Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study by Qing-jun Guo, Jing Shan, Yi-feng Xu, Yan-yan Hu, Cui-lan Huo, Jing-yun Song, Chao-qun Wang, Hui Zhou, Chao-qin Yu, Qin Huang

“…This study is the first to reveal that PM alleviates psychological distress via inhibiting NLRP3 inflammasome and improves several markers, including total testosterone.…”
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Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis by Georgios K. Vasileiadis, Yuan Zhang, Tahzeeb Fatima, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Grondal, Kim Hørslev‐Petersen, Kristina Lend, Marte S. Heiberg, Merete Lund Hetland, Michael Nurmohamed, Till Uhlig, Tuulikki Sokka‐Isler, Anna Rudin, Cristina Maglio

“…Results At baseline, levels of adiponectin and leptin were not associated with markers of RA activity, whereas participants with higher resistin levels had higher C‐reactive protein (CRP) levels, swollen joint count, and Disease Activity Score in 28 joints based on CRP compared to participants with lower resistin. …”
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Methanotroph-methylotroph lipid adaptations to changing environmental conditions by Nora Richter, Laura Villanueva, Laura Villanueva, Ellen C. Hopmans, Nicole J. Bale, Jaap S. Sinninghe Damsté, Jaap S. Sinninghe Damsté, Darci Rush

“…Microbial membrane lipids are commonly used as taxonomic markers of specific microbial groups; however, few studies have characterized the changes of membrane lipids under different environmental conditions. …”
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Leveraging genomic insights from the neglected malaria parasites P. malariae and P. ovale using selective whole genome amplification (SWGA) approach by Fathia Ben-Rached, Amit Kumar Subudhi, Chang Li, Mariah Alawi, Rohit Satyam, Sui Xu, Guoding Zhu, Raeece Naeem, Sara Mfarrej, Di Liu, Zenaida Stead, Caroline Askonas, Yaobao Liu, Jun Cao, Arnab Pain

“…Conclusions SWGA approach implemented here provides a powerful tool for enhancing genomic analysis of these neglected parasites, revealing population diversity, drug resistance markers, and hypervariable regions. This methodology constitutes a transformative tool to surmount the challenges of genomic analysis for neglected malaria parasites and can improve malaria research and control.…”
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Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study by Stanislav Rejchrt, Milos Hroch, Rudolf Repak, Tomas Fejfar, Tomas Douda, Darina Kohoutova, Eva Peterova, Jan Bures

“…Histology of biopsy specimens is often indeterminate. Laboratory markers (serum bilirubin>75 μmol/L, carbohydrate antigen 19-9>400 U/mL) and the length of stenosis (>15 mm) can be helpful but are not specific enough. …”
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Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

“…Moreover, increased levels of markers associated with epithelial–mesenchymal transition (EMT) and fibrosis (TNF-α, Acta2, IL-1β, and MMP9), as well as elevated levels of TGF-β, a common downstream signaling factor of TLR4 and PPAR-γ, were identified. …”
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Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma by Wen-Yan Wang, Yue Chen, Qian Chen, Hong-Wei Sun, Nuo-Xuan Niu, Hong-Hui Li, Yu-Dan Cao, Yan-Xia Bai, Xiang Li, Xiang Li

“…It offers enhanced predictive accuracy compared to existing markers and has the potential to guide personalized treatment strategies and clinical decision-making.…”
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Diminished ovarian reserve is associated to euploidy rate: a single center study by Edoardo Carnesi, Stefano Castellano, Stefano Castellano, Elena Albani, Andrea Busnelli, Andrea Busnelli, Antonella Smeraldi, Ozgur Bulbul, Emanuela Morenghi, Valentina Immediata, Paolo Emanuele Levi-Setti, Paolo Emanuele Levi-Setti

“…While ovarian reserve markers such as Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC) traditionally serve as quantitative predictors of fertility, emerging evidence suggests they may also reflect oocyte quality, particularly in patients with Diminished Ovarian Reserve (DOR). …”
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Retinal thickness and vascular density changes in Keratoconus: A systematic review and meta-analysis by Hadi Vahedi, Mirsaeed Abdollahi, Reza Moshfeghinia, Shima Emami, Navid Sobhi, Rana Sorkhabi, Ali Jafarizadeh

“…Understanding these changes may be essential for future research focused on early detection, potential prognosis markers, and further exploration of the retina-corneal connection in KC.…”
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Pathology of Red Blood Cells in Patients with SARS-CoV-2 by Sona Hakobyan, Lina Hakobyan, Liana Abroyan, Aida Avetisyan, Hranush Avagyan, Nane Bayramyan, Lyudmila Niazyan, Mher Davidyants, Knarik Sargsyan, Tehmine Ghalechyan, Anna Semerjyan, Elena Karalova, Zaven Karalyan

“…These findings highlight the potential utility of hematological parameters as markers for disease severity and prognosis in viral infections.…”
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Integrated bioinformatics analysis of the effects of chronic pain on patients with spinal cord injury by Jinlong Zhang, Jinlong Zhang, Longju Qi, Yuyu Sun, Yuyu Sun, Shiyuan Chen, Jinyi Liu, Jiaxi Chen, Fangsu Yan, Wenqi Wang, Qinghua Wang, Liang Chen

“…Lastly, we analyzed the hub genes to explore the transcription factor network, potential therapeutic drugs, and ceRNA networks.ConclusionThe analysis of 15 hub genes as significant biological markers for SCI and chronic pain has led to the identification of several potential drugs for treatment.…”
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T Helper Lymphocyte and Mast Cell Immunohistochemical Pattern in Nonceliac Gluten Sensitivity by Giuseppe Losurdo, Domenico Piscitelli, Federica Pezzuto, Francesco Fortarezza, Claudia Covelli, Antonella Marra, Andrea Iannone, Annacinzia Amoruso, Mariabeatrice Principi, Enzo Ierardi, Alfredo Di Leo

“…Since few data about NCGS histopathology is available, we assessed the markers of lymphocyte and innate immunity activation. …”
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Investigating ITM2B‐associated ataxia in a Taiwanese cerebellar ataxia cohort by Shih‐Yu Fang, Cheng‐Tsung Hsiao, Kang‐Yang Jih, Yu‐Sheun Tsai, Kuan‐Lin Lai, Cheng‐Ta Chou, Yi‐Chu Liao, Yi‐Chung Lee

“…Eight short tandem repeat markers flanking ITM2B were genotyped to analyze the associated haplotype. …”
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Effect of folic acid supplementation on diminished ovarian reserve: study protocol of a single-centre, open-label, randomised, placebo-controlled clinical trial by Yan Wang, Ling Zheng, Kaijun Liao, Dongli Lu, Jiaxin Wu, Binjin Wu, Zhaochun Wu, Zhenghua Jiang

“…The primary outcome is antral follicle count, and the secondary outcomes are ovarian reserve markers, ovarian low-dose stimulation responses and safety.Ethics and dissemination This study was approved by the Ethics Review Committee of Nanping First Hospital Affiliated to Fujian Medical University on 10 February 2021 (approval number: NPSY202002042). …”
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Incidence, Risk Factors, and Modified Risk Assessment Model of Venous Thromboembolism in Non‐Hodgkin Lymphoma Patients by Wen Li, Rui Liu, Ying Shen, GongZhizi Gao, Rui Yang, Yiwen Wang, Ruoyu Yang, Zujie Lin, Ruijun Dong, Wanhong Zhao, Aili He, Ju Bai

“…Existing risk assessment models (RAMs) like the Khorana and ThroLy scores have limitations and are inadequately validated for NHL patients. Coagulation markers such as D‐dimer, thrombin–antithrombin complex (TAT), and thrombomodulin (TM) show a potential predictive value for cancer‐associated VTE but lack extensive research in NHL. …”
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Evaluation of ovarian stiffness and its biological mechanism using shear wave elastography in polycystic ovary syndrome by Yifang He, Shuangping Deng, Yanli Wang, Xiali Wang, Qingqing Huang, Jing Cheng, Dandan Wang, Guorong Lyu

“…In the rat model, increased ovarian stiffness was associated with significant fibrosis and altered expression of fibrosis-related markers. Transcriptomic and proteomic analyses revealed that BM gene alterations were correlated with ovarian stiffness, which was further validated using PCOS patient data from the Gene Expression Omnibus database. …”
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T-cell immune status in patients with acute exacerbation of chronic obstructive pulmonary disease: a case-control study by Xiao-feng Xiong, Xiao-feng Xiong, Min Zhu, Min Zhu, Hong-xia Wu, Zuo-hong Wu, Li-li Fan, De-yun Cheng

“…The distribution of T cell subsets in peripheral blood of AECOPD, SCOPD, and healthy controls (HCs) was measured using multi-color flow cytometry, and the functional status was analyzed by additional staining of activation markers.ResultsA total of 43 HCs, 43 SCOPD patients, and 64 AECOPD patients were evaluated. …”
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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy by M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang

“…Finally, using the proteomic correlates of iLGS, we identified protein markers associated with exceptional longevity irrespective of chronological age and prioritized drugs with repurposing potentials for gerotherapeutics. …”
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Osteopenia Metabolomic Biomarkers for Early Warning of Osteoporosis by Jie Wang, Dandan Yan, Suna Wang, Aihua Zhao, Xuhong Hou, Xiaojiao Zheng, Jingyi Guo, Li Shen, Yuqian Bao, Wei Jia, Xiangtian Yu, Cheng Hu, Zhenlin Zhang

“…Metabolites were further selected to identify osteopenia (nine metabolites in females; eight metabolites in males), and their ability to discriminate osteopenia was improved significantly compared to traditional bone turnover markers (BTMs) (female AUC = 0.717, 95% CI 0.547–0.882, versus BTMs: <i>p</i> = 0.036; male AUC = 0.801, 95% CI 0.636–0.966, versus BTMs: <i>p</i> = 0.007). …”
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Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects by Kaitlin Garofano, Vera Mariani, Kameron Rashid, Sumanun Suwunnakorn, Alfateh Sidahmed, Anelia Horvath, Sanjay B. Maggirwar, Travis J. O’Brien, Minoli A. Perera, Michael Whalen, Norman H. Lee

“…While PLPs aggregated in response to thrombin, they did not display enhanced expression of surface markers P-selectin and activated α2bβ3, in contrast to platelets. …”
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