Clinical and endoscopical and morphofunctional scores in evaluation of development of gastroesophageal reflux disease in various age groups by M. A. Osadchuk, A. M. Zolotovitskaya, N. V. Kireyeva, S. N. Nikolenko, I. M. Kvetnoy

“…It results in more severe damage of esophageal mucosa with development of erosive esophagitis and extraesophageal manifestations. …”
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<i>Cichorium intybus</i> L. Oligo-Polysaccharides (CIO) Exerts Antianxiety and Antidepressant Effects on Mice Experiencing Behavioral Despair and Chronic Unpredicted Mild Stress by Yanqin Luo, Xueyi Bei, Yiwen Zhang, Xinran Sun, Yongzhi Zhao, Fang Chen, Ruile Pan, Qi Chang, Qinghu He, Xinmin Liu, Ning Jiang

“…Moreover, CIO therapy was facilitated by increasing the 5-HT content, alleviating the damage of hippocampal neurons, and upregulating the BDNF/ERK and PI3K/AKT/mTOR cascade. …”
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Perancangan Rencana Pemulihan Bencana Menggunakan NIST SP 800-34 Rev 1, NIST SP 800-53 Rev 5 dan SNI 8799 (Studi Kasus: Unit TI XYZ) by Hafizh Ghozie Afiansyah, Septia Ulfa Sunaringtyas, Amiruddin Amiruddin

“…According to Government Regulation Number 71 of 2019, to overcome the impact of service loss in data centers caused by disasters and threats, it is necessary to have a plan that aims to prevent loss and damage, namely a disaster recovery plan or DRP. This is supported by questionnaires and interviews with structural officials, unit heads, and students of the XYZ Institute, which state that services managed by the IT Unit XYZ are vital for the business processes of lectures, general administration, and student affairs. …”
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LncRNA LUCAT1 offers protection against human coronary artery endothelial cellular oxidative stress injury through modulating hsa-miR-6776-5p/LRRC25 axis and activating autophagy f... by Yanjun Wang, Xin Zhang, Mengmeng Ren, Shu He, Hengjie Bie, Mengyang Duan, Zhiyuan Chen, Qiaowei Jia, Boyu Chi, Xiongkang Gan, Chengcheng Li, Yahong Fu, Hanxiao Zhou, Sheng Zhang, Qian Zhang, Fenghui An, Xiumei Chen, Enzhi Jia

“…Results (1) The expression of LC3, Beclin1, ATG5, and ATG7 demonstrated a consistent decline whereas p62 expression exhibited an opposite increase as atherosclerosis progressed; (2) Autophagy levels was significantly elevated in HCAECs under oxidative stress, while inhibition of the initial stage of autophagy with 3-MA exacerbated cellular damage; (3) The lncRNA LUCAT1/hsa-miR-6776-5p/LRRC25 axis was established through bioinformatic prediction and validated by dual-luciferase reporter assay, which resulted in a significant decrease in autophagy levels in HCAECs; (4) In total, p62, ATG7, lncRNA LUCAT1 and LRRC25 were validated as robust diagnostic biomarkers for CAD. …”
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Nonspecific response of Lake Baikal phytoplankton to anthropogenic impact by A. A. Nikonova, S. S. Vorobyeva

“…This confirms cell membrane damages. In Lake Baikal surface water, we found a higher content of synthetic anionic surfactants (sodium alkylbenzene sulfonates), which are components of detergents and cause oxidation stress of hydrobionts (up to 30 ± 4 μg·L–1). …”
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Dispersion modelling of particulate matter concentrations of sand product plants in a mineral complex by Y. Zehtab Yazdi, N. Mansouri, F. Atabi, H. Aghamohammadi

“…PM2.5 and PM10 resulting from the sand and gravel mining activities could damage the workers in the mineral complex. They exceeded the 24-hour average permissible limits proposed by the United States Environmental Protection Agency about 1 and 33 µg/m3, respectively. …”
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Inhibitory potential of probiotic spore formers grown as mono- and mix-cultures under conditions of different nutrient availability by O. V. Knysh, A. V. Martynov, T. P. Osolodchenko

“…Spore-forming probiotics, due to their high resistance to damaging environmental factors, stand out among other beneficial microorganisms and, therefore, deserve special attention. …”
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Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in strokeResearch in context by Wenqian Liu, Mo Yang, Nanxing Wang, Xiangrong Liu, Chaoyu Wang, Kaibin Shi, Fu-Dong Shi, Yuesong Pan, Mingjun Zhang, Zhiwei Sun, Yongjun Wang, Yilong Wang

“…Funding: This study was supported by The National Natural Science Foundation of China (No. 82425101); Beijing Municipal Science &amp; Technology Commission (No. Z231100004823036); Capital's Funds for Health Improvement and Research (2022-2-2045); National Key Research &amp; Development Program of China (2022YFF1501500, 2022YFF1501501, 2022YFF1501502, 2022YFF1501503, 2022YFF1501504, 2022YFF1501505).…”
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Selective micropulse individual retinal therapy in the navigation- guided treatment for central serous chorioretinopathy with parameter selection by preliminary testing by P.L. Volodin, E.V. Ivanova

“…According to the computer simulation, this mode implies selective destruction of the retinal pigment epithelium with minimal damage to the neurosensory retina and choroid. Parameters were customized for each patient by preliminary testing and evaluation of the results by short-wavelength fundus autofluorescence (488 nm). …”
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Potensi Terapi Fitokanabinoid Mayor dalam Pengobatan Cedera Otak Traumatik: sebuah Tinjauan Literatur Farmakologis by Arief Gunawan Darmanto

“…These major phytocannabinoids are known to influence cannabinoid receptors (CB1 and CB2), which play roles in modulating inflammatory processes, reducing neuronal damage, improving motor and cognitive functions, and regulating recovery mechanisms in the blood-brain barrier and intracranial lymphatics. …”
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A socio-ecological model of the management of leprosy reactions in Indonesia and India using the experiences of affected individuals, family members and healthcare providers by Annisa Ika Putri, Ruth M. H. Peters, Kevin De Sabbata, Brittney S. Mengistu, Regitta I. Agusni, Medhi Denisa Alinda, Joydeepa Darlong, M. Yulianto Listiawan, Cita R. S. Prakoeswa, Stephen L. Walker, Marjolein B. M. Zweekhorst

“…Abstract Background Leprosy reactions (LR) are immune-mediated complications of leprosy that may be associated with severe and irreversible nerve damage. Non-medical aspects, such as financing, service provision, and healthcare resources in the management of LR are generally overlooked as studies tend to concentrate on clinical features and treatment. …”
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The Effect of Cirata Reservoir Sediment on Early Developmental Stage of Common Carp (Cyprinus carpio) Embryo by Yuni Pujihastuti, K. Nirmala, I. Effendi

“…Higher sediment supernatant concentration also resulted in lower hatching percentage of common carp larva. The damage of eggs and larval morphologies in treatments with sediment supernatant was likely caused by the presence Pb and organic matters which act in synergy. …”
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Different rs-fMRI Data Processing Methods in the Study of Vascular Cognitive Impairment by Ying GUAN, Luwen ZHU, Feng WANG, Danna CAO, Xiaoling LI, Qiang TANG

“…Vascular cognitive impairment(VCI)refers to dementia associated with small vessel damage caused by long-term hypertension, diabetes, hyperlipidemia and other cerebrovascular risk factors. …”
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القواعد الناظمة لشركة المضاربة بين النظرية والتطبيق القضائي: دراسة مقارنة بين القانونين الفلسطيني والأردني... by Anas Abu Musa Aloun

“…The research aimed to know the position of the judiciary from the multiple problems raised by the provisions of this contract from its validity, adaptation, distinction from other contracts and termination, and the researcher followed to reach the desired goal an analytical and comparative approach between Palestinian and Jordanian law, and concluded that there are basic controls that must be adhered to by contractors when concluding a speculative contract otherwise invalidity or corruption or conversion of contract into work or lease contract will result, as well as taking into account specific controls when terminating otherwise bearing responsibility for damage by arbitrary termination.   الملخص إن عقد المضاربة من العقود الشائعة في الواقع العملي، حيث يلجأ شخص يملك رأس مال نقدي أو غيره  من الاثمان إلى تاجر ويسلمه رأس المال هذا من أجل تنميته واستثماره، والسبب في قيام هذا العقد إما ان يكون عدم معرفة صاحب رأس المال بالتجارة ويسعى الى تحقيق الربح والاستثمار، أو أنه يريد أن يزيد مداخيله دون أن يبذل مجهود، ونكون هنا أمام نوع من أنواع الشركات ولكن هذه الشركة ذات طبيعة خاصة لا تخضع للقواعد المنصوص عليها في قرار بقانون المتعلق بالشركات 42 لسنة 2021، وانما تخضع لقواعد القانون المدني. …”
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Estudio genético en adultos con glomeruloesclerosis focal y segmentaria by Melissa Pilco-Terán, Amir Shabaka, Mónica Furlano, Ana Tato Ribera, Isabel Galán Carrillo, Eduardo Gutiérrez, Roser Torra, Gema Fernández-Juárez

“…Massive sequencing techniques have revolutionized genetic diagnosis, allowing the identification of more than 60 genes responsible for podocyte damage. This document proposes clinical recommendations for carrying out genetic studies in adults with FSGS, highlighting the need for a correct classification for adequate therapeutic planning and improvement of results in clinical trials.…”
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Mechanism of Electroacupuncture Quchi (LI 11) -Yanglingquan (GB 34) in Rats with Spasticity of Cerebral Apoplexy by Bin GUO, Penghan WANG, Linxing HUANG, Zhiqiang XIE, Lina XIE, Weiai LIU, Lizhen YI, Xin LIU, Zenghui YUE

“…Besides, the number of synaptic vesicles was significantly reduced, the density uneven, the terminal cytoplasm of the postsynaptic cells severely damaged, and the dense density of postsynaptic bands decreased; The electroacupuncture group was denser than the model group, and the synaptic shape was closer to the sham operation group. …”
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Influence law and control mechanism of coal seam permeability on coal and gas outburst by Chaolin ZHANG, Mingliang LIU, Enyuan WANG, Peizhong WANG, Qiaozhen JIANG, Wei ZENG

“…At the same time, the seepage force near the exposed surface is low and quickly transfers to the distant location, unable to further damage the exposed coal seam, resulting in the decrease of outburst strength or even no outburst. …”
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Major facility superfamily sugar transporter protein SsMFSST1 regulates Sporisorium scitamineum mating, pathogenicity, and sugar transport/absorption by Yi Zhang, Yongding He, Meixin Yan, Shilong Zhang, Sisi Zhou, Wankuan Shen

“…Therefore, we speculate that the SsMFSST1 gene may regulate the expression of key genes related to the synthesis pathway of the small molecule signaling substance cAMP or tryptophol, affecting the synthesis of the signaling substance cAMP or tryptophol, thereby affecting the sexual mating and pathogenicity of S.scitamineum. …”
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Identification and characterization of Serratia nematophila and Acinetobacter guillouiae from putrid-skin disease lesions in farmed Chinese spiny frog (Quasipaa spinosa) by Ling Guo, Xiyu Jin, Dan Yang, Li Wei, Jie Chen, Zhihua Lin, Li Ma

“…Histopathological examinations demonstrated that both strains induced hepatocellular damage, nuclear alterations, muscular atrophy, myofibrillar degeneration, and intestinal necrosis. …”
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Effect of Propionic Acid on Diabetes-Induced Impairment of Unfolded Protein Response Signaling and Astrocyte/Microglia Crosstalk in Rat Ventromedial Nucleus of the Hypothalamus by Larysa V. Natrus, Yulia S. Osadchuk, Olha O. Lisakovska, Dmytro O. Labudzinskyi, Yulia G. Klys, Yuri B. Chaikovsky

“…We found T2DM-associated enlargement of ER cisterns, while drug administration slightly improved VMH ultrastructural signs of damage. GRP78 level was 2.1-fold lower in T2DM vs. control. …”
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