by Xueling Shi, Hongyu Zhao, Jiaqi Yu, Peng Cai, Shixiang Zhou, Ning Yang, Duojie Li

“…Objective This study aimed to observe the dynamic changes in the expression of T lymphocytes, natural killer (NK) cells, and PD-1 in patients with first-diagnosed esophageal squamous cell carcinoma (ESCC) before and after chemoradiotherapy (CRT) and evaluate the impact of PD-1 expression in peripheral blood on the short-term outcome of patients with ESCC.Patients and Methods Seventy-three patients with ESCC who were treated with definitive CRT were enrolled. Before and after CRT, flow cytometry was used to detect thePD-1 expression in the peripheral blood and related immune indicators. …”
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Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised... by Li Wang, Tamer Hudali, Shekhar Ghamande, Megan Moore, Bruno Pereira, Christopher J Lindsell, Wesley H Self, Todd W Rice, Matthew W Semler, Kate O’Connor, David B Page, Victor E Ortega, Aaron M Joffe, Swati Gulati, G Patel, Heath D White, Muhammad Ali, Jonathan D Casey, David R Janz, Derek W Russell, Derek J Vonderhaar, Kevin M Dischert, William S Stigler, Emily Adams, Kevin W Gibbs, James M Dargin, A M Joffe, Akram Khan, Simanta Dutta, Janna S Landsperger, Sarah W Robison, Itay Bentov, Joanne M Wozniak, Susan Stempek, Olivia F Krol, Matthew E Prekker, Brian E Driver, Joseph M Brewer, Christopher John Lindsell, David Janz, Stephen P Peters, Rita N Bakhru, Scott Bauer, Christina R Bellinger, Amanda M Brown, Blair Brown, Jerri Brown, Caitlin Bumgarner, Wendy Butcher, Megan Caudle, Arjun B Chatterjee, David J Chodos, Gerardo Corcino, Nathan S Cutler, Travis L Dotson, Daniel C Files, Jonathan L Forbes, John P Gaillard, Katherine A Gershner, Shannon Ginty, Kiadrick R Hood, April Hazelwood, Katherine Hendricks, Kelly Jacobus, Jonathan T Jaffe, Stacy Kay, Chad A Kloefkorn, Jennifer Krall, Margo T Lannan, Cornelia Lane, Cynthia Lanning, Jessica Lyons, William I Mariencheck, Chad R Marion, Matthew A Maslonka, Sara McClintock, Nathaniel M Meier, Matthew C Miles, Peter J Miller, Sophia Mitchell, Wendy C Moore, Katherine Moss, Andrew M Namen, Dustin L Norton, Stella B Ogake, Jill A Ohar, Jessica A Palakshappa, Rodolfo M Pascual, Sandi Pascual, Aaron Pickens, Adam R Schertz, Matt Strong, Alexander O Sy, Braghadheeswar Thyagarajan, Amy Townsend, Russell Worthen, Michael Wlodarski, Charles Yarbrough, Caroline York, Bradley Lloyd, James Dargin, Joanne Wozniak, Christopher Adler, Ahmed Agameya, Michael Colancecco, Daniel Fitelson, Joshua Giaccotto, Gena Han, Louise Kane, Ezra Miller, Timothy Noland, Jaqueline Price, Joseph Plourde, Fraser Mackay, Laura Mahoney, Avignat Patel, Michael Plourde, Zena Saadeh, Sara Shadchehr, Sandeep Somalaraju, Eleanor Summerhill, Ryan Webster, Jordan Winnicki, Ekaterina Yavarovich, Sheetal Gandotra, Anna Altz-Stamm, Cristina Bardita, Mary Clay Boone, Joe W Chiles, Kristina Collins, Abby Drescher, Kevin G Dsouza, Janna Dunn, Stacy Ejem, Josh Gautney, Nicole Harris, Savannah Herder, R Chad Wade, Rutwij Joshi, Daniel Kelmenson, Anne Merrill Mason, Scott R Merriman, Takudzwa Mkorombindo, Jada Nowak, D Sheylan, Lisa Sarratt, Tabitha Stewart, Kadambari Vijaykumar, Gina White, Micah R Whitson, Christopher Barnes, Andrew M Walters, Alejandro C Arroliga, Tasnim Lat, Stephanie Nonas, Milad K Jouzestani, Raya Adi, Chandani Anandkat, Hanae Benchbani, Matthew G Drake, Makrina N Kamel, Ramanpreet Randhawa, Jessica L Tsui

“…The sole secondary outcome is 28-day in-hospital mortality. Enrolment began on 1 February 2019 and is expected to conclude in June 2020.Ethics and dissemination The trial was approved by either the central institutional review board at Vanderbilt University Medical Center or the local institutional review board at each trial site. …”
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Safety and Feasibility of Internal Fixation Using Bioabsorbable Versus Titanium Materials for Short‐Level Lamina Reimplantation: A Comparative Clinical Study by Dingbang Chen, Jinhan Song, Luosheng Zhang, Xin Gao, Quan Huang, Xinghai Yang

“…Methods We retrospectively enrolled patients who underwent short‐segment lamina replantation for intraspinal tumors in our center from February 2020 to November 2022. …”
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Preoperative carcinoembryonic antigen to lymphocyte ratio serves as a prognostic predictor in elderly patients with colorectal cancer: a multicentre retrospective study by Lei Jiang, Ning Tan, Xiaonan Zhang, Jiayi Jiang, Xinyi Li, Gang Deng, Tao Liang, Haohan Ma, Weiping Deng, Lichang Guan, Kaijun Zhang, Xujie Cai, Lishu Xu

“…Objectives The aim of this study is to derive and validate a reliable indicator for predicting an increased risk of postoperative mortality in elderly patients undergoing curative resection for colorectal cancer (CRC).Design This study is of multicentre retrospective design.Setting and participants A total of 1227 CRC patients undergoing curative resection (age ≥65 years) from three distinct cohorts were retrospective enrolled. Participant cohorts consisted of the derivation (n=845), external validation (n=95) and localised validation (n=287) groups. …”
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Neuromuscular Excitation Pattern in Expert Indoor Skydivers by Susanna Rampichini, Eloisa Limonta, Irene Di Giulio, Marta Borrelli, Emiliano Cè, Giuseppe Coratella, Johnny Padulo, Stefano Longo, Fabio Esposito

“…Nine expert indoor skydiving instructors (M/F: 8/1; age 31 ± 7 years; body mass: 70.5 ± 11.1 kg; stature: 1.74 ± 0.09 m) were enrolled. The surface electromyographic signal was recorded on the anterior deltoid, AD; posterior deltoid, PD; pectoralis major, PM; latissimus dorsi, LD; rectus abdominis, Rabd; erector spinae, ES; rectus femoris, RF; and biceps femoris, BF for each position: PRONE, SUPINE, SIT, and head-down (HD). …”
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Clinical Utility of a Structured Program to Reduce the Risk of Health-Related Quality of Life Impairment after Discharge from Intensive Care Unit: A Real-World Experience by Angelica Venni, Francesca Ioia, Silvia Laviola, Francesca Frigieri, Alessandra Pieri, Simona Marilli, Daniela Balzi, Piercarlo Ballo, Stefano Gori, Diletta Guarducci

“…A total of 159 patients hospitalized in our ICU with a length of stay >72 hours were enrolled in an institutional management protocol including specific recommendations: adequate sedation and analgesia protocols, to ensure a valid delirium prevention strategy, and to provide a planned midterm after discharge. …”
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Impact of the Number of Administered Systemic Treatment Lines on Local Response to Radiation Therapy for Multiple Myeloma by Andrea Emanuele Guerini, MD, Eneida Mataj, MD, Paolo Borghetti, MD, Luca Triggiani, Ludovica Pegurri, MD, Stefania Nici, Stefano Riga, Alessandra Tucci, MD, Angelo Belotti, MD, Marco Lorenzo Bonù, MD, Giorgio Facheris, MD, Stefano Maria Magrini, Luigi Spiazzi, Michela Buglione

“…Methods and Materials: This single-center retrospective study enrolled patients who received RT for MM at our institution between January 1, 2005, and January 31, 2023. …”
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