Depth-dependent PD-L1 sampling of head and neck squamous cell carcinoma (HNSCC) – implications for PD-1/PD-L1 checkpoint inhibitor immunotherapy by Madhusudan Roy, Jing-Tang Lin, Sohidul Mondal, Mei-Chun Lin, Chih-Yu Leu, Yen-Lin Huang, Chen-Yuan Dong, Pei-Jen Lou

“…In this study, we selected formalin-fixed, paraffin-embedded (FFPE) tissue blocks from five HNSCC patients. …”
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Analysis of Viability of Core Inflation Components Based on Excluded Items in Uganda. by Munyambonera, Ezra, Mukiza, Chris Ndatira, Niyimpa, Ediga Mfite

“…On the other hand, the EFU items namely petrol, diesel, paraffin, Uganda National Water (UNW), firewood and electricity recorded the least variation in prices with a high persistence during the study period. …”
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Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38 by Knut Husø Lauritzen, Knut Husø Lauritzen, Kuan Yang, Michael Frisk, Mieke C. Louwe, Maria Belland Olsen, Maria Belland Olsen, Mathias Ziegler, William E. Louch, Bente Halvorsen, Bente Halvorsen, Pål Aukrust, Pål Aukrust, Arne Yndestad, Øystein Sandanger, Øystein Sandanger

“…Our results also suggest that MSU crystals activate NLRP3 through autocrine or paracrine ATP signalling.…”
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hAMSCs regulate EMT in the progression of experimental pulmonary fibrosis through delivering miR-181a-5p targeting TGFBR1 by Yanyang Wang, Chan Liu, Nuoxin Wang, Dong Weng, Yan Zhao, Hongyu Yang, Haoyuan Wang, Shangfu Xu, Jianmei Gao, Changhui Lang, Zhenhai Fan, Limei Yu, Zhixu He

“…Furthermore, hAMSCs ameliorated PF by promoting epithelial cell proliferation, reducing epithelial cell apoptosis, and attenuating EMT of epithelial cells through paracrine effects. hAMSCs regulated EMT in PF through delivering miR-181a-5p targeting TGFBR1. …”
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Exosomes Derived from Apelin-Pretreated Mesenchymal Stem Cells Ameliorate Sepsis-Induced Myocardial Dysfunction by Alleviating Cardiomyocyte Pyroptosis via Delivery of miR-34a-5p by Li T, Zhao Y, Cao Z, Shen Y, Chen J, Huang X, Shao Z, Zeng Y, Chen Q, Yan X, Li X, Zhang Y, Hu B

“…Our previous study demonstrated that Apelin pretreatment enhanced the therapeutic benefit of MSCs in myocardial infarction by improving their paracrine effects. This study aimed to determine whether EXOs sourced from Apelin-pretreated MSCs (Apelin-MSC-EXOs) would have potent cardioprotective effects against SMD and elucidate the underlying mechanisms.Methods: MSC-EXOs and Apelin-MSC-EXOs were isolated and identified. …”
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Erişkin HBsAg Pozitif Hastalarda Hepatit A Seroprevalansı by Alper Tahmaz, Süleyman Sırrı Kılıç, Özgür Günal, Sevil Alkan Çeviker

“…Amaç: Hepatit A virüs HAV nadiren fulminan hepatite neden olmakla beraber, özellikle viral hepatit kronik karaciğer hastalığı olan kişilerde görülebilen HAV ko-enfeksiyonu daha ciddi klinik tablolara neden olabilir. …”
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Farklı Canlı Ağırlığa Sahip Yumurtacı Tavuklara Tüy Dökümü Sırasında Uygulanan Döngüsel Yüksek Sıcaklığın İkinci Yumurtlama Dönemi Performansı, Bazı Organ Ağırlıkları ve Bacak Kemi... by Mustafa Akşit, İhsan Bülent Helva

“…Tüy dökümü döneminde tavuklarda, dalak ağırlığı artarken, yumurtalık, yumurta kanalı ve karaciğer ağırlıkları önemli ölçüde azalmıştır. Tüy dökümü döneminde uygulanan döngüsel yüksek sıcaklığın ikinci verim döneminde bazı yumurta kalite özelliklerini olumlu etkilediği ortaya çıkmıştır.…”
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Exploring the association between sleep quality, internet addiction, and related factors among adolescents in Dakshinkali Municipality, Nepal. by Sophiya Acharya, Anisha Chalise, Nirmal Raj Marasine, Shishir Paudel

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Clinical and analytical monitoring of patients with multiple sclerosis on anti-CD20 therapeutics: a real-world safety profile study by André Aires Fernandes, André Aires Fernandes, Ana Lídia Neves, Ana Lídia Neves, Daniela Ferro, Daniela Ferro, Mafalda Seabra, Mafalda Seabra, Teresa Mendonça, Ricardo Soares dos Reis, Ricardo Soares dos Reis, Maria José Sá, Joana Guimarães, Joana Guimarães, Pedro Abreu, Pedro Abreu

“…This study aims to evaluate their safety and tolerability profile in real-world clinical practice.MethodsWe conducted a retrospective cohort study comprising patients diagnosed with multiple sclerosis (MS) treated with anti-CD20 drugs since 2016 followed in the Demyelinating Diseases clinic of a tertiary center. Clinical and paraclinical parameters were evaluated, including complete blood count and immunoglobulins measurements.ResultsA total of 160 with multiple sclerosis (pwMS) were included in our study, of whom 110 (68.8%) were female and 147 are currently receiving anti-CD20 therapies. …”
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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…Specifically, tumor-associated macrophages (TAMs) create an immunosuppressive milieu through the production of a plethora of paracrine factors (IL-6, IL-12, TNF-alpha, TGF-beta, CCL1, CCL18) promoting the acquisition by CSCs of a stem-like, invasive and metastatic phenotype. …”
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Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer by Siyue Zhang, Ning Zhang, Tong Wan, Yinqiao He, Jie Hao, Yiwei Liu, Yidong Liu, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Chao Gao, Qifeng Yang

“…Additionally, ANGPTL4 was found to promote macrophage M2 polarization within the tumor microenvironment via paracrine signaling, further driving TNBC progression. …”
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Predictive factors of fibrotic interstitial lung abnormality on high-resolution computed tomography scans: a prospective observational study by Kazuya Ichikado, Hidenori Ichiyasu, Kazuhiro Iyonaga, Kodai Kawamura, Yuko Yasuda, Keisuke Anan, Hiroko Okabayashi, Kimitaka Akaike, Noritaka Higashi, Takeshi Johkoh, Kiminori Fujimoto, Tetsuo Saito, Jun Morinaga, Minoru Yoshida, Katsuhiko Mitsuzaki, Takuro Sakagami

“…Methods Clinical and paraclinical data of 164 patients enrolled in the initial year of a multicentre prospective observational study (Kumamoto interstitial lung abnormalities study in Japan) involving over 62,000 examinees during routine health examinations were analysed. …”
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Infiltration of CD8+ cytotoxic T-cells and expression of PD-1 and PD-L1 in ovarian clear cell carcinoma by Mengdi Fu, Huimei Zhou, Jiaxin Yang, Dongyan Cao, Zhen Yuan

“…The optimized multiplex immunofluorescence technique was used to stain paraffin sections for immune factors related to the immune microenvironment of OCCC and clinical prognosis. …”
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PLUNC downregulates the expression of PD-L1 by inhibiting the interaction of DDX17/β-catenin in nasopharyngeal carcinoma by Ranran Feng, Yilin Guo, Meilin Chen, Ziying Tian, Yijun Liu, Su Jiang, Jieyu Zhou, Qingluan Liu, Xiayu Li, Wei Xiong, Lei Shi, Songqing Fan, Guiyuan Li, Wenling Zhang

“…Results We found that PLUNC expression was lower in NPC tissues than in paracancer tissues. PD-L1 expression was opposite to that of PLUNC. …”
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Validation of devices for characterization of hybrid 3D printed embroidery TENG for energy harvesting by HASAN TAHIR, Benny Malengier, Carla Hertleer, Lieva Van Langenhove

“…Furthermore, these threads are coated with silicone-paraffin emulsions that improve their running during the embroidery process. …”
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Prospective Evaluation of Unprocessed Core Needle Biopsy DNA and RNA Yield from Lung, Liver, and Kidney Tumors: Implications for Cancer Genomics by Mikhail T. Silk, Nina Mikkilineni, Tarik C. Silk, Emily C. Zabor, Irina Ostrovnaya, Ari A. Hakimi, James J. Hsieh, Etay Ziv, Natasha Rekhtman, Stephen B. Solomon, Jeremy C. Durack

“…., formalin fixation and paraffin embedding (FFPE)) has been previously reported, little is known about the potential yield for molecular analysis at the time of biopsy sample acquisition. …”
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Expression of CD68+ Tumor associated macrophages in relation to β-catenin in carcinoma stomach by Nikhil Sharma, Ranjita Panigrahi, Prita Pradhan, Sabyasachi Parida, Saroj R. Sahoo

“…Designs and Settings: Formalin fixed paraffin embedded (FFPE) blocks from gastrectomy specimens of proven gastric adenocarcinoma were prospectively and retrospectively were studied over a period of two years. …”
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Prognostic value of immune biomarkers in melanoma loco-regional metastases. by Emilia Hugdahl, Sura Aziz, Tor A Klingen, Lars A Akslen

“…Due to limited tumour tissue in the paraffin blocks, 67 of the 78 cases were included for tissue microarrays. …”
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Electrochemical Performances of Electroactive Nano-LayeredOrganic-Inorganic Perovskite Containing Trivalent Iron Ion and its Use for a DNA Biosensor Preparation by Jing Wu, Hanxing Liu, Zhidong Lin, Minghe Cao

“…The resulting hybrid enveloped in paraffin to prepare [H23-AMP]3/2Fe(CN)6 paste electrode (HPE) shows good electrochemical activity and a couple of oxidation and reduction peaks with potential of cyclic voltammometry (CV) at around 440 mV and 30 mV. …”
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Atrophic Myenteric and Submucosal Neurons Are Observed in Parkinson’s Disease by Bodil Ohlsson, Elisabet Englund

“…., fixed in formaldehyde solution, dehydrated and embedded in paraffin, sectioned at 5 μm thickness, and stained with H&E and immunostaining for α-synuclein. …”
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