Integrated metabolome and transcriptome analysis reveals key genes and pathways associated with egg yolk percentage in chicken by Wen Li, Yuxing Luo, Shoujia Zhu, Mengyuan Wang, Xuli Zhao, Zhonghua Ning

“…Collectively, these findings deepen our understanding of how distinct molecular and metabolic pathways in the liver, ovary, and magnum orchestrate yolk proportion and deposition. Such insights may advance future strategies to improve egg quality and productivity in poultry breeding programs.…”
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How efficient are specialized public health services in China? A data envelopment analysis and geographically weighted regression approach by Qian Bai, Qian Bai, Lieyu Huang, Yan Guo, Xin Xu, Zhouyixin Zhang, Yuan Wang, Hao Chen, Ying Bian, Ying Bian

“…The spatially heterogeneous associations between macro-regional factors and efficiency provide in-depth insights in assisting local governments to formulate more targeted and effective interventions, thereby contributing to reduce regional disparities.…”
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A Novel Immune-Related lncRNA-Based Model for Survival Prediction in Clear Cell Renal Cell Carcinoma by Zedan Zhang, Yanlin Tang, Yanjun Liu, Hongkai Zhuang, Enyu Lin, Lu Xie, Xiaoqiang Feng, Kaiwen Tian, Jiayi Zeng, Jiumin Liu, Yuming Yu

“…Identifying immune-related lncRNAs and constructing a model would probably provide new insights into biomarkers and immunotherapy for ccRCC and aid in the prognosis prediction. …”
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Can system dynamics explain long-term hydrological behaviors? The role of endogenous linking structure by X. Zhou, Z. Sheng, K. Manevski, K. Manevski, K. Manevski, R. Zhao, R. Zhao, Q. Zhang, Y. Yang, S. Han, J. Liu, J. Liu, Y. Yang, Y. Yang, Y. Yang

“…However, the novel<span id="page160"/> insights proposed in our study, including the different hierarchies corresponding to distinct mechanisms and timescales and the endogenous linking structure among stocks being a more important driver of the hydrological behaviors, offer potential solutions for better understanding a hydrological system and guidelines for improving the configuration and performance of conventional hydrological models.…”
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Uncertainty quantification in multi-parametric MRI-based meningioma radiotherapy target segmentation by Lana Wang, Zhenyu Yang, Zhenyu Yang, Dominic LaBella, Zachary Reitman, John Ginn, Jingtong Zhao, Justus Adamson, Kyle Lafata, Kyle Lafata, Kyle Lafata, Evan Calabrese, John Kirkpatrick, Chunhao Wang

“…., GTV boundaries, dural tail), providing valuable insights for potential manual corrections. This advancement is particularly valuable given the complex extra-axial nature of meningiomas and involvement with dural tissue. …”
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Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…This genetic and epigenetic crosstalk mechanism provides insights for advancing our understanding of motor neuron disease and developing effective treatments.…”
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Lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation by Anis Adibah Osman, Siok-Fong Chin, Lay-Kek Teh, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Rahman Jamal

“…Conclusions: Our findings highlight the significance of lipids in obesity-related metabolic alterations, providing insights into the pathophysiological mechanisms contributing to obesity. …”
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Exploring the allometry between ear saturated water accumulation and dry mass for diagnosing winter wheat water status during the reproductive growth by Tingxuan Zhuang, Ben Zhao, Syed Tahir Ata-Ul-Karim, Gilles Lemaire, Xiaojun Liu, Yongchao Tian, Yan Zhu, Weixing Cao, Qiang Cao

“…These findings will provide valuable insights into the water status of winter wheat under varying water and nitrogen conditions during the reproductive growth phase. …”
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Identification of key miRNAs and target genes in extracellular vesicles derived from low-intensity pulsed ultrasound-treated stem cells by Xin Yin, Xin Yin, Jialian Yi, Fugang Mao, Qisheng Tang, Xinyu Zhang, Xiaoyu Yang, Hongqing Xie, Linping Wang, Shuifen Sun, Xin Yu, Xin Yu, Jie Liu, Lihong Jiang, Lihong Jiang

“…The identified differentially expressed miRNAs and their potential target mRNAs offer valuable insights into the biological processes influenced by LIPUS treatment. …”
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Effectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol... by Zhuo Chen, Yefeng Cai, Wenjun He, Yiyuan Cai, Lingrui Liu, Qing Zhao, Sensen lv, Dong (Roman) Xu, Chun Hao, Lanping Zhang, Pengfei Guo, Yuning Shi

“…The factorial design allows for the evaluation of the main effects of each framework and their two-way and three-way interactions, offering insights into which combination of frameworks is most effective in enhancing implementation outcomes. …”
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Ultrasonic assisted stir squeeze casting of AA5456/Al2O3–SiC-Gr-MoS2 hybrid nanocomposites: Microstructure and strengthening analysis by B.N. Akash Deep, S. Rajanna, K.N. Krishnamurthy, G.C. Manjunath Patel, T. Ganesha, G.V. Gnanedra Reddy, Mudassir Hasan, Emanoil Linul

“…Fractography analysis identifies various fracture modes, including ductile, brittle, and fatigue, along with their distinct surface features, providing insights into the fracture mechanisms of the AMMHNCs. …”
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Fermented sugarcane juice-derived probiotic Levilactobacillus brevis RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-γ activation by V. B. Chandana Kumari, Ramith Ramu, Sujay S. Huligere, Shashank M. Patil, Shivasharanappa Nayakvadi, Sharath Bijoor, Uma Venkateswaran Manjappara, Mohammad Z. Ahmed, Ling Shing Wong

“…This study also highlights LB13243's distinctive capability to modulate PPAR-γ through its organic acids, particularly hydroxycitric acid, providing novel insights into its therapeutic potential.…”
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Co-creating a person-centered creative engagement intervention for Parkinson's care by Blanca T. M. Spee, Blanca T. M. Spee, Blanca T. M. Spee, Thieme B. Stap, Thieme B. Stap, Marjoke Plijnaer, Gert Pasman, Sara Zeggio, Annelien Duits, Annelien Duits, Julia S. Crone, Suzanne Haeyen, Suzanne Haeyen, Matthew Pelowski, Matthew Pelowski, Bastiaan R. Bloem, Jan-Jurjen Koksma

“…Guidance from the creative therapists was provided as needed to support individual engagement and guide reflection and learning processes. Narratives offered insights into the relevance of autonomy in care, the role of the arts, and the individuality of disease experience, resulting in seven key features of our intervention framework, which include (i) intervention structure (e.g., duration of the intervention and sessions), (ii) freedom in selection of creative media, (iii) environment as a creative playground, (iv) skills of creative therapists, (v) PD-specific considerations, (vi) financial considerations and logistics, and we list (vii) responsibilities of the Design Team.DiscussionThis study establishes an initial framework for a PD-specific creative arts therapy intervention designed as a creative engagement learning environment. …”
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Role of stability analysis and waste discharge concentration of ternary hybrid nanofluid in a non-Newtonian model with slip boundary conditions by Nurhana Mohamad, Shuguang Li, Umair Khan, Anuar Ishak, Ali Elrashidi, Mohammed Zakarya

“…This research provides insights into optimizing nanofluids in pollutant-laden environments, with potential applications in industrial processes involving heat exchangers and pollution control. …”
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Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections by Ryosuke Yamamura, Yu Nagayoshi, Kayo Nishiguchi, Hitomi Kaneko, Keiichi Yamamoto, Koki Matsushita, Miho Shimamura, Akihiro Kunisawa, Korin Sakakida, Takeshi Chujo, Masataka Adachi, Yutaka Kakizoe, Yuichiro Izumi, Takashige Kuwabara, Masashi Mukoyama, Kazuhito Tomizawa

“…Collectively, this work spans basic biology and clinical science, offering valuable insights into the fate of modified nucleosides in bacterial systems and their relevance to infectious diseases.…”
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Comprehensive analysis of antimicrobial resistance dynamics among broiler and duck intensive production systems by Zsombor Szoke, Peter Fauszt, Maja Mikolas, Peter David, Emese Szilagyi-Tolnai, Georgina Pesti-Asboth, Judit Rita Homoki, Ildiko Kovacs-Forgacs, Ferenc Gal, Laszlo Stundl, Levente Czegledi, Aniko Stagel, Sandor Biro, Judit Remenyik, Melinda Paholcsek

“…Despite its limitations, this research provides key insights into AMR trends in two major poultry types, guiding targeted interventions and sustainable management strategies.…”
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Characterization of feeding damage by tea mosquito bug, Helopeltis theivora Waterhouse (Hemiptera: Miridae) on Hainan Dayezhong tea cultivar by Qi Yao, Qi Yao, Qi Yao, You-Ze Lin, You-Ze Lin, You-Ze Lin, Shuang Qin, Shuang Qin, Shuang Qin, Zhu-Feng Lin, Zhu-Feng Lin, Zhu-Feng Lin, Xun-Cong Ji, Xun-Cong Ji, Xun-Cong Ji

“…These findings provide new insights for further research related to the feeding strategy of H. theivora on the HNDYZ tea cultivar.…”
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Exploring the synergistic effect of rose distillation waste and biostimulant beside other organic amendments onRosa damascena seedlings’ growth by Soumia El Malahi, Lahcen Irahoui, Wafaa Mokhtari, Mounia Ennami, Houda Taimourya, Jamaa Zim, Abdallah Zayani, Bahija Zakeri, Khalid Dhassi, Mimoun Mokhtari, Lalla Mina Idrissi Hassani

“…Conclusion: The findings of the study offer valuable insights into the sustainable management of rose production. …”
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Functional near-infrared spectroscopy for the assessment and treatment of patients with disorders of consciousness by Nan Wang, Nan Wang, Nan Wang, Yifang He, Sipeng Zhu, Dongsheng Liu, Xiaoke Chai, Xiaoke Chai, Qiheng He, Tianqing Cao, Jianghong He, Jingqi Li, Juanning Si, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Jizong Zhao, Jizong Zhao

“…BackgroundAdvances in neuroimaging have significantly enhanced our understanding of brain function, providing critical insights into the diagnosis and management of disorders of consciousness (DoC). …”
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uN2CpolyG-mediated p65 nuclear sequestration suppresses the NF-κB-NLRP3 pathway in neuronal intranuclear inclusion disease by Yu Shen, Kaiyan Jiang, Dandan Tan, Min Zhu, Yusen Qiu, Pencheng Huang, Wenquan Zou, Jianwen Deng, Zhaoxia Wang, Ying Xiong, Daojun Hong

“…This mechanism highlights a novel therapeutic target for NIID and provides potentially broader insights into similar mechanisms in other neurodegenerative diseases characterized by misfolded protein aggregates.…”
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