Evaluation of circulating tumor DNA as a prognostic and predictive biomarker in BRAF V600E mutated colorectal cancer—results from the FIRE‐4.5 study by Susanne Klein‐Scory, Alexander Baraniskin, Wolff Schmiegel, Thomas Mika, Roland Schroers, Swantje Held, Kathrin Heinrich, David Tougeron, Dominik P. Modest, Ingo Schwaner, Jan Eucker, Rudolf Pihusch, Martina Stauch, Florian Kaiser, Christoph Kahl, Meinolf Karthaus, Christian Müller, Christof Burkart, Sebastian Stintzing, Volker Heinemann

“…Follow‐up LBs were obtained from 51 patients. Patients converting from BRAF V600E mutant to a BRAF V600 wild‐type status (36%, N = 18) had a superior PFS (8.6 vs 2.3 months; P = 0.0002) and OS (17.4 vs 5.1 months; P < 0.0001) compared to patients with stable or increased mutational allele frequency (12%, N = 6). …”
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Phenolic acids from Anisopus mannii modulates phosphofructokinase 1 to improve glycemic control in patients with type 2 diabetes: A double-blind, randomized, clinical trial by Peter U. Amadi, Justice O. Osuoha, Chidi N. Ekweogu, Suha J. Jarad, Esienanwan E. Efiong, Prince C. Odika, Chioma Ejiofor, Oluchi Aloy-Amadi, Govind S. Gill, Chiamaka W. Adumekwe, Ailun Gaowa, Dawei Zhang, Barbora de Courten, Emmanuel N. Agomuo

“…Phenolic acid-rich fraction from Anisopus mannii (PhAM) contains abundance of ferulic acid, gallic acid, protocatechuic acid, and syringic acid. …”
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Demographic variation and socioeconomic inequalities in all forms of malnutrition among children aged 6 months to 9 years: findings from the Vietnamese General Nutrition Survey 2020 by J Bernadette Moore, Xiaodong Lin, Louise Dye, Van Khanh Tran, Yun Yun Gong, Xiaomian Tan, Pui Yee Tan, Somphos Vicheth Som, Son Duy Nguyen, Do Tranh Tran, Nga Thuy Tran, Samantha Caton, Hannah Ensaff, Geoffry Smith

“…Males (1.43 (1.16, 1.76)), children aged 5–9 years (10.02 (6.71, 14.97) and children from the richest quintile (2.91 (1.20, 7.05)) had increased odds of overweight. …”
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Microbial Load and Antibiotic Resistance of Escherichia coli and Staphylococcus aureus Isolated from Ready-to-Eat (RTE) Khebab Sold on a University Campus and Its Environs in Ghana by Azumah Ayamah, Augustina Angelina Sylverken, Linda Aurelia Ofori

“…Thirty-six (36) khebab samples were purchased from vendors at Kotei, Ayeduase, Kentinkrono, Boadi, KNUST campus, and Ayigya. …”
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A Prospective Single-Arm Cohort Study of Immune-mediated Seizures/Epilepsy Without Encephalopathy (ISEWE) in Children from a Tertiary Care Hospital in South India by Basavanagowda Thanuja, Mahesh Kamate

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Global, regional and national burden of tracheal, bronchus, and lung cancer attributable to ambient particulate matter pollution from 1990 to 2021: an analysis of the global burden of disease study by Jianguo Lu, Xiangmei Zhao, Shaoyin Gan

“…Methods Leveraging data from the Global Burden of Disease (GBD) 2021 study, we analyzed the worldwide burden of TBL cancer resulting from ambient particulate matter pollution using indices including disability-adjusted life years (DALYs), age-standardised rate of DALYs (ASDR). …”
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Time to dietary diversity of complementary feeding improvements and its associated factors among infants aged 6–12 months in Ethiopia: evidence from performance monitoring for action by Feyisa Shasho Bayisa, Teshome Demis Nimani, Samuel Demissie Darcho, Abainash Tekola

“…The aim of this study is to determine the time to improvement in dietary diversity and associated factors in infants aged 6 to 12 months.MethodsThe study used secondary data from the PMA Ethiopia longitudinal panel survey, involving pregnant women from January to March 2024. …”
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Health and Experiences During the COVID-19 Pandemic Among Children and Young People: Analysis of Free-Text Responses From the Children and Young People With Long COVID Study by Natalia K Rojas, Sam Martin, Mario Cortina-Borja, Roz Shafran, Lana Fox-Smith, Terence Stephenson, Brian C F Ching, Anaïs d'Oelsnitz, Tom Norris, Yue Xu, Kelsey McOwat, Emma Dalrymple, Isobel Heyman, Tamsin Ford, Trudie Chalder, Ruth Simmons, Snehal M Pinto Pereira

“…Qualitative explorations reveal heterogeneity, with themes ranging from feelings of loss to growth and development. …”
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Parenting with nutrition education and unconditional cash reduce maternal depressive symptoms and improve quality of life: findings from a cluster randomised controlled trial in urban Bangladesh by Sheikh Jamal Hossain, Fahmida Tofail, Anisur Rahman, Jane Fisher, Jena Derakhshani Hamadani, Syed Moshfiqur Rahman

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Nonsevere Hypoglycemia Episode Clinical and Economic Outcomes: A Comparison between Sulfonylurea and Sodium-Glucose Cotransporter 2 Inhibitor as Add-On to Metformin from a Canadian Perspective by Pendar Farahani

“…Risk difference for NSHEs was calculated for SU and SGLT2i from RCT data. Estimation of NSHEs attributable to SU utilization in Canada was calculated from published data. …”
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The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K+ channels by Xiong Weichen, Fan Huizhen, Zeng Qingye, Deng Zhenhui, Li Guanhui, Lu Wancheng, Zhang Bei, Lai Shian, Chen Xin, Xu Xueqing

“…We previously identified and reported a salivary protein from the Xenopsylla cheopis, FS48, which exhibited inhibitory activity against Kv1.1-1.3 channels when assayed in HEK 293T cells. …”
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Valorization of Glycine max (Soybean) Seed Waste: Optimization of the Microwave-Assisted Extraction (MAE) and Characterization of Polyphenols from Soybean Meal Using Response Surface Methodology (RSM) by Cerile Ypolyte Woumbo, Dieudonné Kuate, Mathilde Julie Klang, Hilaire Macaire Womeni

“…The present study aimed at determining the optimal conditions for extraction of total phenolic compounds from soybean (Glycine max) meal, a by-product of the soybean seeds industry, using a green protocol with microwave-assisted extraction (MAE). …”
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Predictive value of ENLIGHT-DP in patients with metastatic lung adenocarcinoma treated with immune checkpoint inhibitors and platinum chemotherapy directly from histopathology slides using inferred transcriptomics by Eli Pikarsky, Anna Elia, Gal Dinstag, Omer Tirosh, Tuvik Beker, Ranit Aharonov, Hovav Nechushtan, Leon Gugel, Yaron Kinar, Michael Tabi, Tzivia Gottlieb, Aron Popovtzer, Johnathan Arnon, Yakir Rottenberg, Philip Blumenfeld

“…ENLIGHT-DP predicts response to ICI and targeted therapies given H&amp;E slide scans in two steps: (1) predict individual messenger RNA expression directly from high-resolution H&amp;E scanned slides using DeepPT, a digital-pathology-based algorithm. (2) Use these values as input to ENLIGHT, a transcriptome-based platform that predicts response to ICI and targeted therapies derived from drug-specific networks of gene expressions. …”
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Valorization of <i>Cynara cardunculus</i> L. var. <i>scolymus</i> Processing By-Products of Typical Landrace “Carciofo Di Montelupone” from Marche Region (Italy) by Laura Alessandroni, Lorenzo Bellabarba, Samanta Corsetti, Gianni Sagratini

“…Food waste is a growing global problem that originates from a variety of sources, with about 38% of it coming from food processing. …”
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Development of a Solid-Phase Extraction (SPE) Cartridge Based on Chitosan-Metal Oxide Nanoparticles (Ch-MO NPs) for Extraction of Pesticides from Water and Determination by HPLC by Mohamed E. I. Badawy, Mahmoud A. M. El-Nouby, Abd El-Salam M. Marei

“…Factorial experimental design was applied to study the effect of pH, concentration of pesticide, agitation time, and temperature on the efficiency of adsorption of pesticides from water samples. The results indicated that optimum conditions were pH of 7, temperature of 25°C, and agitation time of 25 min. …”
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Comparative Evaluation of Whole Body and Hepatic Insulin Resistance Using Indices from Oral Glucose Tolerance Test in Morbidly Obese Subjects with Nonalcoholic Fatty Liver Disease by Kamran Qureshi, Ronald H. Clements, Fahad Saeed, Gary A. Abrams

“…Whole body IR was significantly higher in both FL and NASH groups (NAFLD) as compared to Normal, while hepatic IR was higher only in NASH from Normal. Conclusions. FL is a manifestation of peripheral IR but not hepatic IR.…”
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Under-Five Mortality in Buea Health District, Southwest Cameroon: Evidence from a Community-Based Birth Cohort Study of Rate, Causes, and Age-Specific Patterns by Ettamba Agborndip, Benjamin Momo Kadia, Domin Sone Majunda Ekaney, Lawrence Tanyi Mbuagbaw, Marie Therese Obama, Julius Atashili

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Molecular characterization of feline caliciviruses isolated from several adult cats with atypical infection showing severe flu-like symptoms on a remote island in Ehime, Japan by Yuki Nishisaka, Hikaru Fujii, Fumiko Ono, Sho Kadekaru, Hiroyuki Kogiku, Yumi Une, Shione Takeguchi, Naomi Ohta, Masumi Eto, Chiharu Takeuchi, Seigou Takeuchi, Tetsuko Miki, Akihiko Tokuda, Keiko Ookawa, Yukinobu Tohya, Keita Ishijima, Akiko Okutani, Ken Maeda, Shumpei Watanabe, Shigeru Morikawa

“…We further isolated typical strains from western Japan (Osaka, Kumamoto, and Ehime) and analyzed the viral genes along with virulent strains from Aoshima. …”
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Factors associated with preventive health services use by older war-displaced Japanese returning from China and by older Korean residents of Japan: a descriptive correlational study by Chu Hyang Oh

“…Abstract Background Among the people with diverse backgrounds and cultural customs living in Japan, two important groups, namely, war-displaced Japanese returning from China and South and North Korean nationals who are naturalized citizens residing in Japan, will experience population aging in the same way as the general Japanese population. …”
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Clinical characteristics, therapeutics, and treatment outcomes of adult patients with anti-melanoma differentiation-associated gene 5 dermatomyositis: A single-center experience from South India by Shivraj Padiyar, Aswin M Nair, Bijesh Yadav, Prathyusha Manikuppam, Jha Avanish, Abhilasha Arvind Manwatkar, John Mathew

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