Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity by Jaeseong Oh, Sojeong Yi, Namyi Gu, Dongseong Shin, Kyung-Sang Yu, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang

“…In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials. During conducting a first-in-human trial for a new molecular entity, we were able to determine the mechanism of dichotomized variability in plasma drug concentrations, which appeared closely related to adverse drug reactions (ADRs) through integrated omics analysis. …”
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New RP-HPLC Method Development and Validation for Dorzolamide in Ophthalmic Dosage Form by Boovizhikannan Thangabalan, Getu Kahsay, Tadele Eticha

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On New Families of Integrals in Analytical Studies of Superconductors within the Conformal Transformation Method by Ryszard Gonczarek, Mateusz Krzyzosiak, Adam Gonczarek, Lucjan Jacak

“…We show that, by applying the conformal transformation method, strongly correlated superconducting systems can be discussed in terms of the Fermi liquid with a variable density of states function. …”
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New and Advanced Methods in Detection of Fruit Juice Adulteration: Focusing on Nano-Biosensor by Samira Shokri, Mahya Soltani, Yeganeh Mazaheri, Alieh Rezagholizade-shirvan, Mansoureh Mohammadi, Nabi Shariatifar, Tayebeh Zeinali

“…Among the new methods for detecting counterfeit fruit juice, the development of bio-nanosensors is particularly notable. …”
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Identification of new process-related impurity in the key intermediate in the synthesis of TCV-116 by Testen Ana, Plevnik Miha, Štefane Bogdan, Cigić Irena Kralj

“…Structural elucidation of impurity was achieved by liquid chromatography hyphenated to different high resolution mass analyzers. …”
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Comparison of New Tau PET-Tracer Candidates With [F]T808 and [F]T807 by Lieven Declercq Pharmacist, Sofie Celen PhD, Joan Lecina PhD, Muneer Ahamed PhD, Thomas Tousseyn Prof, MD, PhD, Diederik Moechars PhD, Jesus Alcazar PhD, Manuela Ariza PhD, Katleen Fierens PhD, Astrid Bottelbergs PhD, Jonas Mariën PhD, Rik Vandenberghe Prof, MD, PhD, Ignacio Jose Andres PhD, Koen Van Laere Prof, MD, PhD, Alfons Verbruggen Prof, PhD, Guy Bormans Prof, PhD

“…In vivo radiometabolite analysis using high-performance liquid chromatography showed the presence of polar radiometabolites in plasma and brain. …”
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Development of a New Cold Metal Transfer Arc Additive Die Manufacturing Process by An Zhang, Yanfeng Xing, Fuyong Yang, Xiaobing Zhang, Hongze Wang, Tiejun Yu

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New Microporous Polymer Electrolyte Based on Polysiloxane Grafted with Imidazolium Iodide Moieties for DSSC by Yan Yang, Jie Tao, Xin Jin, Qi Qin

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Nontarget Metabolites of Rhizomes of Edible Sacred Lotus Provide New Insights into Rhizome Browning by Chenyang Hao, Yuetong Yu, Xueting Zhang, Gangqiang Dong, Yan Liu, Sha Chen

“…In this study, 48 target metabolites were untargeted and identified in 212 rhizome cultivars (tropical and temperate types) using ultraperformance liquid chromatography-electrospray ionization quadrupole time-of-flight high-resolution mass spectrometry; among these, 32 compounds were newly reported in the rhizome. …”
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New discoveries of the action of L-ascorbic acid (vitamin C) - Enhanced efficacy in formulations by Andressa Costa de Oliveira, Ana Lucia Morocho-Jacome, Tércio Elyan Azevedo Martins, Claudinéia Aparecida Sales de Oliveira Pinto, André Rolim Baby, Maria Valéria Robles Velasco

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A New Approach for the Utilization of Technical Egg Albumen Based on Acid–Thermal Coagulation by Plamen Saraliev, Desislav Balev, Desislava Vlahova-Vangelova, Nikolay Kolev, Stefan Dragoev

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Synthesis of N-Tetradecyl-1,10-phenathrolinium-Based New Salts for Biological Applications by Atakilt Abebe, Minaleshewa Atlabachew, Misganaw Liyew, Elsabet Ferede

“…New organic salts were synthesized by quaternizing 1,10-phenanthroline using 1-bromotetradecane. …”
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Biocompatibility of new cement based capping material prepared from eggshell and biopolymer (chitosan). by Hemn M. Sarmamy, Dara H. Saeed

“… Background and Objective: This study aimed to evaluate the biocompatibility of a newly prepared cement-based capping material made from eggshell and biopolymer (chitosan) with Mineral Trioxide Aggrigate MTA and Biodentine. …”
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Metabolomic profiles of <i>Ribes nigrum</i> L. and <i>Lonicera caerulea</i> L. from the collection of the N.I. Vavilov Institute in the setting of Northwest Russia by T. V. Shelenga, V. S. Popov, A. V. Konarev, N. G. Tikhonova, O. A. Tikhonova, Y. A. Kerv, A. E. Smolenskaya, L. L. Malyshev

“…The investigation of L. caerulea and R. nigrum fruit’s accessions from the VIR collection using gas-liquid chromatography with mass spectrometry allows us to obtain new information about the biochemical characteristics of fruits, to identify L. caerulea and R. nigrum varieties with optimal economically valuable characteristics, to determine the specificity of L. caerulea and R. nigrum metabolomic spectra in the setting of Northwest Russia. …”
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Application of Securitization of Leasing Assets by I. V. Linev

“…Interest of participants in securitization of leasing assets consists in distribution of risks between them, emergence of a new source of financing, depreciation of attracted resources, increase of liquidity of a leasing portfolio and optimization by management by balance of the enterprise. …”
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Biosorption of Cr(VI) from AqueousSolution Using New Adsorbent: Equilibrium and Thermodynamic Study by Israa G. Zainal

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A New RMF Stirrer Using AISI4140 Mild Steel: Energy Optimization Application by Citak Hakan, Bicakci Sabri, Coramik Mustafa, Gunes Huseyin, Ege Yavuz

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New Strategy for the Covalent Immobilisation of Phenolic Compounds on Silica Particles to Fight Against Foodborne Pathogens by Alejandro Rivas, Héctor Gómez-Llorente, Oumaima Moumane, Jose Manuel Barat, Édgar Pérez-Esteve

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Quantitative proteomic studies of the intestinal mucosa provide new insights into the molecular mechanism of ulcerative colitis by Yandong Guo, Dahal Pabitra, Lei Pan, Lanbo Gong, Aimin Li, Side Liu, Jing Xiong

“…Abstract Background Differentiation between ulcerative colitis (UC) and other intestinal inflammatory diseases is difficult, and the precise etiology of UC is poorly understood. Thus, there is a need for novel diagnostic and prognostic biomarkers for UC. …”
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A new process for extracting vanadium by direct calcification using the heat of molten vanadium slag by Qu J.-W., Zhang T.-A., Lv G.-Z., Chen Y.

“…When the mass ratio of Ca to V was 0.75, under the optimal acid leaching conditions (particle size of calcified vanadium slag less than 0.075 mm, leaching temperature 90 ℃, H2SO4 concentration 200 g.L-1, liquid-to-solid ratio 6:1 ml.g-1, leaching time 60 min, and stirring speed 300r.min-1), the leaching rate of vanadium from calcified vanadium slag could exceed 90%. …”
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