ParSite is a multicolor DNA labeling system that allows for simultaneous imaging of triple genomic loci in living cells. by Xiaohui He, Yadong Sun, Hanhui Ma

“…However, robust methods for tracking genome organization or genomic interactions over time in living cells are lacking. Here, we developed a multicolor DNA labeling system, ParSite, to simultaneously track triple genomic loci in the U2OS cells. …”
Get full text

Cohort profile: Noncommunicable diseases and ideal cardiovascular health among people living with and without HIV in Zambia and Zimbabwe (NCDzz cohort) by Gilles Wandeler, Samuel Bosomprah, Cleophas Chimbetete, Belinda Varaidzo Chihota, Guy Muula, Carolyn Bolton-Moore, Tinei Shamu, Ardele Mandiriri, Esau Banda

“…Here, we describe the study design and population and evaluate their ideal cardiovascular health (ICVH) using the Life’s Simple 7 (LS7) score according to the American Heart Association.Participants Antiretroviral therapy-naïve people living with HIV (PLWH) and people living without HIV (PLWOH) 30 years or older were recruited from three primary care clinics in Lusaka and Harare, and underwent comprehensive clinical, laboratory and behavioural assessments. …”
Get full text

Home-modification interventions addressing falls and participation in activities of daily living among older adults: a scoping review protocol by Gifty M Georlee, Abiram U, Pham Ngoc Dat, Nguyen Khac Tuan, Shashank Mehrotra

“…We plan to conduct the literature search from August 16, 2020 to September 15, 2020. Two reviewers will independently screen eligible studies for inclusion. …”
Get full text

Mitochondrial ROS modulate presynaptic plasticity in the drosophila neuromuscular junction by Irina Stavrovskaya, Bethany Kristi Morin, Stephen Madamba, Cliyahnelle Alexander, Alexis Romano, Samia Alam, Lucas Pavlov, Erna Mitaishvili, Pablo M. Peixoto

“…However, the potential role of mitochondrial ROS in presynaptic function and plasticity remains largely understudied beyond the context of disease. Here, we investigated this potential ROS role in presynaptic function and short-term plasticity by combining optogenetics, whole cell electrophysiological recordings, and live confocal imaging using a well-established protocol for induction and measurement of synaptic potentiation in Drosophila melanogaster neuromuscular junctions (NMJ). …”
Get full text

A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers by Li Chen, Yunrong Li, Xuanxuan Zhang, Lixin Ma, Cheng Zhang, Huanhuan Chen

Get full text

Misères et splendeurs d’un mendicant dans 'Le Seigneur vous le rendra' de Mahi Binebine by Mohamed Semlali

“…Driven by poverty, the mother takes possession of her child’s body and sculpts a deformed being that will be exhibited in the main square of Marrakech to earn a living. If the monstrous is here inseparable from the tale, it also inscribes the hero in a process of transformation made possible by intellectual (literature) and sentimental (love) learning. …”
Get full text

Être élève en Iran au tournant des années 1900 : les écoles de l’Alliance israélite universelle by Alice Bombardier, Leila Koochakzadeh

Get full text

Chemical Defense of an Ozaenine Bombardier Beetle From New Guinea by Thomas Eisner, George E. Ball, Braden Roach, Daniel J. Aneschansley, Maria Eisner, Curtis L. Blankespoor, Jerrold Meinwald

“…We had occasion recently to study 3 live specimens of Pseudozaena orientalis opaca, an ozaenine carabid beetle (subfamily Paussinae, tribe Ozaenini) from New Guinea, and report here on the biology and chemistry of its defensive spray mechanism. …”
Get full text

Death and taphonomy of Holocene stromatolites from Lagoa Vermelha, Brazil by Keim, Carolina Neumann, Farina, Marcos

“…Growing stromatolites are rare nowadays, limiting our understanding on how microbial mats produce stromatolites. Stromatolites from Lagoa Vermelha in Brazil were claimed as living, lithifying structures several years ago, but recently have been reported as dead, bleached skeletons. …”
Get full text

Latest news from the bonobos: Pan paniscus myths and realities by David Beaune

“…Bonobos are our closest living relatives along with chimpanzees. They attract much attention from anthropologists who want to better understand our primate origins and more recently from the public because of their remarkable behavior and matriarchal social system. …”
Get full text

Two Atypical Cases of Hantavirus Infections from Sri Lanka by N. D. B. Ehelepola, B. M. L. S. Basnayake, S. M. B. Y. Sathkumara, K. L. R. Kaluphana

“…Hantavirus infections have very similar clinical pictures and epidemiology to leptospirosis. Here, we present two cases of hantavirus infections from Sri Lanka (in South Asia) initially misdiagnosed as leptospirosis and later further investigated and diagnosed as hantavirus infections with serological confirmation of the diagnosis. …”
Get full text

Putting Africa on the Black Death map: Narratives from genetics and history by Monica H. Green

“…Focusing on the other side of the continent, the present essay argues that previously unutilized evidence—a “living archive” of genetic data combined with a new reading of linguistic and documentary evidence from the 14th through 20th centuries—suggests that plague did have a significant impact on pre-modern East Africa. …”
Get full text

Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice by José Belizário, Luiz Vieira-Cordeiro, Sylvia Enns

“…Under stress conditions, cells in living tissue die by apoptosis or necrosis depending on the activation of the key molecules within a dying cell that either transduce cell survival or death signals that actively destroy the sentenced cell. …”
Get full text

Medical Assistance in Dying for Persons Suffering Solely from Mental Illness in Canada by Chloe Eunice Panganiban, Srushhti Trivedi

“…Deontology: The Duty to Recognize Vulnerability and Relieve Suffering The argument here begins with the fundamental focus of deontology—that moral duty lies in an action rather than in its consequences. …”
Get full text

SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burden by Bethany K. Hughes, Andrew Davis, Deborah Milligan, Ryan Wallis, Federica Mossa, Michael P. Philpott, Linda J. Wainwright, David A. Gunn, Cleo L. Bishop

Get full text

Click beetle larvae from Cretaceous Burmese amber represent an ancient Gondwanan lineage by Robin Kundrata, Simone Policena Rosa, Katerina Triskova, Gabriela Packova, Johana Hoffmannova, Jan Brus

“…One species of Pityobiinae was recently described from Burmese amber based on adults, and we discuss if it can be congeneric with the here-reported larvae. …”
Get full text

Laparoscopic Splenectomy to Salvage Renal Transplants from Severe Acute Antibody-Mediated Rejection by Michael Latzko, Sakshi Jasra, Sana Akbar, Harry Sun, Sadanand Palekar

Get full text

The Experience of Embodiment Scale: An examination of its psychometric properties in women from the Republic of Cyprus. by Viren Swami, Christophe Maïano, Marios Argyrides, Elly Anastasiades

“…The Experience of Embodiment Scale (EES) is a recently developed instrument that assesses experiences of living in the body. Here, we prepared a novel Greek translation of the EES and examined its psychometric properties. …”
Get full text

Decoding HIV-associated neurocognitive disorders: a new perspective from multimodal connectomics by Zhongkai Zhou, Wei Wang, Hui Li, Ying Shi, Lingling Zhao, Yibo Lu, Xingchen Wei, Hongjun Li

“…Currently, HIV-associated neurocognitive disorders (HAND) remains one of the major challenges faced by people living with HIV (PLWH). HAND involves the vulnerability of neural circuits caused by synaptic degeneration and abnormal synaptic pruning. …”
Get full text

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal. by William J Cisneros, Shimaa H A Soliman, Miriam Walter, Lacy M Simons, Daphne Cornish, Simone De Fabritiis, Ariel W Halle, Eun-Young Kim, Steven M Wolinsky, Ramon Lorenzo-Redondo, Ali Shilatifard, Judd F Hultquist

“…Finally, we demonstrate that KL-2 enhances viral reactivation in peripheral blood mononuclear cells (PBMCs) from people living with HIV (PLWH) on suppressive ART, most notably in combination with inhibitor of apoptosis protein antagonists (IAPi). …”
Get full text