Single-cell sequencing analysis reveals cancer-associated pericyte subgroup in esophageal squamous cell carcinoma to predict prognosis by Kai Xiong, Bing Pan, Hao Fang, Ziyou Tao

“…The drug with a better effect on c5_TYMS was docetaxel (binding energy = -8.1, -8.7 kcal/mol); raloxifene may be more effective against c4_SOD2, although raloxifene has a slightly lower binding energy to SOD2 (-6.4 kcal/mol), it has a higher binding energy to PDGFRβ (-8.1 kcal/mol).ConclusionThe present study identified and discovered pericyte subpopulations that were significantly associated with prognosis, which provides new biomarkers for predicting patient prognosis and adds usable targets for immunotherapy, and it is also important for gaining insights into the composition of the TME in ESCC.…”
Get full text

Experimental paradigm to test the effects of providing social support: study protocol of the PROSPECT trial (Study 2) by Vivien Hajak, Simone Grimm, Ewa Gruszczyńska, Aleksandra Kroemeke, Natalia Józefacka, Lisa Marie Warner

“…Discussion In a controlled laboratory experiment, this new experimental paradigm manipulates the conditions under which social support is provided. Insights into the conditions under which the provision of social support is detrimental or beneficial to the provider can inform the development of preventive and interventional approaches across a range of life domains, motivational and developmental research across the lifespan (e.g. prevention of care-giver burnout), and applied clinical contexts (e.g. therapeutic interventions). …”
Get full text

Estimation the pH of CO2-saturated NaCl solutions using gene expression programming: Implications for CO2 sequestration by Mohammad Rasool Dehghani, Parirokh Ebrahimi, Moein Kafi, Hamed Nikravesh, Yousef Kazemzadeh

“…This model provides valuable insights for predicting pH changes in CO2-saturated solutions, essential for carbon sequestration and related environmental studies. …”
Get full text

Disorders of circadian rhythms of heart rate variability in diabetic cardiac autonomic neuropathy: mechanisms and consequences by V.A. Serhiyenko, M.I. Dolynay, V.B. Sehin, Y.V. Lazur, A.A. Serhiyenko

“…Particular attention is paid to the risk factors of diabetic CAN; insights into the mechanisms of excess mortality associated with CAN; the pathogenesis of diabetic CAN; possible pathogenic pathways binding CAN and atherosclerosis progression; genetic and epigenetic factors and CAN; DM and circadian rhythms of HRV; diabetic CAN and circadian rhythm disorders. …”
Get full text

Construction of an Interpretable Model of the Risk of Post-Traumatic Brain Infarction Based on Machine Learning Algorithms: A Retrospective Study by Li S, Li H, Wu B, Pan R, Liu Y, Wang J, Wei D, Gao H

“…Interpretations using the SHAP method offer guidance for personalized treatment of different patients, filling gaps between complex clinical data and actionable insights.Keywords: traumatic brain injury, post-traumatic cerebral infarction, retrospective study, machine learning, prediction model…”
Get full text

Voices from the clinic: a qualitative analysis of physiotherapy strategies in musculoskeletal care for knee osteoarthritis patients by Jennifer Nguyen, Justine M. Naylor, Sarah Dennis, Rebecca Livings, Kathryn Mills, Siobhan M. Schabrun, Jeanette M. Thom

“…Conclusion The study provided unique insights towards physiotherapists’ current usual knee osteoarthritis care and their perceived barriers to delivering guideline-based care. …”
Get full text

Company's diversification strategy and crash risk stock prices emphasizing operational slack and management ability by Majid Moradi, Roqaye Talebi, Hamid Reza Pakdaman

“…It contributes to the fall risk literature. Such insights open a new avenue for future research to investigate how to reduce the risk of collapse through the strategic design of companies' operations and production. …”
Get full text

Heterogeneity in Fluorescence-Stained Sperm Membrane Patterns and Their Dynamic Changes Towards Fertilization in Mice by Momoka Hirai, Satoshi Kishigami

“…These findings provide new insights into sperm heterogeneity and dynamics, and this staining method may also prove useful for assessing sperm quality.…”
Get full text

Multi-Trait Index-Based Selection of Drought Tolerant Wheat: Physiological and Biochemical Profiling by Mohammed Mohi-Ud-Din, Md. Alamgir Hossain, Md. Motiar Rohman, Md. Nesar Uddin, Md. Sabibul Haque, Mahmudul Hasan Tahery, Mirza Hasanuzzaman

“…Overall, the strategic approaches have yielded novel insights into genotype screening that can be directly applied to deepen our understanding of drought tolerance mechanisms in wheat.…”
Get full text

Implementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial. by Menglu Ouyang, Anila Anjum, Francisca Gonzalez Mc Cawley, Mohammad Wasay, Lu Ma, Xin Hu, Xiaoying Chen, Alejandra Malavera, Xi Li, Paula Muñoz Venturelli, H Asita de Silva, Nguyen Huy Thang, Kolawole W Wahab, Jeyaraj D Pandian, Octavio M Pontes-Neto, Carlos Abanto, Venessa Cano-Nigenda, Antonio Arauz, Chao You, Stephen Jan, Lili Song, Craig S Anderson, Hueiming Liu, INTERACT3 Investigators

“…Our process evaluation provides useful insights into the contextual barriers which need to be addressed for effective scale up of the Care Bundle implementation in a global context. …”
Get full text

Finite Element Analysis of Horizontal Bearing Capacity for the Composite Diaphragm Wall Anchor Foundation by Qian Yin, Leyong Wei, Xiaojuan Li, Weiming Gong, Xueying Yang, Guoliang Dai, Shunkai Peng

“…These findings contribute valuable insights to the design and application of underground diaphragm wall foundations in anchor foundation engineering.…”
Get full text

Research hotspots and trends in lung cancer STAS: a bibliometric and visualization analysis by Xiuhua Peng, Hupo Bian, Hongxing Zhao, Dan Jia, Mei Li, Wenhui Li, Pengliang Xu

“…This study’s findings provide new insights and directions for future research in this area.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#myprospero, identifier 589442.…”
Get full text

The RISES Model: A New Approach to Promoting Health Professionals’ Motivation to Engage in Research by D'Arrietta LM, Vangaveti VN, Crowe MJ, Malau-Aduli BS

“…These themes informed the development of the RISES model, a multi-layered framework emphasising a collaborative approach to addressing individual, organisational, and sociocultural factors to support HPs’ sustained research engagement.Conclusion: The study provides valuable insights into the lived experiences of HPs in relation to research, highlighting the intricate interplay of factors affecting their motivation. …”
Get full text

Immune checkpoint inhibitors in cancer patients with autoimmune disease: Safety and efficacy by Jiayuan Le, Yuming Sun, Guangtong Deng, Yating Dian, Yanli Xie, Furong Zeng

“…Hence, we conducted a meta-analysis on safety and efficacy of ICIs in cancer patients with preexisting autoimmune diseases to provide further insights. PubMed, EMBASE, and Cochrane Library were systematically searched until December 20, 2024. …”
Get full text

Antecedents to aggression and the use of coercive measures in inpatient mental health settings: a scoping review protocol by Johan Siqveland, Mette Senneseth, Njål Herman E Sterri, Øyvind Lockertsen, Tonje Lossius Husum, Veronica Lockertsen

“…Objective To investigate the antecedents to episodes of aggression and the use of coercive measures in inpatient mental health settings, organize and explore their relationships and patterns through thematic analysis, identify gaps in the literature and provide insights for future research.Introduction The use of coercive measures in inpatient mental health settings remains controversial and ethically challenging. …”
Get full text

Development and validation of a nomogram-based risk prediction model for carbapenem-resistant Klebsiella pneumoniae in hospitalized patients by Tingting Xu, Yuxin Shi, Xiongjing Cao, Lijuan Xiong

“…This study highlights the critical risk factors associated with hospital-acquired carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, providing valuable insights for clinicians to identify high-risk patients.…”
Get full text

Risk factors and economic losses associated with cystic echinococcosis among livestock in selected pastoral and agro-pastoral areas of Uganda by Leonard Omadang, Othieno Emmanuel, Kokas Ikwap, Erume Joseph, Francis Ejobi, Michael Ocaido

“…Results This is the first study to provide insights into the financial impacts and risk factors towards Cystic Echinococcosis (CE) in livestock in Uganda. …”
Get full text

Novel protein-based prognostic signature linked to immunotherapeutic efficiency in ovarian cancer by Shuo-Fu Chen, Liang-Yun Wang, Yi-Sian Lin, Cho-Yi Chen

“…Conclusions The protein-based signature not only aids in evaluating the prognosis but also provides valuable insights into the tumor immune microenvironments in ovarian cancer. …”
Get full text

Buffalo feed efficiency: optimizing the use of fibrous biomass carbon to enhance production while mitigating rumen methane emission by Metha Wanapat

“…The current advanced analysis using Next-Generation Sequencing (NGS) of rumen microbiomes offered a more insightful understanding of their ability to degrade more fibrous feeds, especially agricultural crop residues, low-quality roughages, and some plastic materials. …”
Get full text

Mathematical analysis of steady-state solutions in compartment and continuum models of cell polarization by Zhenzhen Zheng, Ching-Shan Chou, Tau-Mu Yi, Qing Nie

“…The step-wise approach allows detailed characterization of properties of the steady state of the system, providing more insights for biological regulations during cell polarization. …”
Get full text