Real-World Evidence of Clinical Outcomes of the Use of the Adalimumab Biosimilar SB5 in Rheumatic and Gastrointestinal Immune-Mediated Inflammatory Diseases: 12-Month Data from the... by Bruno Fautrel, Yoram Bouhnik, Carine Salliot, Franck Carbonnel, Mathurin Fumery, Christophe Bernardeau, Yves Maugars, Mathurin Flamant, Fabienne Coury, Ben Braithwaite, Salima Hateb, Janet Addison, the PERFUSE investigators

“…Analyses of clinical data were descriptive, while persistence was assessed using a Kaplan–Meier survival analysis. Results Overall, 911 patients were included: 507 from rheumatology centres [116 with rheumatoid arthritis (RA), 78 psoriatic arthritis (PsA), and 313 ankylosing spondylitis (AS)] and 404 from gastroenterology centres [316 with Crohn’s disease (CD) and 88 ulcerative colitis (UC)]. …”
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Association between insulin resistance indices and outcomes in patients with heart failure with preserved ejection fraction by Weicheng Ni, Ruihao Jiang, Di Xu, Jianhan Zhu, Jing Chen, Yuanzhen Lin, Hao Zhou

“…The mean age of the patients was 70.59 ± 10.6 years, with 5045 (58.04%) being male. The Kaplan-Meier survival analysis revealed that higher degree of the four IR indexes was associated with higher risk of MACE (all log-rank P < 0.05). …”
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The Association Between Mitral Regurgitation and Long-Term Outcomes in Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Retrospective Large Sample Cohor... by Yan N, Wu P, Zhu B, Ma A, Wang X, Hai X, Ma X, Jiang H, Yang S

“…The cumulative 3-year incidence of MACCEs was 19.21% overall, with rates of 15.26%, 20.37%, and 37.37% in the no MR, mild MR, and moderate/severe MR groups, respectively (log-rank p < 0.001). Kaplan–Meier survival curves of MR with all-cause death and RHF were also plotted (log-rank p < 0.001). …”
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Effects of stress hyperglycemia ratio upon long-lasting prognosis in coronary artery disease patients with or lacking chronic renal impairment: findings from a Chinese multi-center... by Jielan Wu, Jin Liu, Ziyao Yuan, Shangyi Tang, Weipeng Zhang, Yulong Xiang, Jinming Chen, Qiqiang Lin, Wei Guo, Yibo He, Haozhang Huang, Xiaozhao Lu, Jingru Deng, Huangtao Ruan, Rengui Jiang, Shiqun Chen, Yong Liu

“…Long-term all-cause and cardiovascular mortality were the primary endpoints. The Kaplan–Meier method, restricted cubic spline (RCS), cox regression analysis, subgroups analysis, and sensitivity analysis were employed to estimate the connection between SHR and all-cause as well as cardiovascular mortality. …”
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PD-1 抗体联合替莫唑胺治疗晚期黑色素瘤的疗效及安全性分析 by 刘巍, 李婧婧, 丁娅, 李丹丹, 文习之, 祝保艳, 张晓实

“…【结果】33例患者接受的中位疗程数为替莫唑胺6.0（1~12）个周期和PD-1抗体7.0（1~27）个周期，客观有效率（ORR）为24.2%（肢端型ORR为38.5%），疾病控制率（DCR）为60.6%，中位无进展生存期（mPFS）为4.3月（95%CI，1.3~7.3），中位疾病控制时间（mDDC）为7.5月（95%CI，2.3~12.7），中位缓解持续时间（mDOR）为11.1月（95%CI，5.5~16.6），中位总生存（mOS）尚未达到，1年生存率为86.1%。Kaplan-Meier法生存分析和COX多因素分析均显示影响PFS的因素有PD-L1表达和BARFV600E/K基因突变状态。…”
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Prognostic value of intraductal carcinoma subtypes and postoperative radiotherapy for localized prostate cancer by Fang Cao, Qing Li, Tianyu Xiong, Yingjie Zheng, Tian Zhang, Mulan Jin, Liming Song, Nianzeng Xing, Yinong Niu

“…Screening cases with pathological results of intraductal carcinoma, subtyping was completed by a pathologist, grouped by intraductal carcinoma (+/-; pattern 1/ 2) and treatment regimen (RP + PORT / RP only), Kaplan-Meier curves were plotted based on the time to biochemical recurrence-free and overall survival of the patients, and Cox regression analyses were performed. …”
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An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…Immunohistochemical analysis revealed that INPP4B expression was significantly higher in drug resistant pancreatic cancer tissues compared to non-drug resistant tissues, and lower in normal tissues than in both cancerous tissue types. Kaplan-Meier curves demonstrated that patients with low INPP4B expression had significantly better progression-free survival (PFS) than those with high expression (HR=2.874, 95% CI: 1.262-6.544, P=0.013). …”
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Uncovering the Mechanisms of BaBaoWuDanYaoMo Against Influenza A Virus and Virus-Induced Inflammation Based on Network Pharmacology and Pharmacological Evaluation by Lei B, Su Y, Chen R, Chen Z, Liu B, Chen Y, Zhou M, Wang X, Ma Q

“…Biao Lei,1,&ast; Yongjie Su,1,&ast; Ruihan Chen,1,&ast; Zexing Chen,1,&ast; Bin Liu,1 Yuou Chen,1,2 Meihua Zhou,1 Xinhua Wang,1,3 Qinhai Ma1 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 2King Med School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 3Institute of Integration of Traditional and Western Medicine, Guangzhou Medical University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qinhai Ma; Xinhua Wang, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China, Email 13268268214@163.com; xinhuaw@gzhmu.edu.cnPurpose: The pro-inflammatory response triggered by influenza viruses can contribute to viral pneumonia, even death. …”
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立体定向放疗与全脑放疗局限性脑转移瘤的疗效预后分析

“…: 【目的】 探讨立体定向放射治疗(SRT)与全脑放射治疗(WBRT)在局限性脑转移瘤治疗中的疗效和预后,为合理应用SRT和WBRT提供依据65377;【方法】 选择2000年1月 ～ 2005年12月收治的转移灶≤4个且最大径≤4 cm脑转移患者60例,按照原发肿瘤类型(肺癌和非肺癌)65380;脑转移灶数目(单发和2 ～ 4个)65380;有无颅外转移和化疗与否四项因素进行匹配设计分为WBRT加SRT65380;单纯SRT和单纯WBRT治疗组,三组的治疗剂量分别为WBRT 30 ～ 36 Gy + SRT 18 ～ 20 Gy65380;SRT 28 ～ 32 Gy和WBRT 30 ～ 40 Gy,分析全组以及据原发肿瘤类型65380;脑转移灶数目65380;有无颅外转移亚组不同治疗方法在局部控制率65380;局部新病灶发生率(χ2检验)和生存率(Kaplan*9鄄Meier法和Log*9鄄rank检验)的差异65377;【结果】 全组局部控制率与局部新病灶发生率分别为80.0%(48/60)和20.0%(12/60)65377;全组患者中位生存时间13个月(3 ～ 36月),第165380;2年生存率分别是38.1%和14.3%65377;WBRT加SRT65380;单纯SRT和单纯WBRT治疗组的局部控制率分别为95.0%65380;80.0%和60.0%(P < 0.05),而局部新病灶发生率则分别为15.0%65380;35.0%和10.0%(P < 0.05)65377;WBRT加SRT65380;单纯SRT和单纯WBRT治疗组的中位生存期分别为865380;9和6个月,生存分析未显示不同治疗方法影响生存预后(P > 0.05),分层分析亦未显示不同治疗方法在不同原发肿瘤亚组中影响生存预后(P > 0.05),然而在单发脑转移患者和无颅外转移患者中,WBRT加SRT和单纯SRT治疗组的生存预后优于单纯WBRT治疗组,中位生存期分别为2365380;16和5个月(P < 0.05),以及1265380;9和5个月(P < 0.05)65377;【结论】 SRT可明显改善局限性脑转移瘤患者的局部控制率,但未行WBRT治疗的患者局部新发脑转移率明显增加65377;在预后较好的单发脑转移瘤患者和无颅外转移患者中,联合应用SRT和WBRT能显著提高生存率65377;…”
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早中期结直肠癌手术前后外周血循环肿瘤细胞的监测及预后分析 by 曹霞

“…利用受试者工作曲线（ROC）及约登指数判定CTC诊断结直肠癌的临界值，采用Kaplan-Meier和Log-rank方法进行生存分析，多因素COX回归分析进行多因素校正，综合评估CTC诊断早中期结直肠癌的价值，然后结合临床病理特征以及术后随访资料，分析外周血循环肿瘤细胞与临床病理特征及预后的关系。…”
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Association of the blood urea nitrogen to serum albumin ratio and all-cause mortality in critical ill acute ischemic stroke patients: a retrospective cohort study of MIMIC-IV datab... by Yongwei Huang, Zongping Li, Jianjun Wang, Jianjun Wang, Decai Wang, Decai Wang, Xiaoshuang Yin

“…The connection between BAR and ACM at various time intervals was ascertained with the multivariate Cox regression (MCR) models after the adjustment for covariates. Kaplan–Meier (KM) survival curves were generated to illustrate variations in BAR and death over various time intervals. …”
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Çağdaş Nusayrî Şeyhlerinin Eserlerinde Tanrı Tasavvuru ve Hz. Ali Algısı by Mehmet Kubat, Mehmet Hanifi Yoldaş

“…Bu görüşe kaynaklık eden Kitâbü’l-Mecmûʿ’da geçen Hz. Ali’nin ulûhiyeti ile ilgili kısımlar sonradan düşmanları tarafından eklenmiştir. …”
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The expression of CCL17 and potential prognostic value on tumor immunity in thyroid carcinoma based on bioinformatics analysis by Xue Gu, Bingfeng Chen, Shengcan Zhang, Xinyu Zhai, Ying Hu, Hui Ye

“…Next, the association of CCL17 with survival in the thyroid carcinoma patients was examined by using the Kaplan–Meier plotter database. Then, weighted gene co-expression network (WGCNA) was employed to analyze the 1424 DEGs to classify 9 modules. …”
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25 años de cirugía de Ross: seguimiento y resultados en pacientes reoperados en nuestro centro by Consuelo M. Sisinni-Ganly, Julio C. Lugo-Adán, Francisco Estévez-Cid, Rocío Casais-Pampín, Juan J. Legarra-Calderón

“…Their characteristics and survival were studied using Kaplan-Meier analysis. Results: The mean follow-up of the patients undergoing RR was 17.5 ± 5 years (median 19 years, range 0-25 years). …”
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Előszó by Ákos Forczek

“…Forczek Ákos a normalitás és abnormalitás határait újraszabó elmedietétikák térnyerését elemzi a kései német felvilágosodás korszakának szétszórtsággal (Zerstreuung) kapcsolatos diskurzusában Meier, Mendelssohn, Kant és Herz írásain keresztül. …”
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Presenting the model of portfolio management in investment funds based on behavioral financial variables by Seyed Mohammad Hadi Shahamat, Mahdi Mohammad Bagheri, Ali Raispour Rajabali, Mohsen Zayandeh Roudi

“…Behavioral finance is a new theoretical branch in finance that is defined by combining the knowledge of psychology, sociology and other social sciences (Meisa Dai et al, 2021). Investment funds On the other hand, in most of the developed countries, investment funds are considered as the central core of the capital market and they direct huge amounts of wandering capital to the productive and active sectors of the society every month. …”
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Replication Study of “Visual Fixation on the Thorax Predicts Bystander Breathing Detection in Simulated Out-of-Hospital Cardiac Arrest” by Marco Pedrotti

“…Ili kupanua ushahidi na data inayopatikana juu ya mada hii, tulijaribu kurudia (Utafiti wa 2; n = 73).Mbinu: Washiriki waliokuwa na kifaa cha kufuatilia macho walipoingia kwenye chumba ambamo midoli – iliyowekwa nasibu kama ya kupumua au isiyopumua – iliyokalazwa sakafuni. …”
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