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14641
Organic synthesis : the disconnection approach /
Published 2008Table of Contents: “…The disconnection approach -- Basic principles : synthons and reagents synthesis of aromatic compounds -- Strategy I : the order of events -- One-group C-X disconnections -- Strategy II : chemoselectivity -- Two-group C-X disconnections -- Strategy III : reversal of polarity, cyclisations, summary of strategy -- Amine synthesis -- Strategy IV : protecting groups -- One group C-C disconnections I : alcohols -- General strategy A : choosing a disconnection -- Strategy V : stereoselectivity A -- One group C-C disconnections II : carbonyl compounds -- Strategy VI : regioselectivity -- Alkene synthesis -- Strategy VII : use of acetylenes (alkines) -- Two-group C-C disconnections I : Diels-Alder reactions -- Strategy VIII : introduction to carbonyl condensations -- Two-group C-C disconnections II : 1,3-difunctionalised compounds -- Strategy IX : control in carbonyl condensations -- Two-group C-C disconnections : 1,5-difunctionalised compounds -- Strategy X : aliphatic nitro compounds in synthesis -- Two-group disconnections IV : 1,2-difunctionalised compounds -- Strategy XI : radical reactions in synthesis -- Two-group disconnection V : 1,4-difunctionalised compounds -- Strategy XII : reconnection -- Two-group C-C disconnections VI : 1,6-diCarbonyl compounds -- General strategy B : strategy of carbonyl disconnections -- Strategy XIII : introduction to ring synthesis : saturated heterocycles -- Three-membered rings -- Strategy XIV : rearrangements in synthesis -- Four-membered rings : photochemistry in synthesis -- Strategy XV : the use of ketenes in synthesis -- Five-membered rings -- Strategy XVI : pericyclic reactions in synthesis : special methods for five-membered rings -- Six-membered rings -- General strategy C : strategy of ring synthesis -- Strategy XVII : stereoselectivity B -- Aromatic heterocycles -- General strategy D : advanced strategy.…”
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14642
AI product cards: a framework for code-bound formal documentation cards in the public administration
Published 2025-01-01Get full text
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14643
FECI-RTDETR a Lightweight Unmanned Aerial Vehicle Infrared Small Target Detector Algorithm Based on RT-DETR
Published 2025-01-01“…Subsequently, we combine the Efficient Additive feature selection mechanism with an intra-scale feature interaction module to form the EA-AIFI module, which strengthens the model’s focus on dense targets and reduces computational burden. …”
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14644
Maritime Small Object Detection Algorithm in Drone Aerial Images Based on Improved YOLOv8
Published 2024-01-01“…Firstly, the attention based intra-scale feature interaction (AIFI) module is used to replace the spatial pyramid pooling fast (SPPF) module on the backbone, enhancing the detection precision of occluded and densely small targets by integrating global and contextual feature information. …”
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14645
The absolute number of circulating Treg cells is reduced in difficult-to-treat RA patients and is ameliorated by low-dose IL-2
Published 2025-02-01“…A total of 381 patients—107, 151, and 123 in each of the three experimental groups—received low-dose IL-2 treatment [0.5 million international units (MIU) per day, subcutaneous injection from day 1 to day 5]. …”
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14646
Evaluation of three novel antigens and costimulatory agents for improvement of M. Tuberculosis specific interferon gamma release assays
Published 2025-02-01“…The same trend was found for the prototypic EUROIMMUN Quan-T-Cell TB assay (3,355 ± 5,425 mlU/ml vs. 2,548 ± 4,145 mlU/ml, p = 0.1) and the QuantiFERON Tb-Gold Plus assay (3,627 ± 5,992 mlU/ml vs. 2,635 m ± 4,475 mlU/ml, p = 0.08, for tube 1; 3,257 ± 5,349 vs. 2,759 ± 4,446 mIU/ml, p = 0.25, for tube 2). …”
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14647
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14648
بررسی عوامل خطر سنتی مرتبط با ویژگیهای بالینی بیماران انفارکتوس میوکارد با بالارونده قطعه ST
Published 2024-08-01“…در بیماران با درگیری دو رگ، TIMIقبل، با شاخص تودهی بدنی ارتباط معنیداری داشت (0/024 = P)نتیجهگیری: بر اساس مطالعهی حاضر، مصرف سیگار، پیشبینیکنندهی قطع خونرسانی دیوارهی قدامی میوکارد و انفارکتوس دیوارهی قدامی بود و هیپرکلسترولمی، ارتباط معکوس با دستیابی به جریان TIMI درجه 3 پس از PCI داشت. …”
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14649
سلولهای میزبان متاثر در بافتهای تولید مثلی مردانه و مسیرهای سیگنالدهی مرتبط با عفونت SARS-Cov-2
Published 2024-06-01Get full text
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14650
Utilisation et résistance d’un nouveau jouet introduit chez des macaques cynomolgus hébergés en milieu standard ou appauvri
Published 2016-01-01“…Les comportements d’interaction exprimés par les animaux envers le nouveau jouet ont été filmés puis relevés à l’aide du logiciel The Observer (Noldus, Pays-Bas) via la méthode de focal sampling lors de quatre périodes d’observations continues de deux heures réparties sur les 48 heures suivant l’introduction du jouet (deux heures le matin et deux heures l’après-midi, pendant deux jours). …”
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14651
Late-life physical activity, midlife-to-late-life activity patterns, APOE ε4 genotype, and cognitive impairment among Chinese older adults: a population-based observational study
Published 2025-01-01“…Cognitive function was evaluated using the Chinese version of Mini-Mental State Examination. Logistic regression models were used to examine associations. …”
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14652
RELIGIJSKI MOTIVI U ROMANU POSLJEDNJI STIPANČIĆI VJENCESLAVA NOVAKA
Published 2020-01-01“…Opisuje se poznata slika "Majke Milosti"(čiji se original danas čuva u trsatskome svetištu). …”
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14653
Analysis of the current situation and risk factors of frailty in elderly patients with type 2 diabetes (老年2型糖尿病患者衰弱现状及影响因素分析)
Published 2024-06-01“…Nutritional status and depression were evaluated using the Mini-Nutritional Assessment Short Form and the Short Geriatric Depression Scale, respectively. …”
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14654
Influence of enteral nutrition support via nasointestinal tube combined with fast-truck surgery on nutritional status, complications and postoperative rehabilitation of patients wi...
Published 2023-07-01“…The nutritional status[serum total protein (TP), prealbumin (PAB)、hemoglobin (Hb)], intestinal mucosal barrier function [intestinal fatty acid-binding protein (I-FABP), plasma D- lactic acid (D-LA)], inflammatory factor [interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor-α(TNF-α), postoperative complication, postoperative rehabilitation[Fugl-meyer Motor Function Rating Scale (FMA), The Mini-Mental State Examination (MMSE), Glasgow Outcome Scale (GOS)] of patients were measured and compared between two groups. …”
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14655
Transfer of aflatoxin M1 and sterigmatocystin from buffalo milk to soft cheeses
Published 2023-11-01“…Bulk milk samples were immediately collected to conduct eight experimental mini-cheese-making procedures, following the traditional production method of mozzarella and ricotta. …”
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14656
Vascular Contractility Relies on Integrity of Progranulin Pathway: Insights Into Mitochondrial Function
Published 2025-02-01“…Methods and Results We used aortae from male and female C57BL6/J wild‐type (PGRN+/+) and B6(Cg)‐Grntm1.1Aidi/J (PGRN−/−) mice. Our results showed suppression of contractile activity in PGRN−/−, followed by reduced α‐smooth muscle actin expression. …”
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14658
Advances in the Study of AI-assisted Diagnosis and Rehabilitation of ASD
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14660
Swarm learning with weak supervision enables automatic breast cancer detection in magnetic resonance imaging
Published 2025-02-01“…Abstract Background Over the next 5 years, new breast cancer screening guidelines recommending magnetic resonance imaging (MRI) for certain patients will significantly increase the volume of imaging data to be analyzed. …”
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