Effect of Berberine on the Inflammatory Response of ANA-1 Cells Induced by Angiotensin Ⅱ Based on TLR4 Signaling Pathway by GAO Dexing, JIA Peizhi, PENG Jun, LIN Wei

“…Compared with the control group, the expression of TLR4, p-p65 protein of the model group after intervention for 12 h was significantly increased, the expression of TLR4, p-p65 protein of the model + the high dose BBR group, the model group + the inhibitor group, the model group + the inhibitor group + the high dose BBR goup was significantly decreased. ⑥ Biochemical test results: compared with the control group, the content of MDA of the model group was significantly increased, SOD activity was significantly decreased, the difference was statistically significant (<italic>P</italic>&lt;0.05), the content of MDA in the model group + the low, medium and high dose BBR group was significantly down-regulated, SOD activity was significantly increased, the difference was statistically significant (<italic>P</italic>&lt;0.05).ConclusionBBR can regulate TLR4 signaling pathway and inhibit the abnormal activation of TLR4 signaling pathway induced by Ang Ⅱ and NF-κB, MAPK signal transduction, and reduce the content of proinflammatory factors and regulate inflammatory response; in addition, BBR can also improve the lipid peroxidation and antioxidant ability of ANA-1 cells induced by Ang Ⅱ, reduce the oxidative stress damage caused by Ang Ⅱ, and protect ANA-1 cells.…”
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Une cave à amphores, une statue en pierre et une tête coupée de la fin de l’âge du Fer à Châteaumeillant (Cher) by Sophie Krausz, Caroline Millereux, Marion Bouchet, Fabienne Olmer

“…Below this ring, the statue was previously and intentionally broken. Following this damage, the upper portion of the statue (head and torso) was deposited in the well, while the base was found in a small pit in Zone B, located 8 m north of the well. …”
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Çarlık Rusya’nın Uyguladığı İstila ve Asimile Siyasetine KarşıBaşkırtların Çıkarttığı İsyanlar XVII. Yüzyılın İkinci Yarısıve XVIII. Yüzyıl by Orhan Doğan

“…Kese Sultan’a Kalmuk Prensi ve damadıve ayrıca Sibirya’da yaşayan Kazaklarla birlikte diğer Türk boylarıda Başkırtlara destek vermişkısa süren kısmî başarılara imza atılmıştı. …”
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Diseño de losas de hormigón con geometría optimizada Design of concrete pavement with optimized slab geometry by Juan Pablo Covarrubias V.

“…Slabs' cracking is determined by calculating concrete fatigue damage and models employed by the design guide AASHTO, 2007, and by means of calibration test sections on large scale. …”
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Contribution à l’histoire de la boulangerie romaine : étude de « pains/galettes » découverts en Gaule by Andreas G. Heiss, Véronique Matterne, Nicolas Monteix, Margaux Tillier, Camille Noûs

“…Protocols of study are still being refined, in particular for the recognition of fermented doughs, and the criteria that would make it possible to differentiate a bread from a flatbread, for example. Without damaging the archaeological specimen, X-ray microtomography allows for an observation of the internal structure of the dough and the gas bubbles (pores) produced by fermentation, as well as inclusions and additions of ingredients other than flour. …”
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Effects of Conditioning Temperature on Pellet Quality, Nutrients Digestibility, and Metabolizable Energy of Broilers Diet by Seyedeh Vajiheh Shakhese Emampour, Abolghasem Golian, Heydar Zarghi, Ali Reza Hesabi Nameghi

“…The use of high conditioning temperatures can damage the nutrients in the feed, leading to reduced nutrient intake and decreased bird performance. …”
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Deviant Behaviors of Students in Educational System: A Meta-synthesis Model-Building Theory by Mehdi Mohammaadi, Farzane Deimehkar Haghighi

“…Students exhibiting deviant behavior often threatened teachers, school officials, and even their parents, disrupted the school environment, and damaged school property.…”
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Predictive factors' modeling of entrepreneurial opportunities in international companies by Ali Farahani, Younos Vakil Alroaia, Farideh Haghshenaskashani, Ali Faez

“…According to the results of the research, the following suggestions are presented: - continuous monitoring of changes and trends in society; these changes, which are influenced by social and economic factors and government policies, create new challenges and opportunities for companies that can make the best use of these opportunities with careful planning; - Creating an open communication channel in the company environment; If there is no open communication in the workplace, people's creativity will be damaged. To bring innovation to the workplace, employees must be informed that the door is always open for discussion…”
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Measurement and Evaluation of Social Resilience Indicators in the Historical Neighborhoods of Tabriz City (Case Study: Sorkhab Neighborhood of Tabriz) by Leila Rahimi, Mahta Choobineh

“…During natural disasters or other man-made issues, the social damages observed at the neighborhood level and dissatisfaction of residents with social conditions are indicative of the neighborhood's inability to adapt to changes. …”
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Designing a cyber insurance implementation model using foundational data theory by Behzad Esmaeilifar, manouchehr Ansari

“…The experience of dealing with cyber risks, the way of cyber insurance, knowledge of cyber damages, and finally the growth of cyber insurance are factors that can help to increase the understanding and implementation of cyber insurance. …”
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Designing and explaining the policy framework for the development of electric vehicles in Iran by Sayed Abbas Karavand, Yazdan Shirmohamadi, Mohammad Taghi Amini

“…A stable economic system is able to produce goods or services that reduce the external debt of the government and prevent imbalance between different economic sectors, and at the same time, it protects agricultural and industrial products against any damage. According to the environmental perspective, organizations and the environment must work together as a team. …”
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Designing and explaining the improvement model of women's employability capacity with emphasis on the 7th development plan by Mahsa Vahidpour, Akbar Etebarian Khorasgani, Mehrban Hadi Peykani, Saeed Daei-Karimzadeh

“…The axes of public culture enhancement in consolidating Iranian Islamic lifestyle, national identity promotion, national solidarity and trust, women's growth and prosperity, family institution consolidation, social health promotion and social damage prevention are emphasized in this program in order to be properly introduced into macro policies. …”
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A Comparative study of Daiva's Sin and its Evolution in the Stories of Ancient Iran and Ta'ziehs of Daiva's Tying Thumb Based on Six Poetic Verses by Mahdi mohamadi, Adel Meghdadian, Abolfazl Tajik

“…Aži dahāka is a destructive demon and devours a third of the creatures and damages fire, water and plants at the end of the world (Hinnells, 1989, p. 85). …”
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Analytical and Comparative Analysis of Copper Industry Development Programs in Iran by Adel Rouhi Jouybari, Seyed Mohammad Esmaiel Jalali

“…This research has examined the damage and analysis of the strengths and weaknesses of Iran’s copper industry program, reviewed the current situation and copper industry development programs, compared it with India, and addressed the challenges ahead. …”
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Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology by Elliot Gould, Hannah S. Fraser, Timothy H. Parker, Shinichi Nakagawa, Simon C. Griffith, Peter A. Vesk, Fiona Fidler, Daniel G. Hamilton, Robin N. Abbey-Lee, Jessica K. Abbott, Luis A. Aguirre, Carles Alcaraz, Irith Aloni, Drew Altschul, Kunal Arekar, Jeff W. Atkins, Joe Atkinson, Christopher M. Baker, Meghan Barrett, Kristian Bell, Suleiman Kehinde Bello, Iván Beltrán, Bernd J. Berauer, Michael Grant Bertram, Peter D. Billman, Charlie K. Blake, Shannon Blake, Louis Bliard, Andrea Bonisoli-Alquati, Timothée Bonnet, Camille Nina Marion Bordes, Aneesh P. H. Bose, Thomas Botterill-James, Melissa Anna Boyd, Sarah A. Boyle, Tom Bradfer-Lawrence, Jennifer Bradham, Jack A. Brand, Martin I. Brengdahl, Martin Bulla, Luc Bussière, Ettore Camerlenghi, Sara E. Campbell, Leonardo L. F. Campos, Anthony Caravaggi, Pedro Cardoso, Charles J. W. Carroll, Therese A. Catanach, Xuan Chen, Heung Ying Janet Chik, Emily Sarah Choy, Alec Philip Christie, Angela Chuang, Amanda J. Chunco, Bethany L. Clark, Andrea Contina, Garth A. Covernton, Murray P. Cox, Kimberly A. Cressman, Marco Crotti, Connor Davidson Crouch, Pietro B. D’Amelio, Alexandra Allison de Sousa, Timm Fabian Döbert, Ralph Dobler, Adam J. Dobson, Tim S. Doherty, Szymon Marian Drobniak, Alexandra Grace Duffy, Alison B. Duncan, Robert P. Dunn, Jamie Dunning, Trishna Dutta, Luke Eberhart-Hertel, Jared Alan Elmore, Mahmoud Medhat Elsherif, Holly M. English, David C. Ensminger, Ulrich Rainer Ernst, Stephen M. Ferguson, Esteban Fernandez-Juricic, Thalita Ferreira-Arruda, John Fieberg, Elizabeth A. Finch, Evan A. Fiorenza, David N. Fisher, Amélie Fontaine, Wolfgang Forstmeier, Yoan Fourcade, Graham S. Frank, Cathryn A. Freund, Eduardo Fuentes-Lillo, Sara L. Gandy, Dustin G. Gannon, Ana I. García-Cervigón, Alexis C. Garretson, Xuezhen Ge, William L. Geary, Charly Géron, Marc Gilles, Antje Girndt, Daniel Gliksman, Harrison B. Goldspiel, Dylan G. E. Gomes, Megan Kate Good, Sarah C. Goslee, J. Stephen Gosnell, Eliza M. Grames, Paolo Gratton, Nicholas M. Grebe, Skye M. Greenler, Maaike Griffioen, Daniel M. Griffith, Frances J. Griffith, Jake J. Grossman, Ali Güncan, Stef Haesen, James G. Hagan, Heather A. Hager, Jonathan Philo Harris, Natasha Dean Harrison, Sarah Syedia Hasnain, Justin Chase Havird, Andrew J. Heaton, María Laura Herrera-Chaustre, Tanner J. Howard, Bin-Yan Hsu, Fabiola Iannarilli, Esperanza C. Iranzo, Erik N. K. Iverson, Saheed Olaide Jimoh, Douglas H. Johnson, Martin Johnsson, Jesse Jorna, Tommaso Jucker, Martin Jung, Ineta Kačergytė, Oliver Kaltz, Alison Ke, Clint D. Kelly, Katharine Keogan, Friedrich Wolfgang Keppeler, Alexander K. Killion, Dongmin Kim, David P. Kochan, Peter Korsten, Shan Kothari, Jonas Kuppler, Jillian M. Kusch, Malgorzata Lagisz, Kristen Marianne Lalla, Daniel J. Larkin, Courtney L. Larson, Katherine S. Lauck, M. Elise Lauterbur, Alan Law, Don-Jean Léandri-Breton, Jonas J. Lembrechts, Kiara L’Herpiniere, Eva J. P. Lievens, Daniela Oliveira de Lima, Shane Lindsay, Martin Luquet, Ross MacLeod, Kirsty H. Macphie, Kit Magellan, Magdalena M. Mair, Lisa E. Malm, Stefano Mammola, Caitlin P. Mandeville, Michael Manhart, Laura Milena Manrique-Garzon, Elina Mäntylä, Philippe Marchand, Benjamin Michael Marshall, Charles A. Martin, Dominic Andreas Martin, Jake Mitchell Martin, April Robin Martinig, Erin S. McCallum, Mark McCauley, Sabrina M. McNew, Scott J. Meiners, Thomas Merkling, Marcus Michelangeli, Maria Moiron, Bruno Moreira, Jennifer Mortensen, Benjamin Mos, Taofeek Olatunbosun Muraina, Penelope Wrenn Murphy, Luca Nelli, Petri Niemelä, Josh Nightingale, Gustav Nilsonne, Sergio Nolazco, Sabine S. Nooten, Jessie Lanterman Novotny, Agnes Birgitta Olin, Chris L. Organ, Kate L. Ostevik, Facundo Xavier Palacio, Matthieu Paquet, Darren James Parker, David J. Pascall, Valerie J. Pasquarella, John Harold Paterson, Ana Payo-Payo, Karen Marie Pedersen, Grégoire Perez, Kayla I. Perry, Patrice Pottier, Michael J. Proulx, Raphaël Proulx, Jessica L Pruett, Veronarindra Ramananjato, Finaritra Tolotra Randimbiarison, Onja H. Razafindratsima, Diana J. Rennison, Federico Riva, Sepand Riyahi, Michael James Roast, Felipe Pereira Rocha, Dominique G. Roche, Cristian Román-Palacios, Michael S. Rosenberg, Jessica Ross, Freya E. Rowland, Deusdedith Rugemalila, Avery L. Russell, Suvi Ruuskanen, Patrick Saccone, Asaf Sadeh, Stephen M. Salazar, Kris Sales, Pablo Salmón, Alfredo Sánchez-Tójar, Leticia Pereira Santos, Francesca Santostefano, Hayden T. Schilling, Marcus Schmidt, Tim Schmoll, Adam C. Schneider, Allie E. Schrock, Julia Schroeder, Nicolas Schtickzelle, Nick L. Schultz, Drew A. Scott, Michael Peter Scroggie, Julie Teresa Shapiro, Nitika Sharma, Caroline L. Shearer, Diego Simón, Michael I. Sitvarin, Fabrício Luiz Skupien, Heather Lea Slinn, Grania Polly Smith, Jeremy A. Smith, Rahel Sollmann, Kaitlin Stack Whitney, Shannon Michael Still, Erica F. Stuber, Guy F. Sutton, Ben Swallow, Conor Claverie Taff, Elina Takola, Andrew J. Tanentzap, Rocío Tarjuelo, Richard J. Telford, Christopher J. Thawley, Hugo Thierry, Jacqueline Thomson, Svenja Tidau, Emily M. Tompkins, Claire Marie Tortorelli, Andrew Trlica, Biz R. Turnell, Lara Urban, Stijn Van de Vondel, Jessica Eva Megan van der Wal, Jens Van Eeckhoven, Francis van Oordt, K. Michelle Vanderwel, Mark C. Vanderwel, Karen J. Vanderwolf, Juliana Vélez, Diana Carolina Vergara-Florez, Brian C. Verrelli, Marcus Vinícius Vieira, Nora Villamil, Valerio Vitali, Julien Vollering, Jeffrey Walker, Xanthe J. Walker, Jonathan A. Walter, Pawel Waryszak, Ryan J. Weaver, Ronja E. M. Wedegärtner, Daniel L. Weller, Shannon Whelan, Rachel Louise White, David William Wolfson, Andrew Wood, Scott W. Yanco, Jian D. L. Yen, Casey Youngflesh, Giacomo Zilio, Cédric Zimmer, Gregory Mark Zimmerman, Rachel A. Zitomer

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Improving the experience of health services for trans and gender-diverse young people and their families: an exploratory qualitative study by Melissa Stepney, Samantha Martin, Magdalena Mikulak, Sara Ryan, Jay Stewart, Richard Ma, Adam Barnett

“…All young people spoke about the wider trans-hostile environment in the UK and how they felt the circulation of harmful and damaging media stories influenced the care that they received. …”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…In this scenario, a placebo is not suspected to cause damage and the available treatment is meant for mild conditions that pose low-risk adverse effects, which is said to justify its use. …”
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The Bioethics-CSR Divide by Caio Caesar Dib

“…These spheres should develop “reflexion mechanisms” that enable the exchange of their social knowledge and provide effective, non-damaging solutions to social issues. See Gunther Teubner, “Substantive and Reflexive Elements in Modern Law,” Law & Society Review 17, no. 2 (1983): 239–85, https://doi.org/10.2307/3053348. …”
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