Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors by Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu

“…The biological evaluation of compound 8 was performed by transwell, flow cytometry, laser scanning confocal microscopy, Western blot, CTESA and immunohistochemistry. …”
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Medium- to long-term health condition of patients post-COVID-19, exercise intolerance and potential mechanisms: A narrative review and perspective by Fabian Schwendinger, Denis Infanger, Debbie J Maurer, Thomas Radtke, Justin Carrard, Julia M Kröpfl, Aglaia Emmenegger, Henner Hanssen, Christoph Hauser, Udo Schwehr, Hans H Hirsch, Julijana Ivanisevic, Karoline Leuzinger, Aurélien E Martinez, Marc Maurer, Thomas Sigrist, Lukas Streese, Roland von Känel, Timo Hinrichs, Arno Schmidt-Trucksäss

“…Endothelial dysfunction was seen on micro- and macrovascular levels using retinal vessel imaging methods and brachial artery flow-mediated dilation, respectively. Studies reporting blood biomarkers of disease-specific impairment and endothelial dysfunction yielded upregulated inflammation, hypercoagulability, organ and endothelial damage up to several months after infection. …”
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The United States and the Challenges of the Hashemite Kingdom of Jordan’s Internal Stability: A Historical Retrospective by L. R. Khlebnikova

“…Moreover, it was the steady flow of foreign assistance that allowed the Jordanian monarchy to halt promised reforms. …”
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Experimental and Numerical Investigation on Infilled Vertical Well LASER-Assisted SAGD by Ding Chao, Wu Yongbin, Yang Guo, Luo Chihui

“…The scaled two-dimensional physical experiment results show that the solvent-assisted vertical well huff-n-puff has the key mechanism of reducing injection pressure and porous flow resistance, expanding the sweep region of injected fluid and accelerating thermal communication. …”
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The role of homogenization cycles and Poloxamer 188 on the quality of mitochondria isolated for use in mitochondrial transplantation therapy by Ryosuke Takegawa, Kei Hayashida, Atsushi Murao, Yusuke Endo, Cyrus E. Kuschner, Jacob Kazmi, Eriko Nakamura, Ping Wang, Lance B. Becker

“…MitoTracker Deep Red (MTDR) staining and flow cytometry were used to assess mitochondrial purity, while the JC-1 assay evaluated membrane potential. …”
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Laser Beam Welding of AA5052, AA5083, and AA6061 Aluminum Alloys by A. El-Batahgy, M. Kutsuna

“…Porosity was prevented by accurate cleaning of the base metal prior to welding and optimizing the flow rate of argon shielding gas. Solidification cracking was avoided through two different approaches. …”
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The Intracellular Growth of M. tuberculosis Is More Associated with High Glucose Levels Than with Impaired Responses of Monocytes from T2D Patients by Martha Torres, María Teresa Herrera, Guadalupe Fabián-San-Miguel, Yolanda Gonzalez

“…To evaluate whether M. tuberculosis infection susceptibility is associated with an intrinsic factor in monocytes from type 2 diabetes (T2D) patients or it is associated with hyperglycemia per se, we analyzed TLR-2 and TLR-4 expression by flow cytometry and the cytokines IL-1β, IL-6, IL-8, IL-10, and TNF-α by cytometric bead array assays, either stimulated with TLR-2 and TLR-4 ligands or infected with M. tuberculosis in the whole blood from T2D patients (n=43) and healthy subjects (n=26) or in CD14+ monocytes from healthy subjects cultured in high glucose (HG) (30 mM). …”
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Granulocyte-Macrophage Colony-Stimulating Factor-Activated Neutrophils Express B7-H4 That Correlates with Gastric Cancer Progression and Poor Patient Survival by Zhi-guo Shan, Zong-bao Yan, Liu-sheng Peng, Ping Cheng, Yong-sheng Teng, Fang-yuan Mao, Kun Fan, Yuan Zhuang, Yong-liang Zhao

“…Here, immunohistochemistry, real-time PCR, and flow cytometry analyses were performed to examine levels and phenotype of neutrophils in samples from 41 patients with GC, and also isolated, stimulated, and/or cultured neutrophils for in vitro regulation assays. …”
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Hardcoded vulnerability detection approach for IoT device firmware by Chao MU, Xin WANG, Ming YANG, Heng ZHANG, Zhenya CHEN, Xiaoming WU

“…With the popularization of IoT devices, more and more valuable data is generated.Analyzing and mining big data based on IoT devices has become a hot topic in the academic and industrial circles in recent years.However, due to the lack of necessary detection and protection methods, many IoT devices have serious information security risks.In particular, device hard-coded information is closely related to system encryption and decryption, identity authentication and other functions, which can provide confidentiality protection for core data.Once this information is exploited by malicious attackers, serious consequences such as sensitive information leakage, backdoor attacks, and unauthorized logins will occur.In response to this problem, a multi-type character recognition and positioning scheme was designed and a hard-coded vulnerability detection method in executable files was proposed based on the study of the characteristics of hard-coded vulnerabilities in IoT devices.The proposed method extracted the firmware of IoT devices and filtered all executable files as the source to be analyzed.Then, a solution to identify and locate three types of hard-coded characters was provided.Further, the reachability of the function, where the hard-coded character was located, was analyzed according to the function call relationship.Meanwhile, the instruction heterogeneity was mitigated by an intermediate representation (IR) model.The character and parameter hard-coded values was obtained through a data flow analysis approach.A symbolic execution method was devised to determine the trigger conditions of the hard-coded vulnerabilities, and then the vulnerability detection result was output.On the one hand, the proposed method introduced the method of symbolic execution based on the use of the intermediate representation model, which eliminated the dependency of instruction architecture and reduces the false positive rate of vulnerabilities; On the other hand, this method can integrate characters, files, and cryptographic implementation to realize the different characteristics of three types of hard-coded characters, which increased the coverage of vulnerability detection and improves the versatility of the detection method.The experimental results show that the proposed method can effectively detect three types of hard-coded vulnerabilities of characters, files and cryptographic implementation in various IoT devices, and has good detection accuracy, which can provide certain guidance for the deployment of subsequent security protection technologies.…”
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CAR T-cell detection scoping review: an essential biomarker in critical need of standardization by Naomi Taylor, Nirali N Shah, David P Turicek, Victoria M Giordani, Josquin Moraly

“…Across the array of CAR T-cell constructs, flow cytometry and quantitative PCR were identified as the two primary techniques for detecting CAR T-cells. …”
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Aspects of Growth Hormone and Insulin-Like Growth Factor-I Related to Neuroprotection, Regeneration, and Functional Plasticity in the Adult Brain by N. David Åberg, Katarina Gustafson Brywe, Jörgen Isgaard

“…The functional role of GH and IGF-I in the adult brain will be reviewed with reference to neurotransmitters, glucose metabolism, cerebral blood flow, gap junctional communication, dendritic arborization, exercise, enriched environment, depression, learning, memory, and aging.Briefly, these findings suggest that IGF-I functions as a putative regenerative agent in the adult CNS. …”
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Synthesis and Characterization of Green Zinc Oxide Nanoparticles with Antiproliferative Effects through Apoptosis Induction and MicroRNA Modulation in Breast Cancer Cells by Amir Hossein Aalami, Mohammad Mesgari, Amirhossein Sahebkar

“…Moreover, apoptosis assays were performed using morphological analysis, fluorescent dyes, flow cytometry, and evaluation of caspase-3 and caspase-8 gene expression. …”
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Investigating the Efficiency of Coffee Husks in Bio-Retention Model for Storm Water Treatment. by Musasizi, Joseph

“…Storm water from rooftops, paved areas, bare soil and sloped lawns transports eroded soil, animal wastes, litter, salts, pesticides, fertilizers, oil and grease and other potential pollutants which flows directly into the streams and rivers. This spoils the stream water quality and thereby causing a decline in aquatic biota. …”
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Student Councils and Management Of Discipline in Selected Secondary Schools in Kamwenge District. by Wilson, Hakiza

“…The researcher recommended that teachers in charge of students’ Council should ensure that there is effective flow of information between administration and students; school councils should also be empowered with skills that will enable them to thwart any planned strikes and the Ministry of Education should come up with a policy framework for training of student leaders which will lead to improvement of discipline in Ugandan secondary schools.…”
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Addressing Shortcomings in Contingency Standards of Care by Alexander Quan

“…For example, moving ICU patients to lower levels of care once they have sufficiently recovered is a challenge for doctors, who often call other hospitals to find open beds. …”
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Prevalence and predictors of permanent pacemaker implantation in patients with aortic stenosis undergoing transcatheter aortic valve implantation: a prospective cohort study by Erlend Eriksen, Ronak Rajani, Sahrai Saeed, Svein Rotevatn, Daanyaal Wasim, Øyvind Bleie, Abukar Mohamed Ali, Erik Jerome Stene Packer, Håvard Keilegavlen

“…Among the 548 eligible patients, 173 (31.6%) underwent pacemaker implantation ≤30 days following TAVI, evenly distributed between females and males (29.6% vs 33.6%, p=0.317), with higher implant rates at low-volume phase (2012–2015) and lower implant rates at high-volume phase (2016–2019) (45.8% vs 23.9%, p<0.001). …”
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Over 20-year Follow-up Result of Total Knee Arthroplasty for Knee Arthropathy: A Single Center Cohort Study by XU Yiming, HU Mingwei, ZHU Wei, YU Muyang, LIN Jin, JIN Jin, QIAN Wenwei, FENG Bin, WENG Xisheng

“…The HSS score at the last follow-up was lower than that at 10- year postoperative follow-up[(84.69±11.03) scores vs. (95.25±13.32) scores, P < 0.05], but significantly improved compared with the preoperative[(84.69±11.03) scores vs. (58.75±7.19) scores, P < 0.05]. …”
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Risk Factors for Acute Febrile Reaction after Zoledronic Acid Treatment for Primary Osteoporosis by WU Hongliang, ZHENG Sihang, ZHANG Enchong, HOSSAIN Mohammad Showkat, GONG Helong, XING Ruida, JING Shengjie, LI Yan

“…The group with medication history had a lower fever rate (<italic>P</italic>&lt;0.01, area under ROC curve was 0.34). …”
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HHO–LSSVM prediction model of blast casting muck pile morphology based on Gaussian distribution by Ning MA, Li MA, Yinda LI, Tianxiang LI, Sen YANG, Fuming LIU, You ZHOU, Xiaomin WANG, Qifeng ZHANG, Mengbo LI

“…The minimum resistance line, row spacing, explosive consumption, step height, lower mouth width of goaf, slope angle, and upper mouth width of goaf were selected as input parameters for the prediction model. …”
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The Impact of Acute Aerobic Exercise on General and Food-Related Inhibitory Function Among Young Adults with Obesity: An Event-Related Potential (ERP) Study by Chun Xie, Tao Huang, Yingying Wang, Peisi Wang, Yanxia Chen, Jiali Qian, Guozhuang Chen, Kun Wang

“…Additionally, food stimuli (both high- and low-calorie) resulted in lower No-go accuracy and smaller N2 amplitudes compared to neutral stimuli. …”
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