Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data by Zhou J, Jiao S, Huang J, Dai T, Xu Y, Xia D, Feng Z, Chen J, Li Z, Hu L, Meng Q

“…JiangFei Zhou,1,* SongSong Jiao,1,* Jian Huang,2,* TianMing Dai,3,* YangYang Xu,1,* Dong Xia,4,* ZhenCheng Feng,1 JunJie Chen,1 ZhiWu Li,5 LiQiong Hu,4 QingQi Meng1,3 1Department of Orthopedics, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 2Qingdao Medical College, Qingdao University, Qingdao, 266071, People’s Republic of China; 3Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 4Critical Care Medicine Department, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 5Department of Orthopedics, the 2nd People’s Hospital of Bijie, Guizhou, 551700, People’s Republic of China*These authors contributed equally to this workCorrespondence: LiQiong Hu; QingQi Meng, Email 13929526981@163.com; mengqingqi@jnu.edu.cnBackground: Synovitis is one of the key pathological feature driving osteoarthritis (OA) development. …”
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Whole-Genome Methylation Sequencing Analysis and Functional Verification of LIM-Homeobox Family Genes in Cervical Cancer by Yu R, Yu Q, Shi J, Meng X, Deng Z, Suo J, Yang H

“…Rong Yu,1,* Qin Yu,1,* Jie Shi,2,* Xue Meng,3 Zhiyuan Deng,3 Jing Suo,4 Hao Yang1 1Department of Radiation Oncology, Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia Autonomous Region, 010020, People’s Republic of China; 2Department of Gynecology and Oncology, Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia Autonomous Region, 010020, People’s Republic of China; 3Department of Graduate School, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, 010059, People’s Republic of China; 4Department of Gynecology and Obstetrics, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, 010050, China*These authors contributed equally to this workCorrespondence: Hao Yang, Department of Radiation Oncology, Peking University Cancer Hospital (Inner Mongolia Campus) & Affiliated Cancer Hospital of Inner Mongolia Medical University, No. 42, Zhao Wu Da Road, Huhhot, Inner Mongolia Autonomous Region, 010020, People’s Republic of China, Tel +86 471-3280801, Email hdgeu98@163.com Jing Suo, Department of Gynecology and Oncology, Affiliated People’s Hospital of Inner Mongolia Medical University, 1 Tongdao North Street, Hohhot, Inner Mongolia Autonomous Region, 010050, People’s Republic of China, Tel +86 471-3451350, Email suojing49@sina.comBackground: Gene methylation in cells is an important factor in tumorigenesis, and radiotherapy can change DNA methylation in cells. …”
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PLL-g-HPA Hydrogel Loaded Human Umbilical Cord Mesenchymal Stem Cells Promote Burn Wound Healing in Rat Model by Regulating Inflammation Response by Tian L, Wang Z, Lei T, Feng L, Li Y, Wang K, Zhang Y, Zhang C, Liu J, Xing H, Ren W

“…Linqiang Tian,1,2 Zhaodong Wang,1,2 Tingting Lei,1,3 Lili Feng,1 Yanyan Li,1 Kunxi Wang,1 Yue Zhang,1 Chengshu Zhang,4 Jie Liu,1 Hongxia Xing,3 Wenjing Ren5 1Henan Key Medical Laboratory of Traumatics and Orthopaedics’ Research, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, People’s Republic of China; 2Department of Orthopedics Surgery, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, People’s Republic of China; 3Department of Neurology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, People’s Republic of China; 4Department of Burn and Plastic Surgery, General Hospital of PINGMEI SHENMA Group, Pingdingshan, People’s Republic of China; 5Clinical Medical Center of Tissue Engineering and Regeneration, Xinxiang Medical University, Xinxiang, People’s Republic of ChinaCorrespondence: Hongxia Xing; Wenjing Ren, Email xhxwh02@163.com; xxmu_rwj@163.comPurpose: Treatment of severe burn wound injury remains a significant clinical challenge as serious infections/complex repair process and irregulating inflammation response. …”
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Co-Delivery of Dacarbazine and miRNA 34a Combinations to Synergistically Improve Malignant Melanoma Treatments by Ding B, Li M, Zhang J, Zhang X, Gao H, Gao J, Shen C, Zhou Y, Li F, Liu A

“…Baoyue Ding,1,2,* Mingjuan Li,2,* Jie Zhang,2,* Xiaojuan Zhang,2 Huan Gao,2 Jianqing Gao,3 Chunyan Shen,4 Yan Zhou,4 Fanzhu Li,5 Ailin Liu1 1Department of Pharmaceutical Analysis, Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, The School of Pharmacy, Fujian Medical University, Fuzhou, 350122, People’s Republic of China; 2Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, Jiaxing University College of Medicine, Jiaxing, Zhejiang, People’s Republic of China; 3Institute of Pharmaceutics, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058 People’s Republic of China; 4Jiaxing Institute for Food, Drug and Product Quality Control, Jiaxing, Zhejiang, People’s Republic of China; 5Zhejiang Chinese Medical University, School of Pharmaceutical Science, Hangzhou, 310053, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fanzhu Li; Ailin Liu, Email lifanzhu@zcmu.edu.cn; ailinliu@mail.fjmu.edu.cnPurpose: The incidence of malignant melanoma (MM) has risen over the past three decades, and despite advancements in treatment, there is still a need to improve treatment modalities. …”
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The Association Between Insomnia and Temporomandibular Disorders in Orthodontic Patients by Dong Y, Zhou X, Xiang J, Zheng Y, Zheng Y, Xiong X, Wang J

“…Yanhua Dong,* Xueman Zhou,* Jie Xiang, Yunhao Zheng, Yingcheng Zheng, Xin Xiong, Jun Wang State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Xiong; Jun Wang, West China Hospital of Stomatology, Sichuan University, No. 14 section 3, Renmin South Road, Chengdu, 610041, People’s Republic of China, Email drxiongxin@scu.edu.cn; wangjunv@scu.edu.cnObjective: This cross-sectional study aimed to investigate the association between insomnia and the presence of temporomandibular disorders (TMD) and its subtypes in orthodontic patients.Methods: A total of 648 adult orthodontic patients (158 males and 490 females, median age 26) were included and completed a questionnaire containing sociodemographic information, insomnia severity index (ISI), the five major temporomandibular disorder symptoms (5Ts) checklist, and self-reported sleep bruxism. …”
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Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway by Huang X, Liu J, Wu X, Mo Y, Luo X, Yang Y, Yang C, Liang X, Liang R, Chen Y, Fan Z, Lu W, Chen Y, Hua Q

“…Xiajie Huang,1,2,* Jie Liu,1,* Xiaomei Wu,1 Yangzhou Mo,1 Xiping Luo,1 Yongge Yang,1 Chaoquan Yang,1 Xinyun Liang,1 Rongyuan Liang,1 Yeping Chen,1 Zezhen Fan,1 William Lu,3 Yan Chen,1 Qikai Hua1 1Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China; 2Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, Guangxi Medical University, Nanning, People’s Republic of China; 3Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Chen; Qikai Hua, Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China, Email cy003@connect.hku.hk; hqk100@yeah.netPurpose: Microinjury can trigger in situ tissue repair. …”
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Molecular Epidemiological Characteristics of blaIMP-4-Carrying Klebsiella pneumoniae ST-11 in Hospitalized Patients by Xue YE, Zhang D, Du S, Chen D, Liu S, Peng T, Li C, Zhang J, Wang X

“…Yu e Xue,1,* Dongmei Zhang,1,* Shuaixian Du,2,* Du Chen,3,* Shihan Liu,2 Tianfeng Peng,4 Chong Li,5 Jianchu Zhang,1 Xiaorong Wang1 1Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 3Department of Neurology, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China; 4Emergency Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 5Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaorong Wang; Jianchu Zhang, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Number 1277, Jie Fang Rode, Wuhan, Hubei, 430022, People’s Republic of China, Tel + 86-27-85726707, Email rong-100@163.com; zsn0928@163.comPurpose: To investigate the molecular epidemiology and risk factors of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection.Patients and Methods: Patient’s clinical data and CRKP strains were collected from November 2017 to December 2018 at a tertiary hospital in Wuhan, China. …”
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Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study by Xiao S, Ou J, Qiu W, Ye C, Li N, Chen S, Lai Y, Deng Z, Wu F, Shen Y

“…Shan Xiao,1,&ast; Jie Ou,2,&ast; Wangli Qiu,3,&ast; Chunxin Ye,1 Na Li,1 Sida Chen,1 Yuting Lai,1 Zhishan Deng,4 Fan Wu,4 Yan Shen1 1Department of Pulmonary and Critical Care Medicine, Shenzhen Longgang District Central Hospital, Shenzhen, People’s Republic of China; 2State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, People’s Republic of China; 4State Key Laboratory of Respiratory Disease & Guangzhou Institute of Respiratory Health & National Clinical Research Center for Respiratory Disease & National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yan Shen, Email drshenyan2022@163.com Fan Wu, Email wu.fan@vip.163.comBackground: Preserved ratio impaired spirometry (PRISm) is defined as forced expiratory volume in one second (FEV1)/forced vital capacity (FVC)≥ 0.70 and FEV1< 80% predicted. …”
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Significance of the Lesion&ndash;Pleura Relationship in Differentiating Peripheral Inflammatory Lesions and Lung Cancers by Tao Y, Zhang WT, Ding C, Fu BJ, Lv FJ, Chu ZG

“…Yang Tao,&ast; Wen-Tao Zhang,&ast; Can Ding, Bin-Jie Fu, Fa-Jin Lv, Zhi-Gang Chu Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Fa-Jin Lv; Zhi-Gang Chu, Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1&num; Youyi Road, Yuanjiagang, Yuzhong District, Chongqing, People’s Republic of China, 400016, Tel +86 18723032809, Fax +86 23 68811487, Email cyscitg@hospital.cqmu.edu.cn; chuzg0815@163.comPurpose: To determine the significance of lesion–pleura relationship in differentiating peripheral inflammatory lesions (PILs) and peripheral lung cancers (PLCs).Patients and Methods: From January 2017 to April 2022, a total of 743 patients with 501 PLCs and 292 PILs (≥ 1.5 cm) were retrospectively enrolled. …”
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USC-Derived Small Extracellular Vesicles-Functionalized Scaffolds Promote Scarless Vaginal Defect Repair via Delivery of Decorin and DUSP3 Proteins by Xu Y, Li J, Qiu Y, Wu F, Xue Z, Liu B, Fan H, Zhou Y, Wu Q

“…Yiyun Xu,1,&ast; Jie Li,1,&ast; Yu Qiu,1 Fuyue Wu,2 Zhuowei Xue,1 Bin Liu,1 Hongjie Fan,1 Yuedi Zhou,1 Qingkai Wu1 1Department of Obstetrics and Gynecology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People’s Republic of China; 2Organoid Regeneration Research Center, ReMed Regenerative Medicine Clinical Application Institute, Shanghai, 201114, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qingkai Wu; Yuedi Zhou, Email wuqingkai@sjtu.edu.cn; zhouyuedi@126.comBackground: Scar formation following large-area vaginal defects post-vaginoplasty is a major clinical challenge. …”
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Sharp needle reconstructs peripheral outflow for patients with malfunctional arteriovenous fistula by Yong Xu, Shu-Yuan Zhu, Yuan-Ming Li, Xin-Xin Liu, Hao Zhang, Lu-Fang Wang

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Effect of General Anesthesia Combined with Transversus Abdominis Plane Block on Postoperative Sleep Disorders in Elderly Patients Undergoing Gastrointestinal Tumor Surgery: A Prosp... by Pu J, Guo C, Xiao Y, Cao Y, Liu Z, Jin Y, Hu Y

“…Jie Pu,1 Chendong Guo,1 Yue Xiao,2 Yanan Cao,1 Zhenhua Liu,3 Yuzhong Jin,3 Yimin Hu4 1Department of Anesthesiology, The Second People’s Hospital of Changzhou, Nanjing Medical University, Changzhou, 213003, People’s Republic of China; 2Department of Anesthesiology, Sichuan Cancer Hospital, Chengdu, 100062, People’s Republic of China; 3Changzhou Wujin Hospital of Traditional Chinese Medicine, Changzhou, 213161, People’s Republic of China; 4Department of Anesthesiology, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, People’s Republic of ChinaCorrespondence: Yimin Hu, Department of Anesthesiology, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, People’s Republic of China, Tel +86 18951767577, Email guyueym@njmu.edu.cnPurpose: The aim of this study was to investigate the effect of general anesthesia combined with transversus abdominis plane block on postoperative sleep disorders in elderly patients undergoing gastrointestinal tumor surgery.Methods: For elderly patients with gastrointestinal malignant tumors, we recruited 94 patients, aged 65– 80, who were scheduled for radical laparoscopic surgery. …”
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