A case of de novo neuroendocrine prostate cancer presented with elevated level of serum CEA carrying BRCA2 mutation: case report and literature review by Weizhe Han, Nihati Rexiati, Fang Yu, Yongzhi Wang, Yueli Tian, Jianyuan Wu, Gang Wang, Tao Liu, Zhonghua Yang

Subjects: “…neuroendocrine prostate cancer (NEPC)…”
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Characterization and genome analysis of lytic Vibrio phage VPK8 with potential in lysing Vibrio parahaemolyticus isolates from clinical and seafood sources by Valalak Jintasakul, Jiranan Pattano, Sutima Preeprem, Pimonsri Mittraparp-arthorn

“…Phage morphology was characterized by transmission electron microscopy (TEM), while genomic features were analyzed using next-generation sequencing. Lytic characteristics, including latent period and burst size, were determined through one-step growth curves, and bacterial growth reduction was evaluated over a 24-h. …”
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Timeliness metrics for screening and preventing TB in household contacts of pulmonary TB patients in Kenya by D. Nair, P. Thekkur, I. Mbithi, M. Khogali, R. Zachariah, S. Dar Berger, S. Satyanarayana, A. M. V. Kumar, I. Kathure, J. Mwangi, A. F. Bochner, A. McClelland, J. M. Chakaya, A. D. Harries

“…In 68% of 1,115 HHCs, screening outcomes were ascertained within 1 day of line-listing (“Next 1”). In 65% of 1,105 HHCs eligible for further evaluation, anti-TB treatment, TPT or a decision for no drugs was made within 7 days of screening (“Second 7”). …”
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Long term effectiveness of intraoperative radiotherapy given as a boost in adjuvant treatment for oral cavity cancers by Grzegorz Woźniak, Tomasz Rutkowski, Wojciech Majewski, Aleksandra Napieralska, Jerzy Wydmański, Agnieszka Czarniecka, Cezary Szymczyk, Adam Bekman, Żaneta Kaniszewska Dorsz, Tomasz Latusek, Bogusław Maciejewski

“…The 5-year overall survival (OS) was 56% and decreased to 45% during the next 5 years. There were no differences in the LTC, DFS and OS regarding sex, T-stage, grade and tumour localization, although a small group of analysed cases may raise some uncertainties. …”
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Median effective dose of remimazolam combined with sufentanil for inhibiting laryngeal mask airway insertion responses in children of different ages by Hongyun Li, Jinxia Wang, Rong Wei, Yan Jiang

“…If a positive response to LMA insertion, such as movement, swallowing, coughing, hiccups, or other reactions, was observed during the insertion, the dose was increased by 0.03 mg/kg for the next patient; if there was no response, the dose was decreased by 0.03 mg/kg instead. …”
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Granger Test and ARDL Model for the Socio-Economic Challenges Investigation: Public Expenditure Components, Economic Growth, and Inflation by Fatma Zohra Hamadouche, Bekhta Hamadouche, Malak Mohammad Ghandour, Aicha Hamadouche, Brahim Boutrig

“…In the short term, capital expenditure is the only variable with a significant relationship with inflation, where a 1% increase drives inflation up by 1.08% in the same year and 1.13% in the next. The error correction term (-0.75) highlights a strong adjustment mechanism, with deviations from long-term equilibrium corrected within approximately 16 months. …”
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A conceptual model for advanced/metastatic gastric or gastroesophageal junction cancer: a review of qualitative studies and results from patient interviews by France Ginchereau Sowell, Thom de Milliano, Keri J. S. Brady, Ginamarie Foglia, Medha Sasane, Samira Bensfia, Matthew Reaney

“…Abstract Background Despite approvals of new first-line immunotherapies for advanced/metastatic gastric cancer/gastroesophageal junction cancer (aGC/GEJC), patients’ median survival is around 14 months and their health-related quality of life (HRQoL) is affected by disease-related symptoms and treatment-related side effects. …”
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Nanopore-based random genomic sampling for intraoperative molecular diagnosis by Francesco E. Emiliani, Abdol Aziz Ould Ismail, Edward G. Hughes, Gregory J. Tsongalis, George J. Zanazzi, Chun-Chieh Lin

“…Results In our retrospective cohort of 26 malignant brain tumors, iSCORED demonstrated 100% concordance in CNV detection, including chromosomal alterations and oncogene amplifications, when compared to clinically validated assays such as Next-Generation Sequencing and Chromosomal Microarray. …”
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Association of HLA-B Gene Polymorphisms with Type 2 Diabetes in Pashtun Ethnic Population of Khyber Pakhtunkhwa, Pakistan by Asif Jan, Muhammad Saeed, Muhammad Hussain Afridi, Fazli Khuda, Muhammad Shabbir, Hamayun Khan, Sajid Ali, Muhammad Hassan, Samiullah, Rani Akbar, Zakiullah

“…WES results identified a total of n=17 SNPs in HLA-B gene. In the next phase, first 5 out of n=17 reported SNPs were genotyped using MassARRAY® system in order to validate WES results and to confirm association of selected SNPs with T2D. …”
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Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review by Lauren M Henry, Morkeh Blay-Tofey, Clara E Haeffner, Cassandra N Raymond, Elizabeth Tandilashvili, Nancy Terry, Miryam Kiderman, Olivia Metcalf, Melissa A Brotman, Silvia Lopez-Guzman

“…To guide future inquiry in this space, a review of the literature is needed to describe the state of research on JITAIs for behavioral health. …”
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Breeding for sustainability: how reproductive biotechnologies can help buffalo farmers combat climate change by Pietro Sampaio Baruselli, Laís Ângelo de Abreu, Vanessa Romário de Paula, Sofía Albertini, Guilherme Felipe Ferreira dos Santos, Lígia Mattos Rebeis, Emanuelle Almeida Gricio, Nelcio A.T. de Carvalho, Otavio Bernardes

“…Also, the urgency in moving to the next generation of buffaloes will increase the production of embryos from genomically defined prepubertal heifers. …”
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A comparative template-switching cDNA approach for HTS-based multiplex detection of three viruses and one viroid commonly found in apple trees by Francisco Mosquera-Yuqui, Daniel Ramos-Lopez, Xiaojun Hu, Yu Yang, Joshua L. Mendoza, Emmanuel Asare, Joshua Habiger, Oscar P. Hurtado-Gonzales, Andres S. Espindola

“…Amplified double-stranded cDNAs were subjected to library preparation using Nanopore SQK-DCS109 and Illumina Nextera XT, and sequenced with MinION and NextSeq2000, respectively. Treatments with oligo d(T)23-VN or its combination with random hexamers yielded the highest relative reads for viruses, while treatments containing the reverse primer pool produced more relative reads for AHVd. …”
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A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging by Cheng Yao, Ruwei Wei, Xiao Luo, Jie Zhou, Xiaodong Zhang, Xicun Lu, Yan Dong, Ruofan Chu, Yuxin Sun, Yu Wang, Wencheng Xia, Dahui Qu, Cong Liu, Jun Ren, Guangbo Ge, Jinquan Chen, Xuhong Qian, Youjun Yang

“…Abstract The shortwave infrared (SWIR) region is an ideal spectral window for next-generation bioimaging to harness improved penetration and reduced phototoxicity. …”
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Mutations in the ARAP3 Gene in Three Families with Primary Lymphedema Negative for Mutations in Known Lymphedema-Associated Genes by Maurizio Ricci, Rita Compagna, Bruno Amato, Sercan Kenanoglu, Dominika Veselenyiova, Danjela Kurti, Mirko Baglivo, Syed Hussain Basha, Roberta Serrani, Giacinto Abele Donato Miggiano, Barbara Aquilanti, Giuseppina Matera, Giuseppe Marceddu, Valeria Velluti, Lucilla Gagliardi, Munis Dundar, Juraj Krajcovic, Matteo Bertelli

“…Retrospectively, we tested the DNA of these 235 patients for new candidate lymphedema-associated genes, including ARAP3. …”
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Cohort profile: maternal and child health and parenting practices during the COVID-19 pandemic in Ceará, Brazil: birth cohort study (Iracema-COVID) by Marcia C Castro, Márcia Maria Tavares Machado, Simone Farías-Antúnez, David Augusto Batista Sá Araújo, Ana Luiza Penna, Francisco Ariclene Oliveira, Camila Machado de Aquino, Antônio Silva Lima Neto, Geziel dos Santos de Sousa

“…The prevalence of maternal common mental disorder symptoms was 32.5% (95% CI 27.8 to 37.6).Future plans Follow-up visits are planned to occur every 6 months for the next five years (2021–2025). Additional topics will be included in future waves (eg, food insecurity and parenting practices). …”
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Lost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severity by Eamonn MM Quigley, Thomas J Borody, Sabine Hazan, Neil Stollman, Huseyin S Bozkurt, Sonya Dave, Andreas J Papoutsis, Jordan Daniels, Brad D Barrows

“…Objective The study objective was to compare gut microbiome diversity and composition in SARS-CoV-2 PCR-positive patients whose symptoms ranged from asymptomatic to severe versus PCR-negative exposed controls.Design Using a cross-sectional design, we performed shotgun next-generation sequencing on stool samples to evaluate gut microbiome composition and diversity in both patients with SARS-CoV-2 PCR-confirmed infections, which had presented to Ventura Clinical Trials for care from March 2020 through October 2021 and SARS-CoV-2 PCR-negative exposed controls. …”
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Role of Aging in Ulcerative Colitis Pathogenesis: A Focus on ETS1 as a Promising Biomarker by Ni M, Peng W, Wang X, Li J

“…After identifying UC-related ARGs, consistent clustering was performed to screen aging-related molecular subtypes, followed by the exploration of differences in the immune microenvironment and pathways between distinct subtypes. Next, core module genes were screened using WGCNA and then the hub genes were characterized using LASSO and random forest methods. …”
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A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases by Eva Lukas, Rada R. Veeneman, Dirk J. A. Smit, Tarunveer S. Ahluwalia, Jentien M. Vermeulen, Gita A. Pathak, Renato Polimanti, Karin J. H. Verweij, Jorien L. Treur

“…First, we estimated genetic correlations and utilized genomic structural equation modeling to identify a common genetic factor for PTSD and CVD. Next, we assessed biological, behavioural, and psychosocial factors as potential mediators. …”
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Pseudoprogression in CAR-T cell therapy for solid tumor: Case report by Xuan Zhao, Xuan Zhao, Yanfen Liu, Yanfen Liu, Guohui Qin, Guohui Qin, Yan Ge, Qinglong Li, Xinfeng Chen, Xinfeng Chen, Ximei Tian, Yong Yu, Jiangtao Ren, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang

“…The hepatic metastases enlarged 1 month after CAR-T cell infusion and then shrunk the next month as seen through computed tomography scanning. …”
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Prediction of drought-flood prone zones in inland mountainous regions under climate change with assessment and enhancement strategies for disaster resilience in high-standard farml... by Yongheng Shen, Qingxia Guo, Zhenghao Liu, Yanli Shen, Yikun Jia, Yuehan Wei

“…The overall findings indicate that: (1) Precipitation (Pr) and the Standardized Precipitation-Evapotranspiration Index (SPEI) have increased in recent years, with Pr expected to continue rising until 2035. (2) The integration of historical data with the predictions from the PSO-LSTM-GAT model reveals significant spatial overlap between historical and future disaster-prone areas and intensive cropland, especially in the central region. (3) Compared to single models, the PSO-LSTM-GAT model demonstrates significantly improved performance and precision in predicting drought- and flood-prone areas. (4) Through the FDRA integrated adjustment mechanism, 6.6668 km² of unsuitable land was identified, and 6.7349 km² of high-quality land was selected as the proposed site for the next round of HSF projects. In the final part of the study, management zoning plans were designed for other areas vulnerable to drought and flood disasters, and specific recommendations for enhancing cropland resilience were provided. …”
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