Physical activity and content in a variety of physically active learning: an observational case study of real-world practices by Jan-Michael Johansen, Mathias Brekke Mandelid, Mathias Brekke Mandelid, Michael Reinboth, Geir Kåre Resaland, Solfrid Bratland-Sanda

“…All enacted PAL were passively observed by the same observer regarding primary bodily movement, duration, subject, location, collaborative or individual work, and task orientation.ResultsOn average, PAL consisted of 57.8% ± 15.7% sedentary time, 22.9% ± 7.5% light intensity PA, and 19.3% ± 10.8% moderate-to-vigorous intensity PA, displaying a large variety in different PAL segments. …”
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Work rate adjustments needed to maintain heart rate and RPE during high-intensity interval training in the heat by Hillary A. Yoder, Hillary A. Yoder, Anne M. Mulholland, Anne M. Mulholland, Hayley V. MacDonald, Jonathan E. Wingo

“…IntroductionHigher work rates may be sustainable when maintaining target rating of perceived exertion (RPE) compared to maintaining target heart rate (THR) during high-intensity interval training (HIIT) exercise in hot conditions, but may also result in greater thermal strain and cardiovascular drift, as well as greater decrements in maximal oxygen uptake (V˙O2max).PurposeTo test the hypotheses that maintaining target RPE compared to THR during HIIT in the heat results in 1) smaller work rate adjustments, 2) greater thermal and cardiovascular strain, and 3) larger decreases in V˙O2max.MethodsEight adults (4 women) completed a graded exercise test on a cycle ergometer in 22°C and then 4 cycling trials in 35°C, consisting of an 8-min warm-up at 70% maximal heart rate (HRmax) or 12 RPE followed by 1 (15HR and 15RPE) or 5 (43HR and 43RPE) rounds of HIIT (1 round = 4 min work at 90% HRmax or 17 RPE and 3 min recovery at 70% HRmax or 12 RPE) totaling 15 min or 43 min of exercise, respectively. …”
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The Undocumented Experience by Izah Tahir

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Exploring the growth performance, antioxidant capacity, and metabolism of Babylonia areolata in response to yeast selenium supplementation by Yunting Wang, Waqas Ahmed, Sajid Mehmood, Mohsin Mahmood, Lu Wang, Wenjie Ou, Jiannan Li, Jie Yang, Weidong Li, Lianshun Wang

“…Except control group, the experiment involved five other diets, with one containing sodium selenite (1.6 mg Se/kg diet) and three containing graded levels of yeast selenium (L-YSe (2.4 mg Se/kg diet), M-YSe (14.4 mg Se/kg diet), H-YSe (22.5 mg/kg), and one containing yeast (2 g/kg). …”
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Systemic Therapy of Neuroendocrine Neoplasia: Single Center Experience from a Cohort of 110 Consecutive Cases by Karin Mayer, Selina Kiry, Anna Yordanova, Hojjat Ahmadzadehfar, Florian C. Gaertner, Ralph A. Bundschuh, Markus Essler, Maria A. Gonzalez-Carmona, Christian P. Strassburg, Hanno Matthaei, Philipp Lingohr, Savita Bisht, Peter Brossart, Georg Feldmann

“…DCR and PFS for PRRT were 89% and 22 months when administered as monotherapy, versus 100% and 27 months upon combination with somatostatin analog (SSA) therapy. …”
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Investigating a caregiver-assisted social skills group programme for primary and early high school-aged children with acquired brain injury or cerebral palsy: protocol for a pilot... by Koa Whittingham, Roslyn N Boyd, Rose Gilmore, Leanne Sakzewski, Nicola Hilton, Afroz Keramat, Bianca Thompson, Jacqui Barfoot, Christine T Moody

“…Thirty-two school-aged children (grades 3+; 8–13 years) with an ABI or CP and their caregiver(s) will be recruited and randomly assigned to either 12 week PEERS Plus or waitlist usual care. …”
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Factors Influencing the Development of Metachronous Fractures in Patients with Osteoporotic Vertebral Fractures Treated with Conservative Management or Vertebroplasty by Fernando Ruiz Santiago, Lucía Bueno Caravaca, Francisco Garrido Sanz, Paula María Jiménez Gutiérrez, David Luengo Gómez, Mario Rivera Izquierdo, José Manuel Benítez, Antonio Jesús Láinez Ramos-Bossini

“…<b>Results:</b> Of the 90 patients included, 20 (22.2%) developed one or more MFs (15 in CM and 5 in PV groups, respectively; <i>p</i> = 0.037). …”
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Intervertebral Disc Degeneration in Long-Term Postoperative Patients with Adolescent Idiopathic Scoliosis: MRI Evaluation 34-51 Years after Surgery and its Changes during Middle an... by Tsutomu Akazawa, Toshiaki Kotani, Tsuyoshi Sakuma, Yasushi Iijima, Yoshiaki Torii, Jun Ueno, Atsuhiro Yoshida, Ken Tomochika, Sumihisa Orita, Yawara Eguchi, Kazuhide Inage, Yasuhiro Shiga, Junichi Nakamura, Yusuke Matsuura, Takane Suzuki, Hisateru Niki, Seiji Ohtori, Shohei Minami

“…DD was evaluated using the Pfirrmann grading system. Various factors, such as surgical levels, sagittal alignment, and PROMs, were analyzed for their association with DD. …”
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Factors associated with early childhood development: results from the Brazilian National Survey on Child Nutrition (ENANI-2019) by Gilberto Kac, Nadya Helena Alves-Santos, Dayana Rodrigues Farias, Nathalia Cristina Freitas-Costa, Raquel Scincaglia, Paula Normando, Inês Rugani, Elisa Maria de Aquino Lacerda, Sandra Crispim, Alexandra Valeria Maria Brentani, Claudia Regina Lindgren Alves

“…The developmental age was estimated using the graded response models. DQ was calculated by dividing developmental age by chronological age. …”
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Comparison of dark-field chest radiography and CT for the assessment of COVID-19 pneumonia by Florian T. Gassert, Henriette Bast, Henriette Bast, Henriette Bast, Theresa Urban, Theresa Urban, Theresa Urban, Manuela Frank, Manuela Frank, Felix G. Gassert, Konstantin Willer, Konstantin Willer, Rafael C. Schick, Rafael C. Schick, Bernhard Renger, Thomas Koehler, Thomas Koehler, Alexandra Karrer, Andreas P. Sauter, Alexander A. Fingerle, Marcus R. Makowski, Franz Pfeiffer, Franz Pfeiffer, Franz Pfeiffer, Franz Pfeiffer, Daniela Pfeiffer, Daniela Pfeiffer

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Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide by Marla Christen, Marla Christen, Aline Buergin, Aline Buergin, Maamed Mademilov, Maamed Mademilov, Laura Mayer, Laura Mayer, Simon R. Schneider, Simon R. Schneider, Mona Lichtblau, Mona Lichtblau, Talant M. Sooronbaev, Talant M. Sooronbaev, Silvia Ulrich, Silvia Ulrich, Konrad E. Bloch, Konrad E. Bloch, Michael Furian, Michael Furian

“…We assessed electrocardiogram (ECG)-derived signs of cardiac ischemia and the effects of preventive acetazolamide therapy in COPD patients traveling to high altitudes.MethodsPatients with COPD [Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) grades 2–3] and a predicted forced expiratory volume in 1 s (FEV1) of 66 ± 11% (mean ± SD), aged 57 ± 8 years, and living &lt;1,000 m were included in this analysis of secondary outcomes from a randomized placebo-controlled double-blind trial (www.clinicaltrials.gov, NCT03156231). …”
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Prospective Analysis of Confocal Laser Endomicroscopy for Assessment of the Resection Bed for Bladder Tumor by Ben-Max de Ruiter, Jan E. Freund, C. Dilara Savci-Heijink, Jons W. van Hattum, Marinka J. Remmelink, Theo M. de Reijke, Joyce Baard, Guido M. Kamphuis, D. Martijn de Bruin, Jorg R. Oddens

“…Key findings and limitations: Histopathology for 22 CLE-matched RB biopsies revealed rT in four cases (18%) and DM in 13 (59%). …”
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Presenting the model of work and technology curriculum in secondary schools of Fars province by Hamzeh Rahpeyma, Seyedahmad Hashemi, Abbas Gholtash

“…The research findings showed that according to the values ​​of standard coefficients and significant t coefficients, it can be said that the goals and content component (β = 0.63) has a significant role in the model, and the teaching and evaluation method component (β = 0.22) has a significant role in the program model of curriculum work and technology in secondary school. …”
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Clinical Recommendations of Russian Gastroenterological Association and RENDO Endoscopic Society on Diagnosis and Treatment of Gastritis and Duodenitis by V. T. Ivashkin, I. V. Maev, T. L. Lapina, E. D. Fedorov, A. A. Sheptulin, A. S. Trukhmanov, A. V. Kononov, R. A. Abdulkhakov, O. P. Alexeeva, S. A. Alekseenko, D. N. Andreev, E. K. Baranskaya, N. N. Dekhnich, I. L. Klyaritskaya, R. S. Kozlov, E. A. Kogan, M. P. Korolev, N. V. Korochanskaya, S. A. Kurilovich, M. A. Livsan, M. F. Osipenko, P. V. Pavlov, S. S. Pirogov, A. S. Sarsenbaeva, V. I. Simanenkov, A. S. Tertychny, A. V. Tkachev, Yu. P. Uspensky, I. B. Khlynov, V. V. Tsukanov

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A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in... by Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

“…All treatment-emergent adverse events were transient, non-dose dependent, and graded mild to moderate in severity. Nebulization was well-tolerated and completed in an average of 6 min. …”
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SARS-CoV-2 infections in pediatric and young adult recipients of chimeric antigen receptor T-cell therapy: an international registry report by Hongyan Liu, Colleen Callahan, Shannon L Maude, Kevin Owen McNerney, Rebecca M Richards, Paibel Aguayo-Hiraldo, Friso G Calkoen, Julie-An Talano, Amy Moskop, Adriana Balduzzi, Jennifer Krajewski, Hema Dave, Anant Vatsayan, Yimei Li, Kara Lynn Davis

“…SARS-CoV-2-associated illness was graded as asymptomatic, mild, moderate, or severe COVID-19, or multisystem inflammatory syndrome in children (MIS-C). …”
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Photoaging smartphone app promoting poster campaign to reduce smoking prevalence in secondary schools: the Smokerface Randomized Trial: design and baseline characteristics by Michael Kreuter, Fabian N Fries, Titus J Brinker, Ute Mons, David A Groneberg, Anil Batra, Werner Seeger, Felix Herth, Julia Holzapfel, Tanja G Baudson, Katharina Sies, Lena Jakob, Hannah Maria Baumert, Marlene Heckl, Ana Cirac, Janina L Suhre, Verena Mathes, Hannah Spielmann, Nancy Rigotti, Tobias Raupach, Henning Gall, Claudia Bauer, Pat Marek, Chase H Harrison, Lava Taha, Andreas Owczarek, Felix J Hofmann, Roger Thomas

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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

“…Intervention effects were assessed by both random-effects and fixed-effect model meta-analyses, risk of bias assessments were performed by two independent review authors using Cochrane’s risk of bias tool V.2 and the certainty of evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation.Results We included 28 trials randomising a total of 7872 participants. …”
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Two-field mydriatic fundus photography to assess the prevalence of macular disorder in diabetes by T.A. Avanesova, Zh.G. Oganezova, V.V. Anisimova, A.B. Baeva, D.H. Miaev

“…The mean disease duration was 9.02±7.22 years. 58.31% of the patients had a history of hypertension and 13.08% a history of smoking. …”
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Surgical stabilization of rib fractures (SSRF): the WSES and CWIS position paper by Giacomo Sermonesi, Riccardo Bertelli, Fredric M. Pieracci, Zsolt J. Balogh, Raul Coimbra, Joseph M. Galante, Andreas Hecker, Dieter Weber, Zachary M. Bauman, Susan Kartiko, Bhavik Patel, SarahAnn S. Whitbeck, Thomas W. White, Kevin N. Harrell, Daniele Perrina, Alessia Rampini, Brian Tian, Francesco Amico, Solomon G. Beka, Luigi Bonavina, Marco Ceresoli, Lorenzo Cobianchi, Federico Coccolini, Yunfeng Cui, Francesca Dal Mas, Belinda De Simone, Isidoro Di Carlo, Salomone Di Saverio, Agron Dogjani, Andreas Fette, Gustavo P. Fraga, Carlos Augusto Gomes, Jim S. Khan, Andrew W. Kirkpatrick, Vitor F. Kruger, Ari Leppäniemi, Andrey Litvin, Andrea Mingoli, David Costa Navarro, Eliseo Passera, Michele Pisano, Mauro Podda, Emanuele Russo, Boris Sakakushev, Domenico Santonastaso, Massimo Sartelli, Vishal G. Shelat, Edward Tan, Imtiaz Wani, Fikri M. Abu-Zidan, Walter L. Biffl, Ian Civil, Rifat Latifi, Ingo Marzi, Edoardo Picetti, Manos Pikoulis, Vanni Agnoletti, Francesca Bravi, Carlo Vallicelli, Luca Ansaloni, Ernest E. Moore, Fausto Catena

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