Epigenetics of suicidal behavior by R. N. Mustafin, A. V. Kazantseva, R. F. Enikeeva, Yu. D. Davydova, S. B. Malykh, V. V. Viktorov, E. K. Khusnutdinova

“…Published data identified multiple genes including those involved in the functioning of serotonergic (SLC6A4, TPH, 5-HT1A), hypothalamic-pituitary-adrenal systems (FKBP5) and polyamines (SAT and OATL1) associated with suicidal behavior. …”
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Numerical simulation of coal particle motion characteristics in the envelope region of spiral drum based on discrete element method by Zhen Tian, Shan Gao, Lianwei Ma, He Wang, Yang Ge

“…Abstract In order to study the movement characteristics of coal particles in the coal loading process of spiral drums, the spiral drum of a certain type of shearer was taken as the research object, and the intrinsic parameters of the materials were calibrated through the determination results of coal sample properties, the relevant parameters of coal particle adhesion were determined, and a discrete element model of spiral drum coal loading was established. …”
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The lived experience of migrant Syrian mothers’ interaction with the neonatal screening program by Mehmet Akif Sezerol, Zeynep Meva Altaş, Emrullah Arslan

“…A few participants had heard of congenital hypothyroidism (CH), congenital adrenal hyperplasia (CAH), and spinal muscular atrophy (SMA), but they were not aware of the symptoms and effects of these diseases. …”
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Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral Sinularia sandensis through the MAPKs Pathway on Oral Cancer Cells by Rou-Yi Fang, Yueh-Wen Liu, Yih-Gang Goan, Jen-Jie Lin, Jui-Hsin Su, Wen-Tung Wu, Yu-Jen Wu

“…It also curtailed the expression of several key proteins including focal adhesion kinase (FAK), protein kinase C (PKC), growth factor receptor-bound protein 2 (GRB2), Rac, Ras, Rho A, mitogen-activated protein kinase kinase kinase 3 (MEKK3), and mitogen-activated protein kinase kinase 7 (MKK7). …”
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Extracellular vimentin is a damage-associated molecular pattern protein serving as an agonist of TLR4 in human neutrophils by Łukasz Suprewicz, Krzysztof Fiedoruk, Karol Skłodowski, Evan Hutt, Magdalena Zakrzewska, Alicja Walewska, Piotr Deptuła, Agata Lesiak, Sławomir Okła, Peter A. Galie, Alison E. Patteson, Paul A. Janmey, Robert Bucki

“…Results Both eVim and CitVim interact with and trigger TLR4, leading to increased neutrophil migration and adhesion. CitVim stimulated the enhanced migratory ability of neutrophils, activation of NF-κB, and induction of NET formation mainly mediated through reactive oxygen species (ROS)-dependent and TLR4-dependent pathways. …”
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Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study by Lorena González, Carolina Gonzalez-Riano, Pablo Fernández-García, Rubén Cereijo, Aina Valls, Andrea Soria-Gondek, Nativitat Real, Belén Requena, Joan Bel-Comos, Patricia Corrales, David Jiménez-Pavón, Coral Barbas, Francesc Villarroya, David Sánchez-Infantes, Marta Murillo

“…Elevated levels of 1a,1b-dihomo-PGJ2 and adrenic acid suggested potential aging markers. rhGH treatment also significantly reduced meteorin-like (METRNL) and monocyte chemoattractant protein-1 (MCP1) serum levels to control levels. rhGH influences the serum lipidome, promoting changes in maturation and metabolism. …”
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Comparative Evaluation of Functional Outcomes in High Condylar Fractures Treated with Closed Methods with and without Temporomandibular Joint Arthrocentesis: A Research Protocol fo... by Sachindra Dubey, Nitin Bhola, Anchal Agarwal

“…The present procedure aims to alleviate symptoms, improve joint function, and promote healing by removing inflammatory mediators, debris, and adhesions from the joint space. Need of the study: Arthrocentesis offers several advantages over traditional techniques, including reduced trauma, quicker recovery times, and a decreased risk of complications. …”
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Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells by Xiaoming Kang, Xiaoming Kang, Lu Ma, Lu Ma, Lu Ma, Jie Wen, Jie Wen, Wei Gong, Wei Gong, Xianlin Liu, Xianlin Liu, Yihan Hu, Yihan Hu, Zhili Feng, Zhili Feng, Qiancheng Jing, Qiancheng Jing, Yuexiang Cai, Yuexiang Cai, Sijun Li, Xinzhang Cai, Kai Yuan, Yong Feng, Yong Feng, Yong Feng, Yong Feng, Yong Feng

“…Transcriptome analysis revealed that differentially expressed genes were significantly enriched in pathways related to cell proliferation, differentiation, extracellular space and adhesion. Furthermore, significant alterations were noted in the PI3K-Akt signaling pathway and the calcium signaling pathway, which could potentially influence gap junction function and contribute to hearing loss. …”
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Depression in adolescence and young adulthood: the difficulty to integrate motivational/emotional systems by Teodosio Giacolini, Antonio Alcaro, David Conversi, Lorenzo Tarsitani

“…Stress is an expression of the HPA-Hypothalamic-Pituitary-Adrenal axis that articulates with other systems, mainly the autonomic nervous system and the immune-inflammatory system. …”
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Identification of Potential Abnormal Methylation-Modified Genes in Coronary Artery Ectasia by Xiuchun Yang, Yijun Zong, Zhentian Zhang, Yan Zhao, Xueying Gao, Jie Zhang, Qian Hou, Renyi Li, Bing Xiao

“…Some signaling pathways were identified in patients with CAE, including cell adhesion molecule, O-glycan biosynthesis, and the renin–angiotensin system. …”
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Mortero a base de aglutinantes proteínicos y residuos minerales para elementos interiores = Mortar based on protein binders and mineral waste for interior elements by Darío Miguel López-León, María Isabel Prieto-Barrio, Alfonso Cobo-Escamilla

“…Abstract For this work, adaptations have been made of the most outstanding techniques in the history of chemical and hydrothermal treatments aimed at protein extraction for different sources derived from the food industry, on a large scale at present; of which the adhesive properties based mainly on keratin, an organic compound with traces of more than 90% in animal plumage and fur, are taken advantage of. …”
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Gestion, évaluation et stabilisation de cuirs archéologiques provenant de la fouille du boulevard Dr Henri-Henrot à Reims/Durocortorum by Céline Bonnot-Diconne

“…These oxides had penetrated the leather, altered its mechanical properties and rendered it brittle. Cases of nail adhesion on the film coverings, intended to limit the evaporation of the baths, were also noted. …”
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Trimetazidine: Activating AMPK Signal to Ameliorate Coronary Microcirculation Dysfunction after Myocardial Infarction by Xiaolong Qu, Pan Yang, Li Jiao, Yuehui Yin

“…Griess reaction method, immunofluorescence, and western blotting (WB) were employed to detect the expressions of nitric oxide (NO), platelet endothelial cell adhesion molecule-1 (CD31) and vascular endothelial (VE)-cadherin, zonula occludens protein 1 (ZO-1), occludin, vascular endothelial growth factor (VEGF) and adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling-related proteins in endothelial cells and mouse cardiomyocytes. …”
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Aspergillus fumigatus extract modulates human eosinophils via NOD2 and oxidative stress by Hisashi Sasaki, Jun Miyata, Yusuke Kawashima, Ryo Konno, Masaki Ishikawa, Yoshinori Hasegawa, Ryuta Onozato, Yo Otsu, Emiko Matsuyama, Keeya Sunata, Katsunori Masaki, Hiroki Kabata, Yoshifumi Kimizuka, Tomoe Abe, Shigeharu Ueki, Koichiro Asano, Akihiko Kawana, Koichi Fukunaga

“…Results: The A. fumigatus extract changed the expression of adhesion molecules (CD62L and CD11b) and CD69 on the surface of eosinophils, without affecting their viability, via nucleotide-binding oligomerization domain-containing protein 2 (NOD2) but not protease activity. …”
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Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Benediktus Yohan Arman, Rebecca Clarke, Tehmina Bharucha, Laura Gomez Fernandez, John Walsby-Tickle, Michael Deats, Sara Mosca, Qianqi Lin, Sneha Banerjee, Shrikrishna R. Chunekar, Kundan D. Patil, Sunil Gairola, Susanna Dunachie, Hamid A. Merchant, Robert Stokes, Rutendo Kuwana, Alexandrine Maes, Jean-Philippe Charrier, Fay Probert, Céline Caillet, Pavel Matousek, James McCullagh, Paul N. Newton, Nicole Zitzmann, Bevin Gangadharan

“…We demonstrate for the first time that analysis of spectra from the vaccine vial label and its adhesive could be used as a novel approach to detect falsified vaccines. …”
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First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide by Doobyeong Chae, Sae-Woong Oh, Yoon-Seo Choi, Dae-Jung Kang, Chun-Woong Park, Jongsung Lee, Won-Sang Seo

“…Mechanistic studies confirmed that L-PDRN activates the focal adhesion kinase (FAK) and protein kinase B (AKT) signaling pathway through the A2A receptor, similar to PDRN, while also engaging alternative pathways for p38 and ERK phosphorylation, highlighting its signaling versatility. …”
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AcfA Regulates the Virulence and Cell Envelope Stress Response of <i>Vibrio parahaemolyticus</i> by Huan Liu, Huayu Lei, Juanjuan Cao, Zhaobang Xie, Yile Shi, Yanni Zhao

“…The deletion of <i>acfA</i> had no effect on bacterial growth but resulted in a significant reduction in biofilm formation, hemolytic activity, mucus adhesion, and the accumulated mortality of zebrafish, compared to the wild-type strain and the complementary strain <i>acfA</i>⁺. …”
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Como idosas com comprometimento cognitivo lidam com o estressor físico? by Ana Heloisa Nascimento Beserra, Eduardo da Matta Mello Portugal, Patricia Maria Lourenço Dutra, Marcia Cristina Nascimento Dourado, Andrea Camaz Deslandes, Jerson Laks, Helena Sales de Moraes

“… O processo de envelhecimento pode promover alterações no eixo hipotálamo-pituitária-adrenal (HPA), causando desregulação nos níveis de cortisol (resposta e recuperação inadequadas) após um estímulo estressor agudo. …”
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Icariin modulates osteogenic and adipogenic differentiation in ADSCs via the Hippo-YAP/TAZ pathway: a novel therapeutic strategy for osteoporosis by Shaozi Lin, Zuyu Meng, Mei Wang, Zixuan Ye, Mengsha Long, Yiyao Zhang, Fang Liu, Hongling Chen, Menghan Li, Jiajia Qin, Haiquan Liu

“…However, the therapeutic efficacy of ADSCs is hindered by low post-transplantation survival rates and limited capacities for adhesion, migration, and differentiation. Icariin (ICA), the primary active compound of Epimedium, has been shown to promote cell proliferation and induce osteogenic differentiation; however, its specific effects on ADSC osteogenesis and the mechanisms by which ICA enhances osteoporosis treatment through cell transplantation remain inadequately understood.PurposeThis study investigates the effects of different concentrations of ICA on the osteogenic and adipogenic differentiation of rat ADSCs, aiming to elucidate the underlying mechanisms. …”
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Impact of Endurance Exercise Training on Biomarkers of Aortic Endothelial Damage in Diabetic Rats by Mahtab Fouladi, Maryam Mahmoudabady, Zahra Gholamnezhad, Sadegh Shabab, Saeed Niazmand, Hossein Salmani

“…After 6 weeks, biochemical parameters in serum and oxidative stress markers and mRNA expression of endothelial nitric oxide synthase (eNOS), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), and intercellular adhesion molecule-1 (ICAM-1) in aorta tissue were assessed. …”
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