Exploring the relationship between established HIV risk factors and depressive symptoms amongst young women without HIV in two sites in South Africa. by Zanenhlanhla Gumbi, Celia Mehou-Loko, Lindi Masson, Makhosazana Mdladla, Nokuthula Maphumulo, Jo-Ann Passmore, Sanele Mbeje, Linda Gail Bekker, Disebo Potloane, Heather Jaspan, Nina Radzey, Andrea Abrahams, Rushil Harryparsad, Pamela Mkhize, Hilton Humphries

“…Socio-behavioural HIV risk factors associated with depressive symptoms include: age disparate relationships (OR 2.98; 95% CI 1.52-5.84), high (four or more) numbers of lifetime partners (OR 8.15; 95% CI 3.60-18.45) and engaging in sex under the influence of alcohol (OR 2.58; 95% CI 1.32-5.04). …”
Get full text

Investigating the potential immunomodulatory effects of commercial oral probiotic supplements on equine gastrointestinal tract barrier function by Agnieszka Żak-Bochenek, Paulina Żebrowska-Różańska, Joanna Bajzert, Łukasz Łaczmański, Bogumiła Szponar, Natalia Siwińska, Klaudia Gładysz, Katarzyna Sikorska, Anna Chełmońska-Soyta

“…The samples were subjected to microbiome analysis via next-generation sequencing of hypervariable regions V3-V4 and V7-V9 of the 16S rRNA gene for analysis of short-chain fatty acids via HPLC analysis and fecal secretory immunoglobulin A (SIgA) quantification via ELISA.ResultsMicrobiome analysis revealed no significant differences in either alpha or beta diversity parameters between the groups. …”
Get full text

Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status by S. Nooij, N. Plomp, I. M. J. G. Sanders, L. Schout, A. E. van der Meulen, E. M. Terveer, J. M. Norman, N. Karcher, M. F. Larralde, R. H. A. M. Vossen, S. L. Kloet, K. N. Faber, H. J. M. Harmsen, G. F. Zeller, E. J. Kuijper, W. K. Smits, Q. R. Ducarmon

“…We uncovered a higher prevalence and abundance of R. gnavus in Westernized populations and observed bacterial relative abundances up to 83% in newborns. Next, we built a resource of R. gnavus isolates (N = 45) from healthy individuals and Crohn’s disease patients and generated complete R. gnavus genomes using PacBio circular consensus sequencing. …”
Get full text

Thematic Issue on “Red Beetroot as a Source of Nutrients, Bioactive Compounds and Pigments” by Wiesław Wiczkowski

“… [2020] presents for the first time the new bidecarboxylated betanins (which might have a strong bioactivities) in red beetroot extract as well as their generation from betanin/isobetanin and mono-decarboxylated betanins during the process of heating. …”
Get full text

Spatial-Temporal Changes and Influencing Factors of Regional Technological Innovation Efficiency in China: A Three Entity Comparative Perspective by Ye Lei, Zhang Ting, Cao Xianzhong, Zeng Gang

“…Firms are expected to surpass the technological innovation efficiency of research institutes in the next two years; however, there is still a large gap with universities, indicating that firms have not yet become key players in the innovation system. 2) The spatial differences between the technological innovation efficiencies of firms, universities, and research institutes are significant. …”
Get full text

Data-Driven Decision Support Tool Co-Development with a Primary Health Care Practice Based Learning Network [version 2; peer review: 2 approved] by Daniel Lizotte, Eric Sutherland, Paulino Lucamba, Sandra Fitzpatrick, Kelly Angevaare, Sara Bhatti, Jennifer Rayner, Jacqueline Kueper

“…We identified three initial meaningful types of decision support, with target application areas: risk prediction/screening, triaging specialized program referrals, and identifying care access needs. Based on feasibility and expected impact, we started with the goal to support earlier identification of mental health decline after diabetes diagnosis. …”
Get full text

Protective effects of berbamine against arginase-1 deficiency-induced injury in human brain microvascular endothelial cells by Xiaolan Wei, Weiwei Li, Zixuan Chen, Jintu Chen, Yun Chen, Jiangping Cai, Huasong Lin

“…The results demonstrated that ARG1 deficiency inhibited HCMEC/D3 cell viability, migration, adhesion, and angiogenesis, while promoting apoptosis and elevating Arg, NO, and ROS levels in HCMEC/D3 cells. Next, the effect of different BBM concentrations on HCMEC/D3 cell viability was assessed using the CCK-8 assay, revealing that BBM at a concentration of 5 µM had no significant impact on cell viability. …”
Get full text

« Pas de retour à nos maisons sans satisfaction de nos revendications ». Le Hirak du Rif en actes face au Makhzen by Ahmed Chapi

“…However, as security forces start blocking access to the main public squares, we'll see in the second part that, from the end of February 2017, activists develop "surprise demonstrations" in order to circumvent these police restrictions and take to the streets once again. This new form of protest fosters broad popular participation and instills a new protest momentum, as activists are questioned daily by inhabitants about the date of the next demonstration, in turn, prompting them to take to the streets frequently. …”
Get full text

Coupling genome-wide continuous perturbation with biosensor screening reveals the potential targets in yeast isopentanol synthesis network by Qi Xiao, Jingjing Shi, Lixian Wang, Guoping Zhao, Yanfei Zhang

“…Branched-chain higher alcohols, such as isopentanol and isobutanol, have attracted significant attention as next-generation biofuels. Biofuel production through microbial fermentation offers a green, sustainable, and renewable alternative to chemical synthesis. …”
Get full text

Connotation, research status, and development directions of clean coal geology in China by Yuegang TANG, Shaoqing WANG, Xiaoshuai WANG, Xin GUO, Yafeng WANG, Liping XUE, Harold H. Schobert

“…[Issues and Prospects] This study proposes some scientific and technical problems concerning coal formation, organic/inorganic elements, minerals, and clean assessment, positing that future advancements in chemistry, physics, biology, and big data/artificial intelligence (AI) will bring opportunities for the further development of clean coal geology and its applications in large-scale engineering. In the next decade, important research and development directions will include the spatiotemporal distribution of clean coals; the green, intelligent, quality-based combined production of paragenetic and associated minerals like coal gas; clean coal gasification; coal-based novel materials; underground coal-to-chemicals, and ecological restoration. …”
Get full text

Phenomenological understanding of the contribution of bulk and grain boundary precipitates on strengthening in prolonged-aged Al-Zn-Mg-Cu aluminium alloys by Cheng-Ling Tai, Yu-Ning Chiu, Chu-Jen Chen, Shih-Kang Lin, Hsin-Chih Lin, R. Devesh Kumar Misra, Yo-Lun Yang, Chien-Nan Hsiao, Cheng-Si Tsao, Tsai-Fu Chung

“…Prolonged ageing led to a small decrease in tensile strength from 567 MPa to 526 MPa and minor increase in elongation from ∼11 % to ∼13 %. The new knowledge derived from the present study has the potential to transform the futuristic design and processing of next generation of aluminum alloys through tailoring of tensile strength and ductility, where the approach will be different from the conventional ageing process.…”
Get full text

Derivation of atmospheric reaction mechanisms for volatile organic compounds by the SAPRC mechanism generation system (MechGen) by W. P. L. Carter, J. Jiang, J. J. Orlando, K. C. Barsanti, K. C. Barsanti, K. C. Barsanti

“…This paper points out areas where MechGen may need to be modified when the system is next updated. …”
Get full text

Dynamics of land use land cover change and its effect on urban heat island in Halaba Kulito Town by Begonet Dale, Mihret Dananto, Bisrat Kifle

“…Between 1991 and 2001, range land dropped by 33.3 %; nevertheless, in the next two decades, it expanded by 3.3 % and 83.2 %. …”
Get full text

Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency by Xiaofei Zhang, Linzi Ma, Xiaotong Liu, Xingyu Zhou, Ao Wang, Yunhui Lai, Jun Zhang, Ying Li, Shiling Chen

“…Methods and results: In this study, miR-21 was identified as the predominant miRNA with low-expression in follicular fluid exosomes of POI patients and was shown to possess antiapoptotic activity. Next, we loaded miR-21 agomir to MSC-Exo to form Agomir21-Exo, which significantly reversed the apoptosis of granulosa cells in vitro. …”
Get full text

Pair replacement on the spawning success of broodstock Seahorse (Hippocampus barbouri) by . Syafiuddin, M. Zairin Junior, Dedi Jusadi, Odang Carman, Ridwan Affandi

“…It can be concluded that seahorse is not monogamous, either male or female after being spawned may accept other pair for the next spawning. Key words: pair replacement, broodstock, success spawning, Hippocampus barbouri   ABSTRAK Kuda laut, (Hippocampus barbouri) merupakan salah satu sumberdaya hayati laut yang memiliki nilai komersial dan telah banyak diperdagangkan terutama sebagai ikan hias, bahan baku obat tradisional dan juga sebagai suvenir. …”
Get full text

An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity by Pierre Guermonprez, Le Tu Anh, Louis Renaud, Pierre Nioche, Eric Krejci, Aurélie Alleaume-Butaux, Nicolas Battaglini, Vu Thi Thu, Sébastien Sanaur, Benoît Piro

“…This work is an important milestone in the development of the next generation of point-of-care RNA sensors.…”
Get full text

Two-dimensional anion-rich NaCl2 crystal under ambient conditions by Ruobing Yi, Jie Jiang, Yizhou Yang, Yueyu Zhang, Siyan Gao, Yimin Zhao, Jiahao Hu, Xuchang Su, Xinming Xia, Bingquan Peng, Fangfang Dai, Pei Li, Zhao Guan, Haijun Yang, Fangyuan Zhu, Jiefeng Cao, Zhe Wang, Haiping Fang, Lei Zhang, Liang Chen

“…Abstract The two-dimensional (2D) “sandwich” structure composed of a cation plane located between two anion planes, such as anion-rich CrI3, VS2, VSe2, and MnSe2, possesses exotic magnetic and electronic structural properties and is expected to be a typical base for next-generation microelectronic, magnetic, and spintronic devices. …”
Get full text

Selectively expressed RNA molecules as a versatile tool for functionalized cell targeting by Frederik Rastfeld, Marco Hoffmann, Sylvie Krüger, Patrick Bohn, Anne-Sophie Gribling-Burrer, Laura Wagner, Nils Hersch, Carina Stegmayr, Lukas Lövenich, Sven Gerlach, Daniel Köninger, Christina Hoffmann, Helene L. Walter, Dirk Wiedermann, Hajaani Manoharan, Gereon R. Fink, Rudolf Merkel, Heribert Bohlen, Redmond P. Smyth, Maria A. Rueger, Bernd Hoffmann

“…Abstract Targeting of diseased cells is one of the most urgently needed prerequisites for a next generation of potent pharmaceuticals. …”
Get full text

Probiotic administration aggravates dextran sulfate sodium salt-induced inflammation and intestinal epithelium disruption in weaned pig by Kunhong Xie, Weidong Cai, Lingjie Li, Bing Yu, Yuheng Luo, Zhiqing Huang, Xiangbing Mao, Jie Yu, Ping Zheng, Hui Yan, Hua Li, Jun He

“…Abstract Background A. muciniphila (AKK) has attracted extensive research interest as a potential next-generation probiotics, but its role in intestinal pathology is remains unclear. …”
Get full text

Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA by Po-Ku Chen, Joung-Liang Lan, Yi-Ming Chen, Hsin-Hua Chen, Shih-Hsin Chang, Chia-Min Chung, Nurul H. Rutt, Ti-Myen Tan, Raja Nurashirin Raja Mamat, Nur Diana Anuar, Jonathan M. Blackburn, Der-Yuan Chen

“…In Cohort-1, 24 plasma samples (6 ADAb-positive and 6 ADAb-negative patients at baseline and week 24 of adalimumab therapy, respectively) were assayed with immune-related microarray containing 1,636 correctly folded functional proteins. Next, we executed statistically powered autoantibody profiling analysis of 50 samples in Cohort-2 (24 ADAb-positive and 26 ADAb-negative patients). …”
Get full text