Effect of Propionic Acid on Diabetes-Induced Impairment of Unfolded Protein Response Signaling and Astrocyte/Microglia Crosstalk in Rat Ventromedial Nucleus of the Hypothalamus by Larysa V. Natrus, Yulia S. Osadchuk, Olha O. Lisakovska, Dmytro O. Labudzinskyi, Yulia G. Klys, Yuri B. Chaikovsky

“…The aim was to investigate the influence of propionic acid (PA) on the endoplasmic reticulum (ER), unfolded protein response (UPR) state, and astrocyte/microglia markers in rat ventromedial hypothalamus (VMH) after type 2 diabetes mellitus (T2DM). …”
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Examining the association of elevated initial serum lactate with mortality and morbidity in trauma patients: a retrospective study by Pablo Rodríguez-Ortiz, Kyara Berríos-Toledo, Ediel O. Ramos-Meléndez, Lourdes Guerrios-Rivera

“…However, their rapid availability supports their use alongside other clinical markers to guide trauma care decision-making and improve trauma outcomes.…”
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Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy by Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding

“…Then the cell viability, inflammatory factors, and the expression of epithelial–mesenchymal transition (EMT) and fibrosis markers were determined by using Cell Counting Kit-8 (CCK-8) assay, enzyme linked immunosorbent assay (ELISA), western blotting assays, respectively. …”
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The Value of Serum YKL-40 and TNF-α in the Diagnosis of Acute ST-Segment Elevation Myocardial Infarction by Caoyang Fang, Zhenfei Chen, Jing Zhang, Jianyuan Pan, Xiaoqin Jin, Mengsi Yang, Luyao Huang

“…In this study, we demonstrate the utility of serum YKL-40 and TNF-α as diagnostic markers for STEMI and the clinical utility of diagnostic models by combining serum YKL-40 and TNF-α with cTnI.…”
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Annexin V+ Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study by Vibeke Bratseth, Hanna D. Margeirsdottir, Gemma Chiva-Blanch, Martin Heier, Svein Solheim, Harald Arnesen, Knut Dahl-Jørgensen, Ingebjørg Seljeflot

“…Circulating microvesicles (cMVs) are procoagulant cell fragments shed during activation/apoptosis and discussed to be markers of vascular dysfunction and hypercoagulability. …”
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Urine proteomics defines an immune checkpoint-associated nephritis signature by Cassian Yee, Jamie S Lin, James P Long, Shailbala Singh, Yanlan Dong

“…We identified several novel urine biomarkers, including IL-5, Fas, TNFSF4, CD274, IL-20, TNFSF15, TSLP, TREM1 and CCL1 while confirming previously reported markers such as CXCL9 and TNF-α. Using statistical and machine learning methods, we constructed a novel urine biomarker signature—IL-5+Fas—that achieved an area under the curve of 0.94 for diagnosing ICI-AIN.By leveraging high-sensitivity proteomics, we developed a non-invasive strategy for diagnosing ICI-AIN. …”
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Fuzzy Logic-Based Arrival Time Estimation for Indoor Navigation Using Augmented Reality by Muhammad Hidayat Mohammed Sohif, Muhammad Imran Mardzuki, Azhar Mohd Ibrahim, Ahmad Jazlan

“…Mobile applications designed for indoor navigation often rely on expensive and computationally demanding beacons or natural markers to track the user's location along a predetermined path. …”
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Store Separation: Photogrammetric Solution for the Static Ejection Test by Luiz Eduardo Guarino de Vasconcelos, Nelson Paiva Oliveira Leite, André Yoshimi Kusumoto, Leandro Roberto, Cristina Moniz Araujo Lopes

“…The uncertainty associated with the position measurement of each of the markers varies from ±0.02 mm to ±8.00 mm @1σ, depending on the geometry of the viewing angles. …”
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Polymorphism of the prolactin gene and its association with reproductive traits in F2 local crossed chickens by Ega Rosalinda, Heru Sasongko, Dyah Maharani

“…The findings highlight PRL gene polymorphisms as valuable markers for improving reproductive traits in poultry breeding programs.…”
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Momordica Charantia Polysaccharides Attenuates MPP+-Induced Injury in Parkinson’s Disease Mice and Cell Models by Regulating TLR4/MyD88/NF-κB Pathway by Dengjun Guo, Jie Zhou, Meng Zhang, Reyisha Taximaimaiti, Xiaoping Wang, Hai Wang

“…High-performance liquid chromatography and enzyme-linked immunosorbent assay (ELISA) were used to determine neurotransmitters and metabolites, inflammatory factors TNF-α and IL-1β, oxidative stress-related markers SOD, MDA, and GSH in striatum tissues. Western blot was used to determine the protein levels of tyrosine hydroxylase (TH), oxidative stress-related protein Cytochrome C (Cytochrome C), and apoptosis-related proteins Bcl-2, Bax, and cleaved Caspase-3 in tissues and cells. …”
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Randomized, Open-Label Phase 2 Study of Apalutamide plus Androgen Deprivation Therapy versus Apalutamide Monotherapy versus Androgen Deprivation Monotherapy in Patients with Bioche... by Rahul Aggarwal, Joshi J. Alumkal, Russell Z. Szmulewitz, Celestia S. Higano, Alan H. Bryce, Angela Lopez-Gitlitz, Sharon A. McCarthy, Branko Miladinovic, Kelly McQuarrie, Shibu Thomas, Ke Zhang, Eric J. Small

“…Mean changes from baseline in Functional Assessment of Cancer Therapy-Prostate (FACT-P) at 12 months (primary endpoint) and other prespecified assessments of health-related quality of life (HRQoL), PSA nadir, time to PSA progression, time to testosterone recovery, recovered testosterone >150 ng/dL without PSA progression at 24 months, and molecular markers were evaluated. Results. In 90 enrolled patients (apalutamide plus ADT (n = 31), apalutamide (n = 29), ADT (n = 30)), FACT-P at 12 months was not significantly different between apalutamide, ADT and apalutamide, and ADT groups. …”
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Functional Status of Pancreatic α and β Cells in Type 2 Diabetes Mellitus Patients with Different Plasma Triglyceride Levels: A Retrospective Analysis by Hang Guo, Chunlei Ma, Xiaoming Wu, Congqing Pan

“…TG levels can be prognostic markers for T2DM. Methods. A total of 328 patients with T2DM were divided into three groups according to different TG levels: the TGL group: TG < 1.7 mmol/L; TGM group: 1.7 mmol/L ≤ TG < 2.3 mmol/L; and TGH group: TG ≥ 2.3 mmol/L. …”
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Blood Cell Ratio Combinations for Diagnosing Periprosthetic Joint Infections: A Preliminary Study by Yu Y, Wen Y, Xia J, Dong G, Niu Y

“…However, subgroup analysis revealed no significant differences in combined inflammatory biomarker levels between the two groups.Conclusion: PAR and CAR prove to be effective combined inflammatory biomarkers for PJI diagnosis, whereas other markers exhibited limited diagnostic utility for PJI.Keywords: prosthetic joint infection, blood cell ratio combinations, PAR, CAR, MSIS…”
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SARS-CoV-2 SPIKE Antibody Levels can Indicate Immuno-Resilience to Re-infection: a Real-World Study by Yue Jin, Fei Yang, Christopher M. Rank, Stanley Letovsky, Peter Ramge, Simon Jochum

“…Here, we investigate whether specific levels of antibodies, as markers of adaptive immunity, can serve to estimate the risk of symptomatic SARS-CoV-2 (re-) infection. …”
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Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study by Matthew A. Lee, Kate L. Burley, Emma L. Hazelwood, Sally Moore, Sarah J. Lewis, Lucy J. Goudswaard

“…Although evidence from genetic colocalization suggests these associations may not be robust to the effects of horizontal pleiotropy, these proteins may be useful markers of MM risk. Future work should explore the utility of these proteins in disease prediction or prevention using proteomic data from patients with MM or precursor conditions.…”
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Effects of Ginseng Peptides on Laxative in Mice by Qiannan WANG, Wen YANG, Tingfang XUE, Jiaqi ZOU, Tao FENG, Lei YU, Yunfeng BI, Lina WANG

“…Conclusion: GPs has a significant laxative effect on a constipated mouse model, promoting small intestinal peristalsis, alleviating small intestinal villus damage, and promoting the expression of brain gut peptide markers SP and VIP in mice.…”
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Molecular-genetic and cytogenetic analyses of cotton chromosome introgression from <i>Gossypium barbadense</i> L. into the genome of <i>G. hirsutum</i> L. in BC₂F<sub>1... by M. F. Sanamyan, Sh. U. Bobokhujayev, Sh. S. Abdukarimov, O. G. Silkova

“…As a result of molecular genetic analysis of BC2F1 hybrids obtained from crossing monosomic lines of the cotton G. hirsutum from the cytogenetic collection of Uzbekistan with monosomic backcross hybrids BC1F1 G. hirsutum × G. barbadense on the same chromosomes, genetic differences between the hybrids in the profile of chromosome-specific microsatellite SSR markers were found. The predominant introgression of chromosomes 4, 6 and 12 of the At-subgenome and 22 of the Dt-subgenome of G. barbadense was revealed, while chromosomes 2 and 7 of the At-subgenome and 18 of the Dt- subgenome of G. barbadense were characterized by elimination. …”
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A robust multimodal brain MRI-based diagnostic model for migraine: validation across different migraine phases and longitudinal follow-up data by Jong Young Namgung, Eunchan Noh, Yurim Jang, Mi Ji Lee, Bo-yong Park

“…Feature importance and clinical association analyses exhibited that the somatomotor, limbic, and default mode regions could be reliable markers of migraine. Our findings, which demonstrate a robust diagnostic performance using multimodal MRI features and a machine-learning framework, may offer a valuable approach for clinical diagnosis across diverse cohorts and help alleviate the decision-making burden for clinicians.…”
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Systemic Predictors of Diabetic Retinopathy and Diabetic Macular Edema in an Adult Veteran Population by Tran EM, Gregori NZ, Rachitskaya A, Nandan A, Pershing S, Goldberg JL

“…Patients were more likely to be diagnosed with diabetic macular edema if they had systolic blood pressure > 140 mmHg (HR=2.00, CI 1.29– 3.08, p< 0.01) and/or used insulin (HR=2.48, CI 1.53– 4.03, p< 0.01).Conclusion: Markers of systemic health may be useful predictors for incident diabetic retinopathy or diabetic macular edema, evaluated collectively in Veteran patients. …”
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Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study by Zhiwei Xue, Jian Cao, Jianhui Mou, Rui Wang, Peng Liu

“…Additionally, AUC values and ROC curves were used to assess the predictive effectiveness of ln MHR and other markers (ln SII, ln NLR, ln NHHR, ln MHR + ln SII, ln MHR + ln NHHR, and ln MHR + ln NLR). …”
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