Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2: Effects on Intestinal Morphology and Absorption, Renal Function, Bone and Body Composition, and Muscle Func... by P. B. Jeppesen, P. Lund, I. B. Gottschalck, H. B. Nielsen, J. J. Holst, J. Mortensen, S. S. Poulsen, B. Quistorff, P. B. Mortensen

“…In addition, mucosal morphometrics, renal function (by creatinine clearance), body composition and bone mineral density (by DEXA), biochemical markers of bone turnover (by s-CTX and osteocalcin, PTH and vitamin D), and muscle function (NMR, lungfunction, exercise test) were measured. …”
Get full text

H. Wendl Leaf Metabolites Potentiate the Radiosensitivity of Hepatocellular Carcinoma Through Ki67 and PARP Inhibition by Nabil M. Selim PhD, Seham S. El-Hawary PhD, Soheir M. El Zalabani PhD, Rehab Nabil Shamma PhD, Nariman El Sayed Mahdy PhD, Noheir H. Sherif PhD, Khayrya A. Youssif PhD, Usama Ramadan Abdelmohsen PhD, Mai H. Mekkawy PhD, Hanan A. Fahmy PhD

“…Besides, the NE administration and/or γ-irradiation (IRR) significantly reduced the elevated alanine aminotransferase (ALT), total proteins, and albumin levels in HCC-induced rats. Likewise, the tumor markers alpha-fetoprotein (AFP) and gamma-glutamyl transferase (GGT) levels were considerably reduced in HCC rats. …”
Get full text

A study of specific immunoglobulin G4 expression in allergic rhinitis and its value in assessing efficacy and in predicting prognosis of sublingual immunotherapy by Ting‐Ting Wei, Kai Gao, Jun‐Hu Tai, Yong‐Jun Wei, Bin Zhan

“…We compared total nasal symptom score (TNSS), total medication score (TMS), visual analogue scale (VAS) score, inflammatory cytokines, and immune function markers in AR patients before and after SLIT. SLIT reduced TNSS, TMS, VAS scores, IL‐4, IL‐17, eosinophilia percentage (EOS%), and specific immunoglobulin E (sIgE) levels, while increasing INF‐γ, IL‐10, and sIgG4. …”
Get full text

Genetic Characteristics of the Rat Fibroblast Cell Line Rat-1 by Thomas Liehr, Stefanie Kankel, Eva Miriam Buhl, Sarah K. Schröder-Lange, Ralf Weiskirchen

“…We established a karyotype, performed multicolor fluorescence in situ hybridization (mFISH), identified chromosomal losses and gains, and defined an STR profile for Rat-1 with 31 species-specific markers. Interestingly, the chromosomal imbalances found in Rat-1 cells resemble those found in human epithelioid sarcoma or liposarcoma. …”
Get full text

Novel metabolic prognostic score for predicting survival in patients with cancer by Jinyu Shi, Chenan Liu, Xin Zheng, Yue Chen, Heyang Zhang, Tong Liu, Qi Zhang, Li Deng, Hanping Shi

“…DCA and calibration curves indicated that the clinical benefit rate of metabolic disorder burden prognostic markers was high. Patients with a higher metabolic disorder burden had poorer survival rates. …”
Get full text

Serum Levels of IL-33 and Correlation with IL-4, IL-17A, and Hypergammaglobulinemia in Patients with Autoimmune Hepatitis by Ma Liang, Zhang Liwen, Zhuang Yun, Ding Yanbo, Chen Jianping

“…Additionally, the serum levels of IL-33 in AIH patients were correlated positively with markers of hypergammaglobulinemia (IgG, IgM, and IgA) and liver injury (γ-GT/ALP). …”
Get full text

Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation by Lin Liao, Pengyu Tao, Qiming Xu, Jie Chen, Weiwei Liu, Jing Hu, Jianrao Lu

“…Pyroptosis was measured using flow cytometry. Related markers of fibrosis and NOD-like receptor protein 3 (NLRP3) inflammasome activation were measured using western blotting and enzyme-linked immunosorbent assay. …”
Get full text

Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility by Sophie Debaenst, Tamara Jarayseh, Hanna De Saffel, Jan Willem Bek, Matthieu Boone, Ivan Josipovic, Pierre Kibleur, Ronald Y Kwon, Paul J Coucke, Andy Willaert

“…RT-qPCR revealed differential expression of osteogenic markers bglap and col1a1a, highlighting their biomarker potential. …”
Get full text

Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC by Anqi Wang, Sitong Yan, Jiatao Liu, Xiang Chen, Mengyao Hu, Xiao Du, Weijia Jiang, Zhipeng Pan, Lulu Fan, Guoping Sun

“…More importantly, ERS activation increased the expression of several EMT markers by modulating the expression of CREB5. Mechanistically, CREB5 upregulates the transcription of tenascin-C (TNC) by directly binding to its promoter region, thereby promoting EMT in liver cancer cells. …”
Get full text

Development of therapeutic supplement using roasted-cashew-nut to protect cerebral vasoconstriction injury triggered by mixture of petroleum hydrocarbons in the hypothalamus and hi... by J.K. Akintunde, V.O. Akomolafe, R.N. Ugbaja, A.M. Olude, A.D. Folayan

“…Biochemical and molecular markers of brain vasoconstriction injury (BVI) were evaluated using spectrophotometer and RT-PCR analyzer, respectively. …”
Get full text

DHX37 Impacts Prognosis of Hepatocellular Carcinoma and Lung Adenocarcinoma through Immune Infiltration by Yanni Xu, Qiongchao Jiang, Hejun Liu, Xiaoyun Xiao, Dinghong Yang, Phei Er Saw, Baoming Luo

“…In LIHC and LUAD, DHX37 expression showed significant positive correlations with markers of Tregs, myeloid-derived suppressor cells (MDSCs), and T cell exhaustion, contributing to immune tolerance. …”
Get full text

Low Circulating TRAIL Levels Are Associated with Increase of Resistin and Lipocalin-2/ngal Adipokines in Postmenopausal Women by Veronica Tisato, Paola Secchiero, Gloria Bonaccorsi, Carlo Bergamini, Pantaleo Greco, Giorgio Zauli, Carlo Cervellati

“…Our data indicate a link between low circulating levels of TRAIL and markers of obesity-induced diseases (resistin and lipocalin-2/ngal), highlighting a new potential axis of TRAIL functions.…”
Get full text

Thyroid Hormone Activation Regulates the Crosstalk between Breast Cancer and Mesenchymal Stem Cells by Annarita Nappi, Vittoria D’Esposito, Caterina Miro, Alessia Parascandolo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Sepehr Torabinejad, Federica Restolfer, Maddalena Raia, Melania Murolo, Emery Di Cicco, Pietro Formisano, Monica Dentice

“…Methods: Primary human MSCs from healthy female donors were co-cultured with DIO2 knock out (D2KO) and wild type (WT) MCF7 breast cancer cells to assess cell growth, migration, invasion and the expression of known epithelial-mesenchymal transition (EMT)- and inflammation-related markers. Furthermore, a surgery-free intraductal delivery model, i.e., the Mouse-INtraDuctal (MIND) injection method, was used as a tool for in vivo characterization of breast tumor formation and progression. …”
Get full text

Dichotomitin promotes osteoblast differentiation and improves osteoporosis by inhibiting oxidative stress by Meichun Han, Weibin Du, Lei Zhang, Zhenwei Wang, Shengqiang Fang, Yang Zheng, Renfu Quan

“…Serum osteogenic biochemical markers were measured. In vitro, osteogenic differentiation was induced with varying concentrations of DH, followed by ALP and ARS staining. …”
Get full text

Anti-Inflammatory Effects of Concentrated Ethanol Extracts of Edelweiss (Leontopodium alpinum Cass.) Callus Cultures towards Human Keratinocytes and Endothelial Cells by Lulli Daniela, Potapovich Alla, Riccardo Maurelli, Dellambra Elena, Pressi Giovanna, Kostyuk Vladimir, Dal Toso Roberto, De Luca Chiara, Pastore Saveria, Korkina Liudmila

“…Sirtuin-inhibited cell cycle, proliferation, and apoptosis markers were restored by ECC55. The extract inhibited LPS-induced IL-6 and VCAM1 genes in HUVEC, as well as oxLDL-induced selective VCAM1 overexpression. …”
Get full text

Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation by Marianne Nuijsink, Wim C. J. Hop, Peter J. Sterk, Eric J. Duiverman, Johan C. De Jongste

“…The aim of this study was to assess cross-sectional and longitudinal correlations between uEPX and other markers of asthma control and eosinophilic airway inflammation. …”
Get full text

H₂S Prodrug, SG-1002, Protects against Myocardial Oxidative Damage and Hypertrophy In Vitro via Induction of Cystathionine β-Synthase and Antioxidant Proteins by Rahib K. Islam, Erinn Donnelly, Erminia Donnarumma, Fokhrul Hossain, Jason D. Gardner, Kazi N. Islam

“…SG-1002 also decreased the expression of hypertrophic/HF protein markers such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), galectin-3, TIMP1, collagen type III, and TGF-β1 in stressed HL-1 cells. …”
Get full text

Effect of a Yogic Breathing Technique on Immune Parameters among Healthcare Workers: A Randomized Controlled Pilot Study by Archana Balasubramanian, Priyathersini Nagarajan, Mathangi Damal Chandrasekar, Kaviraja Udupa, Emmanuel Bhaskar, Divya Kanchibotla, Saumya Subramanian

“…Among them, 27 were females (71%) and 11 males (29%). Pro-inflammatory markers such as erythrocyte sedimentation rate, C-reactive protein and neutrophil-to-lymphocyte ratio showed a decrease in mean values after 12 weeks in both groups, which was not statistically significant. …”
Get full text

Human PBMC-based humanized mice exhibit myositis features and serve as a drug evaluation model by Akiko Nishidate, Kana Takemoto, Yuki Imura, Mikako Murase, Ryu Yamanaka, Manami Kikuchi, Junpei Anan, Sayuka Kato, Airi Akatsuka, Sachiko Mochizuki, Yuzo Koda

“…The hPBMC mice exhibit elevated serum levels of creatine kinase and aspartate transaminase, markers of myositis, and increased expression levels of myositis-related genes, such as vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and serum amyloid A1, in muscle tissues. …”
Get full text

Memory B cells and their transcriptomic profiles associated with belimumab resistance in systemic lupus erythematosus in the maintenance phase by Takeshi Iwasaki, Takeshi Iwasaki, Hajime Yoshifuji, Koji Kitagori, Shuji Sumitomo, Shuji Akizuki, Ran Nakashima, Hideaki Tsuji, Ryosuke Hiwa, Mirei Shirakashi, Kosaku Murakami, Akira Onishi, Hideo Onizawa, Masao Tanaka, Fumihiko Matsuda, Akio Morinobu, Koichiro Ohmura, Koichiro Ohmura

“…Lower C4 and white blood cell counts may serve as clinical markers of higher memory B cells.…”
Get full text