Farmacovigilância de vacinas contra COVID-19 no Brasil: ações realizadas, lições aprendidas e próximos passos by Roberta Mendes Abreu Silva, Cibelle Mendes Cabral, Jadher Percio, Martha Elizabeth Brasil da Nóbrega, Carla Dinamerica Kobayashi, Adriano Ferreira Martins, Felipe Daniel Cardoso, Victor Bertollo Gomes Porto, Leon Capovilla, Mônica Brauner de Moraes, Paulo Henrique Santos Andrade, Eder Gatti Fernandes

“…Colaborações interinstitucionais, disponibilidade de recursos adicionais, flexibilidade e oportunidade dos sistemas de informação contribuíram para que as ações de preparação e resposta da farmacovigilância de vacinas contra a covid-19 fossem efetivadas de forma abrangente no Brasil.…”
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Green remediation of lead (pb) from Pb-toxic soil by combined use of silicon nanomaterials and leguminous Lens culinaris L. plants by Tayyaba Naz, Muhammad Mazhar Iqbal, Bilal Raza, Muhammad Asad Mubeen, Muhammad Ather Nadeem, Abdullah Ahmed Al-Ghamdi, Mohamed S Elshikh, Muhammad Rizwan, Rashid Iqbal

“…Whereas Si and nano-Si lessened the negative effect of Pb toxicity by significantly reducing its concentration in plant roots and shoot, and improved agro-physiological traits of lentil in normal and Pb-toxic soil conditions. …”
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Impaction bone grafting for acetabular bone defects replacement in revision hip arthroplasty: biomechanical aspects by Vadim N. Golnik, Natalia V. Fedorova, Alexey Y. Larichkin, Svetlana V. Boyko, Andrey A. Panchenko, Alexandr M. Kosinov, Vladimir A. Peleganchuk, Vitaliy V. Pavlov

“…The change in the position of the rotation center and acetabular component in the absence of a radiolucent line is not an absolute sign of loosening.…”
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Performance of Cementless Hip Arthroplasty Stem Types Based on Consolidated Large Registry Data by Logan E. Finger, MD, Matthew F. Gong, MD, Asher Mirvish, BS, Alexandra S. Gabrielli, MD, Ahmad P. Tafti, PhD, Michael J. O’Malley, MD, Brian A. Klatt, MD, Johannes F. Plate, MD, PhD

“…Background: Improvements in cementless total hip arthroplasty have been directed at optimizing osseointegration of the femoral implant to reduce aseptic loosening rates. Stem design plays a critical role in the performance of these implants. …”
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Safety and Efficacy of Polyetheretherketone (PEEK) Cages and Cadaveric Allografts in Transforaminal Lumbar Interbody Fusion (TLIF) for Treating Lumbar Pyogenic Spondylodiscitis by Huo-Liang Zheng, Bo Li, Shao-Kuan Song, Peng-Bo Chen, Xin-Feng Zheng, Lei-Sheng Jiang, Sheng-Dan Jiang

“…At the final follow-up, there were five cases with subsidence of the cage, no case of recurrence, and no case with cage and screw loosening or migration. The mean preoperative VAS and ODI scores were 8.9 and 74.6%, respectively, and improvements in VAS and ODI were 6.6±2.2 and 50.4±21.3%, respectively. …”
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Cementless Metaphyseal Sleeve Fixation in Revision Knee Arthroplasty: Our Experience with an Arabic Population at the Midterm by Abdulrahman D. Algarni

“…Knee radiographs were obtained to evaluate the alignment and osseointegration or loosening of the MS. Results. A total of 52 sleeves (27 tibial and 25 femoral) implanted in 27 RKAs (27 patients) were included. …”
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Interprosthetic Joint Motion in Bipolar Partial Hip Arthroplasty After One-Year Follow-up by Noreen Joyce Yeo, Liberato Antonio Leagogo

“…The bipolar prosthesis was developed to lessen the acetabular erosion encountered with the unipolar prosthesis. …”
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Disparities in well-being outcomes among medical students: a comparative study between medical students with and without disability by Henry J. Seaborne, Lara Z. Chehab, Nikhil Rajapuram, Amanda Sammann

“…Current interventions and modifiable factors are insufficient in lessening severe distress for these students. These findings highlight the necessity for tailored support strategies and structural interventions to improve the well-being of medical students with disabilities, especially for those with intersecting vulnerable identities. …”
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Certain Death: Mike Flanagan’s Gothic Antidote to Traumatic Memory and Other Enlightenment Hang-Overs in <i>Doctor Sleep</i> by Erik Bond

“…Building on Stephen King’s 2013 novel and Stanley Kubrick’s 1980 film <i>The Shining</i>, Flanagan’s <i>Doctor Sleep</i> establishes a new lineage of male writers who value how the Gothic traditions of irrational emotion and doubt can inspire new realms of knowledge to lessen psychological suffering caused by traumatic lineage. …”
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Amelioration of Oxidative Stress in Rats with Chronic Obstructive Pulmonary Disease through Shenqi Huatan Decoction Activation of Peroxisome Proliferator-Activated Receptor Gamma-M... by Jingjing Chen, Wenxiao Qiao, Xiaoming Xue, Dian Li, Ye Zhang, Di Xie, Jinyun Wang, Yaoqin Sun, Shuo Yang, Zhuomin Yang

“…ELISA results showed that SQHT could lower the blood levels of MDA and lipid peroxide and raise SOD and TAOC levels, suggesting that it could lessen oxidative stress. In the lung tissue of rats with COPD, large doses of SQHT intervention dramatically increased AMPK protein expression, AMPK-α, FOXO3a, MnSOD, and PPARγ, indicating that SQHT may reduce oxidative stress by activating the PPARγ-mediated AMPK/FOXO3a signaling pathway. …”
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Optimal Bone Preparation for Triple-Tapered Stems: Does the Sagittal Taper Affect Optimal Femoral Sizing? by Jeff Shi, MD, Kevin Salomon, MD, Victor Shen, BS, Andrew Moore, MD, John T. Wilson, MD, Brian Palumbo, MD

“…The TTP overall mean percent metaphyseal fill was 74 ± 6% in the AP view and 71 ± 5% in the lateral view, both significantly higher than single-tapered preparation which was 67 ± 7% and 65 ± 7%, respectively (P < .001). No fractures or loosening occurred in this series. Conclusions: Preparation of triple-tapered stems collinear to the diaphyseal sagittal femoral axis improves stem size, fit, and fill.…”
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Clinical Features and Surgical Strategies of Distal Radius Posttraumatic Deformity by Ning Zhang, Jiahu Fang

“…There was no reduction loss, internal fixation loosening, or fracture in the regular postoperative review. …”
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Biomechanical analysis of a newly designed and 3D printed plate-locking interbody cage: an observational study of finite element analysis by Shuai Ni, Rui Yang, Sanmao Liu, Yunxiang Hu

“…The 3D-printed porous plate-locking cage was shown to be biomechanically stable compared to the conventional Zero-profile cage, and it is worth noticing that the stress on the plate of the new cage is less than that on screw of the conventional cage, which indicates that the risk of fracture, loosening, and prolapse of the new cage is less likely to occur.…”
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Comparative Analysis of Long-term Success Rates and Patient Satisfaction among Different Implant Placement Techniques for Implant-Supported Restorations: A Prospective Clinical Tri... by Akash Mithran, Vishal B. Parmar, Malav Sheth, Mansi, Soumalya Banerjee, Minu Raju

“…Prosthetic complications, including crown misfit, abutment screw loosening, and esthetic issues, exhibited comparable rates across groups (P > 0.05). …”
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Implementation of carceral medicaid suspension and enrollment programs: perspectives of carceral and medicaid leaders by Sachini Bandara, Brendan Saloner, Hannah Maniates, Minna Song, Noa Krawczyk

“…Participants also called for further loosening of the Medicaid Inmate Exclusion Policy. …”
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Osteoarthritis of the knee joint and its association with metabolic syndrome: A case control study by Rohini Motwani, Arvind Kumar Bodla, Shravan Kumar Peddamadyam, Mrudula Chandrupatla, Nagesh Cherukuri, Maheshwar Lakkireddy, Gunvanti Rathod, Sai Ram Challa, Chowdavarapu Raghavendra Rao, Abhishek Arora, Srikanth Eppakayala, Arcot Reddy Vamsi Krishna

“…It might also emphasize how critical it is to treat MetS symptoms to lessen the severity of OAK. Understanding whether MetS or its components are linked to an increased risk of TKA could provide crucial insights into preventive and therapeutic strategies for managing severe OAK.…”
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SURVIVING HUMANITARIAN CRISIS IN NIGERIA: COPING STRATEGIES OF INTERNALLY DISPLACED PERSONS (IDP) IN BENUE STATE, NORTHCENTRAL, NIGERIA by ISAAC OLAWALE ALBERT, JOEL ABAH

“…The study argues that government and CSOs inchoate interventions have left the IDP with the option of fending for their needs; and this, have led to reducing sufferings, as well as lessening dependence on epileptic humanitarian aids; thereby enhancing and self-reliance. …”
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Non-pharmacological interventions for the prevention of type 2 diabetes in low-income and middle-income countries: a systematic review of randomised controlled trials by K M Saif-Ur-Rahman, Md Shariful Islam, Anupam Sarker, Rina Das, Saraban Ether

“…All the studies demonstrated a low ROB in most of the bias assessment domains with some unclear results in allocation concealments.Conclusions Emphasising non-pharmacological interventions for T2DM prevention can improve health outcomes and lessen the economic burdens, which will be of paramount importance in LMICs.Systematic review registration number CRD42020191507…”
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Topotecan Incorporation Into Avocado Oil-based Nanoemulsion Potentiates Its Inhibitory Effect on the Cellular Growth of Various Human Cancer Cells by Mayson H. Alkhatib, Hadeel M. Bayoumi

“…In MCF-7 and HCT116 cells, cytotoxicity of TOPO-AO-NE was attributed to decreased IL-6 levels relative to a negative control, lessened autophagic LC-3 levels compared to free TOPO-treated cells, and induction of type-I apoptotic cell death. …”
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Microstructure and macro-mechanical properties of residual soil subjected to repeated hygroscopic cycles by Xu-tang Xu, Xiang-long Chen, Ye-qing Cai, Xiang Xu

“…In view of the continuous dissolution of soluble minerals and cementing materials and the repeated release of suction in the soil, the internal particles of the soil were gradually loosened. Accompanied by the continuous expansion and penetration of intergranular pores, connecting cracks were ultimately formed. …”
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