Analysis of the Seismic Demand of High-Performance Buckling-Restrained Braces under a Strong Earthquake and Its Aftershocks by Luqi Xie, Jing Wu, Qing Huang, Chao Tong

“…The results indicate that the AISC threshold value of the CPD with 200 is excessively low for a HPBRBF which suffers the continuous strong aftershocks with near-fault excitations, and a stricter threshold value should be suggested to ensure the ductility and plastic deformation capacity demand of the HPBRB.…”
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Prediction of the axial compression capacity of ECC-CES columns using adaptive sampling and machine learning techniques by Khaled Megahed

“…These models were comprehensively evaluated, displaying a superior prediction performance compared to design standards such as EC4 and AISC360. From evolution metrics, the Gaussian process regression, CatBoost (CATB), and LightGBM (LGBM) models emerged as the most accurate and reliable model, with nearly more than 97% of FE samples within the 10% error range. …”
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钢管混凝土柱钢—混凝土竖向荷载传递机理研究现状 by 张元植, 罗金辉, 李元齐, 沈祖炎

“…首先结合工程中钢管混凝土柱实际受力特点,对传力构造、粘结作用、抗剪连接件这3种传力路径进行阐述,总结了国内外有关钢管混凝土柱中钢管-混凝土之间竖向荷载传递的试验与理论研究成果;探讨了这3种荷载传递路径的研究现状与不足,结合以往研究对钢管混凝土柱粘结受力状态进行分析;对美国规范(AISC)、欧洲规范(EC 4)、日本规范(AIJ)及我国规程(CECS 159:2004)的相关设计条文及构造措施进行归纳,简要分析了各国规范针对组合结构钢-混凝土竖向荷载传递的设计方法及局限性;最后,针对超高层建筑中框架-核心筒结构体系钢管混凝土巨型柱竖向荷载传递问题,提出了几种保障核心混凝土及时有效参与承担竖向荷载的节点构造措施,并结合已有的研究现状提出尚需进一步解决的问题。…”
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Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo by Liam Kempthorne, Deniz Vaizoglu, Alexander J. Cammack, Mireia Carcolé, Martha J. Roberts, Alla Mikheenko, Alessia Fisher, Pacharaporn Suklai, Bhavana Muralidharan, François Kroll, Thomas G. Moens, Lidia Yshii, Stijn Verschoren, Benedikt V. Hölbling, Francisco C. Moreira, Eszter Katona, Rachel Coneys, Paula de Oliveira, Yong-Jie Zhang, Karen Jansen, Lillian M. Daughrity, Alexander McGown, Tennore M. Ramesh, Ludo Van Den Bosch, Gabriele Lignani, Ahad A. Rahim, Alyssa N. Coyne, Leonard Petrucelli, Jason Rihel, Adrian M. Isaacs

“…In C9orf72 patient-derived iPSC-neuron lines, CRISPR-CasRx reduces endogenous sense and antisense repeat RNAs and DPRs and protects against glutamate-induced excitotoxicity. …”
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Methylammonium-free, high-efficiency, and stable all-perovskite tandem solar cells enabled by multifunctional rubidium acetate by Xufeng Liao, Xuefei Jia, Weisheng Li, Xiting Lang, Jianhua Zhang, Xinyu Zhao, Yitong Ji, Qingguo Du, Chun-Hsiao Kuan, Zhiwei Ren, Wenchao Huang, Yang Bai, Kaicheng Zhang, Chuanxiao Xiao, Qianqian Lin, Yi-Bing Cheng, Jinhui Tong

“…When further integrated with a 1.79-electron volt MA-free wide-bandgap PSC, a 29.33% (certified 28.11%) efficient MA-free APTSCs with a high Voc of 2.22 volts is achieved.…”
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Relevant Elements of Standardisation of Federation’s Advisory Programs for Voluntary Sports Clubs by Marisa Moser, Matthias Buser, Siegfried Nagel

“…However, a certain flexibility supports the adoption of input by VSCs and helps prevent resistance. Further research is needed to clarify how the degree of standardisation affects subsequent structural changes at a VSC level. …”
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Human neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components by Malena Herrera Lopez, Matías Bertone Arolfo, Mónica Remedi, Laura Gastaldi, Carlos Wilson, Gonzalo G. Guendulain, Danilo Ceschin, Andrés Cardozo Gizzi, Alfredo Cáceres, Ana Lis Moyano

“…Here we show that hiPSCs and hNRs secrete EVs (hiPSC-EVs and hNR-EVs) with distinctive protein cargoes. …”
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Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening by Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau, Vaibhav Jadhav, Omkar Suhas Vinchure, Nazlican Altinisik, Hannes Windoffer, Sarah Muller, Ina Rothenaigner, Sean Lin, Aruljothi Mariappan, Dhanasekaran Rathinam, Ali Mirsaidi, Olivier Goureau, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Bernd Wollnik, Alysson Muotri, Limor Freifeld, Nathalie Jurisch-Yaksi, Roberto Pallini, Christine R. Rose, Volker Busskamp, Elke Gabriel, Kamyar Hadian, Jay Gopalakrishnan

“…Here, we describe a method that reproducibly generates thousands of organoids across multiple hiPSC lines. These High Quantity brain organoids (Hi-Q brain organoids) exhibit reproducible cytoarchitecture, cell diversity, and functionality, are free from ectopically active cellular stress pathways, and allow cryopreservation and re-culturing. …”
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LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype by Nadia Cobo‐Vuilleumier, Silvia Rodríguez‐Fernandez, Livia López‐Noriega, Petra I. Lorenzo, Jaime M. Franco, Christian C. Lachaud, Eugenia Martin Vazquez, Raquel Araujo Legido, Akaitz Dorronsoro, Raul López‐Férnandez‐Sobrino, Beatriz Fernández‐Santos, Carmen Espejo Serrano, Daniel Salas‐Lloret, Nila vanOverbeek, Mireia Ramos‐Rodriguez, Carmen Mateo‐Rodríguez, Lucia Hidalgo, Sandra Marin‐Canas, Rita Nano, Ana I. Arroba, Antonio Campos Caro, Alfred CO Vertegaal, Alejandro Martín‐Montalvo, Franz Martín, Manuel Aguilar‐Diosdado, Lorenzo Piemonti, Lorenzo Pasquali, Roman González Prieto, Maria Isabel García Sánchez, Decio L. Eizirik, Maria Asuncion Martínez‐Brocca, Marta Vives‐Pi, Benoit R. Gauthier

“…Additionally, BL001 alleviated PBMC‐induced apoptosis and maintained insulin expression in human iPSC‐derived islet organoids. …”
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Modulation of Adipose-Derived Mesenchymal Stem/Stromal Cell Transcriptome by G-CSF Stimulation by Luz M. Avila-Portillo, Fabio Aristizabal, Angela Riveros, Martin C. Abba, Diego Correa

“…Collectively, these data suggest a direct modulatory effect of G-CSF on ADSC function, potentially altering their therapeutic capacity and thus the design of future clinical protocols.…”
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A reduction-secretion system contributes to roxarsone (V) degradation and efflux in Brevundimonas sp. M20 by Xuehui Zong, Xuyang Wang, Minghui Yu, Jiahui Wang, Congcong Li, Bing Wang, Yongan Wang

“…Abstract Roxarsone (V) (Rox(V)) is an organoarsenical compound that poses significant risks to aquatic ecosystems and various diseases. …”
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Seismic Behavior of the Removable Links in Eccentrically Braced Frames with Semirigid Connections by Qiang Shi, Shilin Yan, Xinwu Wang, Haisu Sun, Yan Zhao

“…The EBFs with semirigid connections exhibit good inelastic rotation ability, and the inelastic rotation of all specimens and models exceeds the limit of 2016 AISC specification. Due to the slip between members, the hysteretic curves of those new structures show different degrees of pinching phenomenon and it becomes more obvious with the increase of the length of links. …”
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Deficiency of FABP7 Triggers Premature Neural Differentiation in Idiopathic Normocephalic Autism Organoids by Xiao Han, Yuanlin He, Yuanhao Wang, Wenzhu Hu, Chu Chu, Lei Huang, Yuan Hong, Lu Han, Xu Zhang, Yao Gao, Yuan Lin, Hongxia Ma, Hongbing Shen, Xiaoyan Ke, Yan Liu, Zhibin Hu

“…Here, it is generated induced pluripotent stem cell (iPSC)‐derived cerebral organoids from normocephalic individuals with ASD in a prospective birth cohort with a shared clinical diagnosis. …”
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Comparison of the effects of pulse and direct injection flushing methods after intravenous injection of non-irritating drugs (脉冲式和直接推注式冲管方法用于非刺激性药物输注的效果比较)... by WANG Yali (王亚丽), WEI Yongchun (魏永春), E Haiyan (鄂海燕), DONG Yuxia (董玉霞), SUN Lei (孙磊)

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EPIMR: Prediction of Enhancer-Promoter Interactions by Multi-Scale ResNet on Image Representation by Qiaozhen Meng, Yinuo Lyu, Xiaoqing Peng, Junhai Xu, Jijun Tang, Fei Guo

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Influence of Adipose Tissue-Derived Stem Cells on the Burn Wound Healing Process by Claudio Luciano Franck, Alexandra Cristina Senegaglia, Lidiane Maria Boldrini Leite, Sérgio Adriane Bezerra de Moura, Nathália Forti Francisco, Jurandir Marcondes Ribas Filho

“…Intradermal ADSC transplantation was performed in two stages. …”
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Numerical and analytical evaluation of the compressive performance of Steel Tube (ST)-reinforced Concrete Filled Stainless Steel Tubular (CFSST) columns by Md. Imran Kabir, Munim Shahriar Rehan, Zarif Ahmed, Ann Nazmun Sakib, Muntasir Mohammad Shoeb

“…Furthermore, the FE predicted axial strengths of the columns were compared with those calculated from different design codes, such as ACI 318–14, EC 4, ANSI/AISC 360–16, and AS 2327. Existing design codes underestimated the peak axial strengths of the columns, particularly for long columns. …”
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Strength prediction of ECC-CES columns under eccentric compression using adaptive sampling and ML techniques by Khaled Megahed

“…These models were thoroughly evaluated and demonstrated superior prediction accuracy compared to established design standards like EC4 and AISC360. Based on evaluation metrics, the Gaussian Process Regression (GPR), CatBoost (CATB), and LightGBM (LGBM) models emerged as the most accurate and reliable, with over 97% of the finite element (FE) samples falling within a 10% error range. …”
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Comparison of Immunosuppressive and Angiogenic Properties of Human Amnion-Derived Mesenchymal Stem Cells between 2D and 3D Culture Systems by Vitale Miceli, Mariangela Pampalone, Serena Vella, Anna Paola Carreca, Giandomenico Amico, Pier Giulio Conaldi

“…In our study, we show that a three-dimensional (3D) culture method is effective to induce MSC spheroid formation, to maintain the multipotency and to improve the paracrine activity of a specific population of human amnion-derived MSCs (hAMSCs). …”
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A Chemically Defined Serum-Free Culture System for Spontaneous Human Mesenchymal Stem Cell Spheroid Formation by Yajun Zhao, E. Xiao, Wanqi Lv, Xian Dong, Linhai He, Yixiang Wang, Yi Zhang

“…Compared with monolayer culture, adipose-derived stem cell (ADSC) spheroids enhanced the proliferation and osteogenic capability of ADSCs compared with monolayer culture. …”
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