Assessing inter-basin groundwater input to the Verlorenvlei estuarine lake using stable isotopes and hydrochemistry by A. Welham, J. van Rooyen, A. Watson, J. Miller, R. Chow

“…Inter-basin aquifer contribution was investigated to assist in explaining Verlorenvlei's slow recovery since the recent 2015 – 2018 Western Cape drought. New insights: A proportion of groundwater from outside the topographic and surface-water delineated catchment supports Verlorenvlei during the dry month of April (i.e., G30F Langvlei sub-catchment). …”
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MAMMOTH-Subaru. II. Diverse Populations of Circumgalactic Lyα Nebulae at Cosmic Noon by Mingyu Li, Haibin Zhang, Zheng Cai, Yongming Liang, Nobunari Kashikawa, Ke Ma, Xiaohui Fan, J. Xavier Prochaska, Bjorn H. C. Emonts, Xin Wang, Yunjing Wu, Shiwu Zhang, Qiong Li, Sean D. Johnson, Minghao Yue, Fabrizio Arrigoni Battaia, Sebastiano Cantalupo, Joseph F. Hennawi, Satoshi Kikuta, Yuanhang Ning, Masami Ouchi, Rhythm Shimakawa, Ben Wang, Weichen Wang, Zheng Zheng, Zhen-Ya Zheng

“…Ly α nebulae provide critical insights into the formation and evolution of today’s massive cluster galaxies at cosmic noon.…”
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How can cervical screening meet the needs of vulnerable women? A qualitative comparative study with stakeholder perspectives from seven European countries by Partha Basu, Martin McKee, Adriana Băban, Marc Bardou, Ana Fernandes, Margarida Teixeira, Rebecca Moore, Nuno Lunet, David Ritchie, Romeu Mendes, Eric Lucas, Paolo Giorgi Rossi, Rosa Legood, Berit Andersen, Diana Taut, Keitly Mensah, João Firmino-Machado, Mariana Amorim, Mette Tranberg, Laura Bonvicini, Anneli Uusküla, Pia Kirkegaard, Paola Mantellini, Ines Baia, Liu Sun, Lise Rochaix, Camilla Fiorina, Luca Ghirotto, Anna Tisler, Firmino Machado, Rikke Buus Bøje, Raquel Rico Berrocal, Noemi Auzzi, Kerli Reintamm, Yulia Panayotova, Tatyana Kotzeva, Anna Foss, Rachel Greenley, Letizia Bartolini, Giusy Iorio, Cláudia Gouvinhas, Florian Nicula, Alexandra Tolnai, Vanessa Moore, Isabel Mosquera Metcalfe, Violette Delisle, Irina Todorova, Helena Ros Comesana, Meritxel Mallafré-Larrosa, Ginevra Papi, Nicoleta-Monica Pașca, Christiane Dascher-Nadel, Olivra Djuric

“…In Bulgaria and Romania, participants advocated for the need to secure free access, from screening to follow-up, and emphasised the need for organised screening with target population screening registries.Conclusion The study offers insights into stakeholders' recommendations for enhancing cervical cancer screening services for vulnerable women across seven European countries. …”
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Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk by Wenxi Sun, Ping Sun, Jin Li, Qun Yang, Qing Tian, Shiting Yuan, Xueying Zhang, Peng Chen, Chuanwei Li, Xiaobin Zhang

“…This present study reveals a significant causal relationship between mitochondria-associated proteins and SCZ, offering valuable insights into the disease’s pathogenicity and identifying potential therapeutic targets for drug development.…”
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Comparative profitability of agroecological practices in Ethiopian wheat farming by Stanley Karanja Ng’ang’a, Sylvester Ochieng Ogutu, Degefie Tibebe, Devinia Akinyi, Jonathan Mockshell

“…The analysis considered yield uncertainty, market price fluctuations, and implementation variability to provide robust insights for decision-making.ResultsThe deterministic CBA revealed that among the three practices, the use of certified seeds was the most profitable, with a net present value (NPV) of US$ 2,531 ha–1. …”
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Channel Coding Toward 6G: Technical Overview and Outlook by Mohammad Rowshan, Min Qiu, Yixuan Xie, Xinyi Gu, Jinhong Yuan

“…Our evaluation includes a comparative analysis of error correction performance and the performance of hardware implementation for these coding schemes, providing insights into their potential and suitability for the upcoming 6G era. …”
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Biological control of ticks in domestic environments: Modeling the potential impact of entomopathogenic fungi on the transmission of East Coast fever in cattle by Joseph Wang'ang'a Oundo, Nienke Hartemink, Mart C.M. de Jong, Constantianus J.M. Koenraadt, Shewit Kalayou, Daniel Masiga, Quirine ten Bosch

“…Our model analysis provides insights into the potential impact of EPF when deployed at a population level, and lends support to further research and development of this biological tick control tool.…”
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Identification of Critical Signature in Post‐Traumatic Stress Disorder Using Bioinformatics Analysis and in Vitro Analyses by Lifen Liu, Yang Liu, Rui Li, Yue Teng, Shuyang Zhao, Jinhong Chen, Changjiang Li, Xinyu Hu, Lin Sun

“…Key genes were validated in a mouse model, providing insights into potential target genes for PTSD treatment.…”
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Dissection of the genetic basis and molecular mechanism of ovule number per ovary in oilseed rape (Brassica napus L.) by Muslim Qadir, Muslim Qadir, Muslim Qadir, Xinyi Lin, Farhan Nabi, Kishore Kumar Ashok, Xue-Rong Zhou, Qingbin Sun, Peiman Shi, Xinfa Wang, Jiaqin Shi, Hanzhong Wang

“…These findings propose further insights into the genetic basis and molecular mechanisms of ONPO, which will facilitate future gene cloning and genetic improvement for enhancing seed yield in oilseed rape.…”
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Economic feasibility assessment and parameter sensitivity analysis of rainwater harvesting systems in different climatic zones of China by Chonghua Xue, Feng Xiong, Junqi Li, Xiaojing Li, Jing Li, Yu Wang, Xiangyu Li, Ziyu Cui

“…These findings provide valuable insights for the design and implementation of rainwater harvesting and utilization systems, offering practical guidance for sustainable urban development.…”
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Influence of water masses and environmental variables on fish community in the south bank of Yangtze River Estuary, China by Dongrong Zhang, Dongrong Zhang, Hengtao Xu, Hengtao Xu, Xin Fang, Xin Fang, Wei Huang, Wei Huang, Youzheng Zhang, Youzheng Zhang, Jian Qian, Jian Qian

“…This study enhances our understanding of the temporal and spatial heterogeneity of fish communities in estuarine ecosystems and the factors influencing them, offering valuable insights for the protection and restoration of estuarine marine ecosystems.…”
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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

“…Summary: Early phase dose-finding (EPDF) trials are key in the development of novel therapies, with their findings directly informing subsequent clinical development phases and providing valuable insights for reverse translation. Comprehensive and transparent reporting of these studies is critical for their accurate and critical interpretation, which may improve and expedite therapeutic development. …”
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Detailed genetic analyses highlight genetic variation and genomic regions for lead tolerance in spring wheat by Amira M. I. Mourad, Amira M. I. Mourad, Ahmed Sallam, Ahmed Sallam, Khaled A. Farghaly, Andreas Börner

“…Interestingly, five significant markers were found to be associated with lead tolerance at the seedling and adult growth stages.DiscussionThe results of this study provide new and novel insights into genetic control and genetic variation in lead tolerance at the early growth stage. …”
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Trends in tuberculosis mortality among older adults in China, 2004–2021: a Joinpoint regression and age–period–cohort analysis by Mengdi Zhang, Xin Wang, Yiran Xiao, Qiqi Wang, Fei Huang, Xiang Ren, Xiaomin Guo, Wenshan Sun, Jinqi Deng, Qi Jiang, Jianjun Liu, Wenjing Zheng, Hongyan Yao

“…Variations in age, period, and cohort effects highlight differences by gender, urban and rural areas, and regions, providing insights for targeted intervention strategies.…”
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Differential Expression of IFN-γ, IL-10, TLR1, and TLR2 and Their Potential Effects on Downgrading Leprosy Reaction and Erythema Nodosum Leprosum by Douglas Eulálio Antunes, Isabela Maria Bernardes Goulart, Mayara Ingrid Sousa Lima, Patrícia Terra Alves, Paula Cristina Brígido Tavares, Luiz Ricardo Goulart

“…A study using blood samples of 17 leprosy reaction patients and 17 reaction-free was carried out by means of associations between antigens, receptors, and expression of cytokines, using path analysis providing new insights into the immunological mechanisms involved in triggering leprosy reactions. …”
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Recent advances in the application of Mendelian randomization to chronic kidney disease by Chaofan Wen, Lanlan Chen, Dan Jia, Ziqi Liu, Yidan Lin, Guan Liu, Shuo Zhang, Baoshan Gao

“…Additionally, lifestyle factors, including diet, exercise, and mental wellness activities, play a crucial role in kidney health. New insights also reveal a substantial causal connection between both central and general obesity and CKD onset, while no significant links were found between genetically modified LDL cholesterol or triglyceride levels and kidney function.Conclusion This review not only presents the recent achievements of MR in CKD research but also illuminates the path forwards, underscoring critical unanswered questions and proposing future research directions in this dynamic field.…”
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The Association Between Serum Gamma‐Glutamyl Transferase and Gastrointestinal Cancer Risk: A Systematic Review and Meta‐Analysis by Alireza Ramandi, Jacob George, Amir Hossein Behnoush, Alireza Delavari, Zahra Mohammadi, Hossein Poustchi, Reza Malekzadeh

“…We aim to systematically investigate these studies to provide better insights into the interrelationship between GGT and GI cancers. …”
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Dynamics of water status during fruiting body development of Agaricus bisporus and its relationship to mushroom quality by Lingzhong Wan, Hui Sun, Ying Ni, Jun Tang, Junjie Yu, Juan Wu, Xiaoming Yan, Xiaonan Deng

“…This study would contribute to reveal macroscopic water transport within mushroom tissues and provide theoretical insights for optimizing high-quality mushroom cultivation. …”
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Dopaminergic modulation of propofol-induced activation in VLPO neurons: the role of D1 receptors in sleep-promoting neural circuits by Kun Qian, Kun Qian, Yu Zhang, Yang Liu, Sisi Wu, Zikun Duan, Jianhao Liao, Jianhao Liao, Wei Luo, Mo Zhou, Xuejiao Dou, Xingkui Liu, Tian Yu

“…These results provide new insights into the neural mechanisms underlying general anesthesia and highlight the potential role of dopaminergic signaling in modulating anesthetic effects on sleep-related neural circuits.…”
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Kinetic simulation of uranium migration in granite fissure media of beishan, gansu, China: A case study based on the Laplace transform and inverse transform methods by Xianzhe Duan, Cong Du, Nan Li, Jiaxin Duan, Zhenping Tang

“…Based on the numerical methods, the kinetic migration of nuclide U-238 in the fissure media of granite was simulated, and the effects of parameters such as fissure width, hydraulic gradient, diffusible area ratio and rock porosity on the migration of U-238 were investigated. The following insights were obtained: (1) After 100,000 years, U-238 has a very limited diffusion depth in the matrix domain, with a diffusion range of only a few tens of millimeters, whereas it migrates relatively quickly in the fissure domain, with a maximum migration distance of about 1500 m. (2) Under the same migration time and distance, the relative concentration of nuclide U-238 in the fissure domain increases with larger gap width, hydraulic gradient, and diffusible area ratio, but decreases with higher rock porosity. (3) In the same time range, the rock masses with larger gap widths, hydraulic gradients, and diffusible area ratios have larger migration ranges, while those with higher porosities have smaller migration ranges. (4) While selecting a site for diposal of HLWs, it is recommended to choose rock masses in the granite area of Beishan with no fissures or few fissures; additionally, areas with smaller fissure widths, hydraulic gradients, and diffusible area ratios but higher rock porosity should be prioritized. …”
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