Impact of estimated glomerular filtration rate (eGFR) on in-hospital mortality: an age- and HIV status-specific retrospective cohort study in Uganda by Odong Christopher, Wang Yanmei, Makabayi Emmanuel Yeko, Doreen Mary Nanyunja, Kuule Julius Kabbali

“…This study aimed to explores this association, offering insights into its impact in resource-limited settings. …”
Get full text

Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…This comprehensive approach offers potential insights for understanding and potentially reprogramming aged microglia, with implications for combating age-related neurological disorders.…”
Get full text

Enhancing Diagnostic Accuracy of Lung Nodules in Chest Computed Tomography Using Artificial Intelligence: Retrospective Analysis by Weiqi Liu, You Wu, Zhuozhao Zheng, Mark Bittle, Wei Yu, Hadi Kharrazi

“…ConclusionsThe AI system enhanced lung nodule detection, offering the possibility of earlier disease identification and timely intervention. …”
Get full text

Retrieval and Evaluation of Global Surface Albedo Based on AVHRR GAC Data of the Last 40 Years by Shaopeng Li, Xiongxin Xiao, Christoph Neuhaus, Stefan Wunderle

“…Besides the fact that the new GAC43 product shows the best stability covering the last 40 years, one has to consider the higher proportion of backup inversions before 2000. Overall, GAC43 offers a promising long-term and consistent albedo with good accuracy for future studies such as global climate change, energy balance, and land management policy.…”
Get full text

Examining teen club attendance and viral load suppression among adolescents under differentiated HIV care in Malawi: a sub-optimal scenario by Rachel Chamanga, Tessa Musukwa, Louiser Kalitera, Felix Gent, Harrid Nkhoma, Kwashie Kudiabor, Alice Maida, Dumbani Kayira, Verita Buie, Godfrey Woelk, Thulani Maphosa

“…Methods This cross-sectional study used program data from 35 health facilities in four districts that offered teen club services. We enrolled all ALHIV receiving ART ages 10–19 years who attended teen clubs between July 2018- September 2019 and had documented viral load results. …”
Get full text

The Application of Three-dimensional Shear Wave Elastography in the Detection of Inguinal Lymph Node Metastasis in Gynecological Malignancies by Yuping Shen, Jiulong Dai, Jiami Li, Man Lu

“…This study implements three-dimensional shear wave elastography (3D-SWE), an innovative technique that quantifies the stiffness of inguinal lymph nodes (ILN) in patients with gynecological cancers. This approach offers a more comprehensive assessment of ultrasound elastography compared to traditional methods. …”
Get full text

Synergy of Remote Sensing and Geospatial Technologies to Advance Sustainable Development Goals for Future Coastal Urbanization and Environmental Challenges in a Riverine Megacity by Minza Mumtaz, Syed Humayoun Jahanzaib, Waqar Hussain, Sadia Khan, Youssef M. Youssef, Saleh Qaysi, Abdalla Abdelnabi, Nassir Alarifi, Mahmoud E. Abd-Elmaboud

“…This integrated approach provides valuable insights for urban planners, offering a novel framework for adaptive urban planning strategies and advancing sustainable practices in similar stressed megacity regions.…”
Get full text

Effects of cold-water immersion on health and wellbeing: A systematic review and meta-analysis. by Tara Cain, Jacinta Brinsley, Hunter Bennett, Max Nelson, Carol Maher, Ben Singh

“…<h4>Conclusions</h4>This systematic review suggests that CWI delivers time-dependent effects on inflammation, stress, immunity, sleep quality, and quality of life, offering potential practical applications for health practitioners considering CWI for stress management and wellbeing support. …”
Get full text

Sodium Butyrate: A Multifaceted Modulator in Colorectal Cancer Therapy by Alexandra Laura Mederle, Alexandra Semenescu, George Andrei Drăghici, Cristina Adriana Dehelean, Nicolae-Valentin Vlăduț, Dragoş Vasile Nica

“…<i>Results:</i> This study provides the first exploration of <i>MCL-1</i> and <i>PCNA</i> modulation by NaB in the context of CRC and HCT-116 cells, offering significant translational insights. All treatments reduced cell viability, confluence, and number in a dose-dependent manner (<i>p</i> < 0.0001). …”
Get full text

Predictive modelling and identification of critical variables of mortality risk in COVID-19 patients by Olawande Daramola, Tatenda Duncan Kavu, Maritha J. Kotze, Jeanine L. Marnewick, Oluwafemi A. Sarumi, Boniface Kabaso, Thomas Moser, Karl Stroetmann, Isaac Fwemba, Fisayo Daramola, Martha Nyirenda, Susan J. van Rensburg, Peter S. Nyasulu

“…The study reveals how ML could assist medical practitioners in making informed decisions on handling critically ill COVID-19 patients with comorbidities. It also offers insight into the combined effect of CV, PCA, and SMOTE on the performance of ML models for COVID-19 mortality risk prediction, which has been little explored.…”
Get full text

OPTIMALISASI PENCAHAYAAN ALAMI DENGAN USEFUL DAYLIGHT ILLUMINANCE PADA DESAIN RUMAH TOKO (RUKO) DI KOTA LHOKSEUMAWE by Atthaillah Atthaillah, Amril Bakhtiar, Badriana Badriana

“…Kata Kunci: Pencahayaan Alami; Useful Daylight Illuminance (UDI); Ruko; Rhinoceros & Grasshopper; Ladybug & Honeybee   Abstract_ This study offered a daylight-friendly design of shophouse for Lhokseumawe, which it contributed to the immediate save of energy.  …”
Get full text

Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China by Bangfeng Han, Liu Liu, Zhishen Jiang, Li Ye, Yubin Cao, Jian Pan

“…Background Autogenous tooth transplantation offers significant advantages and promising success rates for replacing non-retainable teeth. …”
Get full text

Hyperbaric oxygen potentiates platelet-rich plasma composition and accelerates bone healing by Wen-Shuo Chang, Chien-Cheng Huang, Tzu-Hao Chen, Ssu-Han Chao, Cheng-Hsien Lin, Ching-Ping Chang, Chi-Sheng Chien

“…Our findings demonstrate that HBOP potentiates the biological activity of PRP, offering promising therapeutic potential for bone fracture healing. …”
Get full text

Sedoanalgesia with dexmedetomidine in daily anesthesia practices: a prospective randomized controlled trial by Ali Kendal Oğuz, Celaleddin Soyalp, Yunus Emre Tunçdemir, Arzu Esen Tekeli, Nureddin Yüzkat

“…Conclusion The dexmedetomidine-propofol combination is an effective and safe anesthetic regimen for deep sedation in outpatient hysteroscopic procedures, offering adequate sedation and superior preservation of respiratory function. …”
Get full text

Summer Research Internship Curriculum to Promote Self-Efficacy, Researcher Identity, and Peer-to-Peer Learning: Retrospective Cohort Study by Yulia A Levites Strekalova, Rachel Liu-Galvin, Samuel Border, Sara Midence, Mishal Khan, Maya VanZanten, John Tomaszewski, Sanjay Jain, Pinaki Sarder

“…HuBMAP, a 400-member research consortium funded by the Common Fund at the National Institutes of Health, offered a 10-week summer research internship that included an academic enrichment curriculum delivered synchronously via the web to all students across multiple sites. …”
Get full text

Carotenoids in the treatment of age-related macular degeneration: a drug delivery system does matter by M.L. Maximov, Zh.G. Oganezova, I.D. Kanner, Voznesenskaya A.A

“…The micro-encapsulated formula offers such an advantage as gradual and controlled release of active substances. …”
Get full text

Synthesizing evidence to guide the design and implementation of effective strategies for discontinuing postoperative antibiotic prophylaxis in surgical settings: an umbrella review... by George Msema Bwire, Renatus B. Magati, Hafidhi H. Ntissi, Tusaligwe Mbilinyi, Martine A. Manguzu, Goodluck G. Nyondo, Belinda J. Njiro, Lilian B. Nkinda, Castory G. Munishi, Obadia Nyongole, Pacifique Ndayishimiye, Mtebe V. Majigo

“…However, studies have shown that PAP offers no additional benefits compared to discontinuation after surgical incision closure, prompting its de-implementation to prevent unnecessary antibiotic use that may contribute to antibiotic resistance. …”
Get full text

Programmed Cell Death Ligand 1 (PD-L1) and major Histocompatibility Complex Class I (MHC Class I) Expression Patterns and Their Pathologic Associations in triple-Negative Breast Ca... by Kaewkedsri P, Intarawichian P, Jessadapattarakul S, Kunprom W, Koonmee S, Thanee M, Somintara O, Wongbuddha A, Chadbunchachai P, Nawapun S, Aphivatanasiri C

“…Patients with negative PD-L1 and high MHC class I expression had the most favorable prognosis, with significant OS for CPS ≥ 1 (HR = 0.447, 95% CI: 0.236– 0.846, p=0.013) and CPS ≥ 10 (HR = 0.516, 95% CI: 0.307– 0.869, p=0.013).Conclusion: These findings support the potential of PD-L1 and MHC class I expression as prognostic markers for TNBC, offering insights to guide treatment decisions and improve patient outcomes.Keywords: triple-negative breast cancer, TNBC, programmed cell death ligand 1, PD-L1, major histocompatibility complex class I, MHC class I, immunohistochemistry, prognosis…”
Get full text

Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy by Jian Cheng, Miaomiao Sun, Xiao Dong, Yang Yang, Xiaohan Qin, Xing Zhou, Yongcheng Fu, Yuanyuan Wang, Jingyue Wang, Da Zhang

“…The SRPS model, incorporating SLC1A5-associated genes, offers robust prognostic utility. Targeting SLC1A5 through advanced drug delivery systems and combined metabolic-immunotherapeutic strategies may enhance treatment specificity and efficacy. …”
Get full text

Foliar application of 24-epibrassinolide enhances leaf nicotine content under low temperature conditions during the mature stage of flue-cured tobacco by regulating cold stress tol... by Haiyang Chen, Shuaitao Zhang, Jianbo Chang, Hongru Wei, Hongchen Li, Chaoyang Li, Junjie Yang, Zhengxiong Song, Zhaojun Wang, Jin Lun, Xuelin Zhang, Lihua Li, Xiaoquan Zhang

“…Furthermore, these findings may be applicable to other cold-sensitive crops, offering broader benefits for improving resilience and productivity under low temperatures. …”
Get full text