Genome-wide identification, characterization and expression analysis of WRKY transcription factors under abiotic stresses in Carthamus tinctorius L by Zhengwei Tan, Dandan Lu, Yongliang Yu, Lei Li, Lanjie Xu, Wei Dong, Qing Yang, Chunming Li, Xiufu Wan, Huizhen Liang

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Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by Graham McIlroy, Charlotte Gaskell, Aimee Jackson, Emily Yafai, Rachel Tasker, Catherine Thomas, Sonia Fox, Rebecca Boucher, Fitsum Ghebretinsea, Claire Harrison, Adam J. Mead, Mary Frances McMullin

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Functionality of endothelial cells differentiated from porcine epiblast stem cells, bone marrow-derived mesenchymal stem cells and adipose-derived mesenchymal stem cells by Yeon-Ji Lee, In-Won Lee, Tae-Suk Kim, Bo-Gyeong Seo, Sang-Ki Baek, Cheol Hwangbo, Joon-Hee Lee

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Composition of antifungal volatile organic compounds in Sextonia rubra fruit by molecular networks by Levasseur, Marceau, Santerre, Cyrille, Segret, Juliette, Elie, Nicolas, Genty, Christophe, Estevez, Yannick, Amusant, Nadine, Houël, Emeline, Eparvier, Véronique, Touboul, David

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Temporal trends of the utilization patterns of sedative-hypnotic medications in children, adolescents and young adults: a 21-year population-based study with joinpoint regression a... by Carltin Chun Ting Kwok, Heidi Ka Ying Lo, Ching Yui Chan, Joe Kwun Nam Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng, Chung Ho, Brian Man Ho Leung, Wilfred Shone Horn Wong, Zoe Hoi Shuen Yu, Edwin Ho Ming Lee, Wing Chung Chang

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Identification of multiple complications as independent risk factors associated with 1-, 3-, and 5-year mortality in hepatitis B-associated cirrhosis patients by Duo Shen, Ling Sha, Ling Yang, Xuefeng Gu

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Implementation of the Lupus Low Disease Activity State in Pediatric Rheumatology Care: The Role of the Visual Analog Scale by Ekemini A. Ogbu, Anna Carmela P. Sagcal‐Gironella, B. Anne Eberhard, Jennifer M. Huggins, Marisa S. Klein‐Gitelman, Karen Onel, Chen Chen, Bin Huang, Hermine I. Brunner

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Whole-genome resequencing landscape of adaptive evolution in Relict gull (Larus relictus) by Chao Yang, Qingxiong Wang, Kuo Sun, Lei Luo, Hao Yuan, Xuejuan Li, Yuan Huang, Hong Xiao

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Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

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纯氧与空气复苏对缺氧新生大鼠肝细胞凋亡 及Bcl-2和Bax 蛋白表达的影响

“…【目的】 为了比较纯氧与空气复苏对缺氧新生大鼠的复苏效果,探讨新生大鼠肝细胞凋亡及Bcl-265380;Bax蛋白表达在缺氧复苏中的作用65377; 【方法】 采用SD新生大鼠建立缺氧模型,并分组进行纯氧与空气复苏65377;实验分为正常对照组(无预缺氧和复氧实验)65380;纯氧复苏组(PO组) 和空气复苏组(RA组) 65377;取肝组织,HE 染色光镜观察肝组织病理变化,TUNEL法测定肝细胞凋亡指数,免疫组化检测肝组织Bcl-265380;Bax蛋白的表达情况65377;【结果】 与正常对照组相比,PO组可见肝细胞肿胀,肝细胞有部分细胞器缺失,肝细胞呈明显的片状坏死,有炎性细胞浸润,肝细胞索排列紊乱65377;RA组肝细胞索排列基本正常, 肝细胞损伤程度,炎细胞浸润及肝细胞肿胀都较PO组轻65377;PO 24 h及72 h亚组的细胞凋亡指数分别为(11.2 ± 3.2)%和(9.2 ± 1.0)%,RA 24 h及72 h亚组的细胞凋亡指数分别为(9.0 ± 2.9)%和(7.4 ± 1.9)%,均低于相应的PO各亚组(P < 0.01)65377;PO 24 h及72 h亚组Bcl-2蛋白表达(11.55 ± 1.06)%和(10.49 ± 1.03)%, 均低于对应的RA各亚组,RA 24 h及72 h亚组Bcl-2蛋白表达分别为(13.06 ± 2.35)%和(11.71 ± 1.69)%65377;PO 24 h及72 h亚组Bax蛋白表达分别为(4.81 ± 1.13)%和(4.62 ± 0.79)%,均高于对应的RA各亚组,RA 24 h及72 h亚组Bax蛋白表达分别为(4.08 ± 0.31)%和(3.88 ± 0.48)%65377;PO组与RA组的细胞凋亡指数65380;Bcl-2及Bax蛋白表达及Bcl-2/Bax比值差异具有统计学意义(P < 0.01), 各组内亚组之间差异无统计学意义(P > 0.05)65377; 【结论】 纯氧复苏较空气复苏后新生大鼠肝细胞的凋亡更严重65377;纯氧复苏促进Bax基因的表达上调,空气复苏可使凋亡抑制基因Bcl-2表达上调,暗示纯氧复苏对新生大鼠肝的损伤要重于空气复苏65377;…”
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Life history, reproductive, and demographic parameters for bottlenose dolphins (Tursiops truncatus) in Sarasota Bay, Florida by Randall S. Wells, Aleta A. Hohn, Michael D. Scott, Jay C. Sweeney, Forrest I. Townsend, Jason B. Allen, Aaron A. Barleycorn, Katherine A. McHugh, Kim Bassos-Hull, Gretchen N. Lovewell, Deborah A. Duffield, Cynthia R. Smith, A. Blair Irvine

“…Mean annual birth rate was 0.071. Mean annual fecundity was 0.182 births/adult female (defined as females 6 yrs or older). …”
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Magnetic hybrid chitin-horse manure humic acid for optimized Cd(II) and Pb(II) adsorption from aquatic environment by Rahmat Basuki, Yusuf Bramastya Apriliyanto, Elva Stiawan, Adya Rizky Pradipta, Bambang Rusdiarso, Budi Riza Putra

“…In addition, up to five adsorption-desorption cycles, the Cd(II) and Pb(II) adsorption was 84.29 % and 88.71 %, respectively. By the eluent 0.1 M HNO3, desorption of Cd(II) and Pb(II) from the adsorbent surface was 93.87 % and 90.71 %, respectively, demonstrating enhanced recycling potential and cost-effectiveness. …”
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Occupational exposures and coronary heart disease in the Hamburg City Health Study (HCHS) – a cross-sectional study by Franziska Labe, Raphael Twerenbold, Betül Toprak, Peter Koch, Birgit-Christiane Zyriax, Sarah Affolderbach, Lukas Damerau, Hanno Hoven, Hajo Zeeb, Robert Herold, Volker Harth

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NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

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Global metabolome changes induced by environmentally relevant conditions in a marine-sourced Penicillium restrictum by Le, Van-Tuyen, Bertrand, Samuel, Brandolini-Bunlon, Marion, Gentil, Emmanuel, Robiou du Pont, Thibaut, Rabesaotra, Vony, Wielgosz-Collin, Gaëtane, Mossion, Aurélie, Grovel, Olivier

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Evaluation of the cross-immunity between Mycobacterium tuberculosis and Mycobacterium abscessus in vitro by Da Xu, Yujie Gu, Guilian Li, Ruihuan Wang, Shiqi Xiao, Hongyang Duan, Jingwei Jiang, Xiuqin Zhao, Kanglin Wan, Xinyue He, Haican Liu, Yongliang Lou

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Effects of MyBFF@school, a multifaceted obesity intervention program, on anthropometry and body composition of overweight and obese primary schoolchildren by Ruziana Mona Wan Mohd Zin, Abdul Halim Mokhtar, Abqariyah Yahya, Fuziah Md. Zain, Rusidah Selamat, Zahari Ishak, Muhammad Yazid Jalaludin

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Nutritional parameters of sheep fed diets based on grass silage with brewery residue and a concentrate with rice bran by Anderson de Moura Zanine, Breno de Moura Gimenez, Daniele de Jesus Ferreira, Michelle de Oliveira Maia Parente, Henrique Nunes Parente, Edson Mauro Santos, Glayciane Costa Gois, Fleming Sena Campos, Luana Milena Pinheiro Rodrigues, Jessica Maria de Sousa Oliveira, Nelquides Braz Viana, Daimy Salas Aguilar, George de Sousa Lima Paiva, Dilier Olivera Viciedo

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Prevalence of dengue and leptospirosis coinfection and associated mortality rates: a systematic review and meta-analysis by Suraj Tiwari, Mahalaqua Nazli Khatib, Rekha MM, Mandeep Kaur, Girish Chandra Sharma, Puneet Sudan, K. Satyam Naidu, Rajesh Singh, Teena Vishwakarma, Sonam Puri, Muhammed Shabil, Anuradha Yadav, Takveer Singh, Sahil Khurana, Rachana Mehta, Prakasini Satapathy, Renu Sah, Abhay M Gaidhane, Ganesh Bushi

“…The pooled mortality rate among co-infected patients was 9.96% (95% CI: 0–53.49%), with moderate heterogeneity (I² = 71%). The prediction interval for mortality ranged from 0.00 to 100%. …”
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The multi-omics signatures of telomere length in childhood by Congrong Wang, Dries S. Martens, Mariona Bustamante, Rossella Alfano, Michelle Plusquin, Lea Maitre, John Wright, Rosemary R. C. McEachan, Johanna Lepeule, Remy Slama, Marina Vafeiadi, Leda Chatzi, Regina Grazuleviciene, Kristine B. Gutzkow, Hector Keun, Eva Borràs, Eduard Sabidó, Angel Carracedo, Georgia Escarami, Augusto Anguita-Ruiz, Dolors Pelegrí-Sisó, Juan R. Gonzalez, Martine Vrijheid, Tim S. Nawrot

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