Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

“…Notably, HIV-negative KS samples showed alterations in NK cell-mediated immunity and cytotoxic response pathways, whereas HIV-positive samples exhibited changes in growth regulation and protein kinase activity pathways at the time of initial diagnosis. …”
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Inhibition of programmed cell death by melanoma cell subpopulations reveals mechanisms of melanoma metastasis and potential therapeutic targets by Yuepeng An, Fu Zhao, Hongling Jia, Siyu Meng, Ziwei Zhang, Shuxiao Li, Jiusi Zhao

“…Melanoma cells often resisted cell death mechanisms, maintaining their growth by inhibiting apoptosis and evading autophagic cell death. …”
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Arginase-1-specific T cells target and modulate tumor-associated macrophages by Mads Hald Andersen, Inés Lecoq, Ayako Wakatsuki Pedersen, Evelina Martinenaite, Shamaila Munir Ahmad, Maria Perez-Penco, Lucia Lara de la Torre, Marion Chapellier, Lars Rønn Olsen, Mia Aaboe-Jørgensen, Hannah Jorinde Glöckner, Anne Mette Askehøj Rømer

“…We previously reported the existence of Arg1-specific memory T cells among peripheral blood mononuclear cells (PBMCs) and described that Arg-1-based immune modulatory vaccines (IMVs) control tumor growth and alter the M1/M2 macrophage ratio in murine models of cancer. …”
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Synthesis and Characterization of Paclitaxel-Loaded Silver Nanoparticles: Evaluation of Cytotoxic Effects and Antimicrobial Activity by Tutku Tunç, Ceylan Hepokur, Afşin Kari̇per

“…Carrier system therapies based on combining cancer drugs with nanoparticles have been reported to control tumor growth and significantly reduce the side effects of cancer drugs. …”
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Oat Nutrition, Traits, and Yield as Affected by the Interaction of Nitrogen Rates and Plant Density in Sandy Soil by Zhiling Lin, Jianqiang Deng, Kai Gao, Zhixin Zhang

“…It was found that the growth of oats in this area was limited by soil N. …”
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Glycogen Storage Disease Type Ia: A Retrospective Claims Analysis of Complications, Resource Utilization, and Cost of Care by Eliza Kruger, Justin Nedzesky, Nina Thomas, Jeffrey D. Dunn, Andrew A. Grimm

“…Chronic complications (eg, gout, osteoarthritis, chronic kidney disease, and neoplasms) were more common in adults with GSDIa, whereas acute complications (eg, poor growth, gastrostomy, seizure, and hypoglycemia) were more common in children with GSDIa. …”
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Aplikasi Pertimbangan Wisata di Pulau Lombok dengan Metode Fuzzy Mamdani & Algoritma Genetika by Zainul Harir, Ida Bagus Ketut Widiartha, Royana Afwani

“…Abstract Tourism in Lombok has an interesting culture, it makes Lombok got three awards at the 2016 World Halal Tourism Awards and became a growth factor for tourist visits by 13% that year. …”
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Integration and Comparative Analysis of Remote Sensing and In Situ Observations of Aerosol Optical Characteristics Beneath Clouds by Jing Chen, Jing Duan, Ling Yang, Yong Chen, Lijun Guo, Juan Cai

“…And (4) overall, the AOD is greater under cloudy-sky conditions than under clear-sky conditions; this result is likely related to the more favorable subcloud humidity conditions for aerosol hygroscopic growth.…”
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Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation by Yu Chen, Lin Mao, Qinxiang Zhou, Dingqun Bai, Yuhan Kong

“…We tested the expression of growth-associated protein-43(Gap-43) and microtubule-associated protein-2(Map-2), K+-Cl- co-transporter 2(KCC2), γ-aminobutyric acid(GABA), and key BDNF-TrkB downstream signaling, the phospholipase C gamma(PLCγ) / CaMK IV / cAMP response element binding protein(CREB), and extracellular signal-regulated protein kinase(ERK1/2) / ribosomal S6 kinase(RSK) using western blotting. …”
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Clinicopathological and molecular characterization of astrocytoma by Xiaoyan Wu, Wenfeng Peng, Xu Zhang, Tao Tang, Ling Deng, Yuxia Xu, Xiaoyun Liu, Fang Wang, Wujian Peng, Jianrong Huang, Xiaoni Zhong

“…These tumors showed a growth pattern similar to traditional intracranial astroblastoma, and the histological manifestations of the four patients were all high-grade, showing features of high-density areas of tumor cells or necrosis. …”
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PRACTICAL TRAINING OF OFFICERS OF THE STATE FIRE SERVICE THROUGH GAME-BASED LEARNING by V. V. Bulgakov, A. A. Lazarev, E. P. Konovalenko, T. A. Mochalova

“…The advantages of the offered methodology are the following: the possibility to design various schemes of practical training through the modular principle of their design; the development in cadets of the skills of team interaction, acquisition of professional experience by them in the process of role performance of duties of chiefs of rescue and fire fighting offices and department guards; the readiness formation to quickly adapt to new circumstances and to cope with non-standard problems in the conditions of limited time; to develop the abilities of critical thinking in young officers, to reflect own activity and to define the directions of professional growth.Practical significance. The proposed methodology demonstrated its effectiveness and practical importance for cadets’ training in the field of rescue and firefighting, as confirmed by, inter alia, the improvement of academic performance in special disciplines. …”
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Fracture-seepage characteristic zones of the overburden of extra-thick coal seams: Evolutionary patterns and their engineering applications by Xiangguo KONG, Tianshuo ZHAO, Haifei LIN, Pengxiang ZHAO, Xu WANG, Yuchu CAI, Pengfei JI, Di HE, Ke LI, Chuanyu XU

“…Results and Conclusions The results indicated that the bed separation and fracture density of the central part of the overburden were 47% and 31%, respectively, of those of its two sides, indicating that both indicators were low in the central part and high on the two sides. …”
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Diagnostic criteria for asthenic accommodative asthenopia in patients with computer vision syndrome by I.G. Ovechkin, I.S. Gadzhiev, Kozhukhov A.A, E.I. Belikova

“…The most typical accommodative disorders in asthenic accommodative asthenopia are the significant reduction of accomodogram growth parameters and the high-frequency component of accommodative microfluctuations. …”
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Early Prediction of Abdominal Aortic Aneurysm Rupture Risk Using Numerical Biomechanical Analysis by Kristina Grassl, Thomas C. Gasser, Florian K. Enzmann, Alexandra Gratl, Josef Klocker, David Wippel, David C. Walcher, Elke R. Gizewski, Sabine H. Wipper

“…<b>Objective</b>: We aimed to predict patient-specific rupture risks and growth behaviors in abdominal aortic aneurysm (AAA) patients using biomechanical evaluation with finite element analysis to establish an additional AAA repair threshold besides diameter and sex. …”
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Management Modalities of Mandible Fracture and Dental Trauma in Pediatric Patients During Mixed Dentition Phase: A Series of Case Study by Lomtu Ronrang, Alice Lyngdoh

“…The prime objectives were the restoration of normal occlusion and alignment of the jawbone, including esthetic and phonetic, without impairing normal growth and development of jawbone and permanent tooth buds. …”
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Comparative Analysis of Multiple Hydrological Models in Assessing Climate Change Impacts on the Mille Watershed, Awash Basin, Ethiopia by Asmare Belay Nigussie, Mihiretie Ayana, Dessalegn Worku Ayalew, Gerawork Feleke, Asnake Enawgaw Amognehegn, Anteneh Yayeh Adamu, Andualem Endalew, Tewodrose Desale Meselaw, Shankar Karuppannan

“…As industrial and economic growth intensifies, greenhouse gases are released into the atmosphere, leading to a shift in global warming and climate change patterns. …”
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Nutrient cycling characteristics along a chronosequence of forest primary succession in the Hailuogou Glacier retreat area, eastern Tibetan Plateau by Danli Yang, Ji Luo, Shumiao Shu, Yan Hu, Hongsong Tang, Xuemei Li

“…Although over 60% of the P and K were stored in the organic soil at site S1, these proportions shifted, with vegetation holding 60.71% of P and 56.86% of K at site S5. (3) Broad-leaved forests exhibited higher nutrient return, cycling, and absorption, thereby accelerating nutrient circulation and depleting soil nutrients to maintain growth. In contrast, coniferous forests were more efficient at nutrient utilization and storage, retaining nutrients and maintaining high biomass and productivity in nutrient-poor environments. …”
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Un manifeste patrimonial pour la gastronomie by Marie-Hélène Bénetière, Isabelle Chave, Julie Faure, Michaël Vottero

“…Heritage specialists, in their daily professional lives, have adapted to the unprecedented growth of applied research in the field of gastronomy. …”
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Engineered Perfluorochemical Cancer-Derived Exosomes Loaded with Indocyanine Green and Camptothecin Provide Targeted Photochemotherapy for Effective Cancer Treatment by Lee YH, Huang CY

“…In a murine melanoma model, we demonstrated that ICFESs indeed targeted homologous tumors with prolonged intratumoral retention compared with free ICG in vivo. Moreover, tumor growth was significantly arrested by ICFESs containing 40/40 μM [ICG]/[CPT] in combination with 30 sec of NIR exposure without systemic toxicity, and the resulting tumors were approximately 15-fold smaller than those treated for 14 days with 40 μM free CPT alone.Conclusion: We suggest that the aforementioned anticancer efficacy was achieved via a dual-stage mechanism, phototherapy followed by chemotherapy. …”
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PENGARUH INVESTMENT OPPORTUNITY SET DAN KEPEMILIKAN MANAJERIAL TERHADAP NILAI PERUSAHAAN YANG DIMEDIASI OLEH KEBIJAKAN DIVIDEN by Luthfy Maghfiroh Ilahi, Ni Putu Santi Suryantini

“…The findings reveal that both the investment opportunity set and managerial ownership positively influence dividend policy. …”
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