Influence of Angiotensin II Subtype 2 Receptor (AT2R) Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II Subt... by Emma S. Jones, M. Jane Black, Robert E. Widdop

“…Adult (20 weeks) and senescent (20 months) spontaneously hypertensive rats (SHRs) were treated with either the AT1R antagonist, candesartan cilexetil (2 mg/kg/day), the AT2R antagonist, PD123319 (10 mg/kg/day), or a combination of the 2 compounds. Mean arterial pressure (MAP) and left ventricular volume were markedly decreased by candesartan cilexetil, however, simultaneous treatment with PD123319 had no additional effect on either parameter. …”
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Transitions in intensive care: Investigating critical slowing down post extubation. by Lucinda Khalil, Sandip V George, Katherine L Brown, Samiran Ray, Simon Arridge

“…While immediate clinical utility is limited, the work marks an important first step towards using dynamical systems theory to understand the dynamics of signals measured at the bedside during intensive care.…”
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Beyond burnout: A comprehensive investigation of burnout, resilience, and career continuity among Palestinian lawyers in a complex socio-political environment. by Muayad K Hattab, Noor Omar Adas, Abdalkarim Ayyoub, Shadi Khalil Abualkibash, Muntaser Nafeth Asmar, Akram Daoud, Ghassan Khaled, Zuheir N Khlaif

“…This article investigates burnout among lawyers and proposes systemic changes to reduce pressure and stress in the legal profession while enhancing resilience among lawyers. …”
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Saturated fat in an evolutionary context by Eirik Garnås

“…Saturated fat is a natural part of a balanced diet; however, caution is warranted in a food environment that differs markedly from the one to which we are adapted.…”
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Changes in the Size of a Ruptured Pheochromocytoma after Transcatheter Arterial Embolization by Takahiro Ichikawa, Chikako Oyabu, Megumi Minamida, Yusuke Ichijo, Yoshitaka Hashimoto, Mai Asano, Hiroya Iwase, Toru Tanaka, Michiaki Fukui

“…Considering that she had marked hypertension (193/115 mmHg), we made a provisional diagnosis of left lateral pain due to a ruptured pheochromocytoma. …”
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Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats by Sheng-Lung Hsu, Hsien-Hui Chung, I-Hung Chen, Yat-Ching Tong

“…Prostatic relaxation induced by loperamide was markedly reduced in HFD when compared to the control. …”
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Comparison of Clinical Trajectories before Initiation of Renal Replacement Therapy between Diabetic Nephropathy and Nephrosclerosis on the KDIGO Guidelines Heat Map by Masanori Abe, Kazuyoshi Okada, Noriaki Maruyama, Hiroyuki Takashima, Osamu Oikawa, Masayoshi Soma

“…The clinical trajectories of diabetic nephropathy and nephrosclerosis differed markedly on the KDIGO heat map.…”
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OHMi Estarreja: an ecosystem highly anthropized where contamination is the unifying element towards interdisciplinarity by Bedell, Jean-Philippe, Guihard-Costa, Anne-Marie, Paiva, Cristiana, Machado, Diogo, Cachada, Anabela, Patinha, Carla, Durães, Nuno, Sousa, Ana Catarina, Beurier, Anne-Gaëlle, Ferreira da Silva, Eduardo

“…This area is highly vulnerable and currently faces a set of natural and anthropogenic pressures. The overall interdisciplinary understanding of the risk induced by the chemical complex was possible by several complementary approaches: (a) spatial-temporal evolution of the contamination level, (b) health studies of the Estarreja population, and (c) societal changes in Estarreja area. …”
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In Vivo Evaluation of the Ameliorating Effects of Small-Volume Resuscitation with Four Different Fluids on Endotoxemia-Induced Kidney Injury by Yan-ling Wang, Jing-hui Chen, Qiong-fang Zhu, Gao-feng Yu, Chen-fang Luo, Gang-jian Luo, Shang-rong Li, Zi-qing Hei

“…LPS injection caused reduced and progressively deteriorated systemic (arterial blood pressure) and renal hemodynamics (renal blood flow and renal vascular resistance index) over time. …”
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Compaction versus Surface Parameters of Certain Solid Catalysts by Anwar Amin, Laila I. Ali, Anwar M. Ibrahim

“…Increasing compaction led to a marked increase in the adsorption capacity as a consequence of plastic deformation associated with the breakage of fragile primary particles and the creation of new surfaces. …”
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“National Champions” and Technological “Little Giants”: Chinese Industrial Policy Between Modernization and Tradition by I. V. Danilin

“…However, the potential for transformative change appears limited due to mounting external pressures and path dependency, which predispose Chinese leadership to replicate established approaches.…”
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Effectiveness of the addition of visual aids to conversational preoperative education in glaucoma filtering surgery: A randomized controlled trial by Peimin Lin, Laiwen Lv, Ruqing Tang, Dehua Li, Xiaoxuan Chen, Jie Fang, Zhenggen Wu, Chukai Huang, Kusheng Wu

“…Anxiety levels, pain scores, blood pressure, and pulse rates were measured at multiple time points. …”
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Silent Neuroleptic Malignant Syndrome: A Case Report of Atypical Antipsychotic Induced Elevation of Creatinine Kinase and Altered Mental Status by Amber N. Edinoff, Hamza Mohammad-Amin, Amira S. Odisho

“…There were two case studies noted that had marked increases in serum CK with risperidone use. …”
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Liver Transplantation: Evolving Patient Selection Criteria by Andy S Yu, Aijaz Ahmed, Emmet B Keeffe

“…These events have led to a marked lengthening of the waiting time for liver transplantation, resulting in increased deaths of those on the waiting list and sicker patients undergoing transplantation. …”
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Cardiac Effects of Thyrotropin Oversuppression with Levothyroxine in Young Women with Differentiated Thyroid Cancer by Kyung-Soon Hong, Jung-Woo Son, Ohk Hyun Ryu, Moon-Gi Choi, Ji Yeon Hong, Seong Jin Lee

“…DTC patients and control subjects were well matched in heart rate and blood pressure. There were marked differences in serum TSH (P=0.001) and free T4 (P=0.002). …”
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Insight into the codon usage patterns and adaptation of Tembusu Virus by Fucheng Guo, Huiming Tan, Jinjin Yang, Rumin Jia, Ruichen Wang, Lie Wu, Fengzhi Pan, Kai Kang, Weitian Xie, Youquan Li, Kewei Fan

“…Furthermore, TMUV exhibits markedly higher adaptation to the CUPs of poultry hosts (duck, goose, and chicken) compared to potential host humans or vector mosquito. …”
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Spatial-temporal characteristics of agricultural economic resilience and spatial spillover effects of driving factors: evidence from provincial panel data in China by Xiaoyu Chen, Haohan Wang, Xingyuan Zhu, Xiao Zhang

“…Strengthening Agricultural Economic Resilience (AER) has become a crucial approach to ensuring food security and promoting sustainable social development, particularly in light of supply shocks such as limited resources, environmental pressures, stagnating agricultural profitability, and diminishing demographic advantages. …”
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Towards Safer Workplace: A Survey-Based Study on Developing a Safety Climate Model for the Indonesian Paper Industry by Nana Rahdiana, Bambang Suhardi, Retno Wulan Damayanti, Novie Susanto, Jafri Mohd Rohani

“…By fostering a proactive safety culture and addressing sector-specific risks, this model has the potential to significantly reduce workplace accidents and improve overall safety performance, marking an important advancement in industry-specific safety research.…”
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Pakistan-Russia Relations within the Framework of the SCO: A Regional Analysis by Hira Yaqoob, Abeeda Qureshi

“…Pakistan's official membership in the Russian-cofounded Shanghai Cooperation Organization (SCO) in 2017 marked a significant development in bilateral relations. …”
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Modelling Seismically Induced Mesothermal Goldfields along the Deep-Rooted Cadillac-Larder Lake Fault, Abitibi, Canada by Pierre Bedeaux, Silvain Rafini, Pierre Pilote, Réal Daigneault

“…These ruptures favour repeated occurrences of seismically triggered hydrothermalism along long-existing fluid pathways having an enhanced permeability and iterative ore formation into supracrustal discharge zones by means of episodic drops and build-ups of pressure. Two-dimensional SSM permits the predictive mapping of these high-potential zones. …”
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