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A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in He...
Published 2025-01-01“…Hae Won Lee,1 Woo Youl Kang,2 Ji Seo Park,1 Jae Hwa Lee,1 Jin Ju Park,1 Mi-Ri Gwon,1 Young-Ran Yoon,1 Sook Jin Seong1 1School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea; 2Clinical Trial Dossier Evaluation Team, Innovative Products Support Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of KoreaCorrespondence: Young-Ran Yoon, Professor, School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, 130 Dongdeok-Ro, Jung-gu, Daegu, 41944, Republic of Korea, Tel +82-53-420-4950, +82-53-420-5218, Email yry@knu.ac.kr Sook Jin Seong, Clinical Associate Professor, School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, 130 Dongduk-Ro, Jung-gu, Daegu, 41944, Republic of Korea, Tel +82-53-200-6351, +82-53-420-5218, Email wintersj@knu.ac.krBackground: YYD601 is a new dual delayed-release formulation of esomeprazole, developed to enhance plasma exposure and prolong the duration of acid suppression.Purpose: This study aimed to evaluate the safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of YYD601 20 mg following single and multiple oral administrations in healthy, fasting adult Koreans, and to compare these outcomes to those of the conventional esomeprazole 20 mg capsule.Methods: A randomized, open-label, two-period crossover study was conducted in 28 participants, who were divided into two treatment groups: one group received YYD601 20 mg, and the other received conventional esomeprazole 20 mg, once daily for five consecutive days. …”
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From Uncle Tom to Nat Turner: An Overview of Slavery in American Film, 1903-2016
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The variety and limits of dairy policies in a context of global market deregulation
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Le rôle d’Internet et des technologies de l’information et de la communication dans le partage de connaissances sur l’adaptation des communautés côtières aux changements climatique...
Published 2015-11-01“…In this context, it is very helpful to associate field actors in the process. Adaptation to climate change and variability in coastal zones is well suited for such a project, since environmental challenges and adaptation solutions are similar all over the world, and knowledge can therefore be used at a global scale.…”
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Coastal Hazard and Vulnerability Assessment in Cameroon
Published 2025-01-01“…In addition, documents on climate change were consulted. Remotely sensed data, combined with GIS tools, helped to determine and assess the associated risks. …”
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Impact of mild traumatic brain injury on health behaviors
Published 2025-01-01“…We focused on understanding the impact of mild traumatic brain injury (TBI) on health-related behaviors and identifying factors associated with such changes. We utilized health check-up records from the Korean National Health Insurance Service database spanning January 1, 2009, to December 31, 2017. …”
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COVID-19 pandemic shifted epidemiology for cancer screening sites: breast, cervix, colon, and rectum
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Cognitive-Behavioral Therapists’ Experience on Relevance of Sleep and Sleep Disorders in Training and Clinical Practice: A Survey Study from Italy
Published 2025-01-01“…Adding information on different countries is important, as national health systems differ significantly, and distinct evidence-based pathways for change may be proposed. …”
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