Monocyte STAT1 phosphorylation and treatment response of JAK inhibitors in chronic nonbacterial osteomyelitis by Motoshi Sonoda, Keishiro Kinoshita, Nobutaka Harada, Sungyeon Park, Shunichi Adachi, Yutaro Yada, Katsuhide Eguchi, Toshifumi Fujiwara, Makiko Kido-Nakahara, Noriko Kinjo, Masataka Ishimura, Shouichi Ohga

“…The early diagnosis and management are challenging due to the lack of reliable diagnostic markers and the occasional intractable cases despite conventional anti-inflammatory treatments. …”
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α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn’s Disease by Su Y, Li J, Chen Y, Bao J, Lei Z, Ma M, Zhang W, Liu Q, Xu B, Hu T, Hu Y

“…The α-MT treatment group also exhibited reduced levels of cytokines involved in T cell differentiation (IFN-γ and TNF-α) and the expression of immune cell surface markers CXCR-3 and LAG-3. Flow cytometry analysis revealed a significant increase in the infiltration of CD4+ and CD8+ T cells in the DSS-treated group compared to the control group. …”
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Effects of biologic therapy on novel indices of lung inhomogeneity in patients with severe type-2 high asthma by Nayia Petousi, Nick P Talbot, Ian Pavord, Peter A Robbins, Nicholas M J Smith, Graham Richmond, Asma Alamoudi, Lorenzo Petralia, Haopeng Xu, Dominic Sandhu, Grant AD Ritchie

“…Here, we assessed changes in lung inhomogeneity in patients with type-2 high asthma treated with biological therapy and explored the relationship between inhomogeneity measures and conventional asthma disease markers.Methods This was an observational study of 91 severe type-2 high asthma patients recruited from a tertiary asthma clinic, of whom 67 subsequently started anti-IL5 or anti-IL5R biologics. …”
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Are we serologically prepared against an avian influenza pandemic and could seasonal flu vaccines help us? by Iván Sanz-Muñoz, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Corina S. Concha-Santos, Marta Hernández, Silvia Rojo-Rello, Marta Domínguez-Gil, Ahmed Mostafa, Luis Martinez-Sobrido, Jose M. Eiros, Aitor Nogales

“…Importantly, HPAI H5N1 viruses with genetic markers of adaptation to mammals have been detected. …”
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Potential diagnostic tools for intensive care unit acquired weakness: A systematic review by Chen Xin, Yubiao Gai, Lili Wei, Yanqiu Wang, Yuhong Luo, Binru Han

“…In the included studies, the gold standard for intensive care unit-acquired weakness diagnosis include the Medical Research Council score, muscle biopsy and electrophysiologic testing, potential diagnostic tools include the manual muscle test, electrophysiologic testing, imaging, serum inflammatory markers, neuromuscular ultrasound, and other parameters. …”
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The effects of altitude training on hormonal response in professional cyclists by Raphael Faiss, Bastien Krumm, Basile Moreillon, Lena Mettraux, Julian Wackernell, James Spragg, Martin Faulhaber

“…Discussion/Conclusion In summary, this study was the first to monitor hormonal markers over 7 weeks before, during, and after a 3-week altitude training camp in a large cohort of professional cyclists. …”
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Systemic Immune-Inflammation Index (SII) and Neutrophil-to-Lymphocyte Ratio (NLR): A Strong Predictor of Disease Severity in Large-Artery Atherosclerosis (LAA) Stroke Patients by Liu K, Yang L, Liu Y, Zhang Y, Zhu J, Zhang H, He Z

“…Keting Liu,1,2,* Li Yang,1,* Yang Liu,3 Yun Zhang,1 Juncheng Zhu,4 Haofeng Zhang,5 Zemin He6 1Department of Neurology, Chengdu Seventh People’s Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, Sichuan Province, 610213, People’s Republic of China; 2Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510515, People’s Republic of China; 3Department of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 610075, People’s Republic of China; 4Department of Radiology, Chengdu Seventh People’s Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, Sichuan Province, 610213, People’s Republic of China; 5Department of Information, Chengdu Seventh People’s Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, Sichuan Province, 610213, People’s Republic of China; 6Department of Thoracic Surgery, The First People’s Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chendu, Sichuan Province, 610200, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zemin He, Email 993092572@qq.comBackground: Systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) are novel inflammatory markers based on neutrophil, platelet and lymphocyte counts. …”
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Prevalence and factors associated with potential clinically significant drug-drug interactions in patients with cardiovascular diseases at hospital admission by Marović Iva, Udovičić Mario, Rudan Diana, Manola Šime, Samardžić Ivana, Vrca Vesna Bačić, Hadžiabdić Maja Ortner, Marinović Ivana

“…The most common interventions regarding identified DDIs included exclusion one of the drugs, dose adjustment, increased monitoring of signs of bleeding, cardiac disorders, hypoglycemia, CNS depression and rhabdomyolysis, blood pressure, markers of renal function and electrolyte status. …”
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Stress Reduction in Perioperative Care: Feasibility Randomized Controlled Trial by Haridimos Kondylakis, Irene Alice Chicchi Giglioli, Dimitrios Katehakis, Hatice Aldemir, Paul Zikas, George Papagiannakis, Santiago Hors-Fraile, Pedro L González-Sanz, Konstantinos Apostolakis, Constantine Stephanidis, Francisco J Núñez-Benjumea, Rosa M Baños-Rivera, Luis Fernandez-Luque, Angelina Kouroubali

“…Psychological metrics such as self-efficacy, self-management, and mental well-being were assessed before and after the intervention, alongside physiological markers of stress. ResultsThe intervention group demonstrated significant improvements across several psychological outcomes. …”
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Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment incl... by Hidekazu Hirano, Naoki Takahashi, Yusuke Amanuma, Nobumi Suzuki, Daisuke Takahari, Takeshi Kawakami, Chie Kudo-Saito, Kengo Nagashima, Narikazu Boku, Ken Kato, Hirokazu Shoji

“…Biomarker analyses of serial blood and tumor samples are planned to clarify predictive markers and molecular mechanisms underlying treatment resistance by multifaceted analytical methods (e.g., flow cytometry, DNA sequencing [DNAseq]/RNA sequencing [RNAseq]). …”
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Usability of volatile organic compounds from exhaled breath compared with those from ruminal fluid, serum, urine, and milk to identify diet-specific metabolite profiles in lactatin... by J. Eichinger, A.-M. Reiche, A. Münger, L. Eggerschwiler, G. Pimentel, P. Fuchsmann, K. Huber, F. Dohme-Meier

“…The identified discriminatory VOC seem suitable as markers to discriminate between HD and SIL cows. Exhaled breath may be a promising, sensitive, and less invasive tool to follow diet- and time-related metabolic changes.…”
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Spot Versus 24-Hour Urine Osmolality Measurement in Autosomal Dominant Polycystic Kidney Disease: A Diagnostic Test Study by Ayub Akbari, Sriram Sriperumbuduri, Shreepryia Mangalgi, Vijay Joshi, Manish Sood, Amos Buh, Mohan Biyani, Christopher McCudden, Gregory L. Hundemer, Pierre Antoine Brown

“…Urine osmolality (osm) measures are surrogate markers of AVP activity. Both 24-hour and spot urine samples are used as indicators of AVP suppression. …”
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Impact of iron chelation with deferasirox on telomere length and oxidative stress in hemodialysis patients: A randomized study by Blanca Olivia Murillo Ortiz, Joel Ramírez Emiliano, Marcos Javier Romero Vázquez, Lauro Fabián Amador Medina, Sandra Martínez Garza, Edna Montserrat Ramos Rodríguez

“…Serum ferritin levels and oxidation markers were evaluated. To evaluate the pharmacokinetics and safety of deferasirox, plasma concentrations were analyzed by HPLC. …”
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Meta Analysis of the Randomized Controlled Trial of Acupuncture for Ankylosing Spondylitis by Ping LI, Yinjie WANG, Jigang TIAN

“…Sensitivity analysis showed that the research was homogeneous and the results of the meta analysis were stable.Conclusion:Acupuncture has certain advantages in the treatment of ankylosing spondylitis, and it is helpful to improve the activity of thoracic spine, the activity of lumbar spine and the inflammatory markers(erythrocyte sedimentation rate, C-reactive protein)in patients with ankylosing spondylitis as a result. …”
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Clinical Characteristics and Treatment Options of Peripheral Spondyloarthritis by ZENG Lulu, JI Xiaojian, HU Lidong, HU Jiawen, ZHANG Yinan, ZHANG Jiaxin, LIU Xingkang, YANG Shiwei, HUANG Feng

“…Compared to axSpA patients, pSpA patients had fewer male patients(62.5% vs. 79.7%, P < 0.001), later onset age(33.8 years vs. 22.0 years, P < 0.001), shorter diagnostic delays(6.0 months vs. 14.2 months, P=0.004), more associated peripheral arthritis(71.7% vs. 9.3%, P < 0.001) and dactylitis(6.5% vs. 0.3%, P < 0.001), more cases of psoriasis(52.7% vs. 1.1%, P < 0.001) and a more common family history of psoriasis(11.4% vs. 3.4%, P < 0.001). pSpA patients had higher levels of inflammatory markers but a lower positive rate of human leukocyte antigen(HLA)-B27(43.5% vs. 87.4%, P < 0.001). …”
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Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach by Yujia Wang, Yan Di, Yongqi Li, Jing Lu, Bofan Ji, Yuxia Zhang, Zhiqing Chen, Sijie Chen, Bicheng Liu, Rining Tang, Yuanyuan Ji

“…ROD mice exhibited substantial bone turnover with an increase in osteoblast and osteoclast markers. Transcriptomic profiling revealed 1907 genes with upregulated expression and 723 genes with downregulated expression in the femurs of ROD mice relative to those of control mice. …”
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Performance of the modified 2022 ACR/EULAR giant cell arteritis classification criteria without age restriction for discriminating from Takayasu arteritis by Takahiko Sugihara, Masayoshi Harigai, Haruhito A. Uchida, Hajime Yoshifuji, Yasuhiro Maejima, Jun Ishizaki, Yoshiko Watanabe, Hiroaki Dobashi, Yoshinori Komagata, Naoto Tamura, Yoshikazu Nakaoka, Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS)

“…The discriminability of a set of large-vessel lesions (bilateral axillary artery and descending thoracic-abdominal aorta) and inflammatory markers was markedly decreased with poor C-statistic value (C-statistic: 0.598, 95% CI: 0.530–0.667). …”
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Thiol-Disulfide Homeostasis in Noise-Induced Hearing Loss in Rats by Enes Aydın, Serpil Mungan Durankaya, Osman Yilmaz, Günay Kirkim, Safiye Aktaş, Salim Neşelioğlu, Özcan Erel, Yüksel Olgun, Abdullah Dalgıç

“…The results from our study suggest that these markers may be used as adjunctive diagnostic tools in NIHL, in addition to audiological studies. …”
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Genome analysis of colistin-resistant Salmonella isolates from human sources in Guizhou of southwestern China, 2019–2023 by Jingtong Wu, Yongxian Wen, Lv You, Xiaoyu Wei, Xiaoyu Wei, Junhua Wang, Ge Zhu, Shijun Li

“…Among the 42 CL-R isolates lacking markers for CL-R, 12 single-nucleotide variations (SNVs) were observed in 24 isolates using genome-wide association study (GWAS) analysis, which was possibly associated with colistin resistance.ConclusionThis study revealed that the majority of CL-R Salmonella isolates in Guizhou province exhibited MDR, with complex resistance mechanisms, representing a significant public health challenge. …”
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MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…Methods The in vitro studies included the effects of DSS duration on MSCs, and the characterization of DSS-Exo and Exo, followed by the assessment of RNA and protein expression levels of peritoneal fibrosis markers and inflammatory cytokines levels after treating human peritoneal mesothelial (HMrSV5) cells. …”
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