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1681
Pre-operative DNA methylation marks as predictors of weight loss outcomes after sleeve gastrectomy
Published 2025-02-01“…Of them, 59,308 DMPs were annotated to genes. KEGG enrichment analysis showed that pathways involved in the signalling of MAPK, Wnt, mTor, FoxO and AMPK, among others, were involved in weight loss trajectory.A stepwise logistic regression using the DMPs with an absolute Δβ >0.2 showed that higher methylation levels in the CpG sites cg02405213 (mapping to JAK2) (OR: 1.20098, [0.9586, 1.5044]) and cg01702330 (OR: 2.4426, [0.5761, 10.3567]), were shown to be associated with a higher probability of achieving >60 %EWL after sleeve gastrectomy, whereas higher methylation levels in the CpG site cg04863892 (mapping to HOXA5) were associated with lower probability of achieving >60 %EWL after sleeve gastrectomy (OR: 0.7966, [0.5637, 1.1259]). …”
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1682
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring
Published 2025-01-01“…The impact of micro/nano plastics (MPs/NPs) on human health is a significant area of research. …”
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1683
Non-lethal sonodynamic therapy mitigates hypertensive renal fibrosis through the PI3K/AKT/mTORC1-autophagy pathway
Published 2025-02-01“…However, enhancing autophagy by activating the PI3K/AKT, AMPK, and mTOR pathways, improves podocyte injury and renal pathological changes, and ameliorates renal function. …”
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1684
RETRACTED: A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice
Published 2021-07-01“…The role of endogenous antimicrobial peptides (AMPs), such as the cathelicidin LL-37, in T2DM is unknown. …”
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1685
Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury
Published 2025-04-01“…Finally, we established that the suppression of NET formation by S100A8/A9 inhibition is primarily mediated through the AMPK/Nrf2/HO-1 signaling pathway. These findings underscore the critical pathological role of S100A8/A9 in TBI and emphasize the need for further exploration of S100A8/A9 inhibitor Paquinimod as a potential therapeutic strategy for TBI.…”
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1686
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1687
A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan
Published 2025-01-01“…Abstract Extramammary Paget disease (EMPD) is a rare skin cancer that typically occurs in the anogenital area of older people. …”
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1688
Influences of Environmental Conditions on the Cracking Tendency of Dry-Mixed Plastering Mortar
Published 2018-01-01“…Cracking tendency is one of the important performances of dry-mixed plastering mortar (DMPM). Environmental condition is a key factor to affect the cracking tendency of DMPM. …”
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1689
A Subgroup of First-Degree Relatives of Crohn's Disease Patients Shows a Profile of Inflammatory Markers in the Blood Which is More Typical of Crohn's Disease Patients Than of Norm...
Published 2006-01-01“…<p><emph>Introduction.</emph> Family member with IBD is the greatest risk factor for developing the disease. …”
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1690
Metastatic Extramammary Paget’s Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of t...
Published 2015-01-01“…Overexpression of Her2 was frequently noted (30%–40%) in both EMPD and MPD patients and when present can be effectively treated with Her2 targeted agents. …”
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1691
Estimation of the Postmortem Duration of Mouse Tissue by Electron Spin Resonance Spectroscopy
Published 2011-01-01“…Postmortem changes in DMPO-AsA∗ and DMPO-OOH were observed in various tissues of mouse. …”
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1692
Regulated Spatial Distribution of Cyclooxygenases and Lipoxygenases in Crohn's Ulcer
Published 2006-01-01“…<p><emph>Background and Aims</emph>. Arachidonic acid metabolism actively participates in the initiation, climaxing, and resolution phases of inflammation, and its close connection with inflammatory bowel diseases has been only recently discovered. …”
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1693
Age-related changes in DNA methylation in a sample of elderly Brazilians
Published 2025-02-01“…., baseline vs. follow-up) as predictors of interest to identify differentially methylated positions (DMPs). Significant DMPs were compared with a list of previously identified age-related DMPs. …”
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1694
Potential Use of Bisphosphonates in Invasive Extramammary Paget’s Disease: An Immunohistochemical Investigation
Published 2013-01-01“…Invasive extramammary Paget’s disease (EMPD) is relatively rare and is reported to be highly metastatic to lymph nodes or even other organs, including bone. …”
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1695
Extramammary Paget Disease of Peristomal Skin Secondary to Bladder Urothelial Carcinoma
Published 2022-02-01“… Extramammary Paget disease (EMPD) is a rare, cutaneous condition, which can present secondary to underlying carcinoma as an eczematoid rash that often mimics other conditions. …”
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1696
Engineering Circuit Analysis /
Published 2012Table of Contents: “…Mesh Analysis: A Comparison -- 4.6.Computer-Aided Circuit Analysis -- Summary And Review -- Reading Further -- Exercises -- ch. 5 Handy Circuit Analysis Techniques -- 5.1.Linearity and Superposition -- 5.2.Source Transformations -- 5.3.Thevenin and Norton Equivalent Circuits -- 5.4.Maximum Power Transfer -- 5.5.Delta-Wye Conversion -- 5.6.Selecting an Approach: A Summary of Various Techniques -- Summary And Review -- Reading Further -- Exercises -- ch. 6 The Operational Amplifier -- 6.1.Background -- 6.2.The Ideal Op Amp: A Cordial Introduction -- 6.3.Cascaded Stages -- 6.4.Circuits for Voltage and Current Sources -- 6.5.Practical Considerations -- 6.6.Comparators and the Instrumentation Amplifier -- Summary And Review -- Reading Further -- Exercises -- ch. 7 Capacitors And Inductors -- 7.1.The Capacitor -- 7.2.The Inductor -- 7.3.Inductance and Capacitance Combinations -- 7.4.Consequences of Linearity -- 7.5.Simple Op Amp Circuits with Capacitors -- 7.6.Duality -- 7.7.Modeling Capacitors and Inductors with PSpice -- Summary And Review -- Reading Further -- Exercises -- ch. 8 Basic Rl And Rc Circuits -- 8.1.The Source-Free RL Circuit -- 8.2.Properties of the Exponential Response -- 8.3.The Source-Free RC Circuit -- 8.4.A More General Perspective -- 8.5.The Unit-Step Function -- 8.6.Driven RL Circuits -- 8.7.Natural and Forced Response -- 8.8.Driven AC Circuits -- 8.9.Predicting the Response of Sequentially Switched Circuits -- Summary And Review -- Reading Further -- Exercises -- ch. 9 The Rcl Circuit -- 9.1.The Source-Free Parallel Circuit -- 9.2.The Overdamped Parallel RLC Circuit -- 9.3.Critical Damping -- 9.4.The Underdamped Parallel RLC Circuit -- 9.5.The Source-Free Series RLC Circuit -- 9.6.The Complete Response of the RLC Circuit -- 9.7.The Lossless LC Circuit -- Summary And Review -- Reading Further -- Exercises -- ch. 10 Sinusoidal Steady-State Analysis -- 10.1.Characteristics of Sinusoids -- 10.2.Forced Response to Sinusoidal Functions -- 10.3.The Complex Forcing Function -- 10.4.The Phasor -- 10.5.Impedance and Admittance -- 10.6.Nodal and Mesh Analysis -- 10.7.Superposition, Source Transformations and Thevenin's Theorem -- 10.8.Phasor Diagrams -- Summary And Review -- Reading Further -- Exercises -- ch. 11 Ac Circuit Power Analysis -- 11.1.Instantaneous Power -- 11.2.Average Power -- 11.3.Effective Values of Current and Voltage -- 11.4.Apparent Power and Power Factor -- 11.5.Complex Power -- Summary And Review -- Reading Further -- Exercises -- ch. 12 Polyphase Circuits -- 12.1.Polyphase Systems -- 12.2.Single-Phase Three-Wire Systems -- 12.3.Three-Phase Y-Y Connection -- 12.4.The Delta (A) Connection -- 12.5.Power Measurement in Three-Phase Systems -- Summary And Review -- Reading Further -- Exercises -- ch. 13 Magnetically Coupled Circuits -- 13.1.Mutual Inductance -- 13.2.Energy Considerations -- 13.3.The Linear Transformer -- 13.4.The Ideal Transformer -- Summary And Review -- Reading Further -- Exercises -- ch. 14 Complex Frequency And The Laplace Transform -- 14.1.Complex Frequency -- 14.2.The Damped Sinusoidal Forcing Function -- 14.3.Definition of the Laplace Transform -- 14.4.Laplace Transforms of Simple Time Functions -- 14.5.Inverse Transform Techniques -- 14.6.Basic Theorems for the Laplace Transform -- 14.7.The Initial-Value and Final-Value Theorems -- Summary And Review -- Reading Further -- Exercises -- ch. 15 Circuit Analysis In The s-Domain -- 15.1.Z(s) and Y(s) -- 15.2.Nodal and Mesh Analysis in the s-Domain -- 15.3.Additional Circuit Analysis Techniques -- 15.4.Poles, Zeros, and Transfer Functions -- 15.5.Convolution -- 15.6.The Complex-Frequency Plane -- 15.7.Natural Response and the s Plane -- 15.8.A Technique for Synthesizing the Voltage Ratio H(s) = V out/V in -- Summary And Review -- Reading Further -- Exercises -- ch. 16 Frequency Response -- 16.1.Parallel Resonance -- 16.2.Bandwidth and High-Q Circuits -- 16.3.Series Resonance -- 16.4.Other Resonant Forms -- 16.5.Scaling -- 16.6.Bode Diagrams -- 16.7.Basic Filter Design -- 16.8.Advanced Filter Design -- Summary And Review -- Reading Further -- Exercises -- ch. 17 Two-Port Networks -- 17.1.One-Port Networks -- 17.2.Admittance Parameters -- 17.3.Some Equivalent Networks -- 17.4.Impedance Parameters -- 17.5.Hybrid Parameters -- 17.6.Transmission Parameters -- Summary And Review -- Reading Further -- Exercises -- ch. 18 Fourier Circuit Analysis -- 18.1.Trigonometric Form of the Fourier Series -- 18.2.The Use of Symmetry -- 18.3.Complete Response to Periodic Forcing Functions -- 18.4.Complex Form of the Fourier Series -- 18.5.Definition of the Fourier Transform -- 18.6.Some Properties of the Fourier Transform -- 18.7.Fourier Transform Pairs for Some Simple Time Functions -- 18.8.The Fourier Transform of a General Periodic Time Function -- 18.9.The System Function and Response in the Frequency Domain -- 18.10.The Physical Significance of the System Function -- Summary And Review -- Reading Further -- Exercises.…”
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1697
TLR2 Expression in Relation to IL-6 and IL-1<mml:math alttext="$eta$"> <mml:mi>β</mml:mi> </mml:math> and their Natural Regulators Production by PMN and...
Published 2006-01-01“…<p>Recently, it has been reported that TLR2 on macrophages plays a unique role in the inflammatory response and host defense to infection with <emph>Borrelia burgdorferi</emph> (<emph>Bb</emph>) which is an etiologic agent of Lyme disease. …”
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1698
FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models
Published 2025-01-01“…DYNE-101 is the conjugate designed to target DMPK and correct spliceopathy for the treatment of DM1. …”
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1699
A Stochastic-Variational Model for Soft Mumford-Shah Segmentation
Published 2006-01-01“…In the current work, we propose a stochastic-variational model for <emph>soft</emph> (or fuzzy) Mumford-Shah segmentation of mixture image patterns. …”
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1700