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    Glycyrrhizin as a potential disease-modifying therapy for epilepsy: insights into targeting pyroptosis to exert neuroprotective and anticonvulsant effects by Lei Wei, Sijie Ou, Youshi Meng, Lanfeng Sun, Lin Zhang, Yuling Lu, Yuan Wu

    Published 2025-01-01
    “…Molecular experiments indicated that glycyrrhizin may regulate pyroptosis through mediation of the high mobility group box 1 (HMGB1)/Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signaling pathway.ConclusionGlycyrrhizin exerts neuroprotective and anticonvulsant effects in epilepsy by regulating pyroptosis via the HMGB1/TLR4/NF-κB signaling pathway, offering novel insights into its potential as a DMT for epilepsy.…”
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    Functional genomic insights into Floricoccus penangensis ML061-4 isolated from leaf surface of Assam tea by Patthanasak Rungsirivanich, Elvina Parlindungan, Jennifer Mahony, Witsanu Supandee, Narumol Thongwai, Douwe van Sinderen

    Published 2025-01-01
    “…This is the first report outlining functional genomic insights regarding a member of the genus Floricoccus.…”
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    Long-term trends in the burden of pulmonary arterial hypertension in China and worldwide: new insights based on GBD 2021 by Zhehao Xu, Jia Ding, Ruiyun Liang, Shuangfeng Xie

    Published 2025-01-01
    “…This study’s comprehensive analysis of PAH burden over three decades provides valuable insights for policymakers and healthcare providers, necessitating concerted efforts to address this critical health issue.…”
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