Enrichment of electrotrophic microorganisms from contrasting shallow-sea hydrothermal environments in bioelectrochemical reactors by Antoine Carissimo, Victoria Comes, Alenica Heussner, Anne-Hélène Prime, Roy E. Price, Gaël Erauso, Pierre-Pol Liebgott, Sven Kerzenmacher, Guillaume Pillot

“…However, their diversity is poorly known, especially in shallow-sea hydrothermal vents where it has not been extensively studied. Bioelectrochemical reactors can be used to investigate such electrotrophic diversity by providing an electrode as an electron donor.MethodsHere, a total of 60 different reactors were set up and inoculated with either a microbial community coming from the shallow, acidic (ca. pH 5.5) and hot (ca. 120°C) hydrothermal system of Panarea, Aeolian islands, Italy, or the shallow, alkaline (pH 11) and mild (40°C) hydrothermal system of Prony Bay, New Caledonia.ResultsWith the alkaline sample, no electrical current increase was seen in any of the 15 reactors operated for 6 days under Prony hydrothermal conditions (pH 10, 30–75°C). …”
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Post-Hercynian ultrahigh-temperature tectono-metamorphic evolution of the Middle Atlas lower crust (central Morocco) revealed by metapelitic granulite xenoliths by A. El Maz, A. Vauchez, J.-M. Dautria

“…The last event susceptible to have affected the lower crust is the alkali magmatism active in the Middle Atlas during the Mio-Plio-Quaternary. …”
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Leveraging Administrative Health Databases to Address Health Challenges in Farming Populations: Scoping Review and Bibliometric Analysis (1975-2024) by Pascal Petit, Nicolas Vuillerme

“…To address these challenges, a complementary approach involves leveraging and reusing data beyond its original purpose. Administrative health databases (AHDs) are increasingly reused in population-based research and digital public health, especially for populations such as farmers, who face distinct environmental risks. …”
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Altered Atlas of Exercise-Responsive MicroRNAs Revealing miR-29a-3p Attacks Armored and Cold Tumors and Boosts Anti-B7-H3 Therapy by Jie Mei, Zhiwen Luo, Yun Cai, Renwen Wan, Zhiwen Qian, Jiahui Chu, Yaying Sun, Yuxin Shi, Ying Jiang, Yan Zhang, Yongmei Yin, Shiyi Chen

“…Single-cell RNA sequencing (scRNA-seq) and cytometry by time-of-flight (CyTOF) demonstrated that miR-29a-3p attacked the armored and cold tumors, thereby shaping an immuno-hot tumor microenvironment (TME). Translationally, liposomes were developed and loaded with miR-29a-3p (lipo@miR-29a-3p), and lipo@miR-29a-3p exhibited promising antitumor effects in a mouse model with great biocompatibility. …”
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Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates by Yangyang Gao, Yuwei Xia, Yixin Chen, Shiqi Zhou, Yingying Fang, Jieru Yu, Leyin Zhang, Leyin Zhang, Leitao Sun, Leitao Sun, Leitao Sun

“…However, complexity of its structural composition poses a greater difficulty for drug design studies.ObjectivesPharmacokinetic/pharmacodynamic (PK/PD) based consideration of ADCs has increasingly become a hot research topic for optimal drug design in recent years, providing possible ideas for obtaining ADCs with desirable properties.MethodsFrom the assessment of the ADC action process based on PK/PD, we introduce the main research strategies of ADCs. …”
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A bibliometric analysis of exosomes in aging from 2007 to 2023 by Zenghui Niu, Meiyu Cui, Yingkun Fu, Lingfeng Zhou, Jiali Wang, Jiali Wang, Yan Lei, Xinrong Fan, Qiang Wang, Jing Yang

“…As research on exosomes continues to advance, its relationship with aging and aging-related diseases has become a hot topic This article analyzes the research hotspots of exosomes in aging and aging-related diseases, aiming to fill the gap in bibliometric research in this field and help researchers better understand the current status and future trends of both fundamental and clinical research in this field.MethodsThe articles were retrieved and exported from WoSCC on December 18, 2023. …”
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Prospective clinical performance of CoVarScan in identifying SARS-CoV-2 Omicron subvariants by Kenneth Zhu, Manoj Sah, Lenin Mahimainathan, Yan Liu, Chao Xing, Karen Roush, Andrew Clark, Jeffrey SoRelle

“…These are the major variants of concern (VOCs) that have dominated since Omicron originally appeared in December 2021. …”
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1-(5-ACETYL-3-METHYL-6-PHENYL-5H-[1,2,4]TRIAZOLO [3,4-b][1,3,4]THIADIAZIN-7-YL)-ETHANONE: DOSE-DEPENDENCE OF ANALGESIC EFFECT, LACK OF OPIOIDERGIC MECHANISM OF ACTION, EFFECT ON BE... by Andriy Koval, Sergiy Shtrygol

“…When determining the acute toxicity of the compound IFT_247, a dose of 2000 mg/kg did not cause a lethal effect in any mouse. Doses of 2500 and 3980 mg/kg caused the death of 1 animal, and a dose of 5010 mg/kg was lethal in all mice. …”
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Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway by Yushi Ding, Suyun Yu, Zhonghong Wei, Rui Deng, Peng Chen, Yifan Sun, Qi Jia, Xiaoman Li, Yuanyuan Wu, Wenxing Chen, Kurt S. Zanker, Aiyun Wang, Yin Lu

“…A phenol red excretion test showed that RSTF has an eliminating phlegm effect. A hot plate method and granuloma experiment proved that RSTF also have analgesic and anti-inflammatory effects. …”
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Utilizing ultrasound for the extraction of polysaccharides from the tuber of Typhonium giganteum Engl.: Extraction conditions, structural characterization and bioactivities by Xi Peng, Jing-Ya Wang, Kui-Xu Gao, Zhi-Kun Wang, Qiao-Ling Deng, Yao Wang, Mei-Bian Hu, Yu-Jie Liu

“…The results also indicated that TGEP-U had better antioxidant and hypoglycemic activity than TGEP-H. …”
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Spatiotemporal analysis of surface Urban Heat Island intensity and the role of vegetation in six major Pakistani cities by Shoaib Ahmad Anees, Kaleem Mehmood, Syed Imran Haider Raza, Sebastian Pfautsch, Munawar Shah, Punyawi Jamjareegulgarn, Fahad Shahzad, Abdullah A. Alarfaj, Sulaiman Ali Alharbi, Waseem Razzaq Khan, Timothy Dube

“…For instance, Islamabad has greater vegetation cover and cool zones over 41.5 km2. …”
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Regional climatic changes and their impact on the level of avalanche hazard in East Kazakhstan by Olga Petrova, Natalya Denissova, Gulzhan Daumova, Yelena Ivashchenko, Evgeny Sergazinov

“…The article examines the territory of East Kazakhstan, where a sharply continental climate prevails with hot summers, cold and snowy winters. The mountainous regions of East Kazakhstan are represented by the Kalba, Altai and Saur-Tarbagatay ranges, they are surrounded by rolling plains. …”
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Effect of sun dry brewer spent yeast on chemical composition, in vitro digestibility, and ruminal degradation kinetics of wheat straw by Geberemariyam Terefe, Mulugeta Walelgne, Dereje Fekadu, Getu Kitaw, Mesfin Dejene, Aeimro Kehaliu, Bethlehem Mekonnen, Yohannse Habteyesus

“…Abstract Background Dry brewer spent yeast (DBSY) has high crude protein (CP) (43.2%) and metabolizable energy (14.3 MJ/kg) contents and it is an alternative animal feed for the improvement of the productive and reproductive performance of the animals. …”
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Ferroptosis in kidney disease: a bibliometric analysis from 2012 to 2024 by Yuxin Hu, Yuxin Hu, Yuxin Hu, Jingyi Tang, Jingyi Tang, Jingyi Tang, Hanzhang Hong, Hanzhang Hong, Yexin Chen, Yexin Chen, Beibei Ye, Ziheng Gao, Ziheng Gao, Gegongming Zhu, Lin Wang, Lin Wang, Lin Wang, Weijing Liu, Weijing Liu, Weijing Liu, Yaoxian Wang, Yaoxian Wang, Yaoxian Wang

“…Keywords associated with glutathione, lipid peroxidation, and nitric oxide had high frequency in the early studies. In recent years, however, there has been a shift towards biomarkers, inflammation and necrosis, which indicate current and future research directions in this area.ConclusionThe global landscape of the ferroptosis research in kidney disease from 2012 to 2024 was presented. …”
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Differential expression of circulating microRNAs in lactating Holstein and Jersey cows exposed to heat stress by Jihwan Lee, Doosan Kim, Byeonghwi Lim, Gyeonglim Ryu, Hyeonguk Baek, Joohwan Kim, Seungmin Ha, Sangbum Kim, Seunghwan Lee, Taejeong Choi, Inchul Choi

“…Background: South Korea has recently faced record-high temperatures, which have adversely affected dairy production. …”
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Design of Command and Dispatch System for Automatic Reading of Meter Images in Substations by UAV Inspection Photos by Guanghong Deng, Liangpei Lin, Baihao Lin, Wenlong Jing, Xiaodan Zhao, Yong Li, Rui Yang, Shidun Xie, Pengfeng Wei

“…The application of the combination of unmanned aerial vehicles (UAVs) and artificial intelligence is a hot topic in the intelligent inspection of substations, and meter reading is a very challenging task. …”
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Development of a sustainable, green, and solar-powered filtration system for E. coli removal and greywater treatment by R. Abdallat, A.N. Bdour, A. Abu Haifa, F.F. Al-Rawash, L. Almakhadmeh, S. Hazaimeh

“…BACKGROUND AND OBJECTIVES: Jordan's limited water resources have reduced daily water consumption, leading to a highly concentrated greywater production rate of 54 million cubic meters per year. …”
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Screening and identification of vascular endothelial cell targeting peptide in gastric cancer through novel integrated in vitro and in vivo strategy by Yan-ting Zhang, Sheng-hui Wang, Li Zhao, Hui-min Wang, Lin Wang, Rong-rong Shi, Si-chao Liang, Bao-feng Li, Bei Chen

“…Abstract Purpose Antiangiogenesis therapy has become a hot field in cancer research. Given that tumor blood vessels often express specific markers related to angiogenesis, the study of these heterogeneous molecules in different tumor vessels holds promise for advancing anti-angiogenic therapy. …”
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Torrefaction of bamboo pellets using a fixed counterflow multibaffle reactor for renewable energy applications by W. Hidayat, B.A. Wijaya, B. Saputra, I.T. Rani, S. Kim, S. Lee, J. Yoo, B.B. Park, L. Suryanegara, M.A.R. Lubis

“…The baffles in the reactor column held the pellets, while hot gas flowed through them. Torrefaction was conducted at 280 degrees Celsius with a 3–5 minutes resident time, and the gas flow rate was 4.25 cubic meters per minute. …”
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Multi-omics and machine learning-driven CD8+ T cell heterogeneity score for head and neck squamous cell carcinoma by Di He, Zhan Yang, Tian Zhang, Yaxian Luo, Lianjie Peng, Jiatao Yan, Tao Qiu, Jingyu Zhang, Luying Qin, Zhichao Liu, Mouyuan Sun

“…By analyzing the gene expression related to CD8+ T cells, we have differentiated HNSCC into cold and hot tumor subtypes, uncovering disparities in clinical prognosis and responses to immunotherapy. …”
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