Early Treatment with Empagliflozin and GABA Improves β-Cell Mass and Glucose Tolerance in Streptozotocin-Treated Mice by Caroline Daems, Sophie Welsch, Hasnae Boughaleb, Juliette Vanderroost, Annie Robert, Etienne Sokal, Philippe A. Lysy

“…EMPA-treated T1D mice had higher islet density, with preserved architecture, compared to T1D mice, and EMPA-treated T1D mice also differed from T1D mice by the total absence of immune cell infiltration within islets. …”
Get full text

Equality in the Miyaoka–Yau inequality and uniformization of non-positively curved klt pairs by Claudon, Benoît, Graf, Patrick, Guenancia, Henri

“…Let $(X, \Delta )$ be a compact Kähler klt pair, where $K_X + \Delta $ is ample or numerically trivial, and $\Delta $ has standard coefficients. …”
Get full text

R Inguinal/R Scrotum Extramammary Paget’s Disease with Diffuse Spine Metastasis Complicated by Microangiopathic Hemolytic Anemia by Alay Mansurov, Eric Christenson

“…As we know, there are only few reports of spinal metastases in patients with EMPD. To the best of our knowledge, this is the first case report of EMPD complicated by MAHA.…”
Get full text

Utilization of fermented sago pulp as a source of carbohydrate in feed for Nile tilapia Oreochromis niloticus by I Kadek Sumiana, Julie Ekasari, Dedi Jusadi, Mia Setiawati

“…Pada uji ini dilakukan tiga perlakuan pakan dengan empat ulangan, yaitu pakan acuan, ampas sagu tanpa fermentasi (AS), dan ampas sagu fermentasi (ASF). …”
Get full text

A degree theory for locally compact perturbations of Fredholm maps in Banach spaces

“…<p>We present an integer valued degree theory for locally compact perturbations of Fredholm maps of index zero between (open sets in) Banach spaces <emph>quasi-Fredholm maps</emph>, for short). The construction is based on the Brouwer degree theory and on the notion of orientation for nonlinear Fredholm maps given by the authors in some previous papers. …”
Get full text

Mechanisms of reduced sensitization by extensive hydrolysis of milk protein concentrate: Impact on the immune response of Th1/Th2 and Treg/Th17 cells in mice by Qiang Cui, Jianjun Cheng, Mingruo Guo

“…However, there was limited information about the sensitization of extensive hydrolysate of milk protein concentrate (EMPH). In this study, the mechanism by which EMPH reduce sensitization was studied by constructing a milk protein concentrate (MPC) sensitization evaluation animal model. …”
Get full text

Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study by Wenhao Cheng, Yinghui Li, Wei Yang, Siyang Wu, Mengmeng Wei, Yang Gao, Chen Kang, Shuofeng Zhang, Yingfei Li

Get full text

Antimicrobial proteins from oyster hemolymph improve the efficacy of conventional antibiotics. by Kate Summer, Qi Guo, Lei Liu, Bronwyn Barkla, Sarah Giles, Kirsten Benkendorff

“…Antimicrobial proteins and peptides (AMPPs) are considered among the most promising antibiotic alternatives and complementary therapies. …”
Get full text

Effect of the Nitrification Inhibitor 3,4-Dimethylpyrazole Phosphate on the Deep Placement of Nitrogen Fertilizers for Soybean Cultivation by Soshi Hatano, Yoichi Fujita, Yoshifumi Nagumo, Norikuni Ohtake, Kuni Sueyoshi, Yoshihiko Takahashi, Takashi Sato, Sayuri Tanabata, Kyoko Higuchi, Akihiro Saito, Takuji Ohyama

“…The increasing DMPP concentration did not markedly increase the nitrification inhibition. …”
Get full text

On monotone solutions of some classes of difference equations

“…Kulenovi&#263; and G. Ladas, <emph>Dynamics of Second Order Rational Difference Equations. …”
Get full text

Testicular Nitric Oxide and Thiobarbituric Acid Reactive Substances Levels in Obstructive Azoospermia: A Possible Role in Pathophysiology of Infertility

“…<p><emph>Objective</emph>. The aim of the study is to evaluate the levels of nitrite/nitrate and thiobarbituric acid reactive substances (TBARS) and their relationship with seminal parameters in experimental obstructive azoospermic rats to explain the possible mechanism of impaired sperm quality in obstructive azoospermia. …”
Get full text

Synthesis, Characterization, and Biotoxicity of <mml:math alttext="${fchem{N}hspace{-6.5pt} aisebox{9pt}{huge$frown$}hspace{-6.5pt}fchem{N}}$"> <mml:mrow>...

“…In the search for better fungicides, bactericides, nematicides, and insecticides studies were conducted to assess the growth-inhibiting potential of the synthesized complexes against various pathogenic fungal, bacterial strains, root-knot nematode <emph>Meloidogyne incognita</emph>, and insect <emph>Trogoderma granarium</emph> These studies demonstrate that the concentrations reached levels which are sufficient to inhibit and kill the pathogens, nematode, and insect.…”
Get full text

A novel wind power forecast diffusion model based on prior knowledge by Li Han, Yingjie Cheng, Shuo Chen, Shiqi Wang, Junjie Wang

“…Abstract To improve the forecast accuracy of wind power, diffusion model based on prior knowledge (DMPK) is proposed. Different from the traditional diffusion model (DM), where the noise perturbation in the diffusion or generation process is random, the noise added in DMPK is modified aiming to the characteristics of wind power signals. …”
Get full text

Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics by Krutika Patidar, Nikhil Pillai, Saroj Dhakal, Lindsay B. Avery, Panteleimon D. Mavroudis

Get full text

Adjuvant Bidirectional Chemotherapy with Intraperitoneal Pemetrexed Combined with Intravenous Cisplatin for Diffuse Malignant Peritoneal Mesothelioma by Lana Bijelic, O. Anthony Stuart, Paul Sugarbaker

“…Cytoreductive surgery (CRS) with heated intraoperative intraperitoneal chemotherapy (HIPEC) has emerged as optimal treatment for diffuse malignant peritoneal mesothelioma (DMPM) showing median survivals of 36–92 months. …”
Get full text

Note on Quasi-Numerically Positive Log Canonical Divisors by Shigetaka Fukuda

“…We propose a subconjecture that implies the semiampleness conjecture for quasi-numerically positive log canonical divisors and prove the ampleness in some elementary cases.…”
Get full text

MICROSATELLITES-BASED EVALUATION OF THE PEAR CULTIVARS SELECTED FROM NIKITSKY BOTANICAL GARDENS GERMPLASM BY THEIR ECONOMICALLY VALUABLE CHARACTERISTICS by Y. V. Plugatar, R. D. Babina, I. I. Suprun, T. S. Naumenko, Y. I. Alekseev

“…For the genetic polymorphism analyses of the studied cultivars, seven microsatellite DNA-markers – EMPc108, EMPc117, EMPc115, CH04e03 and CH01d09, CH01f07a, CH01d08 – grouped into 2 multiplex sets were used. …”
Get full text

Parameter Estimation in a Coupled System of Nonlinear Size-Structured Populations by Azmy S. Ackleh, H.T. Banks, Keng Deng, Shuhua Hu

“…Convergence results for the parameter estimationtechnique are established. Ample numerical simulations andstatistical evidence are provided to demonstrate the feasibilityof this approach.…”
Get full text

A Systematic Review and Meta-Analysis of Mapping Biopsy for Primary Extramammary Paget’s Disease in Reducing Recurrence Following Surgical Excision by Thirrisha Murugan, Louis Choon Kit Wong, MD, Xing-Yi Sarah Ong, MD, Sze Huey Tan, PhD, Joey Wee-Shan Tan, MSc, Ying Liu, PhD, Nicholas B. Shannon, PhD, MD, Jianbang Chiang, MBBS, MRCP, MMed, Eileen Poon, MBBS, MRCP, MMED, Jason Yongsheng Chan, MBBS, MRCP, MMed, FAMS, PhD, Valerie Shiwen Yang, MB BChir, PhD, MRCP, FAMS, Nagavalli Somasundaram, MBBS, MRCP, MMED, Mohamad Farid, MBBS, MRCP, MMed, Ru Xin Wong, MBBS, FRCR, Wen Long Nei, MBBS, FRCR, Jin Wei Kwek, MBBS, FRCR, FAMS, Choon Hua Thng, MBBS, FRCR, FAMS, Tiffany Hennedige, MBBS, FRCR, MMed, MCI, Po Yin Tang, BMEDSc, MBBS, FRCPath, FRCAPA, Sathiyamoorthy Selvarajan, MBBS, PGDCP, FRCPath, MCS, FAMS, Kae Jack Tay, MBBS, MRCS, MMed, MCI, FAMS, Mohamed Rezal Abdul, MB, BCh, BAO, LRCP&SI, MSurg, Jolene Si Min Wong, MBBS, MMed, FRCS, Chin Jin Seo, MB, BCh, BAO, MMed, FRCS, Khee Chee Soo, MBBS, MD, FRACS, FACS, Claramae Shulyn Chia, MBBS, MMed, FRCS, Chin-Ann Johnny Ong, MBBS, MMed, FRCS, PhD

“…To examine the association between the performance of mapping biopsies and surgical outcomes postexcision of extramammary Paget’s disease (EMPD). Background:. Primary EMPD is a rare entity associated with poorly defined surgical margins and difficult-to-access sites of lesions. …”
Get full text

Direct calibration using atmospheric particles and performance evaluation of Particle Size Magnifier (PSM) 2.0 for sub-10&thinsp;nm particle measurements by Y. Liu, Y. Liu, A. Yli-Kujala, F. Schmidt-Ott, S. Holm, L. Ahonen, T. Chan, J. Enroth, J. Vanhanen, R. Cai, T. Petäjä, M. Kulmala, Y. Chen, J. Kangasluoma

“…PSM 2.0 was then operated in Hyytiälä for ambient particle measurements in parallel with a Half Mini differential mobility particle sizer (DMPS). During new particle formation (NPF) events, comparable total particle concentrations were observed between the Half Mini DMPS and PSM 2.0 based on Hyytiälä atmospheric particle calibration. …”
Get full text