PB2 and PA mutations contribute to the pathogenicity of mouse-adapted pdmH1N1-Venus reporter influenza A virus in a mammalian model by Shixiang Wu, Ruonan Yi, Yingying Tao, Huimin Wu, Li Wu, Jiasheng Song, Xin Zhang, Beibei Yang, Xing Wu, Yulong He, Jianhong Shu, Huapeng Feng

Subjects: “…reporter influenza virus…”
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Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells by Cheng C, Sun M, Li J, Xue Y, Cai X, Liu J, Wang X, Xu S, Xie Y, Zhang J

“…Here, we screened nucleic acid aptamers against the widespread HuNoV GII.4 and emerging HuNoV GII.17.Methods: After ten rounds of sieving for HuNoV GII.4 and GII.17 virus-like particles (VLPs), eight ssDNA aptamers were generated and characterized for each genotype.Results: Four of the eight aptamers generated for GII.4 VLP had dissociation constants (Kd) less than 100 nM, and all aptamers for GII.17 VLP had Kd less than 10 nM. …”
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Discovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calculations by Abbas Khan, Abrar Mohammad Sayaf, Anwar Mohammad, Fahad M. Alshabrmi, Tarek Benameur, Dong-Qing Wei, Kar Kheng Yeoh, Abdelali Agouni

Subjects: “…Ebola virus…”
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Natural exposure to Chikungunya virus in golden-headed lion tamarin (Leontopithecus chrysomelas, Kuhl, 1820) from non-protected areas in southern Bahia, Brazil: Implications and significance. by Sofía Bernal-Valle, María Angélica Monteiro de Mello Mares-Guia, Filipe Vieira Santos de Abreu, Fabrício Souza Campos, Cirilo Henrique de Oliveira, Antônio Victor Veloso Ramos, Reizane Pereira Lordelo, Kristel De Vleeschouwer, Leonardo de Carvalho Oliveira, Hllytchaikra Ferraz Fehlberg, Ana Maria Bispo Filippis, Bergmann Morais Ribeiro, Paulo Michel Roehe, Anaiá da Paixão Sevá, Danilo Simonini-Teixeira, George Rego Albuquerque

“…Chikungunya virus (CHIKV) is primarily associated with non-human-primates (NHPs) in Africa, which also infect humans. …”
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Asymptomatic infection and antibody prevalence to co-occurring avian influenza viruses vary substantially between sympatric seabird species following H5N1 outbreaks by Fiona Greco, Hannah M. Ravenswater, Francisco Ruiz-Raya, Chiara D’Avino, Mark A. Newell, Josie Hewitt, Erin Taylor, Ella Benninghaus, Francis Daunt, Gidona Goodman, David Steel, Jenny Park, Emma Philip, Saumya S. Thomas, Marek J. Slomka, Marco Falchieri, Scott M. Reid, Joe James, Ashley C. Banyard, Sarah J. Burthe, Emma J. A. Cunningham

“…Recent emergence of high pathogenicity avian influenza virus (HPAIV) (H5N1 clade 2.3.4.4b) led to substantial global mortality across a range of host species. …”
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PENGARUH ORAL N-ACETYLCYSTEIN TERHADAP POLA FAKTOR PERTUMBUHAN ENDOTEL VASKULAR (VEGF) DAN FAKTOR PERTUMBUHAN FIBROBLAS (FGF) PADA MODEL KERETA LISTRIK TIKUS by Elisabeth Prajanti Sintaningrum, Iswinarno Doso Saputro, Lobredia Zarasade

“…Highlights: • Kadar rata-rata VEGF pada kelompok tikus yang menerima NAC lebih tinggi daripada kelompok kontrol…”
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Dentat Girus İçerisine İnfüze Edilen T4'ün Uzun Dönemli Etkinleşme Yanıtları Üzerine Etkisi ve Mitojen İle Aktive Olan Protein Kinazın Rolü by Nurcan Dursun, Cem Süer, Arzu Dilek Güler, Ercan Babur, Burak Tan

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Peptide-Based Vaccinology: Experimental and Computational Approaches to Target Hypervariable Viruses through the Fine Characterization of Protective Epitopes Recognized by Monoclonal Antibodies and the Identification of T-Cell-Activating Peptides by Matteo Castelli, Francesca Cappelletti, Roberta Antonia Diotti, Giuseppe Sautto, Elena Criscuolo, Matteo Dal Peraro, Nicola Clementi

“…This is particularly important for the selective targeting of conserved regions shared among hypervariable viruses. Studying postinfection and postimmunization sera, as well as cloning and characterization of monoclonal antibodies (mAbs), still represents the best approach to identify protective epitopes. …”
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Contemporary Antiviral Drug Regimens for the Prevention and Treatment of Orolabial and Anogenital Herpes Simplex Virus Infection in the Normal Host: Four Approved Indications and 13 Off-Label Uses by Fred Y Aoki

“…Herpes simplex virus (HSV) orolabial and anogenital infection causes substantial and recurring disease in healthy individuals due directly to infection of these sites and, indirectly, due to its complications. …”
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<i>Hovenia dulcis Thunb</i>. Honey Exerts Antiviral Effect Against Influenza A Virus Infection Through Mitochondrial Stress-Mediated Enhancement of Innate Immunity by Eun-Bin Kwon, Buyun Kim, Young-Eun Kim, Sung-Joon Na, Sang Mi Han, Soon Ok Woo, Hong Min Choi, Siwon Moon, Young Soo Kim, Jang-Gi Choi

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Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma by Xintao Jia, Qiuyu He, Mei Zeng, Yuhua Chen, Yan Liu

“…Epstein-Barr virus-latent membrane protein 1 (EBV-LMP1) was associated with lymphoma, but its specific mechanism is still controversial. …”
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A lineage 1 branch porcine reproductive and respiratory syndrome virus live vaccine candidate provides broad cross-protection against HP-like PRRSV in piglets by Chao Li, Jinhao Li, Bangjun Gong, Hu Xu, Zhenyang Guo, Lirun Xiang, Siyu Zhang, Qi Sun, Jing Zhao, Menglin Zhang, Yan-Dong Tang, Chaoliang Leng, Jianan Wu, Qian Wang, Jinmei Peng, Guohui Zhou, Huairan Liu, Tongqing An, Xuehui Cai, Zhi-Jun Tian, Hongliang Zhang

“…Multiple porcine reproductive and respiratory syndrome virus (PRRSV) subtypes coinfect numerous pig farms in China, and commercial PRRSV vaccines offer limited cross-protection against heterologous strains. …”
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Adenoviral Vector-Based Vaccine Expressing Hemagglutinin Stem Region with Autophagy-Inducing Peptide Confers Cross-Protection Against Group 1 and 2 Influenza A Viruses by Wen-Chien Wang, Ekramy E. Sayedahmed, Marwa Alhashimi, Ahmed Elkashif, Vivek Gairola, Muralimanohara S. T. Murala, Suryaprakash Sambhara, Suresh K. Mittal

“…This combination shows promise as a potential universal influenza vaccine, providing broader protection against influenza A viruses.…”
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Collection of SARS-CoV-2 Virus from the Air of a Clinic within a University Student Health Care Center and Analyses of the Viral Genomic Sequence by John A. Lednicky, Sripriya N. Shankar, Maha A. Elbadry, Julia C. Gibson, Md. Mahbubul Alam, Caroline J. Stephenson, Arantzazu Eiguren-Fernandez, J. Glenn Morris, Carla N. Mavian, Marco Salemi, James R. Clugston, Chang-Yu Wu

“…To determine whether the virus detected was viable (‘live’), attempts were made to isolate the virus in cell cultures. …”
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Production and characterization of nervous necrosis virus vaccine antigens in wild type and CRISPR/Cas9 genome edited Nicotiana benthamiana and edible crop lettuce Lactuca sativa by Iva Andrasevic, Hang Su, Espen Rimstad, Jihong Liu Clarke

Subjects: “…Nervous necrosis virus (NNV)…”
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Liver cancer risk and changes in lifestyle habits after successful hepatitis C virus therapy post-DAA HCV therapy: lifestyle changes and liver cancer risk by Núria Granel, Gemma Iserte, Concepció Bartres, Neus Llarch, Anna Pla, Víctor Sapena, Zoe Mariño, Sabela Lens, Ramón Vilana, Isabel Nuñez, Anna Darnell, Ernest Belmonte, Ángeles García-Criado, Alba Díaz, Marco Sanduzzi-Zamparelli, Carla Fuster, Sergio Muñoz-Martínez, Carmen Ayuso, Jordi Rimola, Alejandro Forner, Alexandre Soler, Ferran Torres, José Ríos, Jordi Bruix, Andrew M. Moon, Xavier Forns, María Reig

“…Abstract Background The eradication of the Hepatitis C Virus (HCV) reduce the risk of liver cancer (LC), but lifestyle changes after cure may counterbalance its benefit. …”
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Nature's defense against emerging neurodegenerative threats: Dynamic simulation, PCA, DCCM identified potential plant-based antiviral lead targeting borna disease virus nucleoprotein. by Noimul Hasan Siddiquee, Md Ifteker Hossain, Farhana Mansoor Priya, Sakia Binte Azam, Md Enamul Kabir Talukder, Durjoy Barua, Salina Malek, Niloy Saha, Sidratul Muntaha, Ridoy Paul, Israt Jahan Ritu, Farjana Islam Tuly, Abir Hossain

“…The rare zoonotic Borna disease virus (BDV) causes fatal neurological disease in various animals, with a high mortality rate exceeding 90% in central Europe. …”
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Caracterización sociodemográfica y conductual de hombres con infección por el virus de inmunodeficiencia humana. Área de salud I.... by Katiuska Díaz Quintero, María Lina Valdés Gómez, Leticia Castro Morejón, Julio César Díaz Marrero, José Aurelio Díaz Quiñones, Esther Yarinely Hernández Dieguez

“…<strong>Fundamento:</strong> la principal batalla contra el virus de inmunodeficiencia humana/sida es la prevención, para ello es necesario tener en cuenta los grupos más vulnerables y los factores de riesgo asociados.…”
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Economic and Clinical Benefits of Bivalent Respiratory Syncytial Virus Prefusion F (RSVpreF) Maternal Vaccine for Prevention of RSV in Infants: A Cost-Effectiveness Analysis for Mexico by José Luis Huerta, Robyn Kendall, Luka Ivkovic, Carlos Molina, Amy W. Law, Diana Mendes

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Protection Conferred by Gallid Alphaherpesvirus 2 Vaccines Against Immunosuppression Induced by Very Virulent Plus (vv+) Marek’s Disease Virus Strains in Commercial Meat Type Chickens by Nagwa Khaled, Carissa Gaghan, Abdelhamid M. Fares, Christa Goodell, William Stanley, Raveendra R. Kulkarni, Isabel M. Gimeno

“…Very virulent plus Marek’s disease virus (vv+MDV) induces severe immunosuppression in commercial chickens. …”
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