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    Potential therapeutic benefits of curcumin in depression or anxiety induced by chronic diseases: a systematic review of mechanistic and clinical evidence by Jiyuan Yuan, Jiyuan Yuan, Jiyuan Yuan, Chao Pi, Hongping Shen, Bi Zhou, Yumeng Wei, Nathupakorn Dechsupa, Ling Zhao, Ling Zhao

    Published 2025-08-01
    “…Nevertheless, this review provides a comprehensive overview of the current clinical and mechanistic evidence supporting curcumin's role as an adjunctive treatment for depression and anxiety associated with various chronic diseases such as type 2 diabetes, obesity, migraines, arthritis, coronary heart disease, irritable bowel syndrome, inflammatory bowel disease, and metabolic syndromes.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?…”
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    Xenobiotic-induced liver injury: Molecular mechanisms and disease progression by Lu Wang, Zigong Shao, Xiaobei Wang, Wenqiu Lu, Hong Sun

    Published 2025-09-01
    “…Evidence from recent cohort studies and in vivo models highlights that even low-dose, chronic exposures can lead to subtle yet progressive liver dysfunction, often modulated by host factors such as sex, age, diet, and pre-existing metabolic conditions. Mechanistically, xenobiotics exert hepatotoxic effects through pathways including cytochrome P450-mediated bioactivation, oxidative stress, mitochondrial impairment, DNA damage, inflammation, and immune dysregulation. …”
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