Effect of Electroacupuncture Preconditioning on Inflammatory Factors of Rabbits after Spinal Cord Ischemia-Reperfusion Injury by Mengli YAO, Xianghua CHEN, Zhaohui CHEN, Hai WANG

“…Objective:To observe the effects of electroacupuncture preconditioning on the pathological changes of spinal cord tissue and the expression of inflammatory cytokines such as interleukin-1β(IL-1β), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), interleukin-1 receptor antagonist(IL-1Rα)after spinal cord ischemia-reperfusion injury, and to explore the protective mechanism of electroacupuncture on spinal cord ischemia-reperfusion injury in rabbits.Methods:A total of twenty-four New Zealand white rabbits were randomly divided into the sham operation group, the model group and the electroacupuncture group according to the random number table method, with eight cases in each group.The model was made by Zivin method in the model group and the electroacupuncture group, the abdominal cavity was opened after intravenous anesthesia at ear margin, the abdominal aorta was exposed and temporarily clamped, and the rabbit model of spinal cord ischemia-reperfusion injury was established after ischemia for thirty minutes.The model preparation and experimental animal treatment of the sham operation group were the same as those of the model group, however, the dissection was fully exposed without clamping the abdominal aorta.At thirty minutes before the induction of rabbit spinal cord ischemia-reperfusion model, SDZ-II electroacupuncture instrument was used to acupuncture bilateral"Xuanzhong"and"Yanglingquan"acupoints in the electroacupuncture group, intervention for thirty minutes.All rabbits were killed after intervention for twelve hours, and the L2-5 segments of spinal cord tissue were captured.HE staining method was used to observe the pathological changes of spinal cord tissues in the three groups; Immunohistochemical method was used to observe the localization and content changes of IL-1β, IL-6 and TNF-α; Enzyme-linked immunosorbent assay(ELISA)was used to detect the contents of IL-1β, IL-6, TNF-α and IL-1Rα in serum before modeling and 4, 8, 12 hours after ischemia-reperfusion.Results:①HE staining results: compared with the sham operation group, the number of neurons in spinal cord tissue in the model group decreased, the color of nucleus and cytoplasm of cells became lighter, and the boundary of nuclear membrane was not clear.In severe cases, the nucleus dissolved or even nucleolus disappeared, there were transparent areas around cells, and axons showed different degrees of degeneration such as enlargement, swelling and disappearance; compared with the model group, the number of neurons in the electroacupuncture group increased, the structure of most neurons was clear, the atrophy degree of nucleolus and nucleus was light, only a small amount of cells became deformed and necrosis, the damage degree of cells were lighter, and the density of surviving neurons increased.②Immunohistochemistry results: compared with the sham operation group, the expressions of IL-1β, IL-6 and TNF-α of spinal cord tissue in the model group were significantly increased(<italic>P</italic>&lt;0.05);compared with the model group, the contents of IL-1β, IL-6 and TNF-α in the spinal cord of rabbits in the electroacupuncture group were significantly decreased(<italic>P</italic>&lt;0.05).③ELISA results: Before modeling, there was no significant difference in the three groups(<italic>P</italic>&gt;0.05);compared with before modeling, the expressions of IL-1β, IL-6, TNF-α, IL-1Rα in serum of the three groups increased in different degrees at 4, 8 and 12 h after ischemia-reperfusion, with significantly significance(<italic>P</italic>&lt;0.05);compared with the sham operation group at the same time, the expressions of IL-1β, IL-6, TNF-α and IL-1Rα in the model group increased significantly at 4, 8 and 12 h after reperfusion(<italic>P</italic>&lt;0.05);compared with the model group at the same time, the expression of IL-1β and TNF-α in the electroacupuncture group decreased significantly at 4, 8, 12 h after reperfusion(<italic>P</italic>&lt;0.05).Conclusion:Electroacupuncture pretreatment can effectively alleviate the pathological injury of spinal cord and has a good protective effect on spinal cord ischemia-reperfusion injury, which may be related to inhibit the expression of IL-1β, IL-6 and TNF-α and promote the expression of IL-1Rα.…”
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Hubungan Risiko Tsunami terhadap Tingkat Ansietas pada Anak-anak di SDN 02 Ulak Karang Selatan (Zona Merah) dan SDN 33 Kalumbuk (Zona Hijau) by Septia Endike, Yaslinda Yaunin2 , Rima Yaunin, Rima Semiarty

“…For those who survived at the tsunami attack, it is not only a physical and property damage, but rather on the mental trauma that is not easily forgotten and can lead to mental disorders such as anxiety. …”
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Editorial by Zulmar Fachin

“…Diante da imensa contribuição acadêmica recebida, o IDCC enaltece os seus Membros Honorários: Alberto de Paula Machado (OAB Nacional), Carlos Mário da Silva Velloso (STF), Dalmo de Abreu Dallari (USP), Flávio Pansieri (ABDConst), Francesco Rubino (Itália), Francisco Rezek (STF), Gonçalo de Melo Bandeira (Portugal), José Augusto Delgado (STJ), J. …”
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Doctrinal Approaches on determining the Content of Intellectual Property Right by O. V. Pikhurets, A. O. Pikhurets

“…Personal non-property copyrights do not have economical content, are not negotiable, despite the existence of a legal norm on compensation for non-pecuniary damage due to the violation of personal rights. …”
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Maroteaux-Lamy综合征的ARSB基因分析及新突变的致病性鉴定 by 郭东炜, 潘伟绵, 杜敏联, 郭奕斌

“…2）新突变鉴定结果：对正常ARSB酶蛋白和p.S94L突变酶蛋白的空间构 象的预测比对结果显示，两者有明显区别；跨物种保守性分析结果显示， p.94突变点所在氨基酸（S）在物种进化 过程中具有高度保守性；PROVEAN、SIFT和PolyPhen-2软件对p.S94L预测结果分别为：Deleterious、Damaging和 Probablydamaging。用上述方法对p.S460F的预测结果及ACMG的综合分析结果也显示该突变可能是致病性 的。…”
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İstanbul Tavrı Kur’ân-I Kerîm Tilâvetinde Kerim Öztürk’ün Kırâati Çerçevesinde Fatiha Sûresi; Makam Analizleri ve Notasyon by Esra Yılmaz

“…Tıpkı mimarideki gibi, damak tadını oluşturan mutfak kültürü gibi sesleri ve seslerle oluşan daha büyük ses kümelerinin (makamlar ve bu makamlara bağlı olarak kullanılan müzik cümlelerinin) geçmişten günümüze meşk usulüyle aktarılmış olan İstanbul coğrafyasındaki şeklinin kullanılmasıyla bu hissiyat oluşur. …”
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Protective Mechanism of Alisol A 24-Acetate on Brain Microvascular Endothelial Cells in Mice with Cerebral Ischemia-Reperfusion Injury by TRPM2/Akt/GSK3β Pathway by LI Huihong, DENG Yunfei, WEI Wei, ZHAN Zengtu, LIN Libin, XUE Xiehua

“…Compared with the model group, the expression levels of p-NF-κB, IL-1β, TNF-α and TRPM2 of the 24A group significantly decreased, while the expression levels of p-Akt and p-GSK3β significantly increased (<italic>P</italic>&lt;0.05).Conclusion24A can effectively improve the neurological function and cognitive function, reduce inflammatory response and ameliorate BMECs damage of CI/RI mice, which may be related to the regulation of TRPM2/Akt/GSK3β pathway.…”
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Effects of Exercise Preconditioning Mediating Oxidative Stress to Regulate PI3K/Akt and Nrf2/HO-1 Pathways to Alleviate Cognitive and Learning Disorders in Rats by KONG Haijun, LI Xinlong, WANG Fenghua, CHEN Xiaoan

“…Serum MDA content, IL-1β, IL-6 and TNF-α levels significantly decreased (<italic>P</italic>&lt;0.05), while SOD and GSH activities significantly increased (<italic>P</italic>&lt;0.05). The damage of neurons in CA1 region was reduced and the number of Nissl corpuscles increased. …”
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A comparative study on disinfection effect of three different disinfectants for oral dental chair water lines (三种不同消毒剂对口腔综合治疗台水路消毒效果的比较)... by WANG Wenjuan (王文娟), LI Yajuan (李雅娟), LI Pei (李培), KONG Li (孔莉), WANG Ting (王婷)

“…Long-term use causes irreparable damage to the inner wall of the pipeline. Silver ionic disinfectant with 60 g/L hydrogen peroxide was optimal in controlling the total number of bacterial colonies and inhibiting bacterial growth time in oral dental chair water lines (DUWLs). …”
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Analysis of the Rights and Obligations of Stakeholders in China’s National Park Concession System by Le ZHONG, Zhicong ZHAO

“…For concessionaires, the ideal state encompasses comprehensive rights as delineated by the Administrative License Law of the People’s Republic of China and associated regulations, including the right to operate without interference, access to policy support, and claim compensation for damage to legal rights and interests. However, the prevailing reality reveals an incomplete scope of these rights across various national parks and pilot national parks, with some failing to adequately safeguard the concessionaire’s rights. …”
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KORELASI BODY MASS INDEX (BMI) DENGAN VO2MAX PADA ATLET SEMI-PROFESIONAL FUTSAL KOTA BLITAR by Lawrenza Berliana Dwi Saputri, Trinovandhi Setyawan, Muhammad Nidomuddin, Hari Pamungkas, Shoffurijal Agyanur, Ashari Husen

“…Jurnal Keperawatan Dan Fisioterapi (Jkf), 6(2), 330–336. https://doi.org/10.35451/jkf.v6i2.2116 Navarro, Vicente Torres, Granell, José Campos, Malavés, R. A. (2017). Influence of fat mass for the VO2max and ventilatory thresholds in young athletes of endurance sport specialties. …”
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Neuroprotective Effect of Crocin on Rats with Focal Cerebral Ischemia-Reperfusion Injury Based on TLR4/NF-κB Pathway by LI Xiaolei, ZHU Haisheng, MA Ruijuan, HU Ke, FENG Lina, WANG Xudong

“…Compared with the sham operation group, the apoptosis index of cortical neurons in the model group increased significantly (<italic>P</italic>&lt;0.05); compared with the model group, the apoptosis index of cortical neurons in the crocin groupand the crocin + lipopolysaccharide group decreased significantly (<italic>P</italic>&lt;0.05); compared with the crocin group, the apoptosis index of cortical neurons in the crocin + lipopolysaccharide group increased significantly (<italic>P</italic>&lt;0.05).(3) Inflammatory factor level: compared with the sham operation group, the level of TNF-α, IL-1β, IL-6 in the model group increased significantly (<italic>P</italic>&lt;0.05); compared with the model group, the level of TNF-α, IL-1β, IL-6 in the crocin group and the crocin + lipopolysaccharide group decreased significantly (<italic>P</italic>&lt;0.05);compared with the crocin group, the level of TNF-α, IL-1β, IL-6 in the crocin + lipopolysaccharide group increased significantly (<italic>P</italic>&lt;0.05). (4) Expression of proteins: compared with the sham operation group, the expression of TLR4, Cleved Caspase-3 and the ratio of p-NF-κB p65/NF-κB p65, p-IκBα/IκBα, Bax/Bcl-2 in the model group increased significantly (<italic>P</italic>&lt;0.05); compared with the model group, the expression of TLR4, Cleved Caspase-3 and the ratios of p-NF-κB p65/NF-κB p65, p-IκBα/IκBα, Bax/Bcl-2 in the crocin group and the crocin + lipopolysaccharide group decreased significantly (<italic>P</italic>&lt;0.05); compared with the crocin group, the expression of TLR4, Cleved Caspase-3 and the ratios of p-NF-κB p65/NF-κB p65, p-IκBα/IκBα, Bax/Bcl-2 in the crocin + lipopolysaccharide group increased significantly (<italic>P</italic>&lt;0.05).ConclusionCrocin can inhibit the inflammatory reaction and cortical neurons apoptosis in FCIR rats, and reduce the damage of cortical neurons. The mechanism may be related to the inhibition of TLR4/NF-κB pathway activation.…”
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Editorial by Jörg Tremmel, Edward Page, Konrad Ott

“…Objections of compensatory (or historical) injustice rest upon the identification of distinct groups of descendants, at least one injured party and at least one causer of the damage; whereas intergenerational justice typically focuses on the way in which inequitable acts or social policies affect the well-being of a typical member of a subsequent generation. …”
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Effect of the Iridoid-rich Fraction from <italic>Valeriana jatamansi</italic> Jones on Oxidative Stress in Rats with Spinal Cord Injury by Jiaojuan HUANG, Wenchun WANG, Deqi XIONG, Hao LU, Wu XIANG, Xiaohua ZHAO, Ruihan ZHOU, Anren ZHANG

“…The results of the HE staining showed that the structure of gray matter and white matter of the spinal cord tissue in the sham-operated group were normal at the perilesional area, the structure of the neurons was also clear, and no significant spinal cord injured was found; compared with the sham-operated group, the spinal cord structure was severely damaged in the model group: the gray matter of the central part of the spinal cord and the white matter of the surrounding part of the spinal cord turned into blur because of injury and a large number of neurons degenerated, a number of nerve cells even appeared necrosis, and the cell structure was seriously destroyed at the same time, and in addition, the nuclear turned into shrinkage or dissolution and passed away, accompanying with varying degrees of neutrophil infiltration and a large number of microglia proliferation; compared with the model group, the spinal cord structure of the treatment group with iridoid-rich fraction from <italic>Valeriana jatamansi</italic> Jones significantly improved, and there were only small areas presenting a neuronal necrosis, a small amount of eosinophils increasing and a small number of eosinophils microglia infiltration in the spinal cord tissue at the perilesional area, and at the same time, the histopathological scores in tissue sections were lower(<italic>P</italic>&lt; 0.05). …”
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Pattern of Professional Development of Human Resources of Knowledge-based Companies(Study case: Science and Technology Park of Iranian Research Organization for Science and Technol... by Bijan Abdollahi, Jafar Salemi, hasan zeinabadi, ghasem Ramezanpour nargesi

“…For growth and excellence, the factors affecting it must be identified and managed (Hult et al, 2004) and if these factors are not known, the nature of the process will be damaged and the resources, efforts, time and money that have been spent will be wasted (Park et al). , 2019). …”
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Analysis of Verena Klemm's Portrayal of the Personality of Hazrat Fatima (PBUH) by Shahla Bakhtiari, Mahdieh Poursaleh Kachomesghali

“…Neglecting these things will cause problems and damage to the research. Therefore, to analyze Klemm's concept, her sources, the appropriateness of the topic, her attention to historical and hadith reports, and her consideration of the religious vision of the text have been examined by citing examples.Discussion of Results and ConclusionThe analysis of Klemm's research concepts and sources regarding the personality of Hazrat Fatima (PBUH) shows that her analysis is not correct. …”
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Features of surgical treatment for gunshot wounds of the heart and great vessels with migration of foreign bodies by I.A. Lurin, E.M. Khoroshun, V.V. Makarov, V.V. Nehoduiko, O.V. Buchnieva, I.V. Veryovkin

“…According to the place of the beginning of the foreign body migration through the vascular bed, cases with damage to the heart and the inferior vena cava predominate. …”
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Rome à la campagne : les décors en pierre de la villa de la Grande Boussue à Nouvelles (Mons, Belgique) by Catherine Coquelet, Roland Dreesen, Éric Goemaere, Éric Leblois, Marie-Thérèse Raepsaet-Charlier

“…In northern Gaul, a few analogous fragments have been found in the 2nd-3rd century domus discovered during excavations in the Notre-Dame basilica in the capital of Tongeren (Belgium), in the 4th-century basilica of Trier and in the wall revetments of the Palatiolum (in Pfalzel, Germany). …”
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Iconic Celebration of Charms and Friendship in Poetry: Fálétí’s “Adébímpé Ọ̀jẹ́dòkun” by Michael Oladejo Afoláyan

“…It was there he disclosed to them that the earlier nervous hunter did a fatal damage to him because when the hunter shot the leopard nervously, he missed the target but hit Adébímpé. …”
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Une pompe hydraulique romaine en bois en contexte d’incendie à Reims/Durocortorum by Cyril Driard

“…The two-cylinder force wooden water pump was used, damaged and discarded in the well during this disaster. …”
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