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    Whole blood ratio of CDK1/CX3CR1 mRNA expression combined to lactate refines the prediction of ICU mortality in septic patients in the Sepsis-3 era: a proof-of-concept study by Marie-Angélique Cazalis, Marie-Angélique Cazalis, Louis Kreitmann, Louis Kreitmann, Guillaume Monneret, Guillaume Monneret, Alexandre Pachot, Alexandre Pachot, Karen Brengel-Pesce, Karen Brengel-Pesce, Jean-François Llitjos, Jean-François Llitjos, Jean-François Llitjos

    Published 2025-01-01
    “…The predictive performance of the mRNA biomarkers combination was assessed in association with lactate level to refine ICU mortality prediction.Main resultsAmong 180 chips from 100 septic patients, we identified 39 upregulated and 2 downregulated differentially expressed genes (DEGs) in survivors vs. non-survivors, both at day 1 and days 2–3 following ICU admission. …”
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  9. 1349

    Shifting vegetation phenology in protected areas: A response to climate change by Irina Ontel, Sorin Avram, Carmen Adriana Gheorghe, Mihaita Iulian Niculae, Ionuț Silviu Pascu, Steliana Rodino

    Published 2025-03-01
    “…This study comprehensively examined the impact of climate change on vegetation phenology within Romanian protected areas (PAs), focusing on critical phenological indicators such as the start of season (SOS), end of season (EOS), length of season (LOS), position of peak (POP), and photosynthetic metrics, including mean spring (MSP) and mean autumn (MAU). …”
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    Exploring the anticancer potential of extracts and compounds from the heartwood of Cotinus coggygria Scop. wild growing in Serbia by Ivana Pašić, Miroslav Novaković, Vele Tešević, Slobodan Milosavljević, Nina Petrović, Tatjana Stanojković, Ivana Z. Matić

    Published 2025-02-01
    “…The extracts and compounds showed selective cytotoxicity against HeLa, MDA-MB-231, HL-60, K562, A375, PC-3, and DU 145 cells. HeLa cells were the most sensitive to the cytotoxicity of MME (IC50 value of 47.45 µg/mL), while leukemia K562 and HL-60 cells were the most sensitive to the MME and EE (IC50 values in the range from 31.04 to 44.57 µg/mL). …”
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    Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today by Dorela-Codruta Lazureanu, Amelia Burlea, Robert Barna, Daniela Cipu, Mihaela Pasca Fenesan, Ioan Icma, Marioara Cornianu

    Published 2025-01-01
    “…Tissues samples were routinely processed, stained with hematoxylin-eosin (HE) and periodic acid–Schiff (PAS), and submitted to complementary immunohistochemistry tests. …”
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