High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis by Arvind Pradip, Daniella Steel, Susanna Jacobsson, Gustav Holmgren, Magnus Ingelman-Sundberg, Peter Sartipy, Petter Björquist, Inger Johansson, Josefina Edsbagge

“…The present study aimed to investigate the use of hiPSC derived hepatocytes for conducting mechanistic toxicity testing by image based high content analysis (HCA). …”
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Expression Analysis of ATP-Binding Cassette Transporters ABCB11 and ABCB4 in Primary Sclerosing Cholangitis and Variety of Pediatric and Adult Cholestatic and Noncholestatic Liver... by Cornelia Thoeni, Ruediger Waldherr, Jutta Scheuerer, Stefanie Schmitteckert, Ralph Roeth, Beate Niesler, Ernest Cutz, Christa Flechtenmacher, Benjamin Goeppert, Peter Schirmacher, Felix Lasitschka

“…We concluded from our study that patients with PSC demonstrate altered expression levels and pattern of ABCB11 and ABCB4 which correlated with disease progression; thereby, ABCB11 and ABCB4 analysis may be a useful tool for assessment of disease stages in PSC.…”
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Prion Diseases and the Gastrointestinal Tract by Gwynivere A Davies, Adam R Bryant, John D Reynolds, Frank R Jirik, Keith A Sharkey

“…This is further supported by the presence of PrPsc in the ganglia of the parasympathetic and sympathetic nerves that innervate the GI tract. …”
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Novel, low-cost bioreactor for in vitro electrical stimulation of cardiac cells by Joseph P. Licata, Jonathan A. Gerstenhaber, Peter I. Lelkes

“…However, there are discrepancies in the literature as to best practices for promoting cardiac differentiation using ES.MethodsThis study presents a novel, 3D printed bioreactor that delivers in vitro ES to human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), promoting cell maturity and functional readiness for implantation. …”
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Engineering Education in the Context of Digitalization and Transition to a Green Economy (SYNERGY 2022 Conference Results Review) by M. F. Galikhanov, V. V. Kondratyev, I. G. Akhmetov, G. R. Ganieva

“…Among the participants were representatives of national research universities and supporting universities of PJSC Gazprom, state authorities and industrial enterprises of Tatarstan. …”
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The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis by Cheng Gong, Xian Qin, Jian Yang, Tao Guo

“…We extracted data on incidence of Portal vein system thrombosis (PVST) from studies that compared various anticoagulation strategies for use with patients who underwent splenectomy with cirrhosis. …”
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Acoustic emissions and electric signal recordings, when cement mortar beams are subjected to three-point bending under various loading protocols by A. Kyriazopoulos

“…The expe¬rimental results of the AE and PSC techniques lead to the conclusion that when the calculated Ib values decrease, the PSC starts increasing strongly.…”
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碱性成纤维生长因子对脂肪干细胞分化为心肌细胞的影响

“…将成功建立心肌梗死(MI)模型的60只大鼠随机分4组(n = 15/组):PBS组?bFGF组?ADSC组及bFGF+ADSC组?建立心梗1周后分别注射PBS?bFGF?…”
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Utility of Lymphoblastoid Cell Lines for Induced Pluripotent Stem Cell Generation by Satish Kumar, Joanne E. Curran, David C. Glahn, John Blangero

“…Further, we investigated the transcriptional changes in mRNA and miRNA levels, using FC-abs ≥ 2.0 and FDR ≤ 0.05 cutoffs; 5,228 mRNAs and 77 miRNAs were differentially expressed during LCL-to-iPSC reprogramming. The functional enrichment analysis of the upregulated genes and activation of human pluripotency pathways in the reprogrammed iPSCs showed that the generated iPSCs possess transcriptional and functional profiles very similar to those of human ESCs.…”
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Gene Editing in Pluripotent Stem Cells and Their Derived Organoids by Hang Zhou, Yun Wang, Li-Ping Liu, Yu-Mei Li, Yun-Wen Zheng

“…Here, we briefly introduce current gene-editing technology and its application in PSCs and their derived organoids, while addressing ethical concerns and safety risks and discussing the latest progress in PSC gene editing. …”
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Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin by Jun Iida, Kazuki Kotani, Kozue Murata, Keisuke Hakamada, Wusiman Maihemuti, Yoshinobu Mandai, Yosuke Hiraoka, Kenji Minatoya, Hidetoshi Masumoto

“…Abstract This study explored the impact of hydrolyzed gelatin (HG) concentration on the retention and therapeutic efficacy of human iPS cell-derived cardiomyocytes (hiPSC-CMs) when injected into the myocardium. …”
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Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats by Yashiro Motooka, Hideaki Tanaka, Yuki Maeda, Misako Katabuchi, Tomoji Mashimo, Shinya Toyokuni

“…Exon 11 constitutes a region where pathogenic variants (PVs) accumulate, and mutations in this region are known to contribute to carcinogenesis. …”
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Porous Single-Crystalline Rare Earth Phosphates Monolith to Enhance Catalytic Activity and Durability by Wenting Li, Lingting Ye, Chaoyang Tu, Kui Xie

“…Porous single-crystalline (PSC) PrPO₄ and SmPO₄ with a large surface area consist of ordered lattices and disordered interconnected pores, resulting in activity similar to nanocrystals and stability resembling bulk crystals. …”
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Inhibition of JAK-STAT ERK/MAPK and Glycogen Synthase Kinase-3 Induces a Change in Gene Expression Profile of Bovine Induced Pluripotent Stem Cells by Luis F. Malaver-Ortega, Huseyin Sumer, Jun Liu, Paul J. Verma

“…Pluripotent stem cells (PSCs) fall in two states, one highly undifferentiated, the naïve state, and the primed state, characterized by the inability to contribute to germinal lineage. …”
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Effect of Xingnao Kaiqiao Acupuncture combined with EEG Biomimetic Electrical Stimulation on Evoked Potential of Patients with Persistent Vegetative State by Lixia DENG, Jiquan LIU, Liangxiang ZHANG, Xiao LV, Xing CHEN, Yigang FENG, Yingying NI

“…Objective:To observe the effect of Xingnao Kaiqiao acupuncture combined with EEG biomimetic electrical stimulation on brainstem auditory evoked potential (BEAP) and somatosensory evoked potential (SEP) in patients with persistent vegetative state (PVS).Methods:A total of ninety patients with PVS treated in the PVS awareness center of Guangdong 999 Brain hospital were randomly divided into Acupuncture group, Bionic electricity group and Combined group, with thirty cases in each group. …”
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The effect of different feed on the spawning performance of mud crab Scylla serrata broodstock by Bethsy J. Pattiasina, Endang Jamal, Agapery Y. Pattinasarany

“…Hatching rate of larvae in PSC treatment was higher compared to PI and PB treatments (p<0.05). …”
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Clostridium Scindens Protects Against Vancomycin‐Induced Cholestasis and Liver Fibrosis by Activating Intestinal FXR‐FGF15/19 Signaling by Jintao Xiao, Yanliang Hou, Xingyang Luo, Yuhao Zhu, Wenhu Li, Bingbing Li, LinXiang Zhou, Xia Chen, Ying Guo, Xiaomei Zhang, Haiyue He, Xiaowei Liu

“…Abstract Primary sclerosing cholangitis (PSC) is characterized by abnormal bile acid metabolites and altered gut microbiota, with no effective treatments available. …”
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Regional Development: New Challenges for Engineering Education (SYNERGY-2021 Conference Results Review) by V. V. Kondratyev, M. F. Galikhanov, F. T. Shageeva, P. N. Osipov, L. V. Ovsienko

“…Among the participants were representatives of international societies for engineering education, ten national research universities and seven supporting universities of PJSC Gazprom, state authorities and industrial enterprises of Tatarstan. …”
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Collection and Determination of Clinical Problems and Outcome Indicators of Expert Consensus on Clinical Application of Ethnic Medicine in the Treatment of Palpitation (Arrhythmia-... by ZHANG Wenjie, LI Jun, CHEN Hengwen, TAN Yuqing, XIE Zicong, WU Ji, MENG Chao, LI Zhaoling, ZHANG Lesong

“…Background Ethnic medicine holds numerous advantages in the treatment of premature ventricular complexes (PVCs). However, there is a concerning trend of abuse of ethnic medicine, particularly in the absence of tailored clinical drug recommendations specifically designed for this purpose. …”
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FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial by Laith Alrubaiy, Rachel Cooney, Tariq Iqbal, Mohammed Nabil Quraishi, Susan Manzoor, Christopher Quince, Palak J Trivedi, Andrew D Beggs, Alexandra Vince, Chris Weston, Benjamin Mullish, Sahida Shabir, Nicola Jackson, Anna Rowe, Victoria Homer, Willem van Schaik, Peter Rimmer, Sarah Al-Shakhshir, Arzoo Patel, Derick Gyimah, Miriam Hares, Elena Efstathiou

“…Introduction Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). …”
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