Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial. by Westyn Branch-Elliman, Ryan Ferguson, Gheorghe Doros, Patricia Woods, Sarah Leatherman, Judith Strymish, Rupak Datta, Rekha Goswami, Matthew D Jankowich, Nishant R Shah, Thomas H Taylor, Sarah T Page, Sara J Schiller, Colleen Shannon, Cynthia Hau, Maura Flynn, Erika Holmberg, Karen Visnaw, Rupali Dhond, Mary Brophy, Paul A Monach

“…This occurred in 5/20 and 1/30 of participants in the sarilumab and SOC arms respectively, with the majority occurring in the initial 9 participants (3/4 in the sarilumab and 1/5 in the SOC) before the sarilumab dose was increased to 400 mg and before remdesivir and dexamethasone were widely adopted. …”
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Reflections on plague in African history (14th–19th c.) by Gérard Chouin

“…Although the plague is commonly described as a pandemic, historical knowledge about the initial Black Death and the many recurrent waves of the disease is largely restricted to Western Europe and the Mediterranean world, where the literate elite left an impressive documentary record that served as resource to the long-lasting and flourishing heuristic tradition of Plague Studies. …”
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Mellom skrifta og barnet – tre barnehagelærarar sine strategiar i høgtlesing av bildebøker med få ord og med fleire ord by Anne Marta Vinsrygg Vadstein

“…Three main strategies have been identified: (a) conversational initiations, (b) content dissemination, and (c) linguistic adaptions. …”
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Silent witnesses: unveiling the epidemic of femicides in North-west Tshwane, South Africa – a decade of analysis by Yaseen Bismilla, K. K. Hlaise, C. Van Wyk

“…The demographic data indicate that young black women are particularly vulnerable, necessitating protective and educational initiatives tailored to this group.…”
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Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi... by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…Subsequently, the regulation of gut microbiome by QAFF was validated by fecal microbiota transplantation (FMT).Results: Eleven flavonoids, including Naringin and hesperidin, were initially identified from QAFF. In vivo experiments demonstrated that QAFF effectively ameliorated colitis symptoms, reduced IL-6, IL-1β, and TNF-α levels, enhanced intestinal barrier integrity, and downregulated PI3K/AKT pathway activation. …”
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The Effects of Self-Monitoring Using a Smartwatch and Smartphone App on Stress Awareness, Self-Efficacy, and Well-Being–Related Outcomes in Police Officers: Longitudinal Mixed Desi... by Herman Jaap de Vries, Roos Delahaij, Marianne van Zwieten, Helen Verhoef, Wim Kamphuis

“… Abstract BackgroundWearable sensor technologies, often referred to as “wearables,” have seen a rapid rise in consumer interest in recent years. Initially often seen as “activity trackers,” wearables have gradually expanded to also estimate sleep, stress, and physiological recovery. …”
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A novel ddPCR™ assay for eDNA detection and quantification of Greater Amberjack Seriola dumerilli and three congeners in US waters: challenges and application to fisheries independ... by P. Joana Dias, Ryan Lehman, Bryan L. Huerta-Beltrán, Ana Wheeler, Crystal L. Hightower, Jessica Heise, Theodore Switzer, Clint Rhode, J. Marcus Drymon, Lynne Stokes, Mark A. Albins, Sean Powers, Nicole Phillips

“…The study presented here is part of a fisheries-independent project initiated to determine an absolute abundance of S. dumerili, to expand biological knowledge of the species and to develop novel tools for fisheries management. …”
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Role of visual function and performance of activities of daily living in cognitive function in patients with mild cognitive impairment: a cross-sectional study by Chunhui Zhou, Ganfeng Yang, Marc Theeboom, Hua Yang, Ruiting Zhu, Zijian Zhou, Dong Zhu

“…Multivariable linear regression models were employed to further explore these relationships and to assess the moderating role of ADLs.ResultsSignificant positive correlations were found between visual function and cognitive performance, particularly with Visual Function Index (VFI) showing a strong initial correlation with the total MoCA score (r = 0.61, p < 0.001), which was attenuated after adjusting for ADL (β = 0.06, p = 0.23). …”
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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury by Jennifer M. Colón-Mercado, Aranza I. Torrado-Tapias, Iris K. Salgado, José M. Santiago, Samuel E. Ocasio Rivera, Dina P. Bracho-Rincon, Luis H. Pagan Rivera, Jorge D. Miranda

“…The cellular-molecular mechanisms are not well understood, but the data suggests that plasticity within the rostral, epicenter, and caudal penumbra of the injury site initiates a cellular-molecular interplay that acts as a rewiring mechanism leading to central neuropathic pain. …”
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Adulthood consequences of spinal deformity surgeries in neurofibromatosis type 1 patients by Arihiko Tsukamoto, Koki Uno, Teppei Suzuki, Masaaki Ito, Keita Nakashima, Kenichiro Kakutani, Yoshiki Takeoka

“…Results The mean age at the initial surgery was 14.6 [4〜49] years, and the mean age at the last observation was 29.4 [18〜56] years. …”
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Epidemiology of Methicillin-resistant Staphylococcus aureus Colonization in Neonates within Neonatal Intensive Care Units: A Systematic Review and Meta-analysis by Seraphine Nkie Esemu, Arnol Bowo-Ngandji, Roland Ndip Ndip, Jane-Francis Tatah Kihla Akoachere, Nene Kaah Keneh, Jean Thierry Ebogo-Belobo, Cyprien Kengne-Ndé, Donatien Serge Mbaga, Nicholas Tendongfor, Hortense Kamga Gonsu, Jean Paul Assam Assam, Lucy Mande Ndip

“…Results: Our systematic review evaluated 62 studies out of an initial 536 records identified. The majority of the selected studies were conducted in high-income countries, primarily in the United States. …”
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Collection and Determination of Clinical Problems and Outcome Indicators of Expert Consensus on Clinical Application of Ethnic Medicine in the Treatment of Palpitation (Arrhythmia-... by ZHANG Wenjie, LI Jun, CHEN Hengwen, TAN Yuqing, XIE Zicong, WU Ji, MENG Chao, LI Zhaoling, ZHANG Lesong

“…Following the integration of the interview results and expert experiences, the consensus steering committee and working group jointly drafted the initial proposals for clinical questions and outcome indicators, subsequently designing a survey questionnaire. …”
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PENGEMBANGAN E-MODUL BERBASIS WEB SEBAGAI BAHAN AJAR FISIKA PADA MATERI GELOMBANG BUNYI DI SMA by Miya Novitasari, Connie Connie, Eko Risdianto

“…At the design stage consists of choosing learning media, choosing the format of teaching materials, and the initial design of electronic teaching materials. The develop phase consists of validating expert judgment (lecturers) and practitioners (teachers). …”
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Clinical follow-up of 2 families with glomerulopathy caused by COQ8B gene variants and literature review by Lei Zhang, Gentzon Hall, Peitong Han, Chunzhen Li, Jieyuan Cui

“…His disease was unresponsive to prior treatment with glucocorticoids and cyclosporine. Oral CoQ10 was initiated based on his genetic diagnosis and was it was effective in reducing proteinuria over the first 5 months months of therapy. …”
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Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease by Zehu Sheng, Lanyang Wang, Ming Chen, Fuxin Zhong, Shijing Wu, Shuyu Liang, Jiaqi Song, Lihua Chen, Yingxi Chen, Shiyu Chen, Weihua Yu, Yang Lü

“…Methods In this study, 211 participants from the Alzheimer’s disease Neuroimaging Initiative (ADNI) with CSF and Plasma β2M, CSF glial fibrillary acidic protein (GFAP), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), Aβ42, phosphorylated-tau (P-tau) and total tau (T-tau) were divided into four groups, stage 0, 1, 2, and suspected non-AD pathology (SNAP) based on the National Institute on Aging- Alzheimer’s Association (NIA-AA) criteria. …”
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Relationship between CCL25/CCR9 Levels in Follicular Fluid and High Ovarian Response in Patients with Polycystic Ovary Syndrome by Yongxin Hao, Qianqian Yin, Fangfang Hu, Xiaoyan Liu, Yaru Yang, Fang Sun, Xiaonan Yan

“…Conversely, no statistically significant differences were observed between the two groups with respect to COS parameters, encompassing initial gonadotropin (Gn) dose, stimulation duration, and total Gn dose. …”
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DIAGNOSTIC VALUE OF LABORATORY TESTS OF WOMEN IN THE DYNAMICS OF TREATMENT OF PERIODONTAL DISEASES CONCOMITANT WITH BACTERIAL VAGINOSIS by T.O. Petrushanko, A.D. Krutikova, E.I. Krutikova

“…The results of the amino test of oral fluid were positive in patients of Group III-A before treatment in 73.3%, after treatment only in 53.3%, while in the subjects of Group III-B the initial result was 80%; after treatment, a decrease to 20% was registered. …”
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Impact of geochemical reactivity on desulphation requirements in a sandstone reservoir containing carbonate and sulphate minerals by Ali M. Al-Behadili, Eric J. Mackay

“…Dissolution of anhydrite (−5.1E-05gmole) present in the initial mineral assemblage is shown to have a significant impact in most scenarios, except where FSSW has been heated up to reservoir temperature, where anhydrite precipitation (5E-05gmole) in situ occurs. …”
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Muhammed et-Trabzonî el-Medenî’nin el-İthâfâtu’s-Seniyye fi’l-Ehâdîsi’l-Kudsiyye Adlı Eseri Özelinde Kudsî Hadis Yorumu by Yunus Yazıcı

“…Süyûtî’nin Cemʿu’l-cevâmiʿi başta olmak üzere Abdurraûf el-Münâvî’nin Künûzü’l-hakaʾik’i, Ali el-Kârî’nin el-Ehâdîsü’l-Kudsiyyetü’l-Erba‘îniyye’si ve Mirkâtü’l-Mefâtîh’i yararlanılan kaynaklardır. …”
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Risk of SARS-CoV-2 infection before and after the Omicron wave in a cohort of healthcare workers in Ontario, Canada by Jorge L. Martinez-Cajas, Ann Jolly, Yanping Gong, Gerald Evans, Santiago Perez-Patrigeon, Bradley Stoner, T. Hugh Guan, Beatriz Alvarado

“…The analysis was divided into two periods: the initial phase of the pandemic (period #1) and the first three Omicron waves (period #2). …”
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