Exosomal coactivator-associated arginine methyltransferase 1 derived from adipocytes accelerates diabetic wound healing by modulating inflammation and promoting angiogenesis by Yongxiang Zhang, Yao Pan, Kai Yang, Xiansun Wu, Yaoyao Zhang, Fengbiao Xu, Tietao Di, Tietao Di, Wang Liu

Get full text

AMPK-ULK1-Mediated Ferritinophagy Drives Ferroptosis in GLA-Induced Testicular Toxicity by Dianyun Wang, Caiying Zhang, Fan Yang, Yang Hu, Chenghong Xing, Guoliang Hu, Jirong Chen, Yi Li, Penghui Liu, Huabin Cao, Xueyan Dai

“…We also demonstrated that nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy, which involves the autophagic degradation of the primary intracellular iron storage protein ferritin, is essential for GLA-induced ferroptosis by showing that NCOA4 knockdown decreased intracellular iron levels and attenuated lipid peroxidation, eventually alleviating GLA-induced cell death. …”
Get full text

Investigating the Impact of hsa_circ_0005255 on Proliferation and Autophagy in Crohn's Disease Intestinal Epithelial Cells Through miR‐23a‐3p‐Mediated NCOA3 Expression by Dong Liu, De‐Run Kong

Get full text

Unraveling the pathogenicity role of the novel compound heterozygous mutations of MED25 gene in a Chinese patient with BVSYS by Linbing Zou, Ruikang Qiu, Zhijun Dai, Yulei Li, Yunjiao Liao, Yan Zhou

“…IntroductionMediator of RNA polymerase II transcription subunit 25 (MED25), a crucial component of the transcriptional coactivator complex, plays a significant role in the transcription of most RNA polymerase II-dependent genes. …”
Get full text

Identification of components in scorpion and centipede traditional Chinese medicine formulations with potentially beneficial actions in asthma: network pharmacology and molecular d... by Yi-Ren Chen, Ya-Da Zhang, Wei Zhang, Bin-Qing Tang

“…Targets with degree values ≥ 16 included TP53, HSP90AA1, HSP90AB1, steroid receptor coactivator (SRC), epidermal growth factor receptor (EGFR), estrogen receptor 1 (ESR1), mitogen-activated protein kinase 1 (MAPK1), mitogen-activated protein kinase 3 (MAPK3), and histone deacetylase 1 (HDAC1). …”
Get full text

Advances in mitochondrial dysfunction in radiation tissue injury by Jianhuang Rong, Qiujie Yu, Guilin Huang, Yueyue Wang, Nini Zhang

“…While the nucleus has long been considered the principal target of ionizing radiation, emerging evidence underscores the pivotal role of mitochondria in mediating radiation-induced damage. This review provides a comprehensive overview of mitochondrial dysfunction in various irradiated tissues, including the intestine, hematopoietic system, heart, lung, brain, and skin. …”
Get full text

Nrf2/UBE3B protects against acute lung injury by inhibiting ferritinophagy through the ubiquitination of NCOA4 by Yunfan Gu, Hui Dong, Yanjun Wang, Beibei Hu, Hong Jiang, Rong Hu

“…UBE3B deficiency enhanced the process of nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy and increased ferrous ion content, whereas overexpression of UBE3B reversed the harmful effects of Nrf2 knockdown on AECII, which may promote AECII ferroptosis. …”
Get full text

Impaired mitochondria-initiated crosstalk with lysosomes reciprocally aggravates mitochondrial defect through LManVI by Shengnan Li, Zhaoliang Shan, Guochun Zhao, Yuwei Li, Minghui Du, Xiuxiu Ti, Yuxue Gao, Wenting Li, Hui Zuo, Yan Wang, Qing Zhang

“…Reciprocally, downregulation of lysosomal LManVI further decreases many mitochondrial genes expression through downregulation of transcriptional coactivator PGC-1, leading to aggravating the dMterf4 RNAi-mediated mitochondrial defect, suggesting that mitochondrial defect can crosstalk with lysosomes to make mitochondrial status worse in a positive feedback way. …”
Get full text

Systematic pan-cancer analysis identified NCOA4 as an immunological and prognostic biomarker and validated in lung adenocarcinoma by An Wang, Yun-ye Mao, Tao Li, Xin Zhou, Yi-bing Bai, Jia-pei Qin, Yi Dong, Ting Wang, Tong Zhang, Zhi-qiang Ma, Yi Hu

“…The potential of nuclear receptor coactivator 4 (NCOA4) as a biomarker has been identified in different types of cancer. …”
Get full text