Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures by Melissa Lo Monaco, Greet Merckx, Jessica Ratajczak, Pascal Gervois, Petra Hilkens, Peter Clegg, Annelies Bronckaers, Jean-Michel Vandeweerd, Ivo Lambrichts

“…Preclinical models used in regenerative cartilage studies include murine, lapine, caprine, ovine, porcine, canine, and equine models, each associated with its specific advantages and limitations. …”
Get full text

The Angiogenic Potential of DPSCs and SCAPs in an In Vivo Model of Dental Pulp Regeneration by Petra Hilkens, Annelies Bronckaers, Jessica Ratajczak, Pascal Gervois, Esther Wolfs, Ivo Lambrichts

“…In this study, human dental pulp stem cells (DPSCs) and stem cells from the apical papilla (SCAPs) were applied in an in vivo model of dental pulp regeneration in order to compare their regenerative potential and confirm their previously demonstrated paracrine angiogenic properties. 3D-printed hydroxyapatite scaffolds containing DPSCs and/or SCAPs were subcutaneously transplanted into immunocompromised mice. …”
Get full text

Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis by Xiangyang Xia, Quanwei Tao, Qunchao Ma, Huiqiang Chen, Jian’an Wang, Hong Yu

“…Mesenchymal stromal cells (MSCs) are promising candidates for regenerative medicine because of their multipotency, immune-privilege, and paracrine properties including the potential to promote angiogenesis. …”
Get full text

Comparison of Gene Expression in Human Embryonic Stem Cells, hESC-Derived Mesenchymal Stem Cells and Human Mesenchymal Stem Cells by Romain Barbet, Isabelle Peiffer, Antoinette Hatzfeld, Pierre Charbord, Jacques A. Hatzfeld

“…The expression in hMSCs of cytokine genes, such as IL6, IL8, or FLT3LG, without expression of the corresponding receptor, suggests a role for these cytokines in the paracrine control of stem cell niches. Our database may be shared with other laboratories in order to explore the considerable clinical potential of hES-MSCs, which appear to represent an intermediate developmental stage between hESCs and hMSCs.…”
Get full text

Protective Effect of Adipose-Derived Mesenchymal Stem Cell Secretome against Hepatocyte Apoptosis Induced by Liver Ischemia-Reperfusion with Partial Hepatectomy Injury by Zhihui Jiao, Yajun Ma, Yue Wang, Tao Liu, Qianzhen Zhang, Xiaoning Liu, Chenxi Piao, Boyang Liu, Hongbin Wang

“…Our findings indicate that ADSCs exert therapeutic effects in a paracrine manner through their secretome, which can be a viable alternative to cell-based regenerative therapies.…”
Get full text

Predictive value of hematologic indices in COVID-19 disease outcomes by Fatemeh Nejatifar, Ali Alavi Foumani, Saman Maroufizadeh, Bardia Afsharian, Zahra Chegini, Amir Mohammad Ghanbari

“…Patients’ demographic, clinical and paraclinical information were obtained on admission and disease outcomes were assessed based on these data. …”
Get full text

Dental Mesenchymal Stem/Stromal Cells and Their Exosomes by Peter Stanko, Ursula Altanerova, Jana Jakubechova, Vanda Repiska, Cestmir Altaner

“…Furthermore, the therapeutic potential of DP-MSCs is realized through paracrine action of extracellularly released components, for which exosomes play an important role. …”
Get full text

Pathological Microenvironment‐Remodeling Nanoparticles to Alleviate Liver Fibrosis: Reversing Hepatocytes‐Hepatic Stellate Cells Malignant Crosstalk by Ling‐Feng Zhang, Wen‐Qi Deng, Xing‐Huan Wang, Qing‐Wen Huang, Su‐Qing Liang, Ze‐Quan Ding, Liang Qi, Yi Wang, Tian‐Jiao Zhou, Lei Xing, Jai‐Woo Lee, Yu‐Kyoung Oh, Hu‐Lin Jiang

“…The secretions released by damaged hepatocytes and activated HSCs interact through autocrine or paracrine mechanisms, involving multiple signaling pathways. …”
Get full text

Mesenchymal Stem Cell Therapy for Cardiac Inflammation: Immunomodulatory Properties and the Influence of Toll-Like Receptors by F. van den Akker, S. C. A. de Jager, J. P. G. Sluijter

“…This happens likely via a paracrine mechanism. As MSC are potent modulators of the immune system, this could influence this postinfarct immune response. …”
Get full text

Mutual coupling of neurons in the circadian master clock: What we can learn from fruit flies by Charlotte Helfrich-Förster, Nils Reinhard

“…Here, we review the organization of the bilateral master clocks in the fly brain, with a focus on synaptic and paracrine connections between the multiple clock neurons, in comparison with other insects and mammals.…”
Get full text

An integrated approach to the treatment of a patient with chronic tonsillitis. Clinical case by Khiyir T. Abdulkerimov, Ksenia I. Kartashova

“…Therapy for CT in outpatient practice is often limited to only washing the lacunae of the palatine tonsils, without the use of local drugs. We observed a 35-year-old patient with a diagnosis of chronic tonsillitis and a history of the disease of more than 1.5 years. …”
Get full text

Modelling of Ethane/Ethylene Separation Using Microporous by Susana Curbelo, Erich A. Müller

“…The results provide qualitative guidelines for the synthesis and design of carbons for lower olefin/paraffin separations.…”
Get full text

Breast Neuroendocrine Tumor. Case Report and Literature Review by Lidia Torres Aja

“…We present the case of a 76-year-old patient who came to the clinic for having a large tumor that occupied almost all of the right breast without axillary lymphadenopathy and which was informed by paraffin biopsy as a neuroendocrine carcinoma. This is the first tumor of this histological characteristic diagnosed in Cienfuegos, reason why its publication is considered of scientific interest.…”
Get full text

Abuso e repressão: fibras do mesmo fio na infância das meninas de Helena Parente Cunha by Lílian Almeida de Oliveira Lima

“…These characters are subjected to a series of oversights that undermines the idealized notion of childhood as a lost paradise. In the course of analysis the ideas of Neil Postman about narrowing the li mits that differentiate adults and children are used, as well as the notion of „privatization of childhood‟, pointed out by Jacinto Sarmento.…”
Get full text

Critical steps and troubleshooting in sample preparation for wood and phloem formation: from sampling to microscopic observation by Angela Balzano, Katarina Čufar, Luka Krže, Maks Merela

“…Some tips are given how to use the Trephor tool in the best way, how to remove the outer hard bark (periderm), how microcores should be handled after removal from the tree, and how they should be oriented for embedding in paraffin, and cutting thin sections for microscopy. …”
Get full text

DULKADIRAN, MEDIA MASYARAKAT SAMPURNAN UNTUK MEMPEROLEH KESELAMATAN, PAHALA, SYAFAAT, DAN SURGA by Nilna Fadlillah

“…Based on the interpretation of cultures theory found out that the Sampurnan society recognizes the concepts that are based on the religious basis, which has ultimate meaning as a way to get the salvation, reward, and paradise. These concepts were then believed as the true and real, which then formulated into various symbols in the Dulkadiran tradition. …”
Get full text

Bounds of Degree-Based Molecular Descriptors for Generalized F-sum Graphs by Jia Bao Liu, Sana Akram, Muhammad Javaid, Abdul Raheem, Roslan Hasni

“…Wiener (1947) and Trinjastic and Gutman (1972) used molecular descriptors to find the boiling point of paraffin and total π-electron energy of the molecules, respectively. …”
Get full text

Successful Treatment for a Large Chronic Expanding Hematoma Treated by Pneumonectomy after Arterial Embolization by Aki Fujiwara-Kuroda, null Nozomu Iwashiro, Masanori Ohara, null Kichizo Kaga

“…We report a case of successful surgical resection of a chronic expanding hematoma with preoperative arterial embolization, 48 years after extraperiosteal paraffin plombage for pulmonary tuberculosis. The operative indication or procedure for a chronic expanding hematoma should be determined carefully, and preoperative preparations as well as strategies should be elaborated for safe surgical resection. …”
Get full text

Breast Cancer in Men: a Rare Case by Lidia Torres Aja, José Alberto Puerto Lorenzo

“…In addition to other examinations, an excisional biopsy of a small fragment of the lesion was performed with a paraffin study, which reported cutaneous metastasis of a shell breast carcinoma according to its clinical presentation. …”
Get full text

Ectopic Oral Tonsillar Tissue: A Case Series with Bilateral and Solitary Presentations and a Review of the Literature by Masashi Kimura, Toru Nagao, Terumi Saito, Saman Warnakulasuriya, Hiroyuki Ohto, Akihito Takahashi, Kanji Komaki, Yoshiyuki Naganawa

“…An ectopic tonsil is defined as tonsillar tissue that develops in areas outside of the four major tonsil groups: the palatine, lingual, pharyngeal, and tubal tonsils. The occurrence of tonsillar tissue in the oral cavity in ectopic locations, its prevalence, and its developmental mechanisms that belong to its formation remain unclear. …”
Get full text